9946

Species: Tetrahymena
Alias: TTHERM_01496790, 422.m00006, 9946, 66, PreTt09946
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-A8

Sequence

Name Sequence Type Origin Length Description Download
9946.AA Protein None 561 None Fasta, JSON
9946.kin_dom Protein Kinase Domain None 135 None Fasta, JSON
9946.NA RNA None 1686 None Fasta, JSON

Protein domain

Protein domains of 9946.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 9946.AA Ciliate-A8 35-172 48 1.5e-82 280.57 In-house 1-151 (151) Show / Hide
Range on Protein: 35-172
Range on HMM: 1-151/151
Sequence Identity: 48% (73 aa)

IEIEKKIGEGFFAEVFQATQINEQRRVAIKKVKDLNKEQKFED-----EKKAMYKIKNQQYAIQIIGELTNKELGYNAIIMEICDC--------TLAEIF
....|....|.|..|.||..||.|..||||..|..|...|..|     ...||.||||..|..|||.....||.|..||..|.|||        .||.|.
YKYQKVLEKGDFSYVVQAYSINHQCQVAIKIIKYMNQQNKINDKEFEKCIQAMQKIKNEKYILQIIECIQDKEQGFIAIVTEFCDCFDFYKKKENLASIL

EKNIDNFTEEQFIALVYQLLKGLLVFQEKGIIHGDLKPENILYNQKKNKFL
|.|...||.||..||.|||||.|||||||||||.|.||.||||...||.|.
ENNLNKFTFEQIVALTYQLLKCLLVFQEKGIIHCDIKPQNILYSWSKNQFI

Kinase 9946.AA Ciliate-E1 41-178 30 9.5e-25 77.7 In-house 1-155 (202) Show / Hide
Range on Protein: 41-178
Range on HMM: 1-155/202
Sequence Identity: 30% (47 aa)

IGEGFFAEVFQATQINEQRRVAIKKVKDLN---KEQKFEDEKKAMY---KIKNQQYAIQIIGELTNKELGYNAIIMEICDCTLAEIFE------------
||.| |. ||.| |.| . .. ..|.  ..   ....|.||.|  |   |.|...| ||||  .  ...   .||.| |.|.| . ..            
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQ

KNIDNFTEEQFIALVYQLLKGLLVFQEKGIIHGDLKPENILYNQKKNKFLIQIVKI
.|  .||..|......||..||  .. ..|||.|.||.|||.|.. ......   |
QNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGI

Kinase 9946.AA CMGC 35-167 18 5.1e-23 71.68 In-house 1-220 (513) Show / Hide
Range on Protein: 35-167
Range on HMM: 1-220/513
Sequence Identity: 18% (40 aa)

IEIEKKIGEGFFAEVFQATQ--------------INEQRRVAIKKVK---DLNKEQ----------KFEDEKKAMYKIK----------------NQQYA
 || |||||| ...|....               .. ...|||||.|   . . ..          .  .| | . ...                .  . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

IQIIGELTNKE---------------LGYNAIIMEICDCTLAEIFEKNID--------NFTEEQ------------FIALV------YQLLKGLL--VFQ
....  .. |.               . .  ...| .|..|... ..| .        ...| .               ..      ||.|.||      
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

EKG--IIHGDLKPENILYNQK
 ..  ||| |||||||| |..
SHWGNIIHRDLKPENILINHN

Kinase 9946.AA CK1 35-163 15 6.3e-15 48.57 In-house 1-164 (339) Show / Hide
Range on Protein: 35-163
Range on HMM: 1-164/339
Sequence Identity: 15% (26 aa)

IEIEKKIGEGFFA-EVFQA-----TQINEQ-----RRVAIKKVK-DLN--KEQKFEDEKKAMYKIKNQQYA------------------IQIIGELTNKE
 ...|||||| |  ... .     . .. .      ..|.|  . . .  . |. |...  ... .....                   . ...  ....
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

LGYNAIIMEICDCTLAEIFE--KNIDN-FTEEQFIALVYQLLKGLLVFQEKGIIHGDLKPENIL
 .|| ..|. .  .| ....  .. .. |.    . . .|.|..| .  ..|.|| |.||.|..
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFC

Kinase 9946.AA Ciliate-E2-Unclassified 35-173 19 7.6e-15 47.95 In-house 1-189 (352) Show / Hide
Range on Protein: 35-173
Range on HMM: 1-189/352
Sequence Identity: 19% (38 aa)

IEIEKKIGEGFFAEVFQATQINEQRRV-------AIKKVKDLNKEQKFEDEKKAMYKIKNQQ---------------------YAIQIIGELTNKELGYN
 .| |.||.| |..|... .....  .        |...|......|  ...  |  ..|..                     . .  . . ..|.  | 
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY-

AIIMEICDCTLAEIFEKNIDN-----------------FTEEQFI-----ALVYQLLKGL-LVFQEKGIIHGDLKPENILYNQKK---NKFLI
 |.|| |.    . . |.  .                 |||.| .      . .|.|.||    ....||| |.||||||.....   .  .|
-IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKII

Kinase 9946.AA S_TKc 35-272 19 1.6e-13 21.58 SMART 1-231 (231) Show / Hide
Range on Protein: 35-272
Range on HMM: 1-231/231
Sequence Identity: 19% (53 aa)

IEIEKKIGEGFFAEVFQATQINEQRRVAIKKVKDLNKEQKFEDEKKAMYKIKNQQYAIQIIGELTNKELGYNAIIMEICDC---TLAEIFEKNIDN----
 || .|||.| |..|.... .. .|.||||..|     .... | . . |  .  . .....   .   ..  ..|| ||    .| .. .|.  .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FTEEQFIALVYQLLKGLLVFQEKGIIHGDLKPENILYNQKKNKFLIQIVKI------KEWKFQVYGSRSSSQQ-------EALHNQR---------LML
 |.| .   ..||....|    ..|||| |||||||| ..         .||      ..         ..          | |.  .          .|
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------HIKICDFGLARQL--------TTFCGTPWYMAPEVLGYGKCKCDWWSCGCIL

LEFVLKRELTLSESLRLKENNSLFDVIQNLQNNPYIEFINQILAKMVCFESEQRLESMQLLQ-----RLNQYI
 |..  ..   .      . . .|..|         |... .. |. ... |.|.   ..||     .. ...
YEMLC-GYPPFP------QMQMMFKKIG------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 9946.AA Ciliate-E2 35-178 18 4.9e-13 41.08 In-house 1-197 (365) Show / Hide
Range on Protein: 35-178
Range on HMM: 1-197/365
Sequence Identity: 18% (38 aa)

IEIEKKIGEGFFAEVFQATQINEQRRVAIK---------------KVKDLNKEQKFEDEKKAMYKIKNQQ----------------------YAIQIIGE
... ||||.| |. |........|...|||               |.|  ..... ....... .....                       . |...  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

LTNKELGYNAIIMEICDC-TLAE------IFEKNI----DNFTEEQFIALVYQLLK---------------GLLVFQEKG-IIHGDLKPENILYNQKKNK
  .|   .  ..|| |.  .| .      ......     .|||.. . . .|.|.               .|    .|. ||| |.||||||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

FLIQIVKI
     .||
-----IKI

Kinase 9946.AA Ciliate-E2a 123-170 40 4.2e-10 25.96 In-house 91-142 (275) Show / Hide
Range on Protein: 123-170
Range on HMM: 91-142/275
Sequence Identity: 40% (21 aa)

KNIDNFTEE--QFIALVYQLL-KGLLVFQEKGIIHGDLKPENILYN-QKKNK
|. ..|.||  .   .  ||| .||. .. ..|.| ||||||||..  .||.
KQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNS

Kinase 9946.AA GSK 136-168 39 1.6e-09 24.64 In-house 121-153 (328) Show / Hide
Range on Protein: 136-168
Range on HMM: 121-153/328
Sequence Identity: 39% (13 aa)

LVYQLLKGLLVFQEKGIIHGDLKPENILYNQKK
..||...||   ...|| | |.||.|||.....
YMYQMFRGLAYLHSHGICHRDIKPQNILVDPDT

Kinase 9946.AA GSK 35-76 31 8.5e-09 22.37 In-house 1-51 (328) Show / Hide
Range on Protein: 35-76
Range on HMM: 1-51/328
Sequence Identity: 31% (16 aa)

IEIEKKIGEGFFAEVFQATQI----NEQRR----VAIKKVKDLNKEQ-KFE
.|. |.|| | |  |.||. .    ....     ||||||   .. .  .|
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRE

Kinase 9946.AA TyrKc 35-268 16 1.1e-08 -82.31 SMART 1-280 (280) Show / Hide
Range on Protein: 35-268
Range on HMM: 1-280/280
Sequence Identity: 16% (49 aa)

IEIEKKIGEGFFAEVFQATQINEQRRVAIKKVKDLNKEQKFEDEKKAMYKI-KNQQYAIQIIGELTNK-----ELGYNAIIMEICDC-TLAEIFEKNIDN
|. .||.|||.| ||...| .   . ||.|..|.   .. | .| . | |. .. .  ....|  | .     . .   |.|| ..   | .   |. ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

FTEEQFIALVYQLLKGLLVFQEKGIIHGDLKPENILYNQKKNKFLIQIVKI------KEWKFQ--------VYGSRSSSQQEALHNQRLMLLEFVLKRE-
.. ....   .|  .|     .|..|| ||   |.|.. ..      .|||      ....          .| ......  ..   | | .|   ... 
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

----------------LTLSESLRLK-EN--NSLFDVIQNLQNNPYIEFINQ--------------ILAKMVCFE-SEQRLESMQLLQRL
                .|. ..     .    | ..||.....  . .                   . |. . |  |.|    .. ...
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase 9946.AA CAMK1 36-64 37 1.1e-08 21.26 In-house 2-33 (276) Show / Hide
Range on Protein: 36-64
Range on HMM: 2-33/276
Sequence Identity: 37% (12 aa)

EIEKKIGEGFFAEVFQATQINE---QRRVAIK
|. |.||.| |.||...|...    .. .|||
EFGKEIGRGAFSEVYLCTHKETQTNGKQYAIK

Kinase 9946.AA Pkinase 35-67 33 8.2e-08 28.7 Pfam 1-33 (293) Show / Hide
Range on Protein: 35-67
Range on HMM: 1-33/293
Sequence Identity: 33% (11 aa)

IEIEKKIGEGFFAEVFQATQINEQRRVAIKKVK
..|..|||.| |..|.... ......||.|..|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIK

Kinase 9946.AA CDK 108-167 30 9.1e-08 20.76 In-house 95-144 (284) Show / Hide
Range on Protein: 108-167
Range on HMM: 95-144/284
Sequence Identity: 30% (18 aa)

IIMEICDCTLAEIFEKNIDNFTEEQFIALVYQLLKGLLVFQEKGIIHGDLKPENILYNQK
...| .|  |... .             . .|||.||    ...|.| |||| |||.| .
MVFEYMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNN

Kinase 9946.AA Ciliate-E2a 36-74 33 1e-07 18.82 In-house 2-40 (275) Show / Hide
Range on Protein: 36-74
Range on HMM: 2-40/275
Sequence Identity: 33% (13 aa)

EIEKKIGEGFFAEVFQATQINEQRRVAIKKVKDLNKEQK
...||||.|.|. |. |.....  . |.||... . .||
KFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQK

Kinase 9946.AA Pkinase_Tyr 35-88 29 2.1e-07 25.73 Pfam 1-64 (270) Show / Hide
Range on Protein: 35-88
Range on HMM: 1-64/270
Sequence Identity: 29% (19 aa)

IEIEKKIGEGFFAEVFQATQI----NEQRRVAIKKVKDLNKEQK-----FEDEKKAMYKI-KNQ
|.. ||.||| | ||...|      |..  ||.|..|.   ..      |  | | | .. ...
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHP

Kinase 9946.AA CDK 36-67 32 2.4e-07 19.38 In-house 2-38 (284) Show / Hide
Range on Protein: 36-67
Range on HMM: 2-38/284
Sequence Identity: 32% (12 aa)

EIEKKIGEGFFAEVFQATQINEQ-----RRVAIKKVK
|. .||||| ...|. |   . .     . ||.||..
EKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIR

Kinase 9946.AA CAMK1 149-175 51 5.2e-07 16.35 In-house 126-154 (276) Show / Hide
Range on Protein: 149-175
Range on HMM: 126-154/276
Sequence Identity: 51% (15 aa)

EKGIIHGDLKPENILYNQKKNKFLIQ--I
.||| | ||||||.||  |.. . |   |
SKGIVHRDLKPENLLYYDKDEDSKIKRSI

Kinase 9946.AA Pkinase 104-167 31 3e-06 23.0 Pfam 73-144 (293) Show / Hide
Range on Protein: 104-167
Range on HMM: 73-144/293
Sequence Identity: 31% (23 aa)

GYNAIIMEICDCT--LAEIF-------EKNIDNFTEEQFIALVYQLLKGLLVFQEKGIIHGDLKPENILYNQK
..  ..|| |...  ... |       ....  |.|.. .  .||.|.||    ..|||| ||||||||....
DHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNN