Gene 21676 (Tetrahymena)
21676
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 21676.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 21676.AA | Ciliate-C7 | 78-233 | 78 | 4.5e-116 | 373.46 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 78-233 Range on HMM: 1-164/164 Sequence Identity: 78% (128 aa) FRFLGQGVQGLVLLAKDSKTKMRYAIKGVQVRDPQGKLDEDLNNQVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQ--------ERNQNKRLN ||||||| |||||||||.||.||||||||||||.||..|.|.||||.||..|||.|.||||||.|..|||||||.||||.||| ||||||||| FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN EISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNAVVSDFGLADNIINKSGYTNNQYM ||||||||.||||||||||||||.|||||||||||||.|||||.|||||||...||.|. |||| EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM |
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| Kinase | 21676.AA | CAMK | 80-253 | 16 | 9e-25 | 76.13 | In-house | 1-313 (425) | Show / Hide |
Range on Protein: 80-253
Range on HMM: 1-313/425
Sequence Identity: 16% (52 aa)
FLGQGVQGLVLLAKDSKTK------------MRYAIKGVQ-----------------VRDPQGKL-----DEDLNNQVKQEVEILKKCR------DSPYV
||.| | | |... .|. ..||| . ... .| .. .|..|.||.||.. | | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
VSLIDQFEG-------------------QQFSYLVL--------T----ECQERNQNK----------------RLNEISAIKYANDIAQGLYYIHSKNC
..|.. .| ... |.|. .. .. . . |..| | .| |.... |.||.|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI
LVNDLKMDNILIDYH-----------------GNAVVSDFGLADNIINKSGYTNN----------------------QYMGNLLYQA-PECCDPS-----
||| .|||.|.. .| ..|||.| .. ....... . | . | | || .
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM
-------DPYIGK
||.|.
QNATDEEKPYYGP
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| Pkinase | 21676.AA | Pkinase | 75-228 | 27 | 7.3e-24 | 85.45 | Pfam | 1-169 (293) | Show / Hide |
Range on Protein: 75-228
Range on HMM: 1-169/293
Sequence Identity: 27% (49 aa)
YSDFRFLGQGVQGLVLLAKDSKTKMRYAIKGVQVRDPQGKLDED---LNNQVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQE-----RNQ--
| | .|.| | | .... .| ..|.| . .|. . |. | .|..|.|.. ..|..| |.| || . |.|. |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY
-----NKRL--NEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNA----VVSDFGLADN--IINKSGYT
.... | ...|. |..||.|.||.... ||| .||||| .|. ..||||| . |.| .|
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MT
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| Kinase | 21676.AA | Ciliate-E2-Unclassified | 75-243 | 20 | 2.5e-22 | 74.3 | In-house | 1-237 (352) | Show / Hide |
Range on Protein: 75-243 Range on HMM: 1-237/352 Sequence Identity: 20% (49 aa) YSDFRFLGQGVQGLVLLAKDSKTKMRY----AIKGVQVRDPQGKLDEDLNNQVKQEVEILK---------------KCRDSPYVVSLIDQFEGQQFSYLV | . .||| .| | .....|.| | .| .|... . .. .| .. ..|....| . ..|..| ....|. .| |.| YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LTEC-----------------------QERNQNKRLNEISAI-----KYANDIAQGLYYIHSKN-CLVNDLKMDNILIDYHG---NAVVSDFGLADNIIN . | . ..|.|.. | |. .|. | ||| |.|.|| .. |.| .|||.| | . ..|||.. .... MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ KSGYTNNQY---------------MGNLLYQ----APEC .... .. .|.. |. |||. NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEV |
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| Kinase | 21676.AA | Ciliate-E2 | 75-242 | 19 | 6.2e-21 | 68.59 | In-house | 1-257 (365) | Show / Hide |
Range on Protein: 75-242 Range on HMM: 1-257/365 Sequence Identity: 19% (51 aa) YSDFRFLGQGVQGLVLLAKDSKTKMRYAIK-------------GVQ-VRDPQGKLDEDLNNQVKQEVEILKKCR---------------DSPYVVSLIDQ | . .||| .| | ..|. |.. ..||| .|. . .. .|.||| |... . ..|... ... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FE--GQQFSYLVLTECQERN------------------QNKRLNEISAIKYANDIAQ---------------GLYYIHSKN-CLVNDLKMDNILIDYHGN |. .. |||. || . . |...| .... |.| .| |.|||| .. |.| .|||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- AVVSDFGLADNIINK----------SGYTNNQ--------YM-------------GNLLYQAPE ..||||. .. .. |.. . || |.. |.||| IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPE |
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| Kinase | 21676.AA | CAMKL | 75-253 | 25 | 7e-20 | 59.99 | In-house | 1-215 (297) | Show / Hide |
Range on Protein: 75-253 Range on HMM: 1-215/297 Sequence Identity: 25% (54 aa) YSDFRFLGQGVQGLVLLAKD-SKTKMRYAIKGVQVR----DPQGKLD------EDLNNQVKQEVEILKKCR--DSPYVVSLIDQFEGQQF------SYLV | . ||.| | | ||.. . |. ..||| . . ||. | |. ...|..|.|. . | ...| . .| ... ||| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV LTECQERN----------QNKR--LNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHG--NAVVSDFGLADNII---NKSGYTNNQYMGNLLY . |. . ..| . | | .| | ...|.||.. |.| .|||.|..| |. ..|||.. .. ...| . . | . | MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY QAPECCDP-SDPYIGK .||| . .||.|. MAPEIFQGNNKPYDGP |
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| Kinase | 21676.AA | Ciliate-E1 | 81-259 | 18 | 1e-17 | 54.57 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 81-259
Range on HMM: 1-202/202
Sequence Identity: 18% (37 aa)
LGQGVQGLVLLAKDSKTK-MRYAIKGVQVRDPQGKLDEDLNNQVKQEVEILKKCRDSPYVVSLIDQFEGQQ--FSYLVLTECQER-----N---------
.|.| ...|. || ... .|.| ..... . . ...... |.. .|.| . |.. .||... .| ........|... .
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQ--NHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQ
----QNKRLNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNAVVSDFGLADNIINKSGYTNNQYMGNLLYQAPECCD-----PSDPYIGKV
... ... .. . .. .|| ..|..| . |.|..||||. || | .|||......|.. .. .. |. ||. . .... .
QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINY
YHDEY
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KSDIY
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| Kinase | 21676.AA | S_TKc | 75-331 | 21 | 8.7e-17 | 63.01 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 75-331 Range on HMM: 1-231/231 Sequence Identity: 21% (62 aa) YSDFRFLGQGVQGLVLLAKDSKTKMRYAIKGVQVRDPQGKLDEDLNNQVKQEVEILKKCRDSPYVVSLIDQFEGQQFSYLVLTECQE--------RNQNK | | .|.| | | .... ||. ..||| . .....|..|||| . |..| |.| |. .. |.|. | ... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG R------LNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNAVVSDFGLADNIINKSGYTNNQYMGNLLYQAPECCDPSDPYIGKVYHDEYL | ..| | .|. |...| |.||.. . ||| .|||.| . ..||||| . . . | . | ||| . | RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-------------GYG K-----------LGITVRQEPSNRGINFNLASNKHKQLNFNDEFKNFVYHKQLKYIIEGLTNFVPRNRMPIKEALI-----ILKGII | | . . .| . . .. .| . ...| .|... .. |..|. . ||| . . KCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 21676.AA | ULK | 75-218 | 23 | 3e-15 | 50.6 | In-house | 1-185 (324) | Show / Hide |
Range on Protein: 75-218 Range on HMM: 1-185/324 Sequence Identity: 23% (44 aa) YSDFRFLGQGVQG-LVLLAKDSKT---KMRYAIKGVQ--------VRDPQGKLDEDLNNQVKQEVEILKKCR--DSPY--VVSLIDQFEGQ--QFSYLVL |. . ||.| | | ... || . .|.| .. ... | . . .. |.|..|.|| .|. .| |.| || . . |... YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQE-G---QYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIM TECQER------NQNKRLNEIS----------AIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNAV------------VSDFGLA |. ..||.|.| ||.. .|..|. ..|..|. |.| .|||| . ..|||.| EYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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| Kinase | 21676.AA | Ciliate-A2 | 163-243 | 32 | 3.1e-12 | 39.06 | In-house | 94-178 (272) | Show / Hide |
Range on Protein: 163-243 Range on HMM: 94-178/272 Sequence Identity: 32% (28 aa) NQNKRLNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGN-AVVSDFGLA---DNIINKSGYTNNQYMGNLLYQAPEC || | ... ....|. | ... |.|.|| . ||. ||||| ... .. ||||| ...|| . .. .. | ..| ||| NQQKFIPDHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKLCDFGLAKKYQPEINSQMFYTSCPKGVFFYYPPEC |
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| Kinase | 21676.AA | STE20 | 75-144 | 24 | 1.2e-10 | 35.37 | In-house | 1-71 (288) | Show / Hide |
Range on Protein: 75-144 Range on HMM: 1-71/288 Sequence Identity: 24% (19 aa) YSDFRFLGQGVQGLVLLAKDSKTKMR----YAIKGVQVRDP---QGKLDEDLNNQVKQEVEILKKCRDSPYVVSLID | ... .||| | | .| . .|. .||| . .... | | . ...|. |.|.|. .|..|. .. YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-----DEWEDIQKEISIMKQCK-HPNIVKYYG |
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| Kinase | 21676.AA | STE | 75-144 | 20 | 1.2e-08 | 26.79 | In-house | 1-97 (359) | Show / Hide |
Range on Protein: 75-144 Range on HMM: 1-97/359 Sequence Identity: 20% (20 aa) YSDFRFLGQGVQGLVLLAKDSK---------------TKMRYAIKGVQVRDPQGKLDE------------DLNNQVKQEVEILKKCRD-SPYVVSLID . . ...|.| | | .|.. | |. ..||| . ... . | | . .|...|..|.|||.. .|..| .. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYG |
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| Kinase | 21676.AA | STE | 165-242 | 23 | 2e-07 | 22.45 | In-house | 145-232 (359) | Show / Hide |
Range on Protein: 165-242 Range on HMM: 145-232/359 Sequence Identity: 23% (22 aa) NKRLNEISAIKYANDIAQG-LYYIHSKNCLVNDLKMDNILIDYHGNAVVSDFGLADNIIN---------------KSGYTNNQYMGNLLYQAPE ..|..| .... .| .| |||.||.. |.| .|||. . .|||.. .... .. .| | . ||| QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE |
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| Kinase | 21676.AA | Ciliate-A2 | 82-133 | 27 | 4e-07 | 21.11 | In-house | 1-55 (272) | Show / Hide |
Range on Protein: 82-133 Range on HMM: 1-55/272 Sequence Identity: 27% (15 aa) GQGVQGLVLLAKD--SKTKMRYAIKGVQVRDPQGK-LDEDLNNQVKQEVEILKKC ||| |.|..... . . |||| . . |. .. .. . . | | ..||.| GQGCFGCVIFVEHMDNHNNEKYAIKIQSIIDGIDQKISQQKLQECKHEAQFLKNC |
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| Kinase | 21676.AA | TyrKc | 75-327 | 17 | 9.4e-07 | -113.49 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 75-327
Range on HMM: 1-280/280
Sequence Identity: 17% (56 aa)
YSDFRFLGQGVQGLVLLAKDSKTKMRYAIKGVQVRDPQGKLDEDLNNQVKQEVEILKKC-RDSPYVVSLIDQFEGQQ------FSYLVLTE------CQE
. . || | | | ... . . |.| .. .| .|..| . | .| |. |. .....| ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD
RNQNKR--LNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNAVVSDFGLADNIINK------SGYTNNQY--MGN----LLYQAPECC---
. ...| |. .... .||.| |.||||| || |.|.. . . .|||||. .| .. . | . |. . ||||
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG
--------------------DPSDPYIG-----KVYHD--EYLKLGITVRQEPS----NRGINFNLASNKHKQLNFNDEFKNFVYHKQLKYIIEGLTNFV
. || | . . ||.| | .| |. | .. . |.. ..
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------F--VCCPDEMYQIMKQCWHED
PRNRMPIKEALIIL
| .| .| ..
PEDRPTFSEIHECF
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| Kinase | 21676.AA | STE20 | 182-218 | 43 | 3.8e-05 | 15.08 | In-house | 128-164 (288) | Show / Hide |
Range on Protein: 182-218 Range on HMM: 128-164/288 Sequence Identity: 43% (16 aa) QGLYYIHSKNCLVNDLKMDNILIDYHGNAVVSDFGLA ||| |.||... |.| ||||.. .|.. .|||.. QGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVC |
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