Gene 27656 (Tetrahymena)
27656
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 27656.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 27656.AA | Ciliate-C7 | 78-240 | 78 | 1.9e-117 | 377.94 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 78-240 Range on HMM: 1-164/164 Sequence Identity: 78% (128 aa) FRFLGSGAQGLVLLAKDLKNQMRYAIKGVQVRDLQGNLYDEFYNQVVQEIDILKQCTGCPYVVSFLDSFEGKQFIYLVLNECQ-GTLKEIIEKNQNKRLN ||||| |.||||||||| |..|||||||||||| |||.... .||| |||.||||| . ||||..|..|||.||||||||||| |||..|||.||||||| FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN EISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVCDFGLGDKLTVKSGYSHNQYV |||||||||||..||||||||||.||||||||||||||||||||||||.|.|| ||.|..|||. EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM |
|||||||||
| Pkinase | 27656.AA | Pkinase | 75-224 | 30 | 2.1e-28 | 101.49 | Pfam | 1-158 (293) | Show / Hide |
Range on Protein: 75-224 Range on HMM: 1-158/293 Sequence Identity: 30% (50 aa) YSDFRFLGSGAQGLVLLAKDLKNQMRYAIKGVQVRDLQGNLYDEFYNQVV-QEIDILKQCTGCPYVVSFLDSFEGKQFIYLVLNECQG-----TLKEIIE | | .|||. | | .... ... ..|.| . .| .. .. .. . .|| |.| . ..|..| ..|.|| |. ||.|. |.| |...|. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR---HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS KNQNKRL--NEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNA----VVCDFGL ..... | ...|.. | .||.|.||.... ||| .||||| ||. .||||| TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGL |
|||||||||
| S_TKc | 27656.AA | S_TKc | 75-359 | 20 | 6.9e-25 | 89.93 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 75-359 Range on HMM: 1-231/231 Sequence Identity: 20% (65 aa) YSDFRFLGSGAQGLVLLAKDLKNQMRYAIKGVQVRDLQGNLYDEFYNQVVQEIDILKQCTGCPYVVSFLDSFEGKQFIYLVLNECQG---TLKEIIEKNQ | | .|.|| | | .... | . ..||| . ... .||.|||. ..|..| ..|.|. ...|.|. | | .|...|.|.. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG NKR----LNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVCDFGLGDKLTVKSGYSHNQYVQINFLLNTNKKFNQFNSKNFKMGNFFY .. ..| | .|.. | ..| |.||.. . ||| .|||.| . .||||| .| . | .| RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------------------------TTFCGTPWY QAPECYDPTDK----------------IGKVYYDEYQNLGVQVKQEPSNREIDFNLVLNKHKPLNYDGEFQNFVYYKNLKQLIDGLTQFVPRNRLPIKEA ||| . .| |. .. .. . |. . .|..|... |. |..|. . || MAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG----------------------------SPEAKDFIRKCLQKDPEKRPTA-EA LI-----VLKGIF | . | LQDEWDIKCHPWF |
|||||||||
| Kinase | 27656.AA | CAMK | 80-224 | 18 | 1.7e-23 | 71.98 | In-house | 1-242 (425) | Show / Hide |
Range on Protein: 80-224
Range on HMM: 1-242/425
Sequence Identity: 18% (46 aa)
FLGSGAQGLVLLAKDLKNQ------------MRYAIKGVQVRDLQGNLYDEFY-----------------------NQVVQEIDILKQCTG------CPY
||.|. | | |... ... ..||| . . |... .| .| .||.|.|.. | |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQN-QDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN
VVSFLDSFEG-------------------KQFIYLVL---NECQGT------LKEIIEKNQN------------KRLNEISAIKYAKDITEGLYYIHSKN
...... .| ....|.|. |.| . |.|. .. .|..| | .| . | ... |.||.|
IIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN
CLVNDLKMDNILIDYN-----------------GNAVVCDFGL
||| .|||.|.| .| ..|||.
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGF
|
|||||||||
| Kinase | 27656.AA | Ciliate-E2-Unclassified | 75-224 | 24 | 8e-23 | 76.02 | In-house | 1-193 (352) | Show / Hide |
Range on Protein: 75-224 Range on HMM: 1-193/352 Sequence Identity: 24% (48 aa) YSDFRFLGSGAQGLVLLAKDLKNQ----MRYAIKGVQVRDLQGNLYDEFYNQVVQEIDILK---------------QCTGCPYVVSFLDSFEGKQFIYLV | . .|.|..| | .... |.. | |..| .. ..| . | ... .|. ..| . .|..| ... |. || ||.| YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LNEC-QGTLKEIIEKNQN---------------KRLNEISAI-----KYAKDITEGLYYIHSKN-CLVNDLKMDNILIDYNG---NAVVCDFGL . | .|.|...|.|. . |.. | |. .|.. | .|| |.|.|| .. |.| .|||.| || . ..|||. MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGI |
|||||||||
| Kinase | 27656.AA | ULK | 75-225 | 24 | 2.3e-22 | 74.97 | In-house | 1-189 (329) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-189/329 Sequence Identity: 24% (46 aa) YSDFRFLGSGAQGLVLLAKDLKNQMRYAIKGVQVRDLQGNLYDEFYNQ---------VVQEIDILKQCT---GCPY----VVSFLDSFEGKQF--IYLVL |. . ||.|. | | ... |.. .|. . | . .. . ....|. . .||.|.|. .... .| ..| || ... ||... YCLNHCLGKGSFGKVYKGRNKKTK-DYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM NECQG-TLKEIIEKNQN--------KRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAV------------VCDFGLG |.| .|...|.||.. |||.| ||.. |.| .|. ..|..|. |.| .||||. . ..|||.. EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
|||||||||
| Kinase | 27656.AA | Ciliate-E2 | 75-231 | 22 | 2.7e-22 | 73.31 | In-house | 1-209 (365) | Show / Hide |
Range on Protein: 75-231
Range on HMM: 1-209/365
Sequence Identity: 22% (49 aa)
YSDFRFLGSGAQGLVLLAKDLKNQMRYAIKGVQVRD---------LQGNLYDEFYNQ------VVQEIDILK--QCTG--------------CPYVVSFL
| . .|.|..| | ..|. |.| ..||| . . ....| ... . |||.|.. .| . .|... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMY
DSFE--GKQFIYLVLNECQG-TLKEIIEKN----------QNKRLNEISAIKYAKDITE---------------GLYYIHSKN-CLVNDLKMDNILIDYN
..|. .. ||||. ||| .|...|..| . |...| .... | |.. .| |.|||| .. |.| .|||.
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---
GNAVVCDFGLGDKLTVK
..|||| |.. .
--IKIIDFGLSKKYDDD
|
|||||||||
| Kinase | 27656.AA | CAMKL | 75-225 | 27 | 4e-22 | 67.26 | In-house | 1-176 (297) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-176/297 Sequence Identity: 27% (49 aa) YSDFRFLGSGAQGLVLLAKD-LKNQMRYAIKGVQVRDLQGNLYDEFYNQ------------VVQEIDILKQC-TG-CPYVVSFLDSFEGKQF------IY | . || |. | | ||.. . .. ..||| . | .. |.. .. . .|| |.|. .| | ...... .| ... || YRIGKTLGKGSFGKVKLATHIRTTGEKVAIK---IIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIY LVLNECQGT---LKEIIEKNQNKR--LNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNG--NAVVCDFGLG ||. |.| | . |.|. ..| . | | .| . | ....|.||.. |.| .|||.|.|| |. ..|||.. LVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS |
|||||||||
| Kinase | 27656.AA | STE | 75-224 | 22 | 3.1e-21 | 71.81 | In-house | 1-193 (359) | Show / Hide |
Range on Protein: 75-224 Range on HMM: 1-193/359 Sequence Identity: 22% (44 aa) YSDFRFLGSGAQGLVLLAKDLK---------------NQMRYAIKGVQVRDLQ-----------GNLYDEFYNQVVQEIDILKQCTG-CPYVVSFLDSFE . . ...|.|| | | .|.. | .. ..||| . ... . | .| .|. .||.|.|.| .|..| ...... WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF GK-------QFIYLVLNECQ-GTLKEIIE------KNQN------KRLNEISAIKYAKDITEG-LYYIHSKNCLVNDLKMDNILIDYNGNAVVCDFGL . . ..... . |.| .||. |..| .|..| ......| .| |||.||.. |.| .|||. . ||||. KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGV |
|||||||||
| Kinase | 27656.AA | ULK | 75-225 | 24 | 3.3e-20 | 68.46 | In-house | 1-185 (324) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-185/324 Sequence Identity: 24% (46 aa) YSDFRFLGSGAQG-LVLLAKDLKN---QMRYAIKGVQVRDLQGNLYDE----FYNQVVQEIDILKQCT--GCPY--VVSFLDSFEGK--QFIYLVLNECQ |. . ||.|. | | ... |. . .|.| .. .. . .. . .. .|| |.|. .|. .| ..| || . .||... |. YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN G-TLKEIIEKNQN-------KRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAV------------VCDFGLG | .|...|.||.. |||.| ||.. |.| .|. ..|..|. |.| .|||| . ..|||.. GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
|||||||||
| Kinase | 27656.AA | PLK-Unclassified | 75-229 | 29 | 5.3e-19 | 67.14 | In-house | 1-157 (264) | Show / Hide |
Range on Protein: 75-229 Range on HMM: 1-157/264 Sequence Identity: 29% (48 aa) YSDFRFLGSGAQGLVLLAKDLKNQMRYAIKGVQVRDLQGNLYDEFYNQVVQEIDILKQCTGCPYVVSFLDSFEGKQFIYLVLNECQ-GTLKEIIEKN--- |. .|||.|. .. ..|.... ||.| . |. .. .. .|| | |. . .| |...|| . .|..| | ||| |.| . YHRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLT---KNRARQKLISEIKIHKSLH-HKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQ --QNKRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVCDFGLGDKLT . |||.|. . | | ..| |.|... |||. ||... | . ||||| ||. LFEKKRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLE |
|||||||||
| Kinase | 27656.AA | STE20 | 75-224 | 24 | 1.2e-18 | 65.06 | In-house | 1-163 (288) | Show / Hide |
Range on Protein: 75-224 Range on HMM: 1-163/288 Sequence Identity: 24% (42 aa) YSDFRFLGSGAQGLVLLAKDLKNQMR----YAIKGVQVRDL---QGNLYDEFYNQVVQEIDILKQCTGCPYVVSFLDSFEGK----QFIYLVLNECQG-T | ... .|.|. | | .| . ... .||| . ... | . . ...||.|.||| .|..|....|. . . ...| |.| . YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-----DEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGS LKEIIEK--NQNK-----RLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVCDFGL | .|... . .| ..|| ... .|| |.||... |.| ||||.. .|.. .|||. LTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGV |
|||||||||
| Kinase | 27656.AA | TyrKc | 75-355 | 17 | 8e-06 | -128.54 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 75-355
Range on HMM: 1-280/280
Sequence Identity: 17% (57 aa)
YSDFRFLGSGAQGLVLLAKDLKNQMRYAIKGVQVRDLQGNLYDEFYNQVVQEIDILKQC-TGCPYVVSFLDSFEGK-------QFIYLVLNECQ-GTLKE
. . ||.|| | | ... . |.| .. .|. |... | .| .. . . ...|. . | ||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD
IIEKNQNKRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVCDFGLGDKLTVK--SGYSHNQYVQINF--LLNTNKKFNQFNSKNFK
. |...| |. .... .| .| |.||||| || |.|.. |. . ..|||| ... . .| .| .|
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKT-------------
MGNFFYQAPECYDPTDKI--------------------GKVYYDE-YQNLGVQVKQEPSNREIDFNLVLNKHKPLNYDG-------EFQNFVYYKNLKQL
| |||| ... |. | . |. ||.|. ...| . . . . . .| ||
MLPIRWMAPECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-------MMSNQEV-IEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQC
IDGLTQFVPRNRLPIKEALIVL
.. | .| .| .
W----HEDPEDRPTFSEIHECF
|
|||||||||