Gene 18408 (Tetrahymena)

18408

Species: Tetrahymena
Alias: 18408, 994, TTHERM_01230130, 284.m00017, PreTt18408
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C5

Sequence

Name Sequence Type Origin Length Description Download
18408.AA Protein None 361 None Fasta, JSON
18408.kin_dom Protein Kinase Domain None 138 None Fasta, JSON
18408.NA RNA None 1086 None Fasta, JSON

Protein domain

Protein domains of 18408.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 18408.AA Ciliate-A8 112-121 40 0.387343 0.63 In-house 1-10 (151) Show / Hide 
Range on Protein: 112-121
Range on HMM: 1-10/151
Sequence Identity: 40% (4 aa)

YKFQRIFEQN
||.|.. |..
YKYQKVLEKG
Kinase 18408.AA Ciliate-C5 147-285 83 5.2e-96 316.58 In-house 1-138 (260) Show / Hide 
Range on Protein: 147-285
Range on HMM: 1-138/260
Sequence Identity: 83% (116 aa)

IYLTSFISQGSFGCVFEAKYKEEIVAVKCSRVNLEKIKEEEDILILLKDTPYVFKSIENFLNETKSIYYQITKRYLCSLKDIMKNFFYQKKITLPLNQII
|||||.||||.|||||||||.|||||||||..|.|||||||.|. |||||||||||||.||||.|| ||||.||| |.|||||..||.||| ||||||||
IYLTSYISQGGFGCVFEAKYNEEIVAVKCSKPNFEKIKEEEKIMKLLKDTPYVFKSIEEFLNEKKSKYYQISKRYSCNLKDIMQSFFDQKK-TLPLNQII

GFAIQMSTVFQKIQEKNLIHSDVKPENILYDSQEKCFIL
||||||||||.|||..|||||||||||||||||||||.|
GFAIQMSTVFEKIQQNNLIHSDVKPENILYDSQEKCFNL
Kinase 18408.AA Ciliate-E1 153-284 21 1.7e-16 50.59 In-house 1-150 (202) Show / Hide 
Range on Protein: 153-284
Range on HMM: 1-150/202
Sequence Identity: 21% (33 aa)

ISQGSFGCVFEA--------KYKEEIVAVKCSRV--NLEKIKEEED-ILILLKDTPYVFKSIENFLNETKSIYYQITKRYLCSLKDIMK--------NFF
|..|||. ||.|        .... |. ... ..  .......|.. |.  .|   |... |. .  .   |...|.  . ||||| ..        . .
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

YQKKITLPLNQIIGFAIQMSTVFQKIQEKNLIHSDVKPENILYDSQEKCFI
 |... .   |..  ..|.   .. .. .|.||.| ||.|||...|... .
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVY
Kinase 18408.AA CMGC 147-279 14 7.5e-10 27.6 In-house 1-220 (513) Show / Hide 
Range on Protein: 147-279
Range on HMM: 1-220/513
Sequence Identity: 14% (33 aa)

IYLTSFISQGSFGCVFEAKYKE----------------EIVAVKCSRVNLEKIK---------------EEEDILILLK----------------DTPYV
    . | .|..| |.... |.                ||||.|  . . ...                 |  ||  |.                . ...
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

FKSIENFLNET---------------KSIYYQITKRYLCSLKDIMKNFF--YQK---------------------KITLPLNQIIGFAIQMSTVFQ--KI
 | .. |  .                    | ..    ..|....||    ||                      .  ... .|  .. |. .      .
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYC

QEKN--LIHSDVKPENILYDSQ
  ..   || | |||||| ...
HSHWGNIIHRDLKPENILINHN
Kinase 18408.AA Ciliate-E3 233-286 35 1.4e-08 23.22 In-house 94-146 (202) Show / Hide 
Range on Protein: 233-286
Range on HMM: 94-146/202
Sequence Identity: 35% (19 aa)

FYQKKITLPLNQIIGFAIQMSTVFQKIQEKNLIHSDVKPENILYDSQEKCFILQ
... .  . .| |.  .||.      | |||.|||| ||.||| |. .   |..
YIK-QQNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIK
Kinase 18408.AA Ciliate-A8 260-284 56 2.9e-08 25.4 In-house 127-151 (151) Show / Hide 
Range on Protein: 260-284
Range on HMM: 127-151/151
Sequence Identity: 56% (14 aa)

QEKNLIHSDVKPENILYDSQEKCFI
|||. ||.|.||.|||| ...  ||
QEKGIIHCDIKPQNILYSWSKNQFI
Kinase 18408.AA STKR 147-174 37 5e-08 21.75 In-house 1-32 (312) Show / Hide 
Range on Protein: 147-174
Range on HMM: 1-32/312
Sequence Identity: 37% (12 aa)

IYLTSFISQGSFGCVFEAKYKE----EIVAVK
| |.  | .| .|.|. .|...    | ||||
IQLIECIGKGRYGEVWKGKWRGNGEKETVAVK
Kinase 18408.AA Gdt 147-190 32 1e-07 22.48 In-house 1-55 (289) Show / Hide 
Range on Protein: 147-190
Range on HMM: 1-55/289
Sequence Identity: 32% (18 aa)

IYLTSFISQGSFGCVFEAKYKEEIVAVK---CSRVN--------LEKIKEEEDIL
| .   .|||.|| |. ...    ||||    . ||         ..|. | |||
IDFKEYCSQGTFGMVYKGIWRSSQVAVKMFKHHYVNYTKTYSQSCDEIYREMDIL
Kinase 18408.AA S_TKc 147-361 16 1.4e-07 -65.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 147-361
Range on HMM: 1-231/231
Sequence Identity: 16% (44 aa)

IYLTSFISQGSFGCVFEAKYKE--EIVAVKCSRVNLEKIKEEEDILILLKDTPYVFKSIENFLNETKSIYYQITKRYL--CSLKDIMKNFFYQKK-ITLP
  .   | .|.||.|. .. |.  .|||.|. .   |.|. | .||    . |.. | .. | .  ...|           .|.|..|.  ....   .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

LNQIIGFAIQMSTVFQKIQEKNLIHSDVKPENILYDSQEKCFILQNLLFDQLKLT---------------------VVIKLDQLSWLEHAAVNR-KV---
  ..  .. |.    . . ... || |.|||||| |.             ..|..                     |.              .. |.   
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------------HIKICDFGLARQLTTFCGTPWYMAPEVL------------GYGKCKCDWW

----------VGSIPTSSAFFLLQNQVILSCEVL----LFFAKKIANRKQYQKFLK--------KIK
          .|  | .   ... ...  | |..      . |  ..|    . |.           
SCGCILYEMLCGYPPFP-QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 18408.AA Type2 147-174 39 1.5e-07 20.78 In-house 1-33 (315) Show / Hide 
Range on Protein: 147-174
Range on HMM: 1-33/315
Sequence Identity: 39% (13 aa)

IYLTSFISQGSFGCVFEAKYKEE-----IVAVK
| |   |..| ||||. |.....     .||||
IQLMELIGKGRFGCVWKAQWHNNNGEKRTVAVK
Kinase 18408.AA TKL 153-194 17 3.4e-07 21.99 In-house 1-81 (364) Show / Hide 
Range on Protein: 153-194
Range on HMM: 1-81/364
Sequence Identity: 17% (14 aa)

ISQGSFGCVFEAKYKE----------EIVAVKCSRVNL-----------------------------EKIKEEEDILILLK
| .|.||.|. .|..           . ||||  ...                              .. .||| |.....
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSR
Kinase 18408.AA Pkinase 147-279 25 0.000115 17.58 Pfam 1-144 (293) Show / Hide 
Range on Protein: 147-279
Range on HMM: 1-144/293
Sequence Identity: 25% (37 aa)

IYLTSFISQGSFGCVFEAKYKEE--IVAVKCSRVNLEKIKE--------EEDILILLKDTPYVFKSIENFLNETKSIYYQITKRYLCSLKDIMKNFFYQK
. . . | .||||||.... | .  |||||. ..  || ..        |  |.  | . |.. . .. | .  |. .| ..    . |.  |  | | .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYIS

---KITL--PLNQIIGFAIQMSTVFQKIQEKNLIHSDVKPENILYDSQ
   . ..  . .... .. |.    . . ... || |.||||||.|..
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNN
Kinase 18408.AA ULK 236-275 37 0.000116 12.29 In-house 123-162 (329) Show / Hide 
Range on Protein: 236-275
Range on HMM: 123-162/329
Sequence Identity: 37% (15 aa)

KKITLPLNQIIGFAIQMSTVFQKIQEKNLIHSDVKPENIL
.| .|. ...| | .|    |. ....| || | ||.|||
EKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNIL
Kinase 18408.AA ULK 147-194 26 0.000185 11.58 In-house 1-68 (329) Show / Hide 
Range on Protein: 147-194
Range on HMM: 1-68/329
Sequence Identity: 26% (18 aa)

IYLTSFISQGSFGCVFEAK-YKE-----EIVAVKC------SRVNLE--------KIKEEEDILILLK
..|   . .|||| |....  |      |.||.|       .. | |         .| | .|.  ||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLK
Kinase 18408.AA TyrKc 147-357 13 0.000711 -159.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 147-357
Range on HMM: 1-280/280
Sequence Identity: 13% (40 aa)

IYLTSFISQGSFGCVFEAKYKEEIVAVKCSR--VNLEKIKEEEDILILL-KDTPYVFKSIENFLN--------ETKSIYYQIT-----KRYLCSLKDIMK
| |   .  | || |.....| . ||||. .    .| . .|  |.  | .. | . . .   .         |   |          | || . ..   
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

NFFYQKKITLPLNQIIGFAIQMSTVFQKIQEKNLIHSDVKPENILYDSQE---------KCFILQN-------LLFD-----QLK--LTV------VIKL
         |.. . . |..| .   . . .||.|| |    |.|....            .|             .     . |  | .      .|. 
---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

D----------------------QLSWLEHA---AVNRKVVGSIPTSSAFFLLQN----------QVILSCEVLLFFAKKIANR---KQYQKFL
                       |  . . .     |. |.  . .       .|          . . .   .   . . ..|   ..  ...
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase 18408.AA TKL 262-278 47 0.043162 3.34 In-house 159-175 (364) Show / Hide 
Range on Protein: 262-278
Range on HMM: 159-175/364
Sequence Identity: 47% (8 aa)

KNLIHSDVKPENILYDS
...|| | |..||| |.
PPIIHRDLKSKNILVDE
Kinase 18408.AA Ciliate-E3 147-164 27 0.277091 0.11 In-house 1-18 (202) Show / Hide 
Range on Protein: 147-164
Range on HMM: 1-18/202
Sequence Identity: 27% (5 aa)

IYLTSFISQGSFGCVFEA
.     . .|.|| |. |
YTVQQILGCGQFGRVYKA