25184

Species: Tetrahymena
Alias: 25184, 62, PreTt25184, TTHERM_01515340, 437.m00003
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C7

Sequence

Name Sequence Type Origin Length Description Download
25184.AA Protein None 474 None Fasta, JSON
25184.kin_dom Protein Kinase Domain None 142 None Fasta, JSON
25184.NA RNA None 1425 None Fasta, JSON

Protein domain

Protein domains of 25184.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 25184.AA Ciliate-C7 45-185 66 5.6e-93 298.42 In-house 1-142 (164) Show / Hide
Range on Protein: 45-185
Range on HMM: 1-142/164
Sequence Identity: 66% (95 aa)

FKYLGKGGQGLVLLAKQKQSNRRYAIKGVKVKDKKGILDENTLKEVQQEINTLNQCKGSPYVANFIGQIEGQQFIYLVLTECL-GSLSELIKQTQNGVLN
|..||.| ||||||||....|.|||||||.|.||.| .|......||||||.|.|||.|||| ... |.||||||||||.||. |.|...|...||  ||
FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN

EITAIKYAKDIAEGLDFIHSRNCVVNDIKMDNILIDYNGNAV
||.|||||||||.|| .|||.||||||.||||||||||||||
EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAV

Kinase 25184.AA AGC 42-183 22 6.9e-23 54.61 In-house 1-193 (395) Show / Hide
Range on Protein: 42-183
Range on HMM: 1-193/395
Sequence Identity: 22% (44 aa)

YDQFKYLGKGGQGLVLLAKQK------QSNRRYAIKGVK----VKDKKGILDENTLKE--------VQQEINTLNQCKG---------SPYVAN-FIGQI
..  | .|||. | | |.. |      .... ||.| .|    ...||    |.|. |        |..| | | .|..         .|.. .      
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

EGQQF--IYLVLTECL---------GS-LSELIKQT--QNGVLNEITAIKYAKD-------IAEGLDFIHS-RNCVVND-IKMDNILIDYNGN
. ..   .|.|.  .          |   . |..|   ..|...| .|  ||         |. .|...|| .. .  | .| .|||.| .|.
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGH

Kinase 25184.AA CAMK 47-186 17 2.9e-20 61.34 In-house 1-236 (425) Show / Hide
Range on Protein: 47-186
Range on HMM: 1-236/425
Sequence Identity: 17% (41 aa)

YLGKGGQGLVLLAKQKQSN------------RRYAIKGVKVKDKKGIL----------------------DENTLKEVQQEINTLNQCKG------SPYV
 ||.|. | | |...|...            ...||| .. |  |.                        .....|.|..||. .....|       | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ANFIGQIEG-------------------QQFIYLVL--TECLGSL------SELIKQTQN-------------GVLNEITAIKYAKDIAEGLDFIHSRNC
 ...  .|                    ....|.|.  .|            . |..  .             | ..|  | .| . |.......||.| 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VVNDIKMDNILIDYNG----------------NAVK
|  |.| .|||.|.|.                | .|
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIK

Pkinase 25184.AA Pkinase 42-186 26 7.4e-20 71.29 Pfam 1-152 (293) Show / Hide
Range on Protein: 42-186
Range on HMM: 1-152/293
Sequence Identity: 26% (41 aa)

YDQFKYLGKGGQGLVLLAKQKQSNRRYAIKGVKVKDKKGILDENTLKEVQQEINTLNQCKGSPYVANFIGQIEGQQFIYLVLTECLG-----SLSELIKQ
|   . .|.|. | | ... | .....|.| .|....|   |.. ..   .||  .. . ..|..  ...  |  . ||.|.  | |     .|...|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

TQNGVL--NEITAIKYAKDIAEGLDFIHSRNCVVNDIKMDNILIDYNGNA---VK
 ..|..   | ....|.. |..||...||....  |.| .||||| ||.    ||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVK

Kinase 25184.AA Ciliate-E2 42-186 20 1.3e-19 63.97 In-house 1-196 (365) Show / Hide
Range on Protein: 42-186
Range on HMM: 1-196/365
Sequence Identity: 20% (42 aa)

YDQFKYLGKGGQGLVLLAKQKQSNRRYAIK-------------GVKVKD-KKGILDENTLKEVQQEINTLNQCK---------------GSPYVANFIGQ
|.  | .|.|..| | ..|... ....|||             .||.|   . |. .| .... |||. ... .                .|.. ...  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IE--GQQFIYLVLTECLG-SLSELIKQT----------QNGVLNEITAIKYAKDIAE---------------GLDFIHSRN-CVVNDIKMDNILIDYNGN
 .   .. ||||.  | | .| ..||.           . . ..|  .... | |..               .| ..||.| ..  ||| .|||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

AVK
 .|
-IK

Kinase 25184.AA Ciliate-E2-Unclassified 42-186 23 8.3e-18 58.36 In-house 1-187 (352) Show / Hide
Range on Protein: 42-186
Range on HMM: 1-187/352
Sequence Identity: 23% (45 aa)

YDQFKYLGKGGQGLVLLAKQKQSNRRYAIKGVKVKDKKG-ILDENTLKEVQQEINTLNQCK------------------GSPYVANFIGQIEGQQFIYLV
|   | .|.||.| | ....|. .  ||.|  |.. ..   . .|   |  .|....|. |                   .|.. ... . . .| ||.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LTECLG-SLSELIKQTQN---------------GVLNEITAI-----KYAKDIAEGLDFIHSRN-CVVNDIKMDNILIDYNGN--AVK
.  | | .|.. ||.  .                 . |  |.     .|.. | .||...|. | ..  ||| .|||.| ||.   .|
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIK

Kinase 25184.AA Ciliate-E1 48-189 22 2.5e-17 53.32 In-house 1-153 (202) Show / Hide
Range on Protein: 48-189
Range on HMM: 1-153/202
Sequence Identity: 22% (35 aa)

LGKGGQGLVLLAKQKQSN-RRYAIKGVKVKDKKGILDENTLKEVQQEINTLNQCKGSPYVANFIGQIEGQQ--FIYLVLTECLGSLSELIK---------
.|.|....|. |||...| . .|.| .....   . ..|.. ....|.. . . |.  |. ..| .|. .|  ........|  || . ..         
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCF---NYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQ

--QTQNGVLNEITAIKYAKDIAEGLDFIHSRNCVVNDIKMDNILIDYNGNAVKGNF
  |.... ...   .. .... .||  .|. |    |||..||||. .|| |.  |
QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDF

Kinase 25184.AA STE 42-186 17 4e-17 57.1 In-house 1-187 (359) Show / Hide
Range on Protein: 42-186
Range on HMM: 1-187/359
Sequence Identity: 17% (34 aa)

YDQFKYLGKGGQGLVLLAKQK------QSNRR---------YAIKGVKVKDKK-----------GILDENTLKEVQQEINTLNQCKG-SPYVANFIGQIE
..  . .|||. | | .|. .      ....          .||| .......            . ... ......||.....|.  .|.. ...|  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

GQ-------QFIYLVLTECL-GSLSELIK------QTQN------GVLNEITAIKYAKDIAEG-LDFIHSRNCVVNDIKMDNILIDYNGNAVK
         . .....  .  |||...||      ...|      ....|   ......| .| |...|| . .  ||| .|||.      ||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VK

Kinase 25184.AA CAMKL 42-186 29 9.1e-17 49.89 In-house 1-169 (297) Show / Hide
Range on Protein: 42-186
Range on HMM: 1-169/297
Sequence Identity: 29% (51 aa)

YDQFKYLGKGGQGLVLLAKQ-KQSNRRYAIKGVKVKDKKGIL-DENTLKE-----------VQQEINTLNQCK--GSPYVANFIGQIEGQQF------IY
|.  | ||||. | | ||.  .  ....||   |. |||.|  |....|            ...||. . . .  . | .  .   || ...      ||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAI---KIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIY

LVLTECLGS---LSELIKQTQN--GVLNEITAIKYAKDIAEGLDFIHSRNCVVNDIKMDNILIDYNGN-AVK
||.  | |    | . |..  .  | . |  | .| . | ......||.. |  ||| .|||.|.|||  .|
LVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIK

Kinase 25184.AA STE20 42-184 24 2.6e-14 49.0 In-house 1-156 (288) Show / Hide
Range on Protein: 42-184
Range on HMM: 1-156/288
Sequence Identity: 24% (39 aa)

YDQFKYLGKGGQGLVLLAKQKQSNRR----YAIKGVKVKDK---KGILDENTLKEVQQEINTLNQCKGSPYVANFIGQIEGQ----QFIYLVLTECLG-S
|. .. .|.|. | | .|  |....     .||| ......   .     . ....|.||. ..||| .|.. ...|         . ...|   | | |
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-----DEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGS

LSELIKQ--TQNG-----VLNEITAIKYAKDIAEGLDFIHSRNCVVNDIKMDNILIDYNGNA
|....|.  . ..     ..||       ... .|||..||....  ||| ||||.. .|..
LTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEV

Kinase 25184.AA S_TKc 42-347 14 3.2e-12 2.33 SMART 1-231 (231) Show / Hide
Range on Protein: 42-347
Range on HMM: 1-231/231
Sequence Identity: 14% (51 aa)

YDQFKYLGKGGQGLVLLAKQKQSNRRYAIKGVKVKDKKGILDENTLKEVQQEINTLNQCKGSPYVANFIGQIEGQQFIYLVLTECLG---SLSELIKQTQ
|.  . .|||. | | ... | ..|..||| .|             . ...||. | .  . |.. .... ..  ...|.|.  | |   .| ..||. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

NGV----LNEITAIKYAKDIAEGLDFIHSRNCVVNDIKMDNILIDYNGNAVK--------------GNFDCQAPECFTQFDIYSKKYKEQGVDV------
 .     ..| .| .|.. |...|...||.. .  |.| .|||.|     .|              |  .  ||| .        .|    .|.      
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQLTTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCI

------KQKPSPRLSINTFLQNTMNISRVLFIRNSFNTQLMDQLNSNQERGIISFEFQLDSKFIEVIDDGAAQDIIKSFNSDIEFIQVMKQKLQKFNQPK
       . | |   ... ... .                                                                            
LYEMLCGYPPFP--QMQMMFKKIG----------------------------------------------------------------------------

QNEVISKQKQEIQNLEDEINDLLLKDQQINQQ-----QIIQ--------PFI
                .|  |.. |  | . .     .. |        |..
---------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF

Kinase 25184.AA Ciliate-A2 126-183 27 5.7e-10 31.09 In-house 80-140 (272) Show / Hide
Range on Protein: 126-183
Range on HMM: 80-140/272
Sequence Identity: 27% (17 aa)

C-LGSLSELIK--QTQNGVLNEITAIKYAKDIAEGLDFIHSRNCVVNDIKMDNILIDYNGN
|  .||.. |.  | | . ...  ....|. | .... .|..| |. |..  ||||| ...
CPECSLQDWIDKFQNQQKFIPDHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQ

Kinase 25184.AA Ciliate-A2 49-101 26 2.3e-08 25.42 In-house 1-56 (272) Show / Hide
Range on Protein: 49-101
Range on HMM: 1-56/272
Sequence Identity: 26% (15 aa)

GKGGQGLVLLAKQK--QSNRRYAIKGVKVKDKKGI-LDENTLKEVQQEINTLNQCK
|.|. |.|.... .  . |  |||| ... |...   ... |.| . |.  |  |.
GQGCFGCVIFVEHMDNHNNEKYAIKIQSIIDGIDQKISQQKLQECKHEAQFLKNCN

Kinase 25184.AA TyrKc 42-301 14 5.3e-07 -109.39 SMART 1-280 (280) Show / Hide
Range on Protein: 42-301
Range on HMM: 1-280/280
Sequence Identity: 14% (48 aa)

YDQFKYLGKGGQGLVLLAKQKQSNRRYAIKGVKVKDKKGILDENTLKEVQQEINTLNQC-KGSPYVANFIGQIEGQ-------QFIYLVLTEC-LGSLSE
    | || |  | | ... |   .  |.| .|            ...  .|.. . .  .  | . ...| .  |       . ...|.  . .|.| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

LIKQTQNGVLNEITAIKYAKDIAEGLDFIHSRNCVVNDIKMDNILIDYNG-----------------------NAVKGNF--DCQ--------APECFTQ
 .. ...  |.  . .... .||.| ...||.||.  |.   |.|.. |.                          .     ..         ||||. .
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-N

FDIYSKKYKEQGVDV-------------KQKPSPR-----LSINTFLQNTMNISRVLFIRN----SFNTQLMDQLNSNQERGIISFEFQLDSKFIEVIDD
. ... |      ||              |.| |      .|    ... ..  |     |    |                           |  |.  
YGKFTTK-----SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------------F--VCCP

GAAQDIIKSFNSD-----IEFIQVMKQKL
 .  .|.|.           | .. ....
DEMYQIMKQCWHEDPEDRPTFSEI-HECF

Kinase 25184.AA Pkinase_Tyr 126-167 20 0.000379 14.67 Pfam 90-133 (270) Show / Hide
Range on Protein: 126-167
Range on HMM: 90-133/270
Sequence Identity: 20% (9 aa)

CLGSLSELIKQT--QNGVLNEITAIKYAKDIAEGLDFIHSRNCV
..|.| .  ..   ... |.  . .... .||.|... .|.||.
PHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCI