Gene 11348 (Tetrahymena)
11348
Group:
Other
Family:
Ciliate-C4
Sequence
Protein domains of 11348.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 11348.AA | Ciliate-C4 | 659-949 | 36 | 6.30000000001e-133 | 428.21 | In-house | 47-361 (361) | Show / Hide |
Range on Protein: 659-949 Range on HMM: 47-361/361 Sequence Identity: 36% (117 aa) IIQY--FFDEGGSIKQQYQNHAGSYLLIQTTQ------IEKLQNEGIFIQQPGGKSLSRELLEIREETLKG-EVIYHIYPTKLHKSLQNHKEQ--LYELI .|. |.. | | .||. | |.| .| | . | .||||. | || |. . | .| | .||. .| |.. . .| EIWFYSFYMRNGQVKEYYQMYQGFKNLPQMMYNEILINYMKDQKDTWIIYELCGKSLRKSLYEIKGEDYCQNERVYKINFKKLYYHLFQDKNNNLCKKFI INLCEVIDLLSSNKIVHSDFRLENILVDTL-DFGDSSAIQGLKIIDFGSSYFLNNRKGVS-NIIPEYMPPEVLKQILGKQ----------KVDVFS---- .|.....|..||.||.|...|||||... |||.|..||..|.|||||....||.|... ...|||||||.|..|...| ..|.|. QHICHALWHLHQNKWVHCDIKPENILVKYKSDFGGSNNIQQVKLIDFGSCFQFNNKKHIQSMATPEYMPPEMLNFIIQEQNEDEQLQQNHQHDMFQYLQN DECPWSVDIWTLGCIIIEIITGIPVWMPQRCLLHSHGVDPKKVTSGFFSHKQRRIDRIFEKQVKFSNQIEQFAKQYLNSTCPTVFKIDQNLYSIIIGIFK .|||||.|||..||...|||||||.||...|..|...| ......|.|.|||.....|..||.||..||.|..|......| ...|||.|...|....| YECPWSIDIWSMGCVMMEIITGIPHWMSYKCRVHHKQV-KNFIKHGIFCHKQQCFENIIQKQKKFCKQIDQYMKEHNYQFC--CQVIDQQLKDLIKKMLK QDPKDRISPKQIINLLKN ..|..||||||..... FNPRERISPKQCCQHPWI |
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| Kinase | 11348.AA | Ciliate-E2 | 750-831 | 21 | 1.6e-13 | 42.81 | In-house | 169-281 (365) | Show / Hide |
Range on Protein: 750-831 Range on HMM: 169-281/365 Sequence Identity: 21% (27 aa) LCEVIDLLSSNK-IVHSDFRLENILVDTLDFGDSSAIQGLKIIDFGSSYFLNNRKGVSNI----------------------------------IPEYMP ... . | |.. |.| | .||||. .|||||| | .... . |.||. IILALEYLHSKNNIIHRDIKPENILF-------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMA PEVLK------QILGK---QKVDVFS ||.|. |...| |.|..| PEILNGKKYDNQQKQKGYDYKCDIWS |
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| Kinase | 11348.AA | S_TKc | 611-947 | 13 | 1.8e-12 | 6.08 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 611-947
Range on HMM: 1-231/231
Sequence Identity: 13% (47 aa)
FSVKNLMNKGTHSEIYKLKNLITNKVQIAKRIQFNSKFAESAFLNEESIIQYFFDEGGSIKQQYQNHAGSYLLIQTTQIEKLQNEGIFIQQPGGKSLSRE
. . .. ||. .. || .. |... |.| |....| .. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------------------------------------EHIRREIQILKK--HHPNIVK
LLEIREETLKGEVIYHIYPT---KLHKSLQNHKE---------QLYELIINLCEVIDLLSSNKIVHSDFRLENILVDTLDFGDSSAIQGLKIIDFGSSYF
|... .. . .. .. |.. ..... . .. .|. .. . |..|.| | ||||.|. .||.|||.. .
LYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----------HIKICDFGLARQ
LNNRKGVSNIIPEYMPPEVLKQILGKQKVDVFSDECPW-SVDIWTLGCIIIEIITGIPVWMPQRCLLHSHGVDPKKVTSGFFSHKQRRIDRIFEKQVKFS
| |.||.|||| ..|.| .|||..| ..| | . | .. . .
L----TTFCGTPWYMAPEVL--------------GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG----------------------------
NQIEQFAKQYLNSTCPTVFKIDQNLYSIIIGIFKQDPKDRISPKQIIN---------LL
.. . ..| .... ||..|.. .. . .
