Gene 27990 (Tetrahymena)
27990
Group:
Other
Family:
Ciliate-A2
Sequence
Protein domains of 27990.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 27990.AA | Ciliate-A2 | 25-277 | 42 | 6.5e-143 | 481.08 | In-house | 2-272 (272) | Show / Hide |
Range on Protein: 25-277 Range on HMM: 2-272/272 Sequence Identity: 42% (117 aa) QGSFGCVIFTHLK-GHENYKYAIKVFDVDDGSKKNCSQEKIQECQKEARALKILSHKNVVAYHSEKQLGLFYFIIMEMC-QSSLHVWSQ--SN-QNIIQD ||.||||||.. . .|.|.|||||.....||.....||.|.|||..||..||...|.|.|.||.|.|.|..|||.||.| ..||..| . .| |..|.| QGCFGCVIFVEHMDNHNNEKYAIKIQSIIDGIDQKISQQKLQECKHEAQFLKNCNHPNIVKYHDEFQIGFYYFIQMEKCPECSLQDWIDKFQNQQKFIPD SLFYSIARQILDGLDYIHNKDWILRDLKPQNILINQEVEKIKIKLCDFGAARYYPKQINPK---STNCFGTLNYMPPEVIKE------IFLQNHKLKQTP ..|...|.||||...|.|||...||||...||||.|... | |||||||.|..|...||.. .....|...|.|||.... .. .....|||. HQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQ-I-IKLCDFGLAKKYQPEINSQMFYTSCPKGVFFYYPPECHFQCFEMNGEQNKKQQIKQTF QGDIWAYGICLLSIGKPILNFNDYIK-----KNWQAPYTPLLSEKAQKLIRFILIQDPKKRP-TVQQIRKKMN .|||||.||||...|........... |.||....|.|.||....|..||..|||||| ..||||.... MGDIWAFGICLYQLGGADQQHCYKLTQCNQKKWWQYQDYPNLDEKCNQIIQQILNCDPKKRPSSIQQIRHHWH |
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| S_TKc | 27990.AA | S_TKc | 17-280 | 24 | 5.6e-33 | 116.8 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 17-280 Range on HMM: 1-231/231 Sequence Identity: 24% (68 aa) VFVSSSQEQGSFGCVIFTHLKGHENYKYAIKVFDVDDGSKKNCSQEKIQECQKEARALKILSHKNVVAYHSEKQLGLFYFIIMEMCQS---SLHVWSQSN . .|.||.| . |. . ..|||. . . ..| . || |.|.| .. | .....||.| .|. ... YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR QNI-----IQDSLFYSIARQILDGLDYIHNKDWILRDLKPQNILINQEVEKIKIKLCDFGAARYYPKQINPKSTNCFGTLNYMPPEVIKEIFLQNHKLKQ . . ....||...|.|.|.. | |||||.|||... ||.|||| || . | . ||..||.|||. . GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------TTFCGTPWYMAPEVL----------GY TP-QGDIWAYGICLLSI--GKPILNFNDYIKKNWQAPYTPLLSEKAQKLIRFILIQDPKKRPTVQQIRK-----KMNDLF .. |.|. |..| |.| ... . |. | .|| .| ||.||||. .. . |. | GKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 27990.AA | TKL | 25-221 | 18 | 3.6e-29 | 102.2 | In-house | 3-279 (364) | Show / Hide |
Range on Protein: 25-221
Range on HMM: 3-279/364
Sequence Identity: 18% (52 aa)
QGSFGCVIFTHLKGHE-------NYKYAIKVFDVDDGSKKN-----------------CSQEKIQECQKEARALKILS---HKNVVAYHS-EKQLGL---
.|.||.| ...|. .. |.|.| ... .... ...| .....| . ....| | |.| . .. .
SGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCV
------F---YFIIMEMC-QSS-LHVWSQSNQNIIQDSLFYSIARQILDGLDYIHNKD--------WILRDLKPQNILINQEVE-----------KIKIK
..|.|| | | ||. ... ..|..| |..| |... | ||||..|||... . ...|
CMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK
LCDFGAARYYPKQINPKSTN------------------CFGTLNYMPPEVIK-EIFLQN--------HKLKQTPQGDIWAYGICL
.|||| .| . | . | . ||...|.|||.. ...... .... ... |....||.|
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
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| Kinase | 27990.AA | Pkinase | 25-219 | 27 | 1.4e-27 | 98.57 | Pfam | 9-200 (293) | Show / Hide |
Range on Protein: 25-219 Range on HMM: 9-200/293 Sequence Identity: 27% (58 aa) QGSFGCVIFTHLKGHENYK---YAIKVFDVDDGSKKNCSQEK-IQECQKEARALKILSHKNVVAYHSEKQLGLFYFIIMEMCQS-----SLH----VWSQ .|||||| |.|. .|.|...... ... . . . |.. .| |.|.|.| .. . . . ..|| |. .|. . SGSFGCV----YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--- SNQNII--QDSLFYSIARQILDGLDYIHNKDWILRDLKPQNILINQEVEKI--KIKLCDFGAAR-YYPKQINPKSTNCFGTLNYMPPEVIKEIFLQNHKL .... . .. ....||| ||.|.|.. | |||||.||||. . | ..|.|||| |. .. |. | ||..||.||||. . WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR------GGQ KQTPQGDIWAYGI . .| |.|..|. YYGPKVDMWSCGC |
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| Kinase | 27990.AA | CAMK | 38-197 | 17 | 5.8e-25 | 76.76 | In-house | 20-293 (425) | Show / Hide |
Range on Protein: 38-197
Range on HMM: 20-293/425
Sequence Identity: 17% (47 aa)
GHEN--------YKYAIKVFDVD----------------DGSKKNC-----SQEKIQECQKEARALKILS-------HKNVVAYHSEKQLGLF-------
| |. |.|||. | . | ||. . .... .. ..| . .| |. |.|.. . . . .
GKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDY
------------YFIIM---EMCQS-----SLHVWSQSNQN---------IIQDSLFY------SIARQILDGLDYIHNKDWILRDLKPQNILINQEVEK
....| |.|. | . ... . |. .. . . |||.....|.|... . ||||| |||... .
ETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDD
I--------------KIKLCDFGAARYYPKQI----------------------NPKSTNCFGTLNYMP-PEVIK
.||..||| |..... ..| . ..||. ||. |||..
SDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLN
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| Kinase | 27990.AA | STE | 25-271 | 20 | 7.1e-25 | 84.84 | In-house | 9-350 (359) | Show / Hide |
Range on Protein: 25-271
Range on HMM: 9-350/359
Sequence Identity: 20% (74 aa)
QGSFGCVIFTHLK--------------GHENYKYAIKVFDVDDGSKKNCS-----------QEKIQECQKEARALKILS--HKNVVAYHSEKQLGL----
.|.|| | . |. . .|||. .... ..|. . .|..|. .|| . .| .. |.|.| |. .
KGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHK
---FYFIIMEMCQ-SSLHVWSQSNQNI-------------IQDSLFYSIARQILDG-LDYIHNKDWILRDLKPQNILINQEVEKIKIKLCDFGAARYYPK
.|.|| . || ... . .. |. |.|||| | |.|.|.. | ||.||.|||. .|||||| . .
NDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTD
---------------QINPKSTNCFGTLNYMPPEVIKE-IFLQNHKLKQTPQGDIWAYGICL--LSIGKPILNFNDYIKKNWQAP---------------
. |.. . || .| ||||. . . . . . ||| |... . ||| . . . ...|
SMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R-DKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIV
--YTPLLS-----------------------EKAQKLIRFILIQDPKKRPTVQQ
| | .. . |. |. ||.||||..|
NGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
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| Kinase | 27990.AA | C8 | 99-221 | 30 | 1.2e-21 | 71.97 | In-house | 99-226 (226) | Show / Hide |
Range on Protein: 99-221 Range on HMM: 99-226/226 Sequence Identity: 30% (40 aa) MEMCQSSL---HVWSQSNQNIIQDSLFYSIARQILDGLDYIHNKDWILRDLKPQNILINQEVEKI-KIKLCDFGAARYYPKQINPKSTNCF---GTLNYM ||.|.. | . .| ... || |..||..||| | . ||.||.|.|. . ... .||||||| | . .| . . . ||. |. MELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYF PPEVIKEIFLQNHKLKQTPQGDIWAYGICL ||..|. .|. . . | |.. |. | APEIEKK--QDNQYKQYRIQSDLFSVGLVL |
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| Kinase | 27990.AA | Ciliate-E2-Unclassified | 25-198 | 21 | 3.7e-21 | 70.16 | In-house | 9-240 (352) | Show / Hide |
Range on Protein: 25-198
Range on HMM: 9-240/352
Sequence Identity: 21% (51 aa)
QGSFGCVIFTHLKGHENYK----YAIKVFDVDDGSKKNCSQEKIQECQKEAR---------------ALKILSHKNVVAYHSEKQLGLFYFIIMEMC-QS
||.||.| | . .. |..|. .... ...| |...| . . . |. . | ..| .. ..| .|.|| | .
QGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGG
SLHVWSQSNQN----------------IIQDSLFY-----SIARQILDGLDYIHNKD-WILRDLKPQNILINQEVEKIKIKLCDFGAARYYPKQ------
.|. . ... . |... ...|||.||.|.| | | ||.||.|||.... .. .||..||| ...| ..
DLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTN
--------INPKSTNCFGTLNYM----PPEVIKE
.. ... . ||.||| .|||...
QQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQG
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| Kinase | 27990.AA | CMGC | 62-196 | 18 | 5e-21 | 65.01 | In-house | 51-297 (513) | Show / Hide |
Range on Protein: 62-196
Range on HMM: 51-297/513
Sequence Identity: 18% (47 aa)
EKIQEC------------QKEARALKILS-----------------HKNVVA-----YHSE--KQLGL----------FYFIIMEMCQSSLHVWSQSNQN
...|.. . | . || |. |.|.| ||.. ... ....| .. .|. ..||.
YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQF
--------IIQDSL------------FYSIA------RQILDGLD--YIHNKD--WILRDLKPQNILINQEVEK-----------------IKIKLCDFG
. .. .||| ||. |.| .. | |||||.|||||.. | ..|.||||
DYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFG
AARYYPKQ--------------------INPKSTNCFGTLNYMPPEVI
||.| . .| |. |. | .||..
LARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL
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| Kinase | 27990.AA | TKL-Unique | 42-221 | 25 | 6.2e-20 | 67.12 | In-house | 21-218 (290) | Show / Hide |
Range on Protein: 42-221 Range on HMM: 21-218/290 Sequence Identity: 25% (53 aa) YKYAIKVFDV-DDGSKKNCSQEKIQECQKEARALKILS-HKNVVAYHSEKQ----LGLFYFIIMEMCQ-SSLHVWSQ---------SNQNIIQDSLFYSI |..|||.| . | |. |..|| .| . .| | |.|.| | ..|.|| |. .||. .. .| . . ...... YPVAIKQFHPNEDSSN-----EMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKM ARQILDGLDYIHNKD--WILRDLKPQNILINQE--VEKIKIKLCDFGAARYYPKQINPKSTNC--------FGTLNYMPPEVIKEIFLQNHKLKQTPQGD |..| .|..|.|... | ||||..|.|.... ...||.|||| .. | .. .... |....|.|||.. | . . . | AIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF-----CQYSEKSD IWAYGICL ....||.| VYSFGIVL |
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| Kinase | 27990.AA | MSK | 125-197 | 41 | 5.7e-17 | 53.91 | In-house | 106-178 (277) | Show / Hide |
Range on Protein: 125-197 Range on HMM: 106-178/277 Sequence Identity: 41% (31 aa) IARQILDGLDYIHNKDWILRDLKPQNILINQEVEKIKIKLCDFGAARYYPKQ-INPKSTNCFGTLNYMPPEVIK | |.. .|..| | | ||||| ||| | . ..|| ||| ||. |.. . . || || ||.||... IMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCF-TLHYMAPEMLR |
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| Kinase | 27990.AA | CAMKL | 127-197 | 32 | 1.8e-14 | 42.46 | In-house | 134-206 (297) | Show / Hide |
Range on Protein: 127-197 Range on HMM: 134-206/297 Sequence Identity: 32% (24 aa) RQILDGLDYIHNKDWILRDLKPQNILINQEVEKIKIKLCDFGAARYYP---KQINPKSTNCFGTLNYMPPEVIK |||.....|.|... . ||.|| |||. . .||..||| . .| .. . | . . |...||.||... RQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQ |
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| TyrKc | 27990.AA | TyrKc | 17-276 | 19 | 2.7e-12 | -23.81 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 17-276 Range on HMM: 1-280/280 Sequence Identity: 19% (59 aa) VFVSSSQEQGSFGCVIFTHLKGHENYKYAIKVFDVDDGSKKNCSQEKIQECQKEARALKIL--SHKNVVAYHSEKQLG-------LFYFIIMEMCQS-SL . | || | ..| .. |.|. | ... .||| .. | .|.|.|. . . ..|.|| . .| ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL HVWSQSNQNIIQDSLFYSIARQILDGLDYIHNKDWILRDLKPQNILINQEVEKIKIKLCDFGAARYYPKQ--------INPKST--NCF--GTLNYMPPE . ..... .. . . |.. || .| .|.| | | ||| |.|.. . .| .||| .|. |.. .. . |.|| KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE VIKEIFLQNHKLKQTPQGDIWAYGICL---------LSIG-----KPILNFNDYIKKNWQAPYTPL--------LSEKAQKLIRFILIQDPKKRPTVQQI .| . | |.. |.|..|.|. | .. |.|. | | ... .... ||..||| ..| CI-------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI RKKM .... HECF |
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| Kinase | 27990.AA | CAMKL | 230-274 | 32 | 3.3e-07 | 18.91 | In-house | 248-293 (297) | Show / Hide |
Range on Protein: 230-274 Range on HMM: 248-293/297 Sequence Identity: 32% (16 aa) NFNDYIKKNWQAPYTPL----LSEKAQKLIRFILIQDPKKRPTVQQIRK |. . .|. . | | .| .. ||| .| .|.||||..||.. NI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMN |
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| Kinase | 27990.AA | CAMK | 247-274 | 39 | 6e-06 | 14.44 | In-house | 394-421 (425) | Show / Hide |
Range on Protein: 247-274 Range on HMM: 394-421/425 Sequence Identity: 39% (11 aa) LSEKAQKLIRFILIQDPKKRPTVQQIRK .|. .. ||| .| ||.||.|..|. . VSQECKDLIRKMLQVDPEKRMTIEQCLN |
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| Kinase | 27990.AA | MSK | 248-278 | 35 | 9.5e-05 | 11.97 | In-house | 247-277 (277) | Show / Hide |
Range on Protein: 248-278 Range on HMM: 247-277/277 Sequence Identity: 35% (11 aa) SEKAQKLIRFILIQDPKKRPTVQQIRKKMND |..|. ||. | |||||.... .|. . SPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK |
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| Kinase | 27990.AA | Pkinase | 245-276 | 38 | 0.000131 | 17.38 | Pfam | 260-293 (293) | Show / Hide |
Range on Protein: 245-276 Range on HMM: 260-293/293 Sequence Identity: 38% (13 aa) PLLSEKAQKLIRFILIQDPKKRPTVQQIRKK--M ...|| ....|. .| .||||||| .|| . . HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 27990.AA | TKL-Unique | 261-276 | 31 | 0.000207 | 11.67 | In-house | 275-290 (290) | Show / Hide |
Range on Protein: 261-276 Range on HMM: 275-290/290 Sequence Identity: 31% (5 aa) QDPKKRPTVQQIRKKM .|| .||....|... HDPSQRPSFDEIIHRL |
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| Kinase | 27990.AA | TKL | 261-276 | 50 | 0.001031 | 9.26 | In-house | 349-364 (364) | Show / Hide |
Range on Protein: 261-276 Range on HMM: 349-364/364 Sequence Identity: 50% (8 aa) QDPKKRPTVQQIRKKM .||.|||. |.| |.. HDPEKRPSFQEILKRL |
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| Kinase | 27990.AA | CAMKL | 25-83 | 26 | 0.001623 | 6.92 | In-house | 9-78 (297) | Show / Hide |
Range on Protein: 25-83 Range on HMM: 9-78/297 Sequence Identity: 26% (19 aa) QGSFGCVIFTHLKGHENYKYAIKVFD-----VDDGSKKN-----CSQEKIQECQKEARALKILS---HKNVV .|||| | . . . . |.|||. | |. .||| . . . ..|.. .| |. |.|.. KGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKH-ESDM-RIRREIQIMKMLNIGKHPNII |
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| Kinase | 27990.AA | Ciliate-E2-Unclassified | 231-272 | 28 | 0.049394 | 2.87 | In-house | 295-346 (352) | Show / Hide |
Range on Protein: 231-272 Range on HMM: 295-346/352 Sequence Identity: 28% (15 aa) FNDYIKKNWQAPYTPL------LSEKAQKLIR----FILIQDPKKRPTVQQI ... ..||.| | | .|..|. .|. .| .|.||.| .|| YQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQI |
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| Kinase | 27990.AA | MSK | 68-103 | 29 | 0.258645 | 0.19 | In-house | 48-84 (277) | Show / Hide |
Range on Protein: 68-103 Range on HMM: 48-84/277 Sequence Identity: 29% (11 aa) QKEARALK-ILSHKNVVAYHSEKQLGLFYFIIMEMCQ |.|...|. . .|.|.| .| . | . ...|| |. QTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCN |
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