Gene 12088 (Tetrahymena)
12088
Group:
Other
Family:
Ciliate-C5
Sequence
Protein domains of 12088.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 12088.AA | Ciliate-C5 | 52-312 | 84 | 5.5e-190 | 630.92 | In-house | 1-260 (260) | Show / Hide |
Range on Protein: 52-312 Range on HMM: 1-260/260 Sequence Identity: 84% (220 aa) IYLTSYISQGGFGCIFEAKHNEEIVAIKCSKTNFQKIEEEEKILNLLKDTPYVFKFIKGFTNQKKSRYYQISKRYSCNLKEIMKSFFDQRKTLPLNQIIG ||||||||||||||.||||.||||||.||||.||.||.|||||..|||||||||| |..|.|.|||.|||||||||||||.||.|||||.|||||||||| IYLTSYISQGGFGCVFEAKYNEEIVAVKCSKPNFEKIKEEEKIMKLLKDTPYVFKSIEEFLNEKKSKYYQISKRYSCNLKDIMQSFFDQKKTLPLNQIIG FAIQMSTVFEKIEQNKLLHSDIKPENILYDSQEKCFYLSDYGESKQFQNGSKTYDLKGYTPKYAAPEITDIQNGIFNIKYDIYGLGVILLELTLGKFLED ||||||||||||.||.|.|||.||||||||||||||.|.||||||.|..|||||||||.|.||||||||| ||.|||||||||||.||||||||||||| FAIQMSTVFEKIQQNNLIHSDVKPENILYDSQEKCFNLCDYGESKSFKDGSKTYDLKGFTRKYAAPEITDD-NGFFNIKYDIYGLGIILLELTLGKFLED SDCSFIRNGSLPKYISKNALYQDINQIIVKMLEKMPSNRIGSFELTKKLNELRLKLENQFI .||.|||||.||.|||||||||||||||.|||||||.||| ||||||.|||||||||.||| EDCTFIRNGKLPNYISKNALYQDINQIIIKMLEKMPQNRIDSFELTKQLNELRLKLESQFI |
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| Kinase | 12088.AA | Ciliate-E1 | 58-234 | 25 | 1.5e-27 | 86.9 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 58-234 Range on HMM: 1-202/202 Sequence Identity: 25% (51 aa) ISQGGFGCIFEA---KHNEEIVAIKCSKTNFQ--------KIEEEEKILNLLKDTPYVFKFIKGFTNQKKSRYYQISKRYSCNLKEIMK---------SF |..|.|. .|.| ..|.. ||.| ...|. .|.|. ||.. .| |....|. . .. ...| ..|.||. .. .. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC FDQRKTLPLNQIIGFAIQMSTVFEKIEQNKLLHSDIKPENILYDSQEKCFYLSDYGESKQFQNGSKT-YDLKGYTPKYAAPEITD------IQNGIFNIK . . . |.. ..|. .. ..|....|.||||.|||...| . . ..| | ||...| .. .. |||| .|. || ..| . |.| QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYK YDIY .||| SDIY |
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| Kinase | 12088.AA | Pkinase | 60-300 | 20 | 8.5e-19 | 67.55 | Pfam | 9-293 (293) | Show / Hide |
Range on Protein: 60-300 Range on HMM: 9-293/293 Sequence Identity: 20% (60 aa) QGGFGCIFEAKHNEE--IVAIKCSKTNFQKIEE--------EEKILNLLKDTPYVFKFIKGFTNQKKSRYYQISKRYSCNLKEIMKSF----FDQRKTL- .|.||| ....| . |||.|. | .| .. | .|.. | . |.. ... |.. |...| . . |. | | ...... SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFY -PLNQIIGFAIQMSTVFEKIEQNKLLHSDIKPENILYDSQEKC---FYLSDYGESKQ--FQNGSKTYDLKGYTPKYAAPEITDIQ-NGIFNIKYDIYGLG . .... .. |. | . ... .| |.||||||.|.. . . ..| | .|| |.| .... | || |.|||. |. . | |....| FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCG-TPWYMAPEV--IRGGQYYGPKVDMWSCG VILLELTLGKFLEDSD--------CSFIRNGSLPKYISKNALY---------------------QDINQIIVKMLEKMPSNRIGSFELTKK--L .|| |. .|... ... |.. |.. . .. ..| ..|.| |. |.. .. . . CILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 12088.AA | Ciliate-E2 | 52-303 | 17 | 1.2e-17 | 57.12 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 52-303 Range on HMM: 1-365/365 Sequence Identity: 17% (68 aa) IYLTSYISQGGFGCIFEAKHNEE-------------------------IVAIKCSKTN-FQKIEEEEKILNLLK---------------DTPYVFKFIKG . . | ||.||.....|. .. |.|.|. | | . |. |..|.. .. . |.. |.. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FTNQKKSRYYQISKRYSC-NLKEIMKSFFDQRKTLPL-------NQIIGFAIQMSTVF---------------EKIEQNK-LLHSDIKPENILYDSQEKC | ..... .| . .. .|....|.. .|. . ..|. . | .| | . ... .| ||||||||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------ FYLSDYGESKQFQ---------NGSKTYDLKG-----------------------YTPKYAAPEITDIQN------GI-FNIKYDIYGLGVILLELTLGK ..| | ||... ...| | . .|| | |||| .. . . | ||. ||||| |. || IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK FLEDSDCSFIRNGSLPKYISKNA--------------------------LYQDINQIIVK----MLEKMPSNRIGSFELTKKLNEL . .. . . |. ..| | ||.| |..||...| .. . PPF--------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | 12088.AA | S_TKc | 52-306 | 21 | 6.6e-16 | 56.31 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 52-306 Range on HMM: 1-231/231 Sequence Identity: 21% (56 aa) IYLTSYISQGGFGCIFEAKHNE--EIVAIKCSKTNFQKIEEEEKILNLLKDTPYVFKFIKGFTNQKKSRYYQISKRYSC---NLKEIMKSFFDQR--KTL . | .|.||. . ..|.. .|||||. | ..|. | .|| . |.. |.. | . ...| . . .|....|. .. . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF PLNQIIGFAIQMSTVFEKIEQNKLLHSDIKPENILYDSQEKCFYLSDYGESKQFQNGSKTYDLKGYTPKYAAPEITDIQNGIFNI-KYDIYGLGVILLEL | .. .. |. | . ... .| |.|||||| |. . ..| | ..|. . || | |||. .. | |.. .|.|| |. PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEM TLGKFLEDSDCSFIRNGSLPKYISKNALYQDINQIIVKMLEKMPSNRIGSFELTK---KLNELRLK |. . . . . . . .. ..| |.|.| |..|.. |. . . . LCGYPPFP-QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 12088.AA | Ciliate-E3 | 165-244 | 36 | 1.3e-15 | 45.39 | In-house | 121-202 (202) | Show / Hide |
Range on Protein: 165-244 Range on HMM: 121-202/202 Sequence Identity: 36% (31 aa) QNKLLHSDIKPENILYDSQEK--CFYLSDYGESKQFQNGS---KTYDLKGYTPKYAAPEITDIQNGIFNIKYDIYGLGVILLELT . .. ||||||.||| |. . .| ||||| .. |.. | || |||||. | |. . |.| .|.....| EKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQY-QGWTPFYAAPEQNDQQQ--ISKESDYYSVGAVFCQLC |
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| Kinase | 12088.AA | Ciliate-E2-Unclassified | 52-292 | 18 | 1.4e-14 | 46.98 | In-house | 1-342 (352) | Show / Hide |
Range on Protein: 52-292
Range on HMM: 1-342/352
Sequence Identity: 18% (64 aa)
IYLTSYISQGGFGCIFEAKHNEE---------IVAIKCS-------KTNFQKIEEEEKILN-------------LLKDTPYVFKFIKGFTNQKKSRYYQI
. | |||||......|... ....... . .. ...|..... .|.. | |. . .. |.| | .
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV
SKRY-SCNLKEIMKSF----------FDQRKT---LPLNQII-----GFAIQMSTVFEKIEQNK-LLHSDIKPENILYDSQEK--CFYLSDYGESKQFQN
.|....|.. |...|. .. .|.. .. | .|.. ... .| ||||||||.|.. | . ..|.| ||. |.
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ
---------------GSKTYDLKGYTPKYA----APEITDIQNGIFN----IKYDIYGLGVILLELTLGKFLEDSDCSFI-------------RNGSLPK
.. .. . || | |||. .|. . .| ||..||||| |. |.. .. .. . | . .
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEV--LQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN
YISKNALYQDIN-----------------QIIVKMLEKMPSNRIG
. || .. . ... |||.| |..||.
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRIT
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| Kinase | 12088.AA | CMGC | 52-205 | 12 | 2.7e-14 | 42.45 | In-house | 1-282 (513) | Show / Hide |
Range on Protein: 52-205
Range on HMM: 1-282/513
Sequence Identity: 12% (35 aa)
IYLTSYISQGGFGCIFEAKH----------------NEEIVAIKCSKTNFQKIEEEE----------------KILNLLK----------------DTPY
..| .| .| ..... ..|||||| | .| . |.. ||| |. . ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN
VFKFIKGFTNQK---------------KSRYYQISKRYSCNLKEIMKSFF------------------------DQRKTLPLNQIIGFAIQMSTVFE--K
. | . |. . | . ..|....|. . | ... .| .. |. . .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY
IEQNK--LLHSDIKPENILYDSQEKCF-------------------YLSDYGESKQFQNG---------------------SKTY
. ... .| |.|||||| ... ... . | | .... . ...|
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPY
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| Kinase | 12088.AA | Ciliate-B2 | 53-237 | 26 | 3e-14 | 29.83 | In-house | 2-197 (197) | Show / Hide |
Range on Protein: 53-237 Range on HMM: 2-197/197 Sequence Identity: 26% (53 aa) YLTSYISQGGFGCIFEAK-----HNEEIVAIKCSKT----NFQKIEEEEKILNLLKDTPYVFKFIKGFTNQKKSRYYQISKRYSCNLKEIMKSFFDQRKT ||. || .||.| |.| . .|.| . . |..| ||. .. .| |.| . ... | . | ||. .. |.| YLCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETIDVL-IMEKCECSLKQELQKIQKQQKC LPLNQIIGFAIQMSTVFEKIEQNKLLHSDIKPENILYDSQEKCFYLSDYGESKQFQNGSKTYDLKGYTPKYAAPE-ITDI--QNGIFNIKY--DIYGLG . . .. |. .. . || ||||.||| .|. . ..|.| | .. .. . || | ||| || . .. | || . ||| .| FNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILF-MQNGNYVYCDFGISSIKKDNQQIK-IKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG |
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| Kinase | 12088.AA | C8 | 56-240 | 23 | 8.6e-14 | 44.35 | In-house | 5-226 (226) | Show / Hide |
Range on Protein: 56-240
Range on HMM: 5-226/226
Sequence Identity: 23% (53 aa)
SYISQGGFGCIFEAKHNEE--IVAIKCSK-TNFQKIEEEEKILNLLKDTPYVFKFIKGFTNQKKSRYYQISKR----YS-----------CNLKE-----
|.|.|..| . .|| .. ...| | .| |.|...|.| .. .| ||. . . |... | . .. | | ..|
QYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYE-MPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELCE
-IMKSFFDQRKTLPLN----QIIGFAIQMSTVFEKIEQNKLLHSDIKPENIL-YDSQEKC--FYLSDYGESKQFQNGSKTYDLKGY----TPKYAAPEIT
.| ..|.|.. . . |||| . |.. . .| ||||.|.| . .|.. |.| |.. | . . . | . | .| ||||
QNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIE
DI---QNGIFNIKYDIYGLGVIL
|. ...|. |.. .|..|
KKQDNQYKQYRIQSDLFSVGLVL
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| Kinase | 12088.AA | TKL | 167-247 | 19 | 4.4e-13 | 43.47 | In-house | 160-286 (364) | Show / Hide |
Range on Protein: 167-247 Range on HMM: 160-286/364 Sequence Identity: 19% (25 aa) KLLHSDIKPENILYDS-------------QEKCFYLSDYGESKQFQ-------------------NGSKTYDLKGYTPKYAAPEITD------------- ...| |.|..||| |. . | ..|.| |. .. |..|| .. || . |||. . PIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE -IQNGIFNIKYDIYGLGVILLELTLGK .... .. | |.| |..| |. .. FCKGFEYSEKCDVYSFGIVLWEILTRC |
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| Kinase | 12088.AA | ULK | 135-291 | 22 | 1.7e-10 | 32.91 | In-house | 108-318 (329) | Show / Hide |
Range on Protein: 135-291 Range on HMM: 108-318/329 Sequence Identity: 22% (47 aa) KSFFDQRKTLPLNQ----------IIGFAIQMSTVFEKIEQNKLLHSDIKPENILYDS-QEK----------CFYLSDYGESKQFQNG------SKTYD- ... ..|.||... .| | .| | . ... | ||||.||| . |.| .. ..| | .|...|. .|. EQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVN ---LKGYTPKYAAPEITDIQ--NGIFN-IKYDIYGLGVILLELTLGKFL----EDSDC-----SFIRNG---------SLPKYI---SKNALYQDINQII |.| || | ||.| | . .. | ||. ||.|. |. || .. . |.|. ... ... . ... ..| EKRLCG-TPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLI VKMLEKMPSNRI .||.. .. || RRMLQYDEKDRI |
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| Kinase | 12088.AA | TyrKc | 52-300 | 15 | 3.1e-07 | -105.75 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 52-300
Range on HMM: 1-280/280
Sequence Identity: 15% (49 aa)
IYLTSYISQGGFGCIFEAKHNEEIVAIKCSK--TNFQKIEEEEKILNLL-KDTPYVFKFIKGFTNQ--------------------------KKSRYYQI
| | . | || ..... . . ||.|. | . . . .| .|. | .. | . ... | | .|.|
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--
SKRYSCNLKEIMKSFFDQRKTLPLNQIIGFAIQMSTVFEKIEQNKLLHSDIKPENILYDSQEKCFYLSDYGESKQFQNG------SKTYDLKG--YTP--
|.. . . |..| . | ...... | |. |.|.... . || | |. .. ...|. |. .
---------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTM
---KYAAPEITDIQNGIFNIKYDIYGLGVILLEL-TLGKFLEDSD----------CSFIRNGSLPKYISKNA------LYQDINQIIVKMLEKMPSNRIG
. ||| . |.|..| |.. || . |. |.|. . ....| .. . ... ||. . . |..|
LPIRWMAPECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT
SFELTKKL
|. ...
FSEIHECF
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| Kinase | 12088.AA | TKL | 58-99 | 16 | 5.3e-07 | 21.28 | In-house | 1-83 (364) | Show / Hide |
Range on Protein: 58-99 Range on HMM: 1-83/364 Sequence Identity: 16% (14 aa) ISQGGFGCIFEAKHNE----------EIVAIKCSKT-------------------------------NFQKIEEEEKILNLLK | .||||... .|.. . ||.| |. .....||| .... |. IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLR |
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| Kinase | 12088.AA | ULK | 52-99 | 22 | 0.002416 | 7.63 | In-house | 1-68 (329) | Show / Hide |
Range on Protein: 52-99 Range on HMM: 1-68/329 Sequence Identity: 22% (15 aa) IYLTSYISQGGFGCIFEA--KHNE----EIVAIKCSK---TNFQK-----------IEEEEKILNLLK ..| . .| || ... | .. |.||.| | .. .. | ||. || YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLK |
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