---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
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| Kinase | 11348.AA | Pkinase | 759-857 | 27 | 1.9e-11 | 41.57 | Pfam | 126-212 (293) | Show / Hide |
Range on Protein: 759-857 Range on HMM: 126-212/293 Sequence Identity: 27% (29 aa) SNKIVHSDFRLENILVD-TLDFGDSSAIQGLKIIDFGSSYFL-NNRKGVSNII---PEYMPPEVLKQILGKQKVDVFSDECPWSVDIWTLGCIIIEIITG |..|.| | .||||.| . . .. .||.|||.. .. . ... . . |.||.|||.. .. . . .||.| .|||..| ..| SMGIIHRDLKPENILIDNNGHIDA-----CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----------GGQYYGPKVDMWSCGCILYEMLCG IPVW | . RPPF |
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| Kinase | 11348.AA | Ciliate-E2-Unclassified | 756-853 | 27 | 4.6e-10 | 31.13 | In-house | 159-266 (352) | Show / Hide |
Range on Protein: 756-853
Range on HMM: 159-266/352
Sequence Identity: 27% (33 aa)
LLSSNKIVHSDFRLENILVDTLDFGDSSAIQGLKIIDFGSSYFLN-----------------NRKGVSNI-IPEYM----PPEVLKQ-ILGKQKVDVFSD
| ..|.|.| | .||||.| .||||||.|.... . . ... |.|| .||||.. ...|
LHHKNNIIHRDIKPENILFDNNGK-----NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-----
ECPWSVDIWTLGCIIIEIITG
..|||.||.|. |...|
---YKCDIWSLGVILYEMLFG
|
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| Kinase | 11348.AA | Ciliate-E2 | 837-945 | 19 | 3e-09 | 27.87 | In-house | 276-361 (365) | Show / Hide |
Range on Protein: 837-945 Range on HMM: 276-361/365 Sequence Identity: 19% (23 aa) SVDIWTLGCIIIEIITGIPVWMPQRCLLHSHGVDPKKVTSGFFSHKQRRIDRIFEKQVKFSNQIEQFAKQYLNSTCPTV---FKIDQNLYSIIIG----I ..||| ||.|. | ..| | . .. | .....|... | .| .. . . .|..|. .| . KCDIWSLGVILYEMLFGKPPF----------------------------QQQIKQCKIDFPCPEWQKDTQ-CI-Q-CKWKSWKKWSQECKDLIKKFGKRM FKQDPKDRIS-PKQIIN .. ||. ||. ..||.| LQKDPEKRITGWEQILN |
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| Kinase | 11348.AA | CAMK | 759-846 | 22 | 4.2e-09 | 24.72 | In-house | 197-323 (425) | Show / Hide |
Range on Protein: 759-846 Range on HMM: 197-323/425 Sequence Identity: 22% (30 aa) SNKIVHSDFRLENILVDTLD-----------FGDSSAIQG-LKIIDFGSSYFLNNRKGVSNI--------------------------IPEYMP-PEVLK |..||| | .||||.|. . | | .. .|||||| . ... .. .. ||||. ||||. SHNIVHRDLKPENILLDDNNDDSDPVEHDEIF-D--WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLN QILGKQKVDVFS------DECPWSVDIWTLGCI . .... . . .. ..|.| .|.| GKGHCNMQ---NATDEEKPYYGPKCDMWSCGVI |
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| Kinase | 11348.AA | STE | 755-853 | 26 | 9.7e-09 | 27.12 | In-house | 166-264 (359) | Show / Hide |
Range on Protein: 755-853 Range on HMM: 166-264/359 Sequence Identity: 26% (32 aa) DLLSSNKIVHSDFRLENILVDTLDFGDSSAIQGLKIIDFGSSYFLNN----------------RKGVS-NII--PEYMPPEVLKQ-ILG-KQKVDVFSDE ..| |..|.| | |||. |..||| . |.. ... . .. | .| |||..| | ... |. YYLHSHHIIHRDIKPANILL-------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDT---- CPWSVDIWTLGCIIIEIITG ..||| ||| ||| .|| ---KCDIWSLGCTIIEMATG |
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| Kinase | 11348.AA | Ciliate-E8 | 752-796 | 44 | 5.8e-08 | 20.98 | In-house | 100-138 (138) | Show / Hide |
Range on Protein: 752-796 Range on HMM: 100-138/138 Sequence Identity: 44% (20 aa) EVIDLLSSNKIVHSDFRLENILVDTLDFGDSSAIQGLKIIDFGSS ... | .| |.|.|| |.|||| | |. |||||| | DAFCYLHNNNIIHCDFKLNNILVQRND--DTK----IKIIDFGFS |
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| Kinase | 11348.AA | AGC | 759-855 | 19 | 1.4e-07 | 14.09 | In-house | 171-303 (395) | Show / Hide |
