Gene 22244 (Tetrahymena)

22244

Species: Tetrahymena
Alias: TTHERM_00217180, PreTt22244, 18.m00270, 22244, 514, 3701.m00031
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: SRPK

Sequence

Name Sequence Type Origin Length Description Download
22244.AA Protein None 785 None Fasta, JSON
22244.kin_dom Protein Kinase Domain None 575 None Fasta, JSON
22244.NA RNA None 2358 None Fasta, JSON

Protein domain

Protein domains of 22244.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 22244.AA SRPK 97-671 45 0.0 1095.23 In-house 1-554 (554) Show / Hide 
Range on Protein: 97-671
Range on HMM: 1-554/554
Sequence Identity: 45% (276 aa)

YVIIQKLGWGHFSTVWLSKDFKYDTYVALKIQKSAPHYLEAAYDEVEILQKVAKQASNPQWIHQLKEYYKDQTRSAKQNENSDRAISKRFYKQAATALIT
|..|.||||||||||||..|..||.|||.||.||||||.|.|.||...||.|.|...||||.|.|||||.|..|                          
YHVIRKLGWGHFSTVWLCWDMQYDRYVAMKIVKSAPHYTETAVDEIKLLQCVRKHDPNPQWMHFLKEYYEDYKR--------------------------

KKQKKQIIYNLKLKITKQLNKPLNDKQKKTFTRDDCQVVQLLNSFVFRGPYGNHFCMVFEILGVNLLEIIKRYNYKGIPMHLARIIAKQVLIGLDFLHRY
                          ..|.|....|.|||||..|..|||.|||.|||||.||.|||..||.|||.|.|||....||.|||||||.|||.
--------------------------DCKEFDPNRCHVVQLLDHFKHRGPNGNHYCMVFEVLGHNLLKWIKHYNYQGMPMHCVKQIARQVLIGLDYLHRK

CGVIHTDLKPENVLLCLTQEEIKAHGIKIDEVPILDPQEEQKQNGHSQKENHSNCNGQQKTDSQNQSAQNPNPQKQEQNDKNNLASKQEQDQQNEDEDDN
||.||||.||||||||..|..||.......|... ..|................|..|...............|.|||..||. ...|..|.||..||.|
CGIIHTDIKPENVLLCVNQDYIKRMAAEWTEWQKMGMQMPSSSMVQTAPQHQTQCQQQKMSKNKKKKMKKKQKQQQEQQEKNQQQKQQMEDDQNDNEDNN

DNDNDDEQEEGATSTAASNQNNQGDKKNLTKKQKKNQRRKAAHKRKKQREKEEKNKQTND-------------------------------QDSNKQQNN
..|||.||..........|..|....|..|.||||||..|..||.||..|.....||.||                               |||.||||.
QEDNDNEQDNKNNQNQENNMENEQEEKENTNKQKKNQKKKEQHKDKKEQECQNVQKQNNDPNFESQNDSQMEQETNSCNNQEHKQEKTMQCQDSTKQQNK

LNDKQAEGQKQQIEEEVKEEDIPEEIRYKFDNWN--GRGDRLQTNVRVKIADLGNACWTHHHFATEIQTRQYRSPETIIGVHYDTTADVWSFACMIFEML
. |.|.|||||..|.|...||..|. ..||..|.  .|...|......||||||||||.||||...||||||||||.|||..|.|.||.||.|||.||..
Q-DQQKEGQKQSEESECESEDMQEQ-AGKFLVWWKNPRNADLDHKIKIKIADLGNACWVHHHFTEDIQTRQYRSPEVIIGAGYNTPADIWSTACMAFELA

TGDFLFEPRKGPNFSKNDDHIAQIQELCNKFTKKFALSGFKSKKYFDKQGNLRRIPSLHYWPLLNVLIEKYHFKEEEAKLFDEFMQVMLKTNPLDRASAH
|||.||||..|...|..|||||.|.|||.|....|||||..|...|.|.|.||.||.|..|||.|||||||....|||| |..|...||..||..||.|.
TGDYLFEPHSGEDYSRDDDHIAHIIELCGKIPWHFALSGKYSREFFNKKGELRHIPKLKPWPLMNVLIEKYEWSHEEAKQFEDFLMPMLHYNPEKRATAK

ECLQTKWI
||||..|.
ECLQHPWL
Kinase 22244.AA CMGC 97-671 13 3.1e-100 330.11 In-house 1-513 (513) Show / Hide 
Range on Protein: 97-671
Range on HMM: 1-513/513
Sequence Identity: 13% (102 aa)

YVIIQKLGWGHFSTVWLSKD--------------FKYDTYVALKIQKSAPHYLEAAY-------------DEVEILQKVAKQASNPQWIHQLKEYYKDQT
| ||.|.|.|....|.  .|               ... .||.|. |... | | |              .|..||... |.  . .|           .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NW-----------Q

RSAKQNENSDRAISKRFYKQAATALITKKQKKQIIYNLKLKITKQLNKPLNDKQKKTFTRDDCQVVQLLNSFVFRGPYGN-------------HFCMVFE
|                                                    . ... ...  .|.|...|..... ||             |...|||
RR---------------------------------------------------D-DPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFE

ILGVNLLEIIKRYN--YKG------------------------IPMHLARIIAKQVLIGLD--FLHRYCG-VIHTDLKPENVLLCLTQEEIKAHGIKIDE
 .. .|...||...  |.|                        ... . | ...|.| ||.  ..|. .| .||.||||||.|.. . | |... .    
YMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRM-M----

VPILDPQEEQKQNGHSQKENHSNCNGQQKTDSQNQSAQNPNPQKQEQNDKNNLASKQEQDQQNEDEDDNDNDNDDEQEEGATSTAASNQNNQGDKKNLTK
. .            |  |                                                                                 
W-K------------S--E---------------------------------------------------------------------------------

KQKKNQRRKAAHKRKKQREKEEKNKQTNDQDSNKQQNNLNDKQAEGQKQQIEEEVKEEDIPEEIRYKFDNWNGRGDRLQTNVRVKIADLGNACWTHHH--
                                                                    | || .    | | |.||.| |.|.|.|.|  
--------------------------------------------------------------------D-WNPC----QKNGRLKICDFGLARWYHPHSD

----------------------FATEIQTRQYRSPETIIG----------VHYDTTADVWSFACMIFEMLTG--------DFLFEPRKGP-----NFSKN
                      . ....|| ||.|| ..|           ||.|. |.||..|...||.||        . || .. .      | ...
HHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSH

DDHIAQIQELCNKFTKKFALSGF-------KSKKYFDKQGNLRRIPSLH-------------------------YWPLLNVLIEKYHFKEE---------
 |....| ... ..| ... .|.       ........ ....... ..                          |.  . . ... .. .         
IDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAM

-----------------------EAKLFDEFMQVMLKTNPLDRASAHECLQTKWI
                       . ... .... ||. .| .| .| ..||  ..
VFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 22244.AA CLK 233-569 16 2.8e-42 124.09 In-house 67-247 (350) Show / Hide 
Range on Protein: 233-569
Range on HMM: 67-247/350
Sequence Identity: 16% (57 aa)

QVVQLLNSFVFRGPY-GNHFCMVFEILGVNLLEIIKRYN------YKGIPMHLARIIAKQVLIGLDFLHRYCGVIHTDLKPENVLLCLT------QEEIK
...... .|    .| ..|.|.|||..| .. . .|  |      |.. |..  | .|.| .  . |||   . .|||||||| ... .      ..   
HCWKMNDWF----DYGHGHICIVFELYGLSIYDFMKSNNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHD-MKLTHTDLKPENICFVDSRFTHFDCTFKY

AHGIKIDEVPILDPQEEQKQNGHSQKENHSNCNGQQKTDSQNQSAQNPNPQKQEQNDKNNLASKQEQDQQNEDEDDNDNDNDDEQEEGATSTAASNQNNQ
 |  ||.                                                                                             
NHKKKIN---------------------------------------------------------------------------------------------

GDKKNLTKKQKKNQRRKAAHKRKKQREKEEKNKQTNDQDSNKQQNNLNDKQAEGQKQQIEEEVKEEDIPEEIRYKFDNWNGRGDRLQTNVRVKIADLGNA
                                                                          |. | . .  .   |  ... | |.|
--------------------------------------------------------------------------KKSNNCVCHYWHVKNTHICVIDFGSA

C---WTHHHFATEIQTRQYRSPETIIGVHYDTTADVWSFACMIFEMLTGDFLF
      | |  | ..||.|| || | |  . .  ||||..| .||  ||. ||
TKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLF
Kinase 22244.AA S_TKc 97-671 11 2.4e-39 137.97 SMART 1-231 (231) Show / Hide 
Range on Protein: 97-671
Range on HMM: 1-231/231
Sequence Identity: 11% (69 aa)

YVIIQKLGWGHFSTVWLSKDFKYDTYVALKIQKSAPHYLEAAYDEVEILQKVAKQASNPQWIHQLKEYYKDQTRSAKQNENSDRAISKRFYKQAATALIT
| |..|.| | |..|.. .. | . .||.|| |                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

KKQKKQIIYNLKLKITKQLNKPLNDKQKKTFTRDDCQ-VVQLLNSFVFRGPYGNHFCMVFEILGV---NLLEIIKRYNYKG----IPMHLARIIAKQVLI
                         .  .   . ..  .|.|. .|.      .|..||.| ..    .|...||.....|    .|   || ...|.. 
---------------------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICC

GLDFLHRYCGVIHTDLKPENVLLCLTQEEIK------AHGIKIDEVPILDPQEEQKQNGHSQKENHSNCNGQQKTDSQNQSAQNPNPQKQEQNDKNNLAS
.|...|.  |.|| ||||||.||.    .||      |  .                                                           
ALEYCHSH-GIIHRDLKPENILLDE---HIKICDFGLARQL-----------------------------------------------------------

KQEQDQQNEDEDDNDNDNDDEQEEGATSTAASNQNNQGDKKNLTKKQKKNQRRKAAHKRKKQREKEEKNKQTNDQDSNKQQNNLNDKQAEGQKQQIEEEV
                                                                                                    
----------------------------------------------------------------------------------------------------

KEEDIPEEIRYKFDNWNGRGDRLQTNVRVKIADLGNACWTHHHFATEIQTRQYRSPETIIGVHYDT-TADVWSFACMIFEMLTGDFLFEPRKGPNFSKND
                                             | . |. |..|| .   .|..  .|.||. |...|||.|  .|.         ..
--------------------------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---------QM

DHIAQIQELCNKFTKKFALSGFKSKKYFDKQGNLRRIPSLHYWPLLNVLIEKYHFKEEEAKLFDEFMQVMLKTNPLDRASAHECLQ-------TKWI
. . ..                                                       . | |.. .|. .| .| .| |.||         |.
QMMFKKIG--------------------------------------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 22244.AA Pkinase 234-576 13 1.4e-32 116.27 Pfam 62-222 (293) Show / Hide 
Range on Protein: 234-576
Range on HMM: 62-222/293
Sequence Identity: 13% (50 aa)

VVQLLNSFVFRGPYGNHFCMVFEIL-GV----NLLEIIKRYNYKGI--PMHLARIIAKQVLIGLDFLHRYCGVIHTDLKPENVLLCLTQEEIKAHGIKID
.|.|. .|      ..| .||.| . |      | ..|.. .....  ... .. ...|.| ||...|. .|.|| ||||||.|.   . .|.|      
IVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILID-NNGHIDA------

EVPILDPQEEQKQNGHSQKENHSNCNGQQKTDSQNQSAQNPNPQKQEQNDKNNLASKQEQDQQNEDEDDNDNDNDDEQEEGATSTAASNQNNQGDKKNLT
                                                                                                    
----------------------------------------------------------------------------------------------------

KKQKKNQRRKAAHKRKKQREKEEKNKQTNDQDSNKQQNNLNDKQAEGQKQQIEEEVKEEDIPEEIRYKFDNWNGRGDRLQTNVRVKIADLGNAC---WTH
                                                                                   .|||.| | |.   . .
-----------------------------------------------------------------------------------CVKICDFGLAKQFDY-N

HHFATEIQ-TRQYRSPETII-GVHYDTTADVWSFACMIFEMLTGDFLFEPR----KGPN
 . .| .  |. |..|| |  | .|.. .|.||. |...|||.| ..|  .    .  .
NS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HD
Kinase 22244.AA DYRK 234-319 39 4.9e-23 82.87 In-house 63-147 (320) Show / Hide 
Range on Protein: 234-319
Range on HMM: 63-147/320
Sequence Identity: 39% (35 aa)

VVQLLNSFVFRGPYGNHFCMVFEILGVNLLEIIKRYNYKGI-PMHLARIIAKQVLIGLDFLHRYCGVIHTDLKPENVLLCL--TQEEIK
.|.....|..|    ||.|.||| |  || | .|... .|  .. | | .|.|.| .|.|||.    || ||||||..|.    . .||
CVHMYDYFYHR----NHLCIVFELLSMNLYEFLKNNHFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIK
Kinase 22244.AA DYRK2 234-311 44 2.7e-22 69.02 In-house 63-135 (318) Show / Hide 
Range on Protein: 234-311
Range on HMM: 63-135/318
Sequence Identity: 44% (35 aa)

VVQLLNSFVFRGPYGNHFCMVFEILGVNLLEIIKRYNYKGIPMHLARIIAKQVLIGLDFLHRYCGVIHTDLKPENVLL
.| .|..|.||    ||.|..|| |..|| | ||. ...|. . | |  |...| .|.|||.   .|| ||||||.||
CVHMLDYFYFR----NHHCITFELLSMNLYEYIKKNHFQGFSLQLVRRFAHSILQCLRFLHKNN-IIHCDLKPENILL
Kinase 22244.AA DYRK 506-671 23 1.2e-19 70.24 In-house 140-320 (320) Show / Hide 
Range on Protein: 506-671
Range on HMM: 140-320/320
Sequence Identity: 23% (44 aa)

Q-TNVRVKIADLGNACWTHHHFATEIQTRQYRSPETIIGVHYDTTADVWSFACMIFEMLTGDFLFEPRKGPNFSKNDDHIAQIQELCNKFTKKFALSGF-
.  . ..|..| | .|  |... | || | ||.|| |.|  |..  |.||. | . |..||  ||     |. . . | .| |.|. ....|..  .|. 
PRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLF-----PG-ENEYDQLACIMEVLGMPPKWMIDKGRC

-KSKKYFDK------------QG------NLRRIPSLHYWPLLNVLIE--KYHFKEEEAKLFDEFMQVMLKTNPLDRASAHECLQTKWI
 . .|.||.            .       .....|..     .    .  .. ..  . ..|  | . .|. .|  | .. . || .|.
RRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase 22244.AA DyrkP 511-569 47 1.6e-18 56.95 In-house 147-205 (323) Show / Hide 
Range on Protein: 511-569
Range on HMM: 147-205/323
Sequence Identity: 47% (28 aa)

VKIADLGNACWTHHHFATEIQTRQYRSPETIIGVHYDTTADVWSFACMIFEMLTGDFLF
||| | | .|. | | .  .| | || || |||  ||   |.||  |.. |. ||  ||
VKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLF
Kinase 22244.AA DYRK2 504-569 38 5.8e-18 54.7 In-house 136-202 (318) Show / Hide 
Range on Protein: 504-569
Range on HMM: 136-202/318
Sequence Identity: 38% (26 aa)

RLQTNVRVKIADLGNACWTHH-HFATEIQTRQYRSPETIIGVHYDTTADVWSFACMIFEMLTGDFLF
. ..   .|..| |  |  |  .. | ||.| ||.|| |.|  |..  | ||| | . |..||  ||
KQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLF
Kinase 22244.AA YAK 234-312 40 3e-17 54.8 In-house 67-140 (347) Show / Hide 
Range on Protein: 234-312
Range on HMM: 67-140/347
Sequence Identity: 40% (32 aa)

VVQLLNSFVFRGPYGNHFCMVFEILGVNLLEIIKRYNYKGIPMHLARIIAKQVLIGLDFLHRYCGVIHTDLKPENVLLC
.. .. .||..    ||||.|||.| .|| | .|  ...|  . | |   ||.| |.  |     .|| ||||||..||
ILRMYDFFVHK----NHFCLVFEMLSNNLYEYLKQNKFCGFSFQLIRQWTKQILDGMCVLEN-KQIIHCDLKPENIMLC
Kinase 22244.AA DYRK1 233-312 39 4.6e-16 52.47 In-house 62-138 (321) Show / Hide 
Range on Protein: 233-312
Range on HMM: 62-138/321
Sequence Identity: 39% (32 aa)

QVVQLLNSFVFRGPYGNHFCMVFEILGVNLLEIIKRYNYKGIPMHLARIIAKQVLIGLDFLHR-YCGVIHTDLKPENVLLC
..|.| . |.||    || |.|||.|  || ....  ...|. . |.| .|.|..  | |.      .|| ||||||.|||
YIVHLKRHFMFR----NHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLC
Kinase 22244.AA DYRK1 511-612 35 4.6e-16 52.47 In-house 145-240 (321) Show / Hide 
Range on Protein: 511-612
Range on HMM: 145-240/321
Sequence Identity: 35% (36 aa)

VKIADLGNACWTHHHFATEIQTRQYRSPETIIGVHYDTTADVWSFACMIFEMLTGDFLFEPRKGPNFSKNDDHIAQIQELCNKFTKKFALSGFKSKKYFD
.|| | | .| . .     || | ||||| ..|..||.  |.||  |.. || ||. ||        |   | . .| |  .   |..  .. |..|||.
IKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLF------SGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFE

KQ
|.
KD
Kinase 22244.AA STE 528-671 17 2.6e-14 47.02 In-house 222-359 (359) Show / Hide 
Range on Protein: 528-671
Range on HMM: 222-359/359
Sequence Identity: 17% (30 aa)

TEIQTRQYRSPETIIG------VHYDTTADVWSFACMIFEMLTGDFLF---EPRKGPNFSKNDDHIAQIQELCNKFTKKFALSGFKSKKYFDKQGNLRRI
| . |  . .|| | .       .||| .|.||. |.| ||.||   .    | .      .  |..| |                              
TFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQ-Q------------------------------

PSLHYWPLLNVLIEKYHFKEEEA---------------------KLFDEFMQVMLKTNPLDRASAHECLQ--TKWI
     . .|   ... . . ..                      . | .|..  |. .| .|..|.. |.   ..|
-----FEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 22244.AA CLK 97-166 31 3.9e-14 38.08 In-house 1-76 (350) Show / Hide 
Range on Protein: 97-166
Range on HMM: 1-76/350
Sequence Identity: 31% (24 aa)

YVIIQKLGWGHFSTVWLSKDFKY-DTYVALKIQKSAPHYLEAAYDEVE-ILQKVAKQ--ASNPQW--IHQLKEYYK
|.|. .|| | |..|   .| |. ..|||||| ...  | |||  |.. |..|...   . |  |  . .. .. .
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFD
Kinase 22244.AA PRP4 531-569 46 6.5e-12 39.97 In-house 167-205 (320) Show / Hide 
Range on Protein: 531-569
Range on HMM: 167-205/320
Sequence Identity: 46% (18 aa)

QTRQYRSPETIIGVHYDTTADVWSFACMIFEMLTGDFLF
. | ||.|| |||. ||   |.|| .| ..|. || ..|
VSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMF
Kinase 22244.AA PRP4 234-310 33 3.8e-11 37.11 In-house 66-138 (320) Show / Hide 
Range on Protein: 234-310
Range on HMM: 66-138/320
Sequence Identity: 33% (26 aa)

VVQLLNSFVFRGPYGNHFCMVFEILGVNLLEIIKRY-NYKGIPMHLARIIAKQVLIGLDFLHRYCGVIHTDLKPENVL
.|.. ..| .|    .| |.||| .  || |..|.|   .|  .   |  |.| .. |  | . |. .| |.|| |.|
CVRMFRHFNHR----QHMCLVFECMSMNLREVLKKYGKDVGLHLKAVRSYAQQLFLALKHLKK-CNILHADIKPDNIL
Kinase 22244.AA YAK 511-561 43 3.8e-09 26.83 In-house 147-197 (347) Show / Hide 
Range on Protein: 511-561
Range on HMM: 147-197/347
Sequence Identity: 43% (22 aa)

VKIADLGNACWTHHHFATEIQTRQYRSPETIIGVHYDTTADVWSFACMIFE
.|| | | .| .     | || | ||||| |... | |  | ||  | . |
IKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAE
Kinase 22244.AA DYRK 97-147 31 2.5e-08 27.54 In-house 1-51 (320) Show / Hide 
Range on Protein: 97-147
Range on HMM: 1-51/320
Sequence Identity: 31% (16 aa)

YVIIQKLGWGHFSTVWLSKDFKYDTYVALKIQKSAPHYLEAAYDEVEILQK
| |.. .| | |. |   .| | . .||.|| .. . ..  |..|..||..
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEY
Kinase 22244.AA STE 234-325 22 7.8e-08 23.88 In-house 92-188 (359) Show / Hide 
Range on Protein: 234-325
Range on HMM: 92-188/359
Sequence Identity: 22% (25 aa)

VVQLLNSFVFRGPY---GNHFCMVFEILGV-NLLEIIK-RYNYKG-----------IPMHLARIIAKQVLIG-LDFLHRYCGVIHTDLKPENVLLCLTQE
.|. . ...  |.    ... ... | ..   | .||| .|  ..           .| .. ..|..|.| | |..||.   .|| |.|| |.||     
IVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----

EIKAHGIKI
      .|.
------VKL
Kinase 22244.AA DyrkP 282-311 53 2e-07 19.8 In-house 111-139 (323) Show / Hide 
Range on Protein: 282-311
Range on HMM: 111-139/323
Sequence Identity: 53% (16 aa)

IAKQVLIGLDFLHRYCGVIHTDLKPENVLL
| .|.||.||..|    .|| ||||||.|.
ITQQILIALDYIHSLR-LIHCDLKPENILM
Kinase 22244.AA DYRK2 97-151 30 5e-06 15.14 In-house 1-55 (318) Show / Hide 
Range on Protein: 97-151
Range on HMM: 1-55/318
Sequence Identity: 30% (17 aa)

YVIIQKLGWGHFSTVWLSKDFKYDTYVALKIQKSAPHYLEAAYDEVEILQKVAKQ
| |   .| | |  |    | |....||.|.      ... || |..||..  .|
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQ
Kinase 22244.AA Pkinase 646-671 30 5.9e-05 18.6 Pfam 268-293 (293) Show / Hide 
Range on Protein: 646-671
Range on HMM: 268-293/293
Sequence Identity: 30% (8 aa)

EFMQVMLKTNPLDRASAHECLQTKWI
.|.  .|. .| .| .|...|| .|.
DFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 22244.AA DYRK1 97-166 28 0.0003 10.27 In-house 1-71 (321) Show / Hide 
Range on Protein: 97-166
Range on HMM: 1-71/321
Sequence Identity: 28% (20 aa)

YVIIQKLGWGHFSTVWLSKDFKYDTYVALKIQKSAPHYLEAAYDEVEILQKVAKQASNPQW-IHQLKEYYK
| |.  .| | |  |    | .   |||.|| |    ... |  |. .|  . |.  . .. | .||. ..
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFM
Kinase 22244.AA TyrKc 97-671 8 0.000744 -160.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 97-671
Range on HMM: 1-280/280
Sequence Identity: 8% (55 aa)

YVIIQKLGWGHFSTVWLSKDFKYDTYVALKIQKSAPHYLEAAYDEVEILQKV-------------AKQAS------NPQWIHQ-------LKEYYKDQTR
 . ..||| |.| .|.. .     . || |  |.    .|. ..| .|. |.             . | .       | .|         ||.| ..  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

SAKQNENSDRAISKRFYKQAATALITKKQKKQIIYNLKLKITKQLNKPLNDKQKKTFTRDDCQVVQLLNSFVFRGPYGNHFCMVFEILGVNLLEIIKRYN
                                                                                                    
K---------------------------------------------------------------------------------------------------

YKGIPMHLARIIAKQVLIGLDFLHRYCGVIHTDLKPENVLLCLTQEEIKAHGIKIDEVPILDPQEEQKQNGHSQKENHSNCNGQQKTDSQNQSAQNPNPQ
   ..|     .. |.  | ..||.                                                                           
---LCMKDLLSFCWQIACGMEYLHSK--------------------------------------------------------------------------

KQEQNDKNNLASKQEQDQQNEDEDDNDNDNDDEQEEGATSTAASNQNNQGDKKNLTKKQKKNQRRKAAHKRKKQREKEEKNKQTNDQDSNKQQNNLNDKQ
                                                                                                    
----------------------------------------------------------------------------------------------------

AEGQKQQIEEEVKEEDIPEEIRYKFDNWNGRGDR------------LQTNVRVKIADLGNACWTHHH----FATEIQTR----QYR--------SPETII
                                 .            .  | .|||.| | .   ...     ...  .     . .        .||.| 
---------------------------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

GVHYDTTADVWSFACMIFEMLTGDFLFEPR---KGPNFSKNDDHIAQIQELCNKFTKKFAL----SGFKSKKYFDKQGNLRRIPSLHYWPLLNVLIEKYH
   . |  |||||  ...|..|      |    .   . .|.. |.....   .  .. .     |                                  
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQ--GYRMPQPPNDYPMS----------------------------------

FKEEEAKLFDEFMQVMLK---TNPLDRASAHECLQTKWI
|        ||  |.|..    .| || .  |.   . .
F----VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 22244.AA PRP4 97-154 29 0.002485 8.15 In-house 1-61 (320) Show / Hide 
Range on Protein: 97-154
Range on HMM: 1-61/320
Sequence Identity: 29% (18 aa)

YVIIQKLGWGHFSTVWLSKDFKYDT-YVALKIQKSAPHYLEAAYDEVEILQKVAKQ--ASN
| .... | | ||.|   .|       || ||  . .        |.|||||   .   .|
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKN
Kinase 22244.AA Pkinase 97-127 35 0.014048 10.2 Pfam 1-31 (293) Show / Hide 
Range on Protein: 97-127
Range on HMM: 1-31/293
Sequence Identity: 35% (11 aa)

YVIIQKLGWGHFSTVWLSKDFKYDTYVALKI
|.|..|.| | |..|.. .. ..   ||.||
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKI
Kinase 22244.AA DyrkP 640-671 28 0.042771 1.92 In-house 292-323 (323) Show / Hide 
Range on Protein: 640-671
Range on HMM: 292-323/323
Sequence Identity: 28% (9 aa)

EAKLFDEFMQVMLKTNPLDRASAHECLQTKWI
.  .| .|.. .|.     | .| | ||  |.
DDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase 22244.AA CLK 636-671 27 0.068477 0.64 In-house 316-350 (350) Show / Hide 
Range on Protein: 636-671
Range on HMM: 316-350/350
Sequence Identity: 27% (10 aa)

FKEEEAKLFDEFMQVMLKTNPLDRASAHECLQTKWI
...|  .|||  .. ||   |  | .. . ||  . 
KDPEHRQLFD-LIRKMLEYDPSKRITCKDALQHPFF