Gene 20038 (Tetrahymena)
20038
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 20038.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 20038.AA | Ciliate-C7 | 24-168 | 67 | 9.7e-96 | 307.39 | In-house | 1-146 (164) | Show / Hide |
Range on Protein: 24-168 Range on HMM: 1-146/164 Sequence Identity: 67% (99 aa) FKYLGQGGQGSVLLAKQKLSNRRYAIKGVKVKDKKGKVDENALKVVQQEINTLNQCKGSPYVVNFLCQIEGQQFFYLVLTECL-GNLSEIINQTKNNVLN |..|||| || |||||.. .|.|||||||.|.||.|..|..... ||||||.|.|||.|||||..|.|.|||||.||||.||. |.|..||....|. || FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN EISAIKYAKDIAEGLQFIHSKNCVVNDIKMENILIDYNGNALVCKF ||||||||||||.||..||||||||||.||.||||||||||.|| | EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDF |
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| Kinase | 20038.AA | AGC | 21-162 | 21 | 3.1e-23 | 55.55 | In-house | 1-193 (395) | Show / Hide |
Range on Protein: 21-162 Range on HMM: 1-193/395 Sequence Identity: 21% (42 aa) YDEFKYLGQGGQGSVLLAKQK------LSNRRYAIKGVK----VKDKKGKVDENALKV--------VQQEINTLNQCKG---------SPYVVN-FLCQI .. | .|.|. | | |.. | ... ||.| .| ...|| . |... |..| | | .|.. .|..|. . FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF EGQQF--FYLVLTECL---------GN-LSEIINQT--KNNVLNEISAIKYAKD-------IAEGLQFIHS-KNCVVND-IKMENILIDYNGN . .. |.|. . | . ...| |. ...| | || |. .|...|| .. . | .| ||||.| .|. QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGH |
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| Kinase | 20038.AA | Ciliate-E2-Unclassified | 21-166 | 24 | 4.6e-22 | 73.34 | In-house | 1-189 (352) | Show / Hide |
Range on Protein: 21-166 Range on HMM: 1-189/352 Sequence Identity: 24% (47 aa) YDEFKYLGQGGQGSVLLAKQKLSNRRYAIKGVKVKDKKG-KVDENALKVVQQEINTLNQCK------------------GSPYVVNFLCQIEGQQFFYLV | | .||||.|.| ....| . ||.| |.. .. | .| .|....|. | .|..|... . . .| .|.| YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LTECLG-NLSEIINQTKN---------------NVLNEISAI-----KYAKDIAEGLQFIHSKN-CVVNDIKMENILIDYNG---NALVC . | | .|...|.. |. . . | |. .|.. | .||...|.|| .. ||| ||||.| || . .. MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKII |
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| Pkinase | 20038.AA | Pkinase | 21-162 | 26 | 5.4e-22 | 78.84 | Pfam | 1-146 (293) | Show / Hide |
Range on Protein: 21-162 Range on HMM: 1-146/293 Sequence Identity: 26% (39 aa) YDEFKYLGQGGQGSVLLAKQKLSNRRYAIKGVKVKDKKGKVDENALKVVQQEINTLNQCKGSPYVVNFLCQIEGQQFFYLVLTECLG-----NLSEIINQ | . .|.|. |.| ... | .....|.| .|....| ..|..... .|| .. . ..|..| ... | . |.|. | | |...| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST TKNNVL--NEISAIKYAKDIAEGLQFIHSKNCVVNDIKMENILIDYNGN ..... | ...|.. |..||...||.... |.| |||||| ||. WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGH |
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| Kinase | 20038.AA | CAMK | 26-161 | 18 | 1.5e-20 | 62.28 | In-house | 1-216 (425) | Show / Hide |
Range on Protein: 26-161 Range on HMM: 1-216/425 Sequence Identity: 18% (40 aa) YLGQGGQGSVLLAKQKLSN------------RRYAIKGVKVKDKKGKV----------------------DENALKVVQQEINTLNQCKG------SPYV ||.|. | | |...|... ...||| .. | |.|. ... .| |..||. .....| | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VNFLCQIEG-------------------QQFFYLVL--TECLGNL------SEIINQTKN-------------NVLNEISAIKYAKDIAEGLQFIHSKNC .... .| ....|.|. .| . . | . .. ..| | .| . |.......||.| IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI VVNDIKMENILIDYNG | |.| ||||.|.|. VHRDLKPENILLDDNN |
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| Kinase | 20038.AA | Ciliate-E2 | 21-167 | 21 | 5.1e-19 | 61.91 | In-house | 1-196 (365) | Show / Hide |
Range on Protein: 21-167 Range on HMM: 1-196/365 Sequence Identity: 21% (44 aa) YDEFKYLGQGGQGSVLLAKQKLSNRRYAIK-------------GVKVKDKKGKVD-ENALKVVQQEINTLNQCK---------------GSPYVVNFLCQ |. | .|||..||| ..|... ....||| .||.| . |. .| .. . |||. ... . .|..... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC IE--GQQFFYLVLTECLG-NLSEIINQT----------KNNVLNEISAIKYAKDIAE---------------GLQFIHSKN-CVVNDIKMENILIDYNGN . .. .|||. | | .| ..|.. . . ..| .... | |.. .|...|||| .. ||| ||||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- ALVCK .| ---IK |
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| Kinase | 20038.AA | Ciliate-E1 | 27-168 | 20 | 2.6e-18 | 56.54 | In-house | 1-153 (202) | Show / Hide |
Range on Protein: 27-168 Range on HMM: 1-153/202 Sequence Identity: 20% (32 aa) LGQGGQGSVLLAKQKLSN-RRYAIKGVKVKDKKGKVDENALKVVQQEINTLNQCKGSPYVVNFLCQIEGQQ--FFYLVLTECLGNLSEIIN--------- .|.|... |. |||. .| . .|.| ...... ..... .. ..... .. |. |..... .|. .| ........| .| . .. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEI--KEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQ --QTKNNVLNEISAIKYAKDIAEGLQFIHSKNCVVNDIKMENILIDYNGNALVCKF |...| ... .. .... .||. .|..| |||..||||. .|| . |.| QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDF |
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| Kinase | 20038.AA | Ciliate-E2b | 21-161 | 28 | 4.7e-15 | 42.36 | In-house | 1-139 (272) | Show / Hide |
Range on Protein: 21-161 Range on HMM: 1-139/272 Sequence Identity: 28% (41 aa) YDEFKYLGQGGQGSVLLAKQ-KLSNRRYAIKGVKVKDKKGKVDENAL-KVVQQEINTLNQCKGSPYVVNFLCQIEGQQFFYLVLTECLG-NLSEIINQTK .. | ||.| ||| | .. | ... ||.| . .| .. .. . | .||.|.| |. |....|. |. |... | | | ..| . . MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCI----SKNQIIQQNMEKHMLQEKNVLEKCN-HPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIG NNVLNEISAIKYAKDIAEGLQFIHSKNCVVNDIKMENILIDYNG |.. . | . | .|. |..| . ||| |||..|..| RLLLSTYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKG |
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| Kinase | 20038.AA | CAMKL | 21-162 | 27 | 9.1e-15 | 43.41 | In-house | 1-165 (297) | Show / Hide |
Range on Protein: 21-162 Range on HMM: 1-165/297 Sequence Identity: 27% (47 aa) YDEFKYLGQGGQGSVLLAKQ-KLSNRRYAIKGVKVKDKKGKV-DENALKV-----------VQQEINTLNQCK--GSPYVVNFLCQIEGQQF------FY |. | ||.|. | | ||. .. ....|| |. |||.. |....| ...||. . . . . | .. .. || ... .| YRIGKTLGKGSFGKVKLATHIRTTGEKVAI---KIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIY LVLTECLGN---LSEIINQTKN--NVLNEISAIKYAKDIAEGLQFIHSKNCVVNDIKMENILIDYNGN ||. | | | . | . .. . | | .| . | ......||.. | ||| ||||.|.||| LVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGN |
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| Kinase | 20038.AA | PKN | 21-161 | 25 | 6.5e-14 | 43.87 | In-house | 1-138 (260) | Show / Hide |
Range on Protein: 21-161 Range on HMM: 1-138/260 Sequence Identity: 25% (36 aa) YDEFKYLGQGGQGSVLLAKQKLSNRRYAIKGVKVKDKKGKVDENALKVVQQEINTLNQCKGSPYVVNFLCQIEGQQFFYLVLTECLGNLSEIINQTKNNV . || | | |||.. | ... |||| .| .| .. . ..| .. . | .. . |..|| . . .. . |. | ... . . | FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESL-MCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMG--GDLMMHIHEDV LNEISAIKYAKDIAEGLQFIHSKNCVVNDIKMENILIDYNG .| |. || . |||..| .. . |.|..|.|.| .| FSEPRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEG |
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| Kinase | 20038.AA | S_TKc | 21-256 | 17 | 2.2e-13 | 19.29 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 21-256 Range on HMM: 1-231/231 Sequence Identity: 17% (48 aa) YDEFKYLGQGGQGSVLLAKQKLSNRRYAIKGVKVKDKKGKVDENALKVVQQEINTLNQCKGSPYVVNFLCQIEGQQFFYLVLTECLG---NLSEIINQTK |. . .|.|. |.| ... | ..|..||| .| . ...||. | . . |..|... .. ...|.|. | | .| ..| . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG NNV----LNEISAIKYAKDIAEGLQFIHSKNCVVNDIKMENILIDYNGNALVCKFFHKARIIQKVRSSCKV--------RAKSKSY----------LIYI . ..| | .|.. |...|...||.. . |.| ||||.| . .| | ||.. ... . . .. ..|. RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICD-FGLARQL----TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYE MIQGWN----LDLVINKHIPLKYNADFQNFVYKKQLQYIIDGLTKFKPRDRLKIKDVLI-----ILKGII |. | ......| ... .|... .. |..|. . ..| . . MLCGYPPFPQMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 20038.AA | Ciliate-A2 | 105-162 | 26 | 3.6e-08 | 24.77 | In-house | 80-140 (272) | Show / Hide |
Range on Protein: 105-162 Range on HMM: 80-140/272 Sequence Identity: 26% (16 aa) C-LGNLSEIIN--QTKNNVLNEISAIKYAKDIAEGLQFIHSKNCVVNDIKMENILIDYNGN | ..|.. | | . ... ....|. | .... .|.|| |. |.. .||||| ... CPECSLQDWIDKFQNQQKFIPDHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQ |
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| Kinase | 20038.AA | Ciliate-A2 | 28-80 | 26 | 1.1e-07 | 23.12 | In-house | 1-56 (272) | Show / Hide |
Range on Protein: 28-80 Range on HMM: 1-56/272 Sequence Identity: 26% (15 aa) GQGGQGSVLLAKQK--LSNRRYAIKGVKVKDKKGK-VDENALKVVQQEINTLNQCK |||. | |.... . | |||| ... |.... .... |. . |. | |. GQGCFGCVIFVEHMDNHNNEKYAIKIQSIIDGIDQKISQQKLQECKHEAQFLKNCN |
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| Kinase | 20038.AA | TyrKc | 21-252 | 13 | 1.2e-05 | -131.37 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 21-252
Range on HMM: 1-280/280
Sequence Identity: 13% (40 aa)
YDEFKYLGQGGQGSVLLAKQKLSNRRYAIKGVKVKDKKGKVDENALKVVQQEINTLNQC-KGSPYVVNFL--CQIEG------QQFFYLVLTECLGNLSE
| || | | | ... | . |.| .| .. .|.. . . . | .|... | .| .. . .. ..|.| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD
IINQTKNNVLNEISAIKYAKDIAEGLQFIHSKNCVVNDIKMENILIDYNGNALVCKF----FHKAR-------IIQKVRS--SCK-----------VRAK
. .... |. .... .||.| ...|||||. |. |.|.. |. . .. | ... .... ..| . .
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY
SKSY---------------LIYIMIQGWN-----------LDLVINKHIPLKYNAD-------FQNFVYKKQLQYIIDGLTKFKPRDRLKIKDVLIIL
.| . | . .. . .| . . . . | .|. . ...| || ... ..
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCW----HEDPEDRPTFSEIHECF
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