Range on Protein: 759-855 Range on HMM: 171-303/395 Sequence Identity: 19% (30 aa) S-NKIVHSD-FRLENILVDTLDFGDSSAIQGLKIIDFGSSYFLNNRKGV--------------------------------------------------- | ..|.| | .|||| | .|. |||.. ..|.... SHMGIIHRDYLKPENILLDED--------GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRT SNII----PEYMPPEVLKQILGKQKVDVFSDECPWSVDIWT--LGCIIIEIITGIP . . ||||.||.| . ..|.|. |||.. | .||.| WTFCGPCTPEYMAPEIL---------------YGKACDWWSFGLGCLMYEMLTGYP |
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| Kinase | 11348.AA | DyrkP | 754-853 | 34 | 2e-06 | 16.21 | In-house | 119-201 (323) | Show / Hide |
Range on Protein: 754-853 Range on HMM: 119-201/323 Sequence Identity: 34% (34 aa) IDLLSSNKIVHSDFRLENILVDTLDFGDSSAIQGLKIIDFGSSYFLNNRKGVSNIIPEYMPPEVLKQILGKQKVDVFSDECPWSVDIWTLGCIIIEIITG .| . | ...| | . ||||. .. |||||||| |. | ||| |.| | | . .|.| ||||. |. || LDYIHSLRLIHCDLKPENILMKSYPKCQ------VKIIDFGSSCFIHDHLSSYVQSRSYRAPEV---IIG-CKYD-------YRIDMWSLGCILAELWTG |
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| Kinase | 11348.AA | TKL | 757-831 | 26 | 4e-06 | 18.15 | In-house | 148-274 (364) | Show / Hide |
Range on Protein: 757-831 Range on HMM: 148-274/364 Sequence Identity: 26% (34 aa) LSSNK--------IVHSDFRLENILVDTLDFGDSSAIQG-------LKIIDFGSSYFL--------------------NNRKGVSNII--PEYMPPEVLK | |.. |.| | .||||| .| . .|| ||| | |. |||| .... | .|.||||. LHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLR -QILGKQKV---------------DVFS |. ..|| ||.| GQMNYTEKVGIDEFCKGFEYSEKCDVYS |
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| Kinase | 11348.AA | DYRK2 | 754-802 | 42 | 9.5e-05 | 11.01 | In-house | 115-158 (318) | Show / Hide |
Range on Protein: 754-802 Range on HMM: 115-158/318 Sequence Identity: 42% (21 aa) IDLLSSNKIVHSDFRLENILVDTLDFGDSSAIQGLKIIDFGSSYFLNN-R ...|. |.|.| | |||| | | | |.|||||| | . | LRFLHKNNIIHCDLKPENIL---LKQWNRSGI---KVIDFGSSCFEHQYR |
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| Kinase | 11348.AA | DYRK2 | 837-855 | 47 | 0.000381 | 9.01 | In-house | 182-200 (318) | Show / Hide |
Range on Protein: 837-855 Range on HMM: 182-200/318 Sequence Identity: 47% (9 aa) SVDIWTLGCIIIEIITGIP ..|.| .|||. |. || | AIDMWSFGCIMAELYTGYP |
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| Kinase | 11348.AA | Ciliate-E2-Unclassified | 611-661 | 12 | 0.00237 | 7.51 | In-house | 294-350 (352) | Show / Hide |
Range on Protein: 611-661 Range on HMM: 294-350/352 Sequence Identity: 12% (7 aa) FSVKNLMNKGTHSEIYKLKNLITNKV----QIAKRIQFNSKFA---ESAFLNEESIIQ . . ..| ....||... .... .. | .....| . ..||. ... YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMN |
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| Kinase | 11348.AA | Pkinase | 917-947 | 21 | 0.044484 | 8.43 | Pfam | 261-293 (293) | Show / Hide |
Range on Protein: 917-947 Range on HMM: 261-293/293 Sequence Identity: 21% (7 aa) KIDQNLYSIIIGIFKQDPKDRISPKQIINL--L ...... ..| .....|||.|....|| . . NWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 11348.AA | Ciliate-E2 | 611-645 | 20 | 0.057083 | 2.53 | In-house | 1-34 (365) | Show / Hide |
Range on Protein: 611-645 Range on HMM: 1-34/365 Sequence Identity: 20% (7 aa) FSVKNLMNKGTHSEIYKLKNLITNKVQIAKRIQFN . . .. .|... .|| |. ..| .. |.|. . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-Q |
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