2011

Species: Tetrahymena
Alias: TTHERM_01333170, 331.m00014, PreTt02011, 2011, 728
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C5

Sequence

Name Sequence Type Origin Length Description Download
2011.AA Protein None 570 None Fasta, JSON
2011.kin_dom Protein Kinase Domain None 269 None Fasta, JSON
2011.NA RNA None 1713 None Fasta, JSON

Protein domain

Protein domains of 2011.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 2011.AA Ciliate-C5 92-360 87 6.9e-192 637.29 In-house 1-260 (260) Show / Hide
Range on Protein: 92-360
Range on HMM: 1-260/260
Sequence Identity: 87% (235 aa)

IYLTSYISQGGNGCVFEAKYNEEIVAVKCSKPKFEKIQEEEKIMKLLKDTPYVFKSIEEFLNKKKSKYYQISKKYSCNLREIMQSFFDKKKPLPLNQIVG
|||||||||||.||||||||||||||||||||.||||.||||||||||||||||||||||||.||||||||||.|||||..|||||||.||.||||||.|
IYLTSYISQGGFGCVFEAKYNEEIVAVKCSKPNFEKIKEEEKIMKLLKDTPYVFKSIEEFLNEKKSKYYQISKRYSCNLKDIMQSFFDQKKTLPLNQIIG

FAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLSQILIYNLKGDFGDSKSFKDGSKTYDLKGFTRKYAAPELTDDNGFFNIKYDIYGLGIILLEL
|||||||||||||||||||||.||||||||||||||||.         |.|.||||||||||||||||||||||||.|||||||||||||||||||||||
FAIQMSTVFEKIQQNNLIHSDVKPENILYDSQEKCFNLC---------DYGESKSFKDGSKTYDLKGFTRKYAAPEITDDNGFFNIKYDIYGLGIILLEL

TLGKFLEDKDCTFIRNGQLPNYICKNALFQDINQIIVQMLEVMPQNRIDSFELTKQLNKLRIKLESEFI
||||||||.||||||||.|||||.||||.|||||||..|||.||||||||||||||||.||.||||.||
TLGKFLEDEDCTFIRNGKLPNYISKNALYQDINQIIIKMLEKMPQNRIDSFELTKQLNELRLKLESQFI

Kinase 2011.AA Ciliate-E1 98-282 23 4e-24 75.64 In-house 1-202 (202) Show / Hide
Range on Protein: 98-282
Range on HMM: 1-202/202
Sequence Identity: 23% (51 aa)

ISQGGNGCVFEAKYNEE--------IVAVKC--SKPKFEKIQEEEK-IMKLLKDTPYVFKSIEEFLNKKKSKYYQISKKYSCNLREIMQ---------SF
|..|. . ||.||...         |. ...  .. .|.....|.. ||| .|   |... |. .  ..   ...|  ...|.| . .|         ..
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

FDKKKPLPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLSQILIYNLKGDFGDSKSFKDGSKT-YDLKGFTRKYAAPELT-------
  ... .   |..  ..|.   .. ..|.|.||.||||.|||...|... .           ||| || .|  ..  .. ||.| .|. ||         
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----------DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEH

DDNGFFNIKYDIY
..|   |.|.|||
NKNQKINYKSDIY

Kinase 2011.AA S_TKc 92-355 20 1.8e-15 49.99 SMART 1-231 (231) Show / Hide
Range on Protein: 92-355
Range on HMM: 1-231/231
Sequence Identity: 20% (56 aa)

IYLTSYISQGGNGCVFEAKYNE--EIVAVKCSKPKFEKIQEEEKIMKLLKDTPYVFKSIEEFLNKKKSKYYQISKKYSC---NLREIMQSFFDKKKP--L
  .   | .|. |.|. .. ..  .|||.|. |   |.|. | .|.|   . |.. | .. | .   ...| .    .    .|......   ....  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLSQILIYNLK-GDFGDSKSFKDGSKTYDLKGFTRKYAAPELTDDNGFFNI-KYDIY
|  ..  .. |.    | . ... || |.|||||| |.             ..| .||| .. .       .    |. | |||.      ..  | |..
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------------HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWW

GLGIILLELTLGKFLEDKDCTFIRNGQLPNYICKNALFQDINQIIVQMLEVMPQNRIDSFELTK--QLNKLRIKL
 .|.|| |.  |. . .         |.   . |    ..  ..| ..|.. |..|.   |. .  .. |.   .
SCGCILYEMLCGYPPFP---------QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 2011.AA CMGC 92-223 15 1.3e-14 43.49 In-house 1-220 (513) Show / Hide
Range on Protein: 92-223
Range on HMM: 1-220/513
Sequence Identity: 15% (34 aa)

IYLTSYISQGGNGCVFEAKY----------------NEEIVAVKCSKPKFEKIQ---------------EEEKIMKLLK----------------DTPYV
    ..| .|  | |....                 ..||||.|  | .|...|                | ||.| |.                . ...
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

FKSIEEFLNKK---------------KSKYYQISKKYSCNLREIMQSFFDK------------------------KKPLPLNQIVGFAIQMSTVFE--KI
 | .. |  |.                 . | .     ..| .....  ..                        .| ... .|  .. |. .  .   .
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYC

QQNN--LIHSDIKPENILYDSQ
 ...   || |.|||||| ...
HSHWGNIIHRDLKPENILINHN

Kinase 2011.AA C8 96-288 22 9.9e-13 40.61 In-house 5-226 (226) Show / Hide
Range on Protein: 96-288
Range on HMM: 5-226/226
Sequence Identity: 22% (52 aa)

SYISQGGNGCVFEAKYNEE--IVAVKCSKPKFE-KIQEEEKIMKLLKDTPYVFKSIEEFLNKKKSKYYQISKK----YS-----------CNLRE-----
 |.|.|. | | .||  ..   .. |  | . . .||..|.||| .. .| ||.  . . |... .| . ..      |           | . |     
QYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYE-MPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELCE

-----IMQSFFDKKKPLPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENIL-YDSQEKCFNLSQILIYNLKGDFGDSKSFKDGSKTYDLKGF----TRK
     . . . .|..... ..    ||||    . |.. | .| ||||.|.| . .|.. |.           ||| .   ..  . .  | .    | .
QNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLC-------DFGFASQVSKNKSHIQSKKMNTCGTWA

YAAPELTDD----NGFFNIKYDIYGLGIIL
| |||   .    . ...|. |.. .|..|
YFAPEIEKKQDNQYKQYRIQSDLFSVGLVL

Kinase 2011.AA Pkinase 100-297 25 1.2e-11 42.32 Pfam 9-211 (293) Show / Hide
Range on Protein: 100-297
Range on HMM: 9-211/293
Sequence Identity: 25% (55 aa)

QGGNGCVFEAKYNEE--IVAVKCSKPKFEKIQE--------EEKIMKLLKDTPYVFKSIEEFLNKKKSKYYQISKKYSCNLREIMQSF----FDKKKPL-
.|. |||....   .  |||||. | . || ..        | .||| | . |.. . .. | .  |...| .     . |   |  |     ...... 
SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFY

-PLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLSQILIYNLK-GDFGDSKS--FKDGSKTYDLKGFTRKYAAPELTDDNGFFNIKYD
 . ...  .. |.    | . ... || |.||||||.|..  .          .| .||| .|      .| .... | |. |.|||.  ..     | |
FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-------CVKICDFGLAKQFDY-NNS-MTTFCG-TPWYMAPEVIRGGQYYGPKVD

IYGLGIILLELTLGKFL
....|.|| |. .|...
MWSCGCILYEMLCGRPP

Kinase 2011.AA Ciliate-B2 93-285 27 3e-11 22.6 In-house 2-197 (197) Show / Hide
Range on Protein: 93-285
Range on HMM: 2-197/197
Sequence Identity: 27% (58 aa)

YLTSYISQGGNGCVFEAKYNEEI------VAVKCSKP----KFEKIQEEEKIMKLLKDTPYVFKSIEEFLNKKKSKYYQISKKYSCNLREIMQSFFDKKK
||. || .|| | ..|  |  ..      .|.|          | ||.| ||||..    .| | |. .  ... .   |  |  | |.. .|    ..|
YLCKYINKGGCGFICEG-YKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETIDVL-IMEKCECSLKQELQKIQKQQK

PLPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLSQILIYNLKGDFGDSKSFKDGSKTYDLKGFTRKYAAPELTDDN------GFFN
  . . ..    |.     ..  .| .| ||||.|||  ....         | .  ||| | | |        |||| ||| ||  ..          .
CFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGN---------YVY-CDFGIS-SIKKDNQQIKIKGFTKKYASPEQMECDHNQTFVTNID

IKYDIYGLG
 . ||| .|
FQSDIYSMG

Kinase 2011.AA Ciliate-E3 205-292 34 1e-10 29.94 In-house 121-202 (202) Show / Hide
Range on Protein: 205-292
Range on HMM: 121-202/202
Sequence Identity: 34% (31 aa)

QNNLIHSDIKPENILYDSQEKCFNLSQILIYNLKGDFGDSKSFKDGS---KTYDLKGFTRKYAAPELTDDNGFFNIKYDIYGLGIILLELT
. |.|||||||.||| |. .    . .|      .||| ||  .       |..  |.|  |||||. .|.. .    |.| .| ....| 
EKNIIHSDIKPDNILVDKNNNQLII-KI------CDFGESKQLRKNKGHTHTQY-QGWTPFYAAPEQ-NDQQQISKESDYYSVGAVFCQLC

Kinase 2011.AA Ciliate-E2 92-351 18 4.9e-10 30.63 In-house 1-365 (365) Show / Hide
Range on Protein: 92-351
Range on HMM: 1-365/365
Sequence Identity: 18% (70 aa)

IYLTSYISQGGNGCVFEA-------------------------KYNEEIVAVKCSKPK-FEKIQEEEKIMKLLK---------------DTPYVFKSIEE
. .   | ||. |.|...                         |..  |.|.|. |..  | |  |..||. ..               . |.. | .| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FLNKKKSKYYQISKKYSC-NLREIMQ---SFFDKK----KPLPLNQIVGFAIQMSTVF---------------EKIQQNN-LIHSDIKPENILYDSQEKC
| .|.....| .   ..  .|.....    .....    |.. ...|  .  |   .|               | . ..|  || ||||||||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

FNLSQILIYNLK-GDFGDSKSFKDGSK--------TYDLKGF------------------------TRKYAAPELTDDNGF--------FNIKYDIYGLG
          .|  ||| || ..| ..           .  .                        |  | |||     .          . | ||. ||
----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLG

IILLELTLGKF---LEDKDCTFIRNGQLPNYICKNALFQDIN------------QIIVQ----MLEVMPQNRIDSFELTKQLNKL
.|| |.  ||.    . |.| .  . . ..   .. . | ..            ..| .    ||.. |..||...|  ..   .
VILYEMLFGKPPFQQQIKQCKIDFPCPEWQKD-TQ-CIQ-CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase 2011.AA Ciliate-E2-Unclassified 92-351 19 1.9e-09 28.93 In-house 1-352 (352) Show / Hide
Range on Protein: 92-351
Range on HMM: 1-352/352
Sequence Identity: 19% (72 aa)

IYLTSYISQGGNGCVFEAKYNEE-------------IVAVKCSKPKFEKIQEEEKIMKLLK------------------DTPYVFKSIEEFLNKKKSKYY
  .   | |||.|.|.... ...             |...|  . |   |  |.|.|. .|                  . |.. | ...|  ..| . |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCF--QDKQNIY

QISKKY-SCNLREIMQSFFD-------------KKKPLPLNQIV-----GFAIQMSTVFEKIQQNN-LIHSDIKPENILYDSQEKCFNLSQILIYNLKGD
 .  .    .|.......               ..| .. .|..      .. |    .|.. ..|  || ||||||||.|.. |         |    |
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-------NYYIKIID

FGDSKSFKD---------------GSKTYDLKGFTRKYA----APELTDDNGFFN---IKYDIYGLGIILLELTLGKFL-EDKDCT--------FIRN--
|| ||  ..                .. .. .  |  |     |||. . ..  .   .| ||..||.|| |.  |..  .|..|.        .| |  
FGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NNA

---GQLPNYICKNALFQDIN-----------------QIIVQMLEVMPQNRIDSFELTKQLNKL
    .. | . ||  |.  .                 ... .||.. | .|| .||  ..   .
YRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI-TFEQILNHPWF

Kinase 2011.AA TKL 169-295 16 2.9e-08 25.89 In-house 124-286 (364) Show / Hide
Range on Protein: 169-295
Range on HMM: 124-286/364
Sequence Identity: 16% (30 aa)

NLREIMQSFFDKKKPLPLNQIVGFAIQMSTVFEKIQQNN--------LIHSDIKPENILYDSQEK--------CFNLSQILIYNLKGDFGDSKSFK----
.|.....          ..|.. .|....   .   ..|        .|| |.|..||| |.  .          .   . |    .||| |....    
SLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI----CDFGLSRFMSQSGN

---------------DGSKTYDLKGFTRKYAAPELTDDNGFFNIKY---------------DIYGLGIILLELTLGK
               ...||   .. |  . |||. ....... |.               |.|  ||.| |.  ..
MNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRC

Kinase 2011.AA CAMK 205-288 21 4.7e-08 21.28 In-house 197-324 (425) Show / Hide
Range on Protein: 205-288
Range on HMM: 197-324/425
Sequence Identity: 21% (28 aa)

QNNLIHSDIKPENILYDSQEK---------CFNLSQILIYNLK-GDFGDSKSFKDG-----------------------SKTYDLKGFTRKYAA-PELTD
..| .| |.||||||.|. ..          | .     .|.|  ||| .. |..|                        . .     |  |.| ||.  
SHNIVHRDLKPENILLDDNNDDSDPVEHDEIF-D--WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLN

D-------------NGFFNIKYDIYGLGIIL
              .   . | |.  .|.||
GKGHCNMQNATDEEKPYYGPKCDMWSCGVIL

Kinase 2011.AA TyrKc 92-348 17 2.1e-07 -103.09 SMART 1-280 (280) Show / Hide
Range on Protein: 92-348
Range on HMM: 1-280/280
Sequence Identity: 17% (56 aa)

IYLTSYISQGGNGCVFEAKYNEEIVAVKCSK--PKFEKIQEEEKIMKLL-KDTPYVFK----SIEE------------------------FLNKKKSKYY
| |   .  |  | |...... . ||||. |     | . .| .||. | .. | . .     ...                        .| |.. |  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

QISKKYSCNLREIMQSFFDKKKPLPLNQIVGFAIQMSTVFEKIQQNNLIHSDIKPENILYDSQEKCFNLSQILIYNLK-GDFGDSKSFKDG------SKT
                       |.. . . |..| .   | . ..|.|| |.   |.|....              | .||| |.  .|.      ...
-----------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----------TVKISDFGLSRDIYDDDQQGESKDY

YDLKG--FTR-----KYAAPELTDDNGFFNIKYDIYGLGIILLEL-TLGKFLEDKD----------CTFIRNG---QLPNYICKNAL-----FQDINQII
|. |.   ..     .  |||   . | |..| |..  |. . |. |.|.     .            ....|     | ...   .      ... ||.
YRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIM

VQMLEVMPQNRIDSFELTKQL
 |  .  | .|    |. ...
KQCWHEDPEDRPTFSEIHECF

Kinase 2011.AA TKL 98-139 19 1.3e-05 16.17 In-house 1-81 (364) Show / Hide
Range on Protein: 98-139
Range on HMM: 1-81/364
Sequence Identity: 19% (16 aa)

ISQGGNGCVFEAKYNE----------EIVAVKCSKPKF-----------------------------EKIQEEEKIMKLLK
| .|| |.|. .|..           . ||||  | .                              .. .||| || ...
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSR

Kinase 2011.AA CAMK 97-160 12 0.009928 3.82 In-house 1-133 (425) Show / Hide
Range on Protein: 97-160
Range on HMM: 1-133/425
Sequence Identity: 12% (16 aa)

YISQGGNGCVFEAKYNEEI--------------VAVKC--------------------------------SKPKFEKIQEEEKIMKLLK------DTPYV
 . .|. | |....  .                ||.|                                 .  . .... | .|||.|.      | | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

FKSIEEFLNKK-----------------KSKYY
 | .| . ...                 ....|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMY