Gene 16546 (Tetrahymena)

16546

Species: Tetrahymena
Alias: 16546, PreTt16546, TTHERM_00092920, 6.m00620, 95, 3836.m02205
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C5

Sequence

Name Sequence Type Origin Length Description Download
16546.AA Protein None 712 None Fasta, JSON
16546.kin_dom Protein Kinase Domain None 261 None Fasta, JSON
16546.NA RNA None 2139 None Fasta, JSON

Protein domain

Protein domains of 16546.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 16546.AA Ciliate-C5 69-329 84 1.5e-188 626.14 In-house 1-260 (260) Show / Hide 
Range on Protein: 69-329
Range on HMM: 1-260/260
Sequence Identity: 84% (221 aa)

IYLTSYISQGAYGCVFEAKYNDEIVAIKCSKANFEKINEEEKILNLLKETPYVFRSIQGFLNEKKSKYYQISKRYSCNLKDIMQSLFDQKKTLPLNQIIG
||||||||||..|||||||||.||||.||||.|||||.|||||..|||.|||||.||..||||||||||||||||||||||||||.||||||||||||||
IYLTSYISQGGFGCVFEAKYNEEIVAVKCSKPNFEKIKEEEKIMKLLKDTPYVFKSIEEFLNEKKSKYYQISKRYSCNLKDIMQSFFDQKKTLPLNQIIG

FAIQMSTVFNKIQQNNFIHSDVKLENILYDSQEKCFNLCDYGDSKLFKDGSCTQNLKAFTRRYAAPEITDLENGSFNIKYDIYGLGIILLELTLGQFLKE
|||||||||.||||||.||||||.||||||||||||||||||.|| |||||.|..||.|||.||||||||  ||.||||||||||||||||||||.||..
FAIQMSTVFEKIQQNNLIHSDVKPENILYDSQEKCFNLCDYGESKSFKDGSKTYDLKGFTRKYAAPEITDD-NGFFNIKYDIYGLGIILLELTLGKFLED

EDCTFIRNGNLPNYLREKDLFKDINQIIIKMLEKEPQKRIDSFELTKELNELRLKLESQFI
|||||||||.||||.....|..||||||||||||.||.|||||||||.|||||||||||||
EDCTFIRNGKLPNYISKNALYQDINQIIIKMLEKMPQNRIDSFELTKQLNELRLKLESQFI
Kinase 16546.AA Ciliate-E1 75-251 25 1.2e-20 64.2 In-house 1-202 (202) Show / Hide 
Range on Protein: 75-251
Range on HMM: 1-202/202
Sequence Identity: 25% (53 aa)

ISQGAYGCVFEA---KYNDEIVAIKCSKANFE--------KINEEEKILNLLKETPYVFRSIQGFLNEKKSKYYQISKRYSCNLKDIMQ---------SL
|..| .. ||.|   ..|.. ||.|  . .|         .|.|. ||.. .|.  |..  |. .  ..   ...|   ..|.||| .|         ..
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

FDQKKTLPLNQIIGFAIQMSTVFNKIQQNNFIHSDVKLENILYDSQEKCFNLCDYGDSKLFKDGSCTQN-LKAFTRRYAAPEITD------LENGSFNIK
  ... .   |..  ..|.   .. ..|.|.||.| | .|||...| . ...|| | ||..|  .  |   | .|  |. ||          .|   |.|
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYK

YDIY
.|||
SDIY
Kinase 16546.AA S_TKc 69-323 20 5.6e-16 57.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 69-323
Range on HMM: 1-231/231
Sequence Identity: 20% (55 aa)

IYLTSYISQGAYGCVFEAKYND--EIVAIKCSKANFEKINEEEKILNLLKETPYVFRSIQGFLNEKKSKYYQISKRYSC---NLKDIMQSLFDQK--KTL
  .   | .||.|.|. .. ..  .|||||. |   |.|  | .||      |.. . .  | .   ...| .    .    .|.|....   ..  . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PLNQIIGFAIQMSTVFNKIQQNNFIHSDVKLENILYDSQEKCFNLCDYGDSKLFKDGSCTQNLKAFTRRYAAPEITDLENGSFNI-KYDIYGLGIILLEL
|  ..  .. |.    . . ....|| |.| |||| |.   .  .|| | ....       .    |. | |||.      ...  | |.. .|.|| |.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEM

TLGQFLKEEDCTFIRNGNLPNYLREKDLFKDINQIIIKMLEKEPQKRIDSFELTK---ELNELRLK
  |. . . .   . .  .          ..  ..| |.|.|.|.||.   |. .   . .     
LCGYPPFP-QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 16546.AA Pkinase 77-317 18 1.6e-15 55.94 Pfam 9-293 (293) Show / Hide 
Range on Protein: 77-317
Range on HMM: 9-293/293
Sequence Identity: 18% (56 aa)

QGAYGCVFEAKYNDE--IVAIKCSKANFEKINE--------EEKILNLLKETPYVFRSIQGFLNEKKSKYYQISKRYSCNLKDIMQSLF-----DQKKTL
.|..|||....  ..  |||.|. |   || ..        | .|.. |   |.. | .  | .  |...| .     . |.   ..||     ......
SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLY--VMDLFDYISTWRHGCF

--PLNQIIGFAIQMSTVFNKIQQNNFIHSDVKLENILYDSQEKC---FNLCDYGDSKL--FKDGSCTQNLKAFTRRYAAPEITDLE-NGSFNIKYDIYGL
  . .... .. |.    . . ....|| |.|.||||.|..  .   . .|| | .|.     .| .. .   |..|.|||.  .  .     | |....
YFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCG-TPWYMAPEV--IRGGQYYGPKVDMWSC

GIILLELTLGQFLKEED------CTFIRNGNLPNYLREKDLF-----------------------KDINQIIIKMLEKEPQKRIDSFELTKE--L
|.|| |. .|...  ..      .   .  .      . | .                       ..  ..| ..|.| |.||.   .. .   .
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 16546.AA Ciliate-E2-Unclassified 69-265 17 3.4e-15 49.18 In-house 1-268 (352) Show / Hide 
Range on Protein: 69-265
Range on HMM: 1-268/352
Sequence Identity: 17% (48 aa)

IYLTSYISQGAYGCVFEAKYNDE---------IVAIKCS-----KANFEKINEEEKILN-----------LLKE------TPYVFRSIQGFLNEKKSKYY
  .   | ||..|.|.... ...         .......     . . |..||.. . |           ....       |.. . .  .  ..| . |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMF--YCFQDKQNIY

QISKRY-SCNLKDIMQS----------LFDQKKT---LPLNQII-----GFAIQMSTVFNKIQQNN-FIHSDVKLENILYDSQEK--CFNLCDYGDSKLF
 .       .|......          ||...|.   .. .|..      .. |    .... ..| .|| | |.||||.|.. |  .  ..|.| ||  
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

KD---------------GSCTQNLKAFTRRYA----APEITDLENGSFN----IKYDIYGLGIILLELTLGQF
..                .. .. .. | .|     |||.  |..   .    .| ||..||.|| |.  |..
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEV--LQGQNYDHSKAYKCDIWSLGVILYEMLFGYY
Kinase 16546.AA C8 73-257 23 2.5e-13 42.73 In-house 5-226 (226) Show / Hide 
Range on Protein: 73-257
Range on HMM: 5-226/226
Sequence Identity: 23% (53 aa)

SYISQGAYGCVFEAKYNDE--IVAIKCSKANFE-KINEEEKILNLLKETPYVFRSIQGFLNEKKSKYYQISKR----YS-----------CNLKD-----
 |.|.|||| | .||  ..   ...|  |   . .|...|.|   . |.| ||   . . ||.. .| . ..      |           | ...     
QYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEY-EMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELCE

-IMQSLFDQKKTLPLN----QIIGFAIQMSTVFNKIQQNNFIHSDVKLENIL-YDSQEKC--FNLCDYGDSKLFKDGSCTQNLKAF----TRRYAAPEIT
  .. |.|....  .     .    ||||    | |.. |..| |.|..|.| . .|..     ||| | .   ..       | .    |  | |||| 
QNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIE

DL---ENGSFNIKYDIYGLGIIL
     ..  ..|. |.. .|..|
KKQDNQYKQYRIQSDLFSVGLVL
Kinase 16546.AA Ciliate-E2 69-312 17 6e-13 40.76 In-house 1-357 (365) Show / Hide 
Range on Protein: 69-312
Range on HMM: 1-357/365
Sequence Identity: 17% (64 aa)

IYLTSYISQGAYGCVFEA--KYNDEIVAIKC------------------------SKANFEKINEEEKILNLLKE---------------TPYVFRSIQG
. .   | ||..|.|...  . ... .|||.                        .| . | |. |..|.. ...                |.. . .  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FLNEKKSKYYQISKRYSC-NLKDIMQSL---FDQK----KTLPLNQIIGFAIQMSTVF---------------NKIQQNN-FIHSDVKLENILYDSQEKC
| .......| .   ..  .|.|....    ....    | . ...|. .  |   .|               . . ..|  || | |.||||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

FNLCDYGDSKLFKD-----------GSCTQNL---------------------KAFTRRYAAPEITDLENGS-------FNIKYDIYGLGIILLELTLGQ
  ..| | || ..|           . ...                        . |  | ||||   .. .        . | ||. ||.|| |.  |.
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

FLKEEDCTFIRNGN----LPNYLREKDLFKDIN---------------QIIIK----MLEKEPQKRIDSFE
.       .. . .    .|..  .|| .. ..               ..| |    ||.|.|.|||...|
PPF-----QQQIKQCKIDFPCPEWQKD-TQ-CIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWE
Kinase 16546.AA TKL 163-317 16 6.6e-13 42.81 In-house 131-364 (364) Show / Hide 
Range on Protein: 163-317
Range on HMM: 131-364/364
Sequence Identity: 16% (38 aa)

LNQIIGFAIQMSTVFNKIQQNN--------FIHSDVKLENILYDS-------------QEKCFNLCDYGDSKLFK-------------------DGSCTQ
..|.. .|....   |   ..|         || | | .||| |.              . |  .||.| |. ..                   ....| 
WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTT

NLKAFTRRYAAPEITDLE--------------NGSFNIKYDIYGLGIILLELTLGQ-FLKEEDC-------------TFIRNGNLPNYLR----------
. .  | |. |||. . .              ..... | |.|  ||.| |.  ..   .....               . . .|.  .           
MTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMC

-EKDLFKDINQIIIKMLEKEPQKRIDSFELTKEL
 ..|  ... ... .  . .|.||    |..|.|
PCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 16546.AA MSK 182-260 32 1.7e-12 38.59 In-house 119-203 (277) Show / Hide 
Range on Protein: 182-260
Range on HMM: 119-203/277
Sequence Identity: 32% (28 aa)

QNNFIHSDVKLENILYDSQ--EKCFNLCDYGDSKLFKDGSCTQNLKA--FTRRYAAPEITDL---ENGSFNIKYDIYGLGIILLEL
|  .|| | |.||||.|..  .    | | | ..||   . .. .|   ||  |.|||. .    ..| ..   |...||.|| ..
QKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQ-DEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILYTM
Kinase 16546.AA CMGC 69-200 13 3.7e-11 31.97 In-house 1-220 (513) Show / Hide 
Range on Protein: 69-200
Range on HMM: 1-220/513
Sequence Identity: 13% (31 aa)

IYLTSYISQGAYGCVFEAKY----------------NDEIVAIKCSKANFEKINEEE----------------KILNLLK----------------ETPY
    ..| .|.|| |....                 ..||||||  | .| . ...                 |||  |.                  ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VFRSIQGFLNEK---------------KSKYYQISKRYSCNLKDIMQSLF------------------------DQKKTLPLNQIIGFAIQMSTVFN--K
. . .  |  ..                 . | .     ..|......                           ..| ... .|  .. |. .  .   
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

IQQNN--FIHSDVKLENILYDSQ
. ...  .|| | | |||| ...
CHSHWGNIIHRDLKPENILINHN
Kinase 16546.AA Ciliate-B2 70-254 24 6.9e-11 21.73 In-house 2-197 (197) Show / Hide 
Range on Protein: 70-254
Range on HMM: 2-197/197
Sequence Identity: 24% (49 aa)

YLTSYISQGAYGCVFEAK-------YNDEIVAIKCS--KANFEKINEEEKILNLLKETPYVFRSIQGFLNEKKSKYYQISKRYSCNLKDIMQSLFDQKKT
||. || .|  | ..|         | | .. |      .. | |..| ||. ..    .| . |  .  ... .   |  .  | ||. .| .  |.| 
YLCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETIDVL-IMEKCECSLKQELQKIQKQQKC

LPLNQIIGFAIQMSTVFNKIQQNNFIHSDVKLENILYDSQEKCFNLCDYGDSKLFKDGSCTQNLKAFTRRYAAPEITDLE-----NGSFNIKYDIYGLG
 . . ..    |.     ..  .| .| |.| .|||  .|.  . .||.| | . |     .. | || .|| ||  .           . . ||| .|
FNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILF-MQNGNYVYCDFGISSIKK-DNQQIKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG
Kinase 16546.AA Ciliate-E3 182-261 33 1.8e-10 29.19 In-house 121-202 (202) Show / Hide 
Range on Protein: 182-261
Range on HMM: 121-202/202
Sequence Identity: 33% (28 aa)

QNNFIHSDVKLENILYDSQEK--CFNLCDYGDSKLFKDGS-CTQNL-KAFTRRYAAPEITDLENGSFNIKYDIYGLGIILLELT
. | |||| | .||| |. .       || | ||. .     |. .   .|  |||||. |  . |.    |.| .| ....| 
EKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQISKES--DYYSVGAVFCQLC
Kinase 16546.AA TyrKc 69-317 17 7.7e-08 -95.88 SMART 1-280 (280) Show / Hide 
Range on Protein: 69-317
Range on HMM: 1-280/280
Sequence Identity: 17% (52 aa)

IYLTSYISQGAYGCVFEAKYNDEIVAIKCSK--ANFEKINEEEKILNLL-KETPYVFRSIQGFLNE-------KKSKYYQISKRYSCNLKDIMQSLFDQK
| |   .  ||.| |...... . ||.|. |  |  | . .| .|.  | .. | . | .   . .       .          .  .|||  ..  .. 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRKHRPK-

KTLPLNQIIGFAIQMSTVFNKIQQNNFIHSDVKLENILYDSQEKC----FNLCDYGDSK-LF----KDGSCTQ--NLKA-FTRRYAAPEITDLENGSFNI
  |.. . . |..| .   . . ..|.|| |    |.|....  .    | |. .....       .  . ..  . |. .  |  |||      | |..
--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKFTT

KYDIYGLGIILLEL-TLGQFLKEED--CTFIRNGNLPNYLREK-------D--------LFKDINQIIIKMLEKEPQKRIDSFELTKEL
| |..  |. . |. |.||   ...    .. |  . .|...        .          ... ||. .  . .| .|    |. ...
KSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 16546.AA TKL 75-116 14 3.1e-07 22.14 In-house 1-83 (364) Show / Hide 
Range on Protein: 75-116
Range on HMM: 1-83/364
Sequence Identity: 14% (12 aa)

ISQGAYGCVFEAKYND----------EIVAIKCSKA-------------------------------NFEKINEEEKILNLLK
| .|..|.|. .|..           . ||.|  |                                ......|| .... |.
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLR
Kinase 16546.AA Ciliate-E2-Unclassified 292-312 57 0.037523 3.29 In-house 325-344 (352) Show / Hide 
Range on Protein: 292-312
Range on HMM: 325-344/352
Sequence Identity: 57% (12 aa)

INQIIIKMLEKEPQKRIDSFE
||... |||.| | ||| .||
INDLLQKMLKKNPNKRI-TFE