Gene 28272 (Tetrahymena)

28272

Species: Tetrahymena
Alias: 28, 28272, 770.m00002, PreTt28272, TTHERM_01889100
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C5

Sequence

Name Sequence Type Origin Length Description Download
28272.AA Protein None 366 None Fasta, JSON
28272.kin_dom Protein Kinase Domain None 260 None Fasta, JSON
28272.NA RNA None 1101 None Fasta, JSON

Protein domain

Protein domains of 28272.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 28272.AA Ciliate-C5 20-279 88 6.6e-195 647.39 In-house 1-260 (260) Show / Hide 
Range on Protein: 20-279
Range on HMM: 1-260/260
Sequence Identity: 88% (231 aa)

IYLTSYISQGRQGCVFEAKYNEEIVAVKCSKPIFQKIEEEQKILKLLKDTPYVLKSIEEFLNEKKSKYYQISKKYSCNLKEIMQSFFNQRKPLPLNQIVG
||||||||||..|||||||||||||||||||| |.||.||.||.|||||||||.|||||||||||||||||||.||||||.||||||.|.|.||||||.|
IYLTSYISQGGFGCVFEAKYNEEIVAVKCSKPNFEKIKEEEKIMKLLKDTPYVFKSIEEFLNEKKSKYYQISKRYSCNLKDIMQSFFDQKKTLPLNQIIG

FAIQMSTVFEKIQQNNLVHSDVKPENILYDSQEKCFNLCDYGDSKSFKDGSKTYDLNAFTRKYAAPELTDENGFFNIKYDIYGLGIILLELTLGKFLEDK
|||||||||||||||||.||||||||||||||||||||||||.|||||||||||||..|||||||||.||.||||||||||||||||||||||||||||.
FAIQMSTVFEKIQQNNLIHSDVKPENILYDSQEKCFNLCDYGESKSFKDGSKTYDLKGFTRKYAAPEITDDNGFFNIKYDIYGLGIILLELTLGKFLEDE

DCTFIRKGQLPNYISKNALFQDINQIIVQMLEIMPENRIDSFELTKQLNNLRLKLESQFI
||||||.|.||||||||||.|||||||..|||.||.|||||||||||||.||||||||||
DCTFIRNGKLPNYISKNALYQDINQIIIKMLEKMPQNRIDSFELTKQLNELRLKLESQFI
Kinase 28272.AA Ciliate-E1 26-201 25 7.5e-25 78.04 In-house 1-202 (202) Show / Hide 
Range on Protein: 26-201
Range on HMM: 1-202/202
Sequence Identity: 25% (51 aa)

ISQGRQGCVFEA---KYNEEIVAVKCSKPIFQ--------KIEEEQKILKLLKDTPYVLKSIEEFLNEKKSKYYQISKKYSCNLKEIMQ---------SF
|..| .. ||.|   ..|.. ||.|  . .|.        .|.|..||.| .|   |... |. .  ..   ...|  ...|.||. .|         ..
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

FNQRKPLPLNQIVGFAIQMSTVFEKIQQNNLVHSDVKPENILYDSQEKCFNLCDYGDSKSFKDGSKT-YDLNAFTRKYAAPELT-------DENGFFNIK
 .. . .   |..  ..|.   .. ..|.|. |.| ||.|||...| . ...|| | || .|  ..  .. . .| .|. ||         ..|   |.|
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYK

YDIY
.|||
SDIY
Kinase 28272.AA S_TKc 20-273 20 9.4e-16 54.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-273
Range on HMM: 1-231/231
Sequence Identity: 20% (53 aa)

IYLTSYISQGRQGCVFEAKYNE--EIVAVKCSKPIFQKIEEEQKILKLLKDTPYVLKSIEEFLNEKKSKYYQISKKYSC---NLKEIMQSFFNQRKP--L
  .   | .|  |.|. .. ..  .|||.|. |   ..|. | .|||   . |.. | .. | .   ...| .    .    .|......   ....  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PLNQIVGFAIQMSTVFEKIQQNNLVHSDVKPENILYDSQEKCFNLCDYGDSKSFKDGSKTYDLNAFTRKYAAPELTDENGFFNI-KYDIYGLGIILLELT
|  ..  .. |.    | . ... .| |.|||||| |.   .  .|| | .. .       .    |. | |||.      ..  | |.. .|.|| |. 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

LGKFLEDKDCTFIRKGQLPNYISKNALFQDINQIIVQMLEIMPENRIDSFELTK---QLNNLRLK
 |. . . .   . |  .          ..  ..| ..|.  ||.|.   |. .     ..    
CGYPPFP-QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 28272.AA CMGC 20-187 14 1.6e-14 43.22 In-house 1-296 (513) Show / Hide 
Range on Protein: 20-187
Range on HMM: 1-296/513
Sequence Identity: 14% (42 aa)

IYLTSYISQGRQGCVFEAKY----------------NEEIVAVKCSKPIFQKIEEEQ----------------KILKLLK----------------DTPY
    ..| .|  | |....                 ..||||.|  |  | . |...                |||| |.                . ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VLKSIEEFLNEK---------------KSKYYQISKKYSCNLKEIMQSFF------------------------NQRKPLPLNQIVGFAIQMSTVFE--K
..| .. |  ..                 . | .     ..|......                          .. | ... .|  .. |. .  .   
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

IQQNN--LVHSDVKPENILYDSQEKCF-------------------NLCDYGDSKSFKDG---------------------SKTYDLNAFTRKYAAPEL
. ...   .| | |||||| ... ...                    .|| | .... .                      ...|  .  || | |||.
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI
Kinase 28272.AA Pkinase 28-216 23 2e-13 48.52 Pfam 9-211 (293) Show / Hide 
Range on Protein: 28-216
Range on HMM: 9-211/293
Sequence Identity: 23% (50 aa)

QGRQGCVFEAKYNEE--IVAVKCSKPIFQKIEE--------EQKILKLLKDTPYVLKSIEEFLNEKKSKYYQISKKYSCNLKEIMQSF----FNQRKPL-
.|  |||....   .  |||||. |   .| ..        | .|.| | . |.... .. | .  |...| .     . |.  |  |      ..... 
SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFY

-PLNQIVGFAIQMSTVFEKIQQNNLVHSDVKPENILYDSQEKC---FNLCDYGDSKSF-KDGSKTYDLNAFTRKYAAPELTDENGFFNIKYDIYGLGIIL
 . ...  .. |.    | . ... .| |.||||||.|..  .   . .|| | .| |    .  ..  . |. |.|||.  ..     | |....|.||
FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCIL

LELTLGKFL
 |. .|...
YEMLCGRPP
Kinase 28272.AA Ciliate-E2-Unclassified 20-270 18 3.1e-13 42.26 In-house 1-352 (352) Show / Hide 
Range on Protein: 20-270
Range on HMM: 1-352/352
Sequence Identity: 18% (65 aa)

IYLTSYISQGRQGCVFEAKYNEE-------------IVAVKCSKPIFQKIEEEQKILKLLK------------------DTPYVLKSIEEFLNEKKSKYY
  .   | || .|.|.... ...             |...|  .     |  |.|... .|                  . |...| ...|  ..| . |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCF--QDKQNIY

QISKKY-SCNLKEIMQSF-------------FNQRKPLPLNQIV-----GFAIQMSTVFEKIQQNN-LVHSDVKPENILYDSQEK--CFNLCDYGDSKSF
 .  .    .|.......              .||| .. .|..      .. |    .|.. ..|  .| | ||||||.|.. |  .  ..|.| ||  
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

KD---------------GSKTYDLNAFTRKYA----APELTDENGFFN---IKYDIYGLGIILLELTLGKFLEDKDCTFI-------------RKGQLPN
..                .. .. .. |  |     |||. ....  .   .| ||..||.|| |.  |..  .  .  .             || .. |
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

YISKNALFQDIN-----------------QIIVQMLEIMPENRIDSFELTKQLNNL
 . ||  |.  .                 ... .||.  |..|| .||  ..   .
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI-TFEQILNHPWF
Kinase 28272.AA Ciliate-B2 21-204 26 5.3e-13 26.82 In-house 2-197 (197) Show / Hide 
Range on Protein: 21-204
Range on HMM: 2-197/197
Sequence Identity: 26% (53 aa)

YLTSYISQGRQGCVFEAKYNEEI------VAVKCSKP----IFQKIEEEQKILKLLKDTPYVLKSIEEFLNEKKSKYYQISKKYSCNLKEIMQSFFNQRK
||. || .| .| ..|  |  ..      .|.|          . |..| ||.|..    .| | |. .  ... .   |  |  | ||. .|    |.|
YLCKYINKGGCGFICEG-YKKHSIREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQINETIDVL-IMEKCECSLKQELQKIQKQQK

PLPLNQIVGFAIQMSTVFEKIQQNNLVHSDVKPENILYDSQEKCFNLCDYGDSKSFKDGSKTYDLNAFTRKYAAPELTDEN------GFFNIKYDIYGLG
  . . ..    |.     ..  .| .| |.||.|||  .|.  . .||.| | | |          || ||| ||  ..          . . ||| .|
CFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILF-MQNGNYVYCDFGIS-SIKKDNQQIKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG
Kinase 28272.AA Ciliate-E3 133-211 30 2.3e-12 35.17 In-house 121-202 (202) Show / Hide 
Range on Protein: 133-211
Range on HMM: 121-202/202
Sequence Identity: 30% (26 aa)

QNNLVHSDVKPENILYDSQEK--CFNLCDYGDSKSFKDGS---KTYDLNAFTRKYAAPELTDENGFFNIKYDIYGLGIILLELT
. |. ||| ||.||| |. .       || | ||  .       |.. . .|  |||||. .... .    |.| .| ....| 
EKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQY-QGWTPFYAAPEQ-NDQQQISKESDYYSVGAVFCQLC
Kinase 28272.AA C8 24-207 21 7.5e-12 37.53 In-house 5-226 (226) Show / Hide 
Range on Protein: 24-207
Range on HMM: 5-226/226
Sequence Identity: 21% (47 aa)

SYISQGRQGCVFEAKYNEE--IVAVKCSKPIFQ-KIEEEQKILKLLKDTPYVLKSIEEFLNEKKSKYYQISKK----YS-----------CNLKE-----
 |.|.|  | | .||  ..   .. |  |   . .|.....| | .. .| |..  . . ||.. .| . ..      |           | ..|     
QYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYE-MPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELCE

-----IMQSFFNQRKPLPLNQIVGFAIQMSTVFEKIQQNNLVHSDVKPENIL-YDSQEKC--FNLCDYGDSKSFKDGSKTYDLNAF----TRKYAAPELT
     . . . |. .... ..    ||||    . |.. | .| |.||.|.| . .|..     ||| | .   ..  . .    .    | .| |||  
QNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIE

DE----NGFFNIKYDIYGLGIIL
 .    . ...|. |.. .|..|
KKQDNQYKQYRIQSDLFSVGLVL
Kinase 28272.AA Ciliate-E2 20-270 17 1e-11 36.48 In-house 1-365 (365) Show / Hide 
Range on Protein: 20-270
Range on HMM: 1-365/365
Sequence Identity: 17% (65 aa)

IYLTSYISQGRQGCVFEA-------------------------KYNEEIVAVKCS--KPIFQKIEEEQKI--------------LKLLKDTPYVLKSIEE
. .   | || .|.|...                         |..  |.|.|.   . |.|.  |.. .              .. . . |...| .| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FLNEKKSKYYQISKKYSC-NLKEIMQSFFNQR-------KPLPLNQIVGFAIQMSTVF---------------EKIQQNN-LVHSDVKPENILYDSQEKC
| .......| .   ..  .|.......  .|       |.. ...|  .  |   .|               | . ..|  .| | ||||||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

FNLCDYGDSKSFKD-----------GSKTYDLN---------------------AFTRKYAAPELTDENGF--------FNIKYDIYGLGIILLELTLGK
  ..| | || ..|           . ...  |                     . |  | |||     .          . | ||. ||.|| |.  ||
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

F---LEDKDCTFIRKGQLPNYISKNALFQDIN------------QIIVQ----MLEIMPENRIDSFELTKQLNNL
.    . |.| .    . ..   .. . | ..            ..| .    ||.  ||.||...|  ..   .
PPFQQQIKQCKIDFPCPEWQKD-TQ-CIQ-CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 28272.AA Ciliate-C8 92-207 22 1.1e-11 38.4 In-house 94-238 (238) Show / Hide 
Range on Protein: 92-207
Range on HMM: 94-238/238
Sequence Identity: 22% (33 aa)

KKYS--CNLKEIMQSFFNQRKPLPLNQIVGFAIQMSTVFEKIQQNNLVHSDVKPENIL-YDSQEKCFN--LCD------YGDSKSFKDGSKTYDLNA--F
.| .  ||||.  . . .. ...  ..    ||||  .   . ..| .| | ||.|.| ...|.. .   |||       | .   ..    |       
EKCQQNCNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKG

TRKY-----------AAPELTDE-----NGFFNIKYDIYGLGIIL
|  |            |||. ..     . .| .| |.| .|..|
TDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 28272.AA TKL 135-214 19 2.4e-10 33.44 In-house 160-286 (364) Show / Hide 
Range on Protein: 135-214
Range on HMM: 160-286/364
Sequence Identity: 19% (25 aa)

NLVHSDVKPENILYDS-------------QEKCFNLCDYGDSKSFK-------------------DGSKTYDLNAFTRKYAAPELTDENGFFNIKY----
...| | |..||| |.              . |  .||.| |....                   ...||      |  . |||. ....... |.    
PIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE

-----------DIYGLGIILLELTLGK
           |.|  ||.| |.  ..
FCKGFEYSEKCDVYSFGIVLWEILTRC
Kinase 28272.AA TKL 26-67 16 4.5e-07 21.53 In-house 1-83 (364) Show / Hide 
Range on Protein: 26-67
Range on HMM: 1-83/364
Sequence Identity: 16% (14 aa)

ISQGRQGCVFEAKYNE----------EIVAVKCSKP-------------------------------IFQKIEEEQKILKLLK
| .|. |.|. .|..           . ||||  |                                .....||| .... |.
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLR
Kinase 28272.AA TyrKc 20-267 15 5.5e-07 -109.66 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-267
Range on HMM: 1-280/280
Sequence Identity: 15% (49 aa)

IYLTSYISQGRQGCVFEAKYNEEIVAVKCSK--PIFQKIEEEQKILKLL-KDTPYVLK----SIEE------------------------FLNEKKSKYY
| |   .  |  | |...... . ||||. |     . . .| .|.. | .. | ...     ...                        .| ... |  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

QISKKYSCNLKEIMQSFFNQRKPLPLNQIVGFAIQMSTVFEKIQQNNLVHSDVKPENILYDSQEKCFNLCDYGDSKSFKDG------SKTYDL----NA-
                       |.. . . |..| .   | . ..|..| |    |.|....  .   .| | |.  .|.      ...|.     .. 
-----------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

--FTRKYAAPELTDENGFFNIKYDIYGLGIILLEL-TLGKFLEDKD----------CTFIRKGQLPNYISKNA------LFQDINQIIVQMLEIMPENRI
  .  .  |||     | |..| |..  |. . |. |.|.     .            ....|  .     .         ... ||. |  .  ||.| 
TMLPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

DSFELTKQL
   |. ...
TFSEIHECF