Gene 10245 (Tetrahymena)
10245
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 10245.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 10245.AA | CMGC | 835-998 | 18 | 2.8e-16 | 49.12 | In-house | 1-249 (513) | Show / Hide |
Range on Protein: 835-998 Range on HMM: 1-249/513 Sequence Identity: 18% (48 aa) FKKIVDLGAGGFAQVYKVIDFKDNQD--------GQKNQELAIKAQNLPTKESVYAA------------TKEFNITKRLS-------------FHKTDS- ...| .| | ...||| .| . || . |.. ||| .| . | | | |.|. ..| . YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN IIKLRYGILINN-----------ITIENHVGLQKEYNLSYFVMELGETNLQQELYIKK--------IPFKPQE------------LHDMM------FSIC |.||.. . .| | | ..| |.|.|. ...| | .. .. .|... . .| . |. IVKLYDIFYHKNSDGNEYEDKHII-S------Q-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQIL RGLY--QLHDAK--IVHMDISLDNIIKTKDQKY--------------------KISDLG ||| .| .. |.| |. || ... .. || | | RGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFG |
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| Kinase | 10245.AA | Ciliate-B2 | 930-998 | 33 | 1.1e-13 | 28.46 | In-house | 78-149 (197) | Show / Hide |
Range on Protein: 930-998 Range on HMM: 78-149/197 Sequence Identity: 33% (24 aa) FVMELGETNLQQELY---IKKIPFKPQELHDMMFSICRGLYQLHDAKIVHMDISLDNIIKTKDQKYKISDLG ..|| | |.||| ... |. | | |.| || |.. |.| || .|| ... .|. .| | LIMEKCECSLKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFG |
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| Kinase | 10245.AA | S_TKc | 835-1149 | 15 | 6.1e-12 | -1.76 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 835-1149
Range on HMM: 1-231/231
Sequence Identity: 15% (51 aa)
FKKIVDLGAGGFAQVYKVIDFKDNQDGQKNQELAIKAQNLPTKESVYAATKEFNITKRLSFHKTDSIIKLRYGILINNITIENHVGLQKEYNLSYFVMEL
.... .| |.|..|||... | ... ||| . . .| .| |. . . |.|| . . . |.|||.
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK-------EHIRREIQILKK----HHPNIVKLYDVFQD---------------DHLYMVMEY
GET---NLQQELYIKKIP-----FKPQELHDMMFSICRGLYQLHDAKIVHMDISLDNIIKTKDQKYKISDLGGGLVQRNEFSQIVSKHLQIKLQYLSPLV
.. .| . . .. . | . . .| ||..| .|. .|.| |. .|| .. ||.| | . ... . |..|
CDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAP--
KKQLEIIQDLQQKNQNYQENIFEIKKDFTLLK-QNDCYALGFIFYMVAT----FNFKNLNNERQSHAQIEQTRQEMIQVLNKYKDSNNQQQEDVLQLYPD
|.. | | ...| |.| .. | . |.|.... ..
----EVL---------------------GYGKCKCDWWSCGCILYEMLCGYPPFP----------------QMQMMFKKIG-----------------SP
YLIESIQRLLDYN-----DIADVFQ---VIEQKERM
... |...|... . ...| .| . . .
EAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 10245.AA | Pkinase | 835-998 | 23 | 4.8e-10 | 36.61 | Pfam | 1-157 (293) | Show / Hide |
Range on Protein: 835-998 Range on HMM: 1-157/293 Sequence Identity: 23% (43 aa) FKKIVDLGAGGFAQVYKVIDFKDNQDGQKNQELAIKAQNLPTKES--VYAATK--EFNITKRLSFHKTDSIIKLRYGILINNITIENHVGLQKEYNLSYF .... .|.|.|..||| .. .... . |.| ......| ..... | | |||. |. |..| |.. . . |. YHIGRKIGSGSFGCVYKCHHKGTGK------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-HPN--IVRL-YDWFED-------------KDHIYM VMELGET-----NLQQELYIK---KIPF--KPQELHDMMFSICRGLYQLHDAKIVHMDISLDNIIKTKDQKY----KISDLG |||. | | ||. . .| ..|. ..| |.|||. .|. .|.| |. ..|| .. ||.| | VMEYCEGGLYVMDLF--DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFG |
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| Kinase | 10245.AA | Ciliate-A1 | 929-998 | 28 | 8.3e-10 | 29.5 | In-house | 77-146 (301) | Show / Hide |
Range on Protein: 929-998 Range on HMM: 77-146/301 Sequence Identity: 28% (20 aa) YFVMELGETNLQQELYIKKIPFKPQELHDMMFSICRGLYQLHDAKIVHMDISLDNIIKTKDQKYKISDLG ...|| . ...... . | | .. | |. .|| |.| |. .||. | |.|| ||| FIIMEYCQYGNLFNYCYQNDYMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLG |
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| Kinase | 10245.AA | Ciliate-E2-Unclassified | 835-998 | 24 | 9e-10 | 30.09 | In-house | 1-192 (352) | Show / Hide |
Range on Protein: 835-998 Range on HMM: 1-192/352 Sequence Identity: 24% (48 aa) FKKIVDLGAGGFAQVYKVIDFKDNQD-----GQKNQELAIKAQNLPTKESVYAATKEFNITKRLSFHKTDSIIKLRYGILI---NNITIENHVGLQKEYN .|.| .| |||..|||... |..| |.|. . | .. | . .. ..|. | .. | . | . ||. . . . . |.. | YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQ---ILLNHPHPFIVKMFYCFQDKQN LSYFVMELGE-TNLQQELYIKK----------------IPFKPQELH-----DMMFSICRGLYQLHDAK-IVHMDISLDNIIKTKDQ---KYKISDLG . |.|||. | .|.| . ..| | |. ... |. || .|| . |.| || ..||. .... . ||.|.| I-YIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFG |
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| Kinase | 10245.AA | Ciliate-E4 | 928-996 | 27 | 6.1e-09 | 26.41 | In-house | 79-150 (150) | Show / Hide |
Range on Protein: 928-996 Range on HMM: 79-150/150 Sequence Identity: 27% (20 aa) SYFVMELGETNLQQELYIKK---IPFKPQELHDMMFSICRGLYQLHDAKIVHMDISLDNIIKTKDQKYKISD .| .|| ..|||.. .| ..| ..|. .. |. ..| | | | |. || . . || | LYWFMEYLQKDLQQHIKQHKQQGQHFDESEIWQIAFCCINAMYYLQQVNITHGDLKPSNIFFDQYFMVKIAD |
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| Kinase | 10245.AA | Ciliate-E1 | 922-1048 | 20 | 1.1e-08 | 24.91 | In-house | 66-202 (202) | Show / Hide |
Range on Protein: 922-1048 Range on HMM: 66-202/202 Sequence Identity: 20% (28 aa) QKEYNLSYFVMELGETNLQQELY------------IKKIPFKPQELHDMMFSICRGLYQLHDAKIVHMDISLDNIIKTKDQKYKISDLGGGLV-QRNEFS ...........|. . .|...| ... |. |.. ..| . || .||. .| |.|| .||..... .|...|.| ... . |. . IDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQ QIVSKHLQIKLQYLSPLVKKQLEIIQDLQQKNQNYQENIF |.. |. . . | .| ... | . .... ||. .|. QCQYKGYTHY--YYPPEQYNCPEQ-EHNKNQKINYKSDIY |
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| Kinase | 10245.AA | SAK | 926-998 | 36 | 1.1e-08 | 25.42 | In-house | 72-145 (254) | Show / Hide |
Range on Protein: 926-998 Range on HMM: 72-145/254 Sequence Identity: 36% (27 aa) NLSYFVMELGETNLQQELYIKKI--PFKPQELHDMMFSICRGLYQLHDAKIVHMDISLDNIIKTKDQKYKISDLG | | |.|. . | . |.|.. || .| ..| | |. || |.| |..| ||. |.| . || | | NYVYLVLEMCH-NGEMHRYMKHRMRPFTEEEARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFG |
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| Kinase | 10245.AA | WEE | 962-998 | 29 | 1.7e-07 | 21.27 | In-house | 120-177 (297) | Show / Hide |
Range on Protein: 962-998 Range on HMM: 120-177/297 Sequence Identity: 29% (17 aa) ICRGLYQLHDA-KIVHMDISLDNIIKTKDQ--------------------KYKISDLG ||.|| .|. .||||| .|| .|.. ..|| |.| ICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFG |
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| Kinase | 10245.AA | Ciliate-E2 | 835-904 | 18 | 1.3e-05 | 15.25 | In-house | 1-97 (365) | Show / Hide |
Range on Protein: 835-904 Range on HMM: 1-97/365 Sequence Identity: 18% (18 aa) FKKIVDLGAGGFAQVYKVIDFKDNQ-----------------DGQKNQELAIKAQNLPTKESVYAATKEF----------NITKRLSFHKTDSIIKL .|.| .| |.|..|||. . |... ...|... |.| .. .|.. ... | . |.. . . |||. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKM |
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| Kinase | 10245.AA | ULK | 962-998 | 30 | 3.3e-05 | 14.23 | In-house | 139-187 (329) | Show / Hide |
Range on Protein: 962-998 Range on HMM: 139-187/329 Sequence Identity: 30% (15 aa) ICRGLYQLHDAKIVHMDISLDNIIKTKDQK------------YKISDLG |. |. ||. .|.| || ..|| ...| .||.| | ILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFG |
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| Kinase | 10245.AA | WEE | 835-859 | 32 | 0.000131 | 11.46 | In-house | 1-25 (297) | Show / Hide |
Range on Protein: 835-859 Range on HMM: 1-25/297 Sequence Identity: 32% (8 aa) FKKIVDLGAGGFAQVYKVIDFKDNQ |. . .| | |..|||.... |.. FQEVQKIGEGSFGEVYKCRCRIDGC |
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| Kinase | 10245.AA | TyrKc | 835-1097 | 13 | 0.000137 | -148.42 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 835-1097
Range on HMM: 1-280/280
Sequence Identity: 13% (44 aa)
FKKIVDLGAGGFAQVYK-VIDFKDNQDGQKNQELAIKAQNLPTKESVYAATKEFNITKRL-SFHKTDSIIKLRYGILIN--NITIENHVGLQKEY---NL
... || | | .||| . . .. |.| . . . . .| .| ..| |. |..| .. | .
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA---REDFMREARIMCKLGGHHP--NIVRLYGVCTQQGRN------------FMYIEP
SYFVMELGET-NLQQELYIKKIPFKPQELHDMMFSICRGLYQLHDAKIVHMDISLDNIIKTKDQKYKISDLGGGLVQRNEFS-------QIVSK----HL
. |||. . .|.. | .. .....|..... |..| ||. ...| |. |. .... |||| || . . .| .
LMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDF--GLSRDIYDDDQQGESKDYYRKKEHKGG
Q------------IKLQ----------------------YLSPLV-----KKQLEIIQDLQQKNQNYQENI-----FEIKKDFTLLKQNDCYALGFIFYM
|. . .. |.|....| . | | . .. .
KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF-------------VCCPDEMYQI
VATFNFKNLNNERQSHAQIEQTRQEM
. . ..| . ..| ....
MKQCWHEDP-EDRPTFSEI---HECF
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| Kinase | 10245.AA | Ciliate-E2 | 929-998 | 22 | 0.000406 | 10.01 | In-house | 110-201 (365) | Show / Hide |
Range on Protein: 929-998 Range on HMM: 110-201/365 Sequence Identity: 22% (22 aa) YFVMELGET-NLQQELYIKKIPFKPQ----------ELHDMMFSICR---------------GLYQLHDAK-IVHMDISLDNIIKTKDQKYKISDLG |.|||. . .|.. ....|. .. . | ..| |.. .| || . |.| || ..||. ||.|.| YLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFG |
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| Kinase | 10245.AA | ULK | 835-870 | 33 | 0.001815 | 8.07 | In-house | 1-34 (329) | Show / Hide |
Range on Protein: 835-870 Range on HMM: 1-34/329 Sequence Identity: 33% (12 aa) FKKIVDLGAGGFAQVYKVIDFKDNQDGQKNQELAIK . .. || | |..||| .. |.. | ..|. |.| YCLNHCLGKGSFGKVYKGRNKKTK-D-YVNEKVACK |
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| Kinase | 10245.AA | SAK | 835-851 | 47 | 0.041921 | 2.65 | In-house | 1-17 (254) | Show / Hide |
Range on Protein: 835-851 Range on HMM: 1-17/254 Sequence Identity: 47% (8 aa) FKKIVDLGAGGFAQVYK .. || |||| ||. YQVQHLLGKGGFACVYR |
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| Kinase | 10245.AA | Ciliate-E1 | 841-873 | 20 | 0.117724 | 1.74 | In-house | 1-34 (202) | Show / Hide |
Range on Protein: 841-873 Range on HMM: 1-34/202 Sequence Identity: 20% (7 aa) LGAGGFAQVYKVIDFKDN-QDGQKNQELAIKAQN .|.|.|..|.| . ..| . .. .. . ..| IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYN |
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| Kinase | 10245.AA | Ciliate-A1 | 835-859 | 16 | 0.180235 | 0.69 | In-house | 1-25 (301) | Show / Hide |
Range on Protein: 835-859 Range on HMM: 1-25/301 Sequence Identity: 16% (4 aa) FKKIVDLGAGGFAQVYKVIDFKDNQ . .. |.| .| ...| .. YHVVQLIDKGSFGVVMRAYDIQNQK |
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