Gene 3066 (Tetrahymena)

3066

Species: Tetrahymena
Alias: 483.m00006, 1206, 3066, TTHERM_01582400, PreTt03066
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C7

Sequence

Name Sequence Type Origin Length Description Download
3066.AA Protein None 258 None Fasta, JSON
3066.kin_dom Protein Kinase Domain None 166 None Fasta, JSON
3066.NA RNA None 774 None Fasta, JSON

Protein domain

Protein domains of 3066.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 3066.AA Ciliate-C7 96-258 81 7.50000000001e-124 398.75 In-house 1-164 (164) Show / Hide 
Range on Protein: 96-258
Range on HMM: 1-164/164
Sequence Identity: 81% (134 aa)

FRFLGQGQQGLVLLAKNSKTNMRYAIKGVQVRDSFGNLDEDLNNRVRQEVEILQKCRDSPYVVRLLDQFEGQQFSYLVLTECQ-GTLTQILERNQNKRLN
||||||||||||||||..|||||||||||||||. ||.|.|.||.|.||..||..|.||||||.||.|||||||.||||.||| |||.||.|||||||||
FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN

EISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLTNKSGYAINQYV
||||||||.||||||||||||.|.|||||||||||||.|||||.|||||||||.||.|.||||.
EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM
Pkinase 3066.AA Pkinase 93-243 29 2.2e-27 97.94 Pfam 1-159 (293) Show / Hide 
Range on Protein: 93-243
Range on HMM: 1-159/293
Sequence Identity: 29% (47 aa)

YSDFRFLGQGQQGLVLLAKNSKTNMRYAIKGVQVRDSFGNLDEDLNNRVRQEVEILQKCRDSPYVVRLLDQFEGQQFSYLVLTECQG-----TLTQILER
|   | .|.|  | | .... .|. ..|.| . .|.   . |. . ..  .|..|.... ..|..|||.| ||  .  |.|.  |.|      |  ....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

NQNKRL--NEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNA----VVSDFGLA
 .....   |  ...|.  |..||.|.||....  ||| .||||| .|.      ..|||||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA
Kinase 3066.AA CAMKL 93-243 25 7.6e-23 69.6 In-house 1-176 (297) Show / Hide 
Range on Protein: 93-243
Range on HMM: 1-176/297
Sequence Identity: 25% (46 aa)

YSDFRFLGQGQQGLVLLAKN-SKTNMRYAIKGVQVR----DSFGNLD------EDLNNRVRQEVEILQKCR--DSPYVVRLLDQFEGQQF------SYLV
|   . ||.|  | | ||.. . |. ..||| .  .    | . .        |.   |.|.|..|... .    | ...|.. .| ...       |||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LTECQGT---LTQILERNQNKR--LNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHG--NAVVSDFGLA
.  |.|    | . .... ..|  . |  | .|   |  ...|.||.     |.| .|||.|..|  |. ..|||..
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS
Kinase 3066.AA CAMK 98-243 18 1e-22 69.4 In-house 1-243 (425) Show / Hide 
Range on Protein: 98-243
Range on HMM: 1-243/425
Sequence Identity: 18% (46 aa)

FLGQGQQGLVLLAKNSKTN------------MRYAIKGVQVRDSFGNL----------------------DEDLNNRVRQEVEILQKCR------DSPYV
 ||.|. | | |... .|.             ..||| .  .   ..                       ..    .||.|.||..|..      | | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRLLDQFEG-------------------QQFSYLVL---TECQGT------LTQILERNQN------------KRLNEISAIKYANDIAQGLYYIHSKSC
..|.. .|                    ... |.|.     |.|       .  | |. ..            .|..|  | .|   |.... |.||.  
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LVNDLKMDNILIDYH-----------------GNAVVSDFGLA
   ||| .|||.|..                 .|  ..|||.|
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFA
Kinase 3066.AA Ciliate-E2-Unclassified 93-243 22 1.3e-22 75.25 In-house 1-194 (352) Show / Hide 
Range on Protein: 93-243
Range on HMM: 1-194/352
Sequence Identity: 22% (43 aa)

YSDFRFLGQGQQGLVLLAKNSKTNMRYAIKGVQVRDSFG-NLDEDLNNRVRQEVEILQKCR------------------DSPYVVRLLDQFEGQQFSYLV
|   . .|||..| | .....|..  ||.|   .  ..  .. .  . .  .| .....                    ..|..|.....|. .|  |.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LTEC-QGTLTQILE---------------RNQNKRLNEISAI-----KYANDIAQGLYYIHSKS-CLVNDLKMDNILIDYHG---NAVVSDFGLA
.  | .|.| |...               ..|.|.. |  |.     .|.  | ||| |.|.|  ..  |.| .|||.|  |   .  ..|||..
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGIS
Kinase 3066.AA Ciliate-E1 99-256 18 2.6e-22 69.67 In-house 1-169 (202) Show / Hide 
Range on Protein: 99-256
Range on HMM: 1-169/202
Sequence Identity: 18% (32 aa)

LGQGQQGLVLLAKNSKTN-MRYAIKGVQVRDSFGNLDEDLNNRVRQEVEILQKCRDSPYVVRLLDQFEGQQ--FSYLVLTECQGTLTQILE---------
.|.| ...|. ||. ..|   .|.| ..... .   ......  ... .|..  .   |.. ..|... .|  ........|. .|.. |.         
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNY--NQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQ

--RNQNKRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLTNKSGYAINQ
  ..... ...   .. . .. .|| ..|..  .  |.|..||||.  || | .|||....| |.. . ...
QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQY
Kinase 3066.AA ULK 93-243 23 2.7e-21 71.15 In-house 1-189 (329) Show / Hide 
Range on Protein: 93-243
Range on HMM: 1-189/329
Sequence Identity: 23% (46 aa)

YSDFRFLGQGQQGLVLLAKNSKT----NMRYAIKGVQ---VRDSF----GNLDEDLNNRVRQEVEILQKCRD---SPY----VVRLLDQFEGQQF--SYL
|.  . ||.|. | |  ..| ||    |  .|.| ..    . .     |   . . . ...|..|..|  .   ...    .|.|.| || ...   |.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEG---QYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYI

VLTECQG-TLTQILERNQN--------KRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAV------------VSDFGLA
..  |.| .| |....|..        |||.|  ||..  .|..|. ..|.. .   |.| .||||. .                ..|||.|
IMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA
Kinase 3066.AA Ciliate-E2 93-249 19 2.7e-21 69.85 In-house 1-209 (365) Show / Hide 
Range on Protein: 93-249
Range on HMM: 1-209/365
Sequence Identity: 19% (42 aa)

YSDFRFLGQGQQGLVLLAKNSKT-----------------------NMRYAIKGVQVRD-SFGNLDEDLNNRVR------QEVEILQKCRDSPYVVRLLD
|   . .|||..| | ..|. |.                       .. ||.| .. ..  . .  ........      .| .||..  ..|..... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQL-NHPNIIKMYE

QFE--GQQFSYLVLTECQG-TLTQILERN----------QNKRLNEISAIKYANDIAQ---------------GLYYIHSKS-CLVNDLKMDNILIDYHG
 |.   ..  |||.  ||| .| .... |          . |...|  ....   |.|               .| |.|||  ..  |.| .|||.    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

NAVVSDFGLADNLTNK
   ..||||. .....
-IKIIDFGLSKKYDDD
Kinase 3066.AA ULK 93-243 24 4.6e-21 71.51 In-house 1-185 (324) Show / Hide 
Range on Protein: 93-243
Range on HMM: 1-185/324
Sequence Identity: 24% (46 aa)

YSDFRFLGQGQQG-LVLLAKNSKT---NMRYAIKGVQVR-DSFGNLD---EDLNNRVRQEVEILQKCR--DSPY--VVRLLDQFEGQ--QFSYLVLTECQ
|.  . ||.|. |  |  ..| ||   |  .|.| ..    .  ...   . . .  ..|..|..|     .|.  .|.|.| || .   . |...  |.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

G-TLTQILERNQN-------KRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAV------------VSDFGLA
| .| |....|..       |||.|  ||..  .|..|. ..|.. .   |.| .||||  .                ..|||.|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA
Kinase 3066.AA STE 93-248 20 1.9e-17 58.25 In-house 1-199 (359) Show / Hide 
Range on Protein: 93-248
Range on HMM: 1-199/359
Sequence Identity: 20% (41 aa)

YSDFRFLGQGQQGLVLLAKNSK---------------TNMRYAIKGVQVRDS-----------FGNLDEDLNNRVRQEVEILQKCRD-SPYVVRLLDQFE
. . ...|.|  | | .|.| |               |. ..||| . ....             | ...  ... .|..|..||.. .|..|. .. ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

GQ-------QFSYLVLTECQ-GTLTQILE------RNQN------KRLNEISAIKYANDIAQG-LYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLAD
         .  ....  .  |.|..|..      ...|      .|..|   .... .| .| |||.||.     |.| .|||.     .  .|||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

NLTN
.||.
QLTD
Kinase 3066.AA SAK 93-246 29 5.6e-16 50.66 In-house 1-150 (254) Show / Hide 
Range on Protein: 93-246
Range on HMM: 1-150/254
Sequence Identity: 29% (46 aa)

YSDFRFLGQGQQGLVLLAKNSKTNMRYAIKGVQVRDSFGNLDEDLNNRVRQEVEILQKCRDSPYVVRLLDQFEGQQFSYLVLTECQ-GTLTQILERNQNK
|     ||.|    |  ||  .| .  ||| .  .   .     . .|||.||||  . .  | .. |   || . . ||||  |. | .   . ... .
YQVQHLLGKGGFACVYRAKCIHTHQEVAIKMIDKKLMQKT---GMVQRVRNEVEIHCQLKH-PSILELYNYFEDNNYVYLVLEMCHNGEMHRYM-KHRMR

RLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNL
   |  | .. ..|  |. |.||   .  || . |||.    .  . |||||  |
PFTEEEARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQL
Kinase 3066.AA S_TKc 93-258 19 7.9e-11 -18.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 93-258
Range on HMM: 1-231/231
Sequence Identity: 19% (49 aa)

YSDFRFLGQGQQGLVLLAKNSKTNMRYAIKGVQVRDSFGNLDEDLNNRVRQEVEILQKCRDSPYVVRLLDQFEGQQFSYLVLTECQG---TLTQILERNQ
|   | .|.|  | | .... ||. ..||| .              ...|.|..||.|  . |..|.|.| |.  .. |.|.  | |   .| .......
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

NKR----LNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLTNKS-------------GYAI------------------
 ..    ..|  | .|.  |...| |.||.  .  ||| .|||.|   .  ..|||||  |  ..             ||                    
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCG

------------------------------------------------NQYV
                                                 ...
YPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase 3066.AA TyrKc 93-258 13 0.000551 -158.19 SMART 1-280 (280) Show / Hide 
Range on Protein: 93-258
Range on HMM: 1-280/280
Sequence Identity: 13% (41 aa)

YSDFRFLGQGQQGLVLLAKNSKTNMRYAIKGVQVRDSFGNLDEDLNNRVRQEVEILQKC-RDSPYVVRLLDQFEGQQ------FSYLVLTE--CQGTLTQ
 .  . || |. | | ... .   .  |.| ..                ..| .|. |   . | .|||.     |.        .....|  . | | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

ILERNQNKRLNEISAIKYANDIAQGLYYIHSKSCLVNDLKMDNILIDYHGNAVVSDFGLADNLTNK----------------SG----------------
 | ....| |.    .... .||.|  |.||| |   ||   |.|..  . . .|||||. .....                .|                
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

--------------------------YAI-------------------------N-----------------------------------QYV
                          |                           |                                   .. 
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF