Gene 11215 (Tetrahymena)

11215

Species: Tetrahymena
Alias: 3824.m02974, 3.m01780, PreTt11215, 181, 11215, TTHERM_00047360
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
11215.AA Protein None 1026 None Fasta, JSON
11215.kin_dom Protein Kinase Domain None 225 None Fasta, JSON
11215.NA RNA None 3081 None Fasta, JSON

Protein domain

Protein domains of 11215.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc 11215.AA S_TKc 757-991 16 8.5e-11 -18.6 SMART 1-231 (231) Show / Hide 
Range on Protein: 757-991
Range on HMM: 1-231/231
Sequence Identity: 16% (46 aa)

FSDDCT-------ETIKIIYKE--NQYCLKKFKNLSAFNLRRVNNYIENLRVLASPRIIRSFGKTVSYSKHTFDLFILLDFKER---NLMQAIKEKLI--
.    .       .  | . |.   .. .|. |       ... . |. |.    | |.. ..  ..      .|.. ... .    .|.. ||..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----ISFNDKLSVLWQITQAIQQIHGNVAQDNMIHGNLKPENILLSSKKKVFLQDF------------------YVLKNRENKYKPKNEGLTQ-AADIWS
    ..  .  ....|| .|.. .|    . . ||  ||||||||..   . . ||                   ||            | .  ..|.||
LRFPFPE-HARFYMYQICCALEYCH---SH-GIIHRDLKPENILLDE--HIKICDFGLARQLTTFCGTPWYMAPEVL------------GYGKCKCDWWS

LGLITYFLFT-DHLIDTEKAEYLISEQVLLNQIYKPGNSDIRVIYNLIERMLDSNPSNRPDIEEIVS-----HLKPII
.| | | ...   . .         .|.....|      .  ..  .|...|. .|..|| . |.        . | .
CGCILYEMLCGYPPFP--------QMQMMFKKIG-----SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 11215.AA Ciliate-E2-Unclassified 832-991 17 3.5e-09 28.02 In-house 107-352 (352) Show / Hide 
Range on Protein: 832-991
Range on HMM: 107-352/352
Sequence Identity: 17% (44 aa)

NLMQAIKEK-----------------LIISFNDKL-----SVLWQITQAIQQIHGNVAQDNMIHGNLKPENILLSSKK---KVFLQDFYVLKNRENK---
.|.| ||..                  |.. .  .       ..|| |.....|    . | || ..||||||.....   .. . ||   |. ..    
DLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH---HKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNC

------------------------YKP--------KNEGLT----QAADIWSLGLITYFLFTDHL--IDTEKAEYL--------------ISEQVLLNQI
                        |.|        ....       ..|||||| | |.. .  .   |. . ..               . .. . ..|
DTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNI

YKPGNS------DIRVIY-----NLIERMLDSNPSNRPDIEEIVSHLKPII
..|  .      ..   .     .|. .||. ||..|...|.|  |  |..
QFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNH--PWF
Kinase 11215.AA CDKL 850-894 41 5e-08 23.53 In-house 102-143 (286) Show / Hide 
Range on Protein: 850-894
Range on HMM: 102-143/286
Sequence Identity: 41% (19 aa)

SVLWQITQAIQQIHGNVAQDNMIHGNLKPENILLS-SKKKVFLQDF
...||| .||.. |    . | || . ||||||.. ... | | ||
KYMWQILKAINFCH----KHNCIHRDIKPENILITPKNGQVKLCDF
Kinase 11215.AA Ciliate-C3 848-894 40 5.4e-08 25.02 In-house 98-140 (140) Show / Hide 
Range on Protein: 848-894
Range on HMM: 98-140/140
Sequence Identity: 40% (19 aa)

KLSVLWQITQAIQQIHGNVAQDNMIHGNLKPENILLSSKKKVFLQDF
|| .  || |||. .|      |..|| .|..|||. ||... . ||
KLQISKQILQAIDYLH----EHNIVHGDIKFSNILINSKDEIKIIDF
Kinase 11215.AA Pkinase 912-987 13 1.5e-07 27.82 Pfam 190-293 (293) Show / Hide 
Range on Protein: 912-987
Range on HMM: 190-293/293
Sequence Identity: 13% (14 aa)

TQAADIWSLGLITYFLFTDHLIDTEK------AEYLISEQVLLNQIYKPGNSDI--------------------RVIYNLIERMLDSNPSNRPDIEEIVS
....|.||.|.| | ... ...  ..       .. . ....  ..  .   ..                    .    .|...|. .|. || .|.|. 
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

H--L
|  .
HPWF
Kinase 11215.AA Ciliate-E1 824-913 19 2.9e-07 20.2 In-house 74-174 (202) Show / Hide 
Range on Protein: 824-913
Range on HMM: 74-174/202
Sequence Identity: 19% (20 aa)

ILLDFKERNLMQAIK-------------EKLIISFNDKLSVLWQITQAIQQIHGNVAQDNMIHGNLKPENILLSSKKKVFLQDFYVLK--NRENKYKPKN
|.... . .| . ..             ..   .|  |..   |. ......|    | | ||...||.||| .....  ..||.. |  . ....  . 
IIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELH----QYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQY

EGLTQ
.| |.
KGYTH
Kinase 11215.AA CAMKL 913-986 22 5.8e-07 18.11 In-house 215-294 (297) Show / Hide 
Range on Protein: 913-986
Range on HMM: 215-294/297
Sequence Identity: 22% (19 aa)

QAADIWSLGLITYFLFTDHL----------IDTEKAEYLISEQVLLNQIYKPGNSDIRVIYNLIERMLDSNPSNRPDIEEIVSH
...||||.| | |.. . .|          ... . ...  . ..  .. ..   . ... .|| .||  ||. || |..|..|
PKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCR-DLIRKMLQVNPEKRPTIHQIMNH
Kinase 11215.AA TKL 954-987 26 8.2e-07 20.58 In-house 331-364 (364) Show / Hide 
Range on Protein: 954-987
Range on HMM: 331-364/364
Sequence Identity: 26% (9 aa)

PGNSDIRVIYNLIERMLDSNPSNRPDIEEIVSHL
| ..  . . .|...  |..|..||  .||...|
PCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 11215.AA Ciliate-C1 964-986 43 5e-06 11.02 In-house 303-325 (328) Show / Hide 
Range on Protein: 964-986
Range on HMM: 303-325/328
Sequence Identity: 43% (10 aa)

NLIERMLDSNPSNRPDIEEIVSH
.|| .||  || .|....|| .|
DLINQMLAYNPQKRITLQEIKCH
Kinase 11215.AA Ciliate-E6 823-881 23 1e-05 14.63 In-house 26-84 (154) Show / Hide 
Range on Protein: 823-881
Range on HMM: 26-84/154
Sequence Identity: 23% (15 aa)

FILLDFKERNLMQAIK-EKLIISFNDK---LSVLWQITQAIQQIHGNVAQDNMIHGNLKPENI
||..   |.|| . |.  |.. ..|..   . .. |. .|.. .|    ..| ...|....||
FIVMERCEMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLH----SKNYVLQNITLKNI
Kinase 11215.AA MARK 964-986 60 2e-05 13.87 In-house 237-259 (262) Show / Hide 
Range on Protein: 964-986
Range on HMM: 237-259/262
Sequence Identity: 60% (14 aa)

NLIERMLDSNPSNRPDIEEIVSH
||| |.|  ||. ||.||||..|
NLIQRLLTVNPEERPTIEEIMKH
Kinase 11215.AA CAMK 964-986 39 0.000202 9.37 In-house 400-422 (425) Show / Hide 
Range on Protein: 964-986
Range on HMM: 400-422/425
Sequence Identity: 39% (9 aa)

NLIERMLDSNPSNRPDIEEIVSH
.|| .||  .|..|. ||.. .|
DLIRKMLQVDPEKRMTIEQCLNH
Kinase 11215.AA Ciliate-E6 911-921 54 0.00029 9.88 In-house 144-154 (154) Show / Hide 
Range on Protein: 911-921
Range on HMM: 144-154/154
Sequence Identity: 54% (6 aa)

LTQAADIWSLG
.|| .||||..
WTQEGDIWSVC
TyrKc 11215.AA TyrKc 734-987 13 0.000327 -154.52 SMART 1-280 (280) Show / Hide 
Range on Protein: 734-987
Range on HMM: 1-280/280
Sequence Identity: 13% (43 aa)

IKLDSIIVEQDFKIEELAEKQIIFSDDCTETIKIIYKENQYCLKKFKNLSAFNLRRVNNYIENLRVL--ASPRIIRSFGKTVS------YSKHTFDLFIL
|.|. .. |  | .  ...         .  .| . ..               ..   . .. .. |    | |.| .|  ..      |..  . .. .
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA--------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEY

LDFKERNLMQAIKEKLI-ISFNDKLSVLWQITQAIQQIHGNVAQDNMIHGNLKPENILLSSKK-----------KVFLQ-------DFYV-----LKN--
 .    .| . ....   ..  |.||  ||| .  . .| .    | ||  |   |.|.....           ..          | |.      ..  
MPH--GDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTM

-----------RENKYKPKNEGLTQAADIWSLGLITYFLFTDHLIDTE------KAEYLISEQVLLNQIYKPGNS--------DIRVIYNLIERMLDSNP
           ...|.       | . |.|| |   . .||.     .      .  . . |.|      ..  .            .|.....  . .|
LPIRWMAPECINYGKF-------TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDP

SNRPDIEEIVSHL
..||  .||.. .
EDRPTFSEIHECF
Kinase 11215.AA MARK 913-929 47 0.000463 9.36 In-house 185-201 (262) Show / Hide 
Range on Protein: 913-929
Range on HMM: 185-201/262
Sequence Identity: 47% (8 aa)

QAADIWSLGLITYFLFT
...|||||| . ||. .
PKVDIWSLGVVLYFMVC
Kinase 11215.AA CAMK 907-929 26 0.000486 8.12 In-house 307-329 (425) Show / Hide 
Range on Protein: 907-929
Range on HMM: 307-329/425
Sequence Identity: 26% (6 aa)

KNEGLTQAADIWSLGLITYFLFT
.... ....|.||.| |.|.. .
EKPYYGPKCDMWSCGVILYIMLC
Kinase 11215.AA CAMK 872-894 27 0.000506 8.06 In-house 201-240 (425) Show / Hide 
Range on Protein: 872-894
Range on HMM: 201-240/425
Sequence Identity: 27% (11 aa)

IHGNLKPENILLSSKK-----------------KVFLQDF
.|  ||||||||....                 .. . ||
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDF
Kinase 11215.AA Ciliate-C1 854-885 50 0.001508 4.46 In-house 137-164 (328) Show / Hide 
Range on Protein: 854-885
Range on HMM: 137-164/328
Sequence Identity: 50% (16 aa)

QITQAIQQIHGNVAQDNMIHGNLKPENILLSS
|  ..|| ||    | |  |  ||||||||..
QLINVIQYIH----QNNICHRDLKPENILLDE
Kinase 11215.AA CAMKL 872-894 40 0.002398 6.37 In-house 149-173 (297) Show / Hide 
Range on Protein: 872-894
Range on HMM: 149-173/297
Sequence Identity: 40% (10 aa)

IHGNLKPENILLSSKK--KVFLQDF
.|  .|||||||....  .. . ||
VHRDIKPENILLDENGNNNIKIIDF
Kinase 11215.AA MARK 872-889 35 0.005712 5.74 In-house 126-145 (262) Show / Hide 
Range on Protein: 872-889
Range on HMM: 126-145/262
Sequence Identity: 35% (7 aa)

IHGNLKPENILLSSKK--KV
.|  .||||||. ...  ..
VHRDIKPENILIDENGNHNI
Kinase 11215.AA TKL 841-894 16 0.010245 5.62 In-house 178-247 (364) Show / Hide 
Range on Protein: 841-894
Range on HMM: 178-247/364
Sequence Identity: 16% (12 aa)

LIISFNDKLSVLWQITQAIQQIHGNVA----QDNMIHGNLKPENILLSSKKK--------------VFLQDF
|.  .. ...   .| ....  | .        ..|| .||..|||. .. .              . . ||
LH--WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDF
Kinase 11215.AA Pkinase 833-886 25 4.108898 1.48 Pfam 91-144 (293) Show / Hide 
Range on Protein: 833-886
Range on HMM: 91-144/293
Sequence Identity: 25% (15 aa)

LMQAIK--EKLII--SFNDKLSVLWQITQAIQQIHGNVAQDNMIHGNLKPENILLSSK
|.  |.  ..  .  | ..  ....|| .... .| .    . ||  |||||||....
LFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM----GIIHRDLKPENILIDNN