Gene 12538 (Tetrahymena)

12538

Species: Tetrahymena
Alias: TTHERM_00227280, 19.m00330, 843, 12538, PreTt12538
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
12538.AA Protein None 272 None Fasta, JSON
12538.kin_dom Protein Kinase Domain None 200 None Fasta, JSON
12538.NA RNA None 819 None Fasta, JSON

Protein domain

Protein domains of 12538.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 12538.AA CMGC 1-200 19 4e-68 222.63 In-house 132-513 (513) Show / Hide 
Range on Protein: 1-200
Range on HMM: 132-513/513
Sequence Identity: 19% (74 aa)

MVFDYIDQNLQTFIKEFEN-----KKCYIPLIQ------------IKIVL-----------GIY--EMHVNG--FMHRDIKPANILITQQ----------
.||.|.|..|  .||.  .     .. . .  .            ||  .           |.    .| ..  ..|||.||.||||...          
LVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWK

----------GQVKVADLGLARQVTQK---------------------RQTFTPGWITLWYRPLEMLCNQTNYS---------KAVDIWSLGCVFGEMVR
          |..|..| ||||.. .                      ....|.   |.|||. | |.. ..|.         ...|.||.||.|.||..
SEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYT

--------LVPLFRGQTE-----------LEQALKIIQSLGLPT---------------EFQDFDS---------------------FHE----------
        . ||| |..|           ..|  ||.. || ||               | ....                      . |          
GYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNN

-RVSDQAFSYEKNFPY-----------------------------------LSEDGIDLLKGMLNINPSKRLTAKQCKEHRFF
     .  . .. ||                                    .....|||||.|| ..|.||.||.|. .| .|
RFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 12538.AA CDK 1-200 32 2.3e-66 211.28 In-house 95-284 (284) Show / Hide 
Range on Protein: 1-200
Range on HMM: 95-284/284
Sequence Identity: 32% (72 aa)

MVFDYIDQNLQTFIKEFENKKCYIPLIQIKIVLGIYEMHVNGFMHRDIKPANILITQQGQ-----VKVADLGLARQVTQ------KRQTFTPGWITLWYR
|||.|.|. | ....        |  .   .  |.. .| |..||||.||.||||. .|.     .|.|| ||||          ...|.|.  .|||||
MVFEYMDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYR

PLEMLCNQTNYS--KAVDIWSLGCVFGEMVR---LVPLFRGQTELEQALKIIQSLGLPTE--------FQDFDSFHERVSDQAFSYEKNFPYLSEDGIDL
. | |  ...||   ..|.||.||.|.||..     ||| |..|..|  ||.. .| |||        ..|.                          ||
APELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------DL

LKGMLNINPSKRLTAKQCKEHRFF
| .||  .|.||..|.|. .| .|
LNKMLCYDPKKRISAEQALQHPYF
Kinase 12538.AA RCK 2-200 34 2e-45 141.9 In-house 78-298 (298) Show / Hide 
Range on Protein: 2-200
Range on HMM: 78-298/298
Sequence Identity: 34% (78 aa)

VFDYIDQNLQTFIKEFENKKCYIPLIQ--IK-----IVLGIYEMHVNGFMHRDIKPANILITQ---------QGQVKVADLGLARQVTQKRQTFTPGWIT
|| | |.||  ..|.|  .. |.| .|  ||     | .|.  || .||.|||.|| ||..|          |. .|.|| ||.| . . .. .|    |
VFEYMDMNLYQMMKDFKERRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREI-RSKPPYTDYVST

LWYRPLEMLCNQTNYSKAVDIWSLGCVFGEMVRLVPLFRGQTELEQALKIIQSLGLPTEFQDFDSFHERVSDQAFSY--------EKNFPYLSEDGIDLL
 |||  | |  .|.|.. .|||..||.. |   | ||| |. |. |  ||.. .| |.  .| . ... .|   | .        .. .| .| |.|.|.
RWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNK-KDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELM

KGMLNINPSKRLTAKQCKEHRFF
. ||...|.|| ||.|. .|..|
EKMLQWDPQKRITAQQALQHPYF
Kinase 12538.AA Pkinase 38-200 31 6.9e-45 159.79 Pfam 124-293 (293) Show / Hide 
Range on Protein: 38-200
Range on HMM: 124-293/293
Sequence Identity: 31% (56 aa)

MHVNGFMHRDIKPANILITQQGQV----KVADLGLARQV-TQKRQTFTPGWITLWYRPLEMLCNQTNYSKAVDIWSLGCVFGEMVRLVPLFRGQ----TE
.| .|..|||.||.|||| ..|..    |..| |||.|. . . . .|    |.||.. | .  .. |...||.||.||.. ||.   |.|.|.    . 
CHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-

LEQALKIIQSLGLPTEFQDFDS------FHERVSDQAFSYEKNFPYLSEDGIDLLKGMLNINPSKRLTAKQCKEHRFF
..|  .| . .| |..|. . .      |  |  . .|  ... ...||...|..|..|. .|.||.||.|...| .|
HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 12538.AA CDC2 1-144 40 1.3e-44 134.7 In-house 77-230 (301) Show / Hide 
Range on Protein: 1-144
Range on HMM: 77-230/301
Sequence Identity: 40% (63 aa)

MVFDYIDQNLQTFIKEFENKKCYIPLIQIK-----IVLGIYEMHVNGFMHRDIKPANILITQQGQVKVADLGLARQVTQKRQTFTPG--WITLWYRPLEM
|||.|.|..|  . .. . |. ..|.. .|     |. |.   | .. ||||.|| ||||  .|..|.|| |||| ..    | |..   .|||||. | 
MVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEI

LCNQTNYSKAVDIWSLGCVFGEM---VRLVPLFRGQTELEQALKIIQSLGLPTE
|  .  || .||.||.||.| ||   |   ||| |. | .|  || . || |.|
LLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNE
Kinase 12538.AA PITSLRE 38-200 37 4.5e-44 152.75 In-house 122-295 (295) Show / Hide 
Range on Protein: 38-200
Range on HMM: 122-295/295
Sequence Identity: 37% (65 aa)

MHVNGFMHRDIKPANILITQQGQVKVADLGLARQVTQKRQTFTPGWITLWYRPLEMLCNQTNYSKAVDIWSLGCVFGEMVRLVPLFRGQTELEQALKIIQ
|| |  |||| | .|.|.. .|. |..| ||||   . .  .||. .|||||  |.|  .  || .||.|| ||.|.|.. . ||| |. |..|  .| .
MHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEFITMKPLFQGKSEIDQINCIFK

SLGLPTE-----FQDFDSFHERVSDQAFSY---EKNFP---YLSEDGIDLLKGMLNINPSKRLTAKQCKEHRFF
 .| |||     ..... .    ...   |    | ||   ..|. | ||| .||  || .|.|| .   | .|
EMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase 12538.AA CDK5 1-200 31 1.3e-43 135.34 In-house 75-287 (287) Show / Hide 
Range on Protein: 1-200
Range on HMM: 75-287/287
Sequence Identity: 31% (69 aa)

MVFDYIDQNLQTFIKEFENKKCYIPLIQIKIVL-----GIYEMHVNGFMHRDIKPANILITQQGQVKVADLGLARQVTQKRQTFTPGWITLWYRPLEMLC
.|| ..|| |  .. ...    .. .  ||  .     |.   | .  .||| || | || ..|. | || ||||      ....   .||||||   | 
LVFEFCDQDLKKYMDSCNG---EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLM

NQTNYSKAVDIWSLGCVFGEMV-RLVPLFRGQTELEQALKIIQSLGLPTEFQ--------DFD--SFHERVSDQAFSYEKNFPYLSEDGIDLLKGMLNIN
    ||  .|.|| ||.| ||.  . ||| |  . .|  .| . .| |.| .        |.        . .   |...  | |.| | |||..|| .|
GSKHYSTSIDMWSCGCIFAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCN

PSKRLTAKQCKEHRFF
| .|..||.  .| .|
PNQRISAKAALHHPYF
Kinase 12538.AA CDK4 1-200 37 8e-43 144.63 In-house 86-290 (290) Show / Hide 
Range on Protein: 1-200
Range on HMM: 86-290/290
Sequence Identity: 37% (79 aa)

MVFDYIDQNLQTFIKEFEN---KKCYIPLIQIKIVLGIYEMHVNGFMHRDIKPANILITQQGQVKVADLGLARQVTQKRQTFTPGWITLWYRPLEMLCNQ
|||  .|. |.|..         .| |  .   .. |.   | .   ||| || |||.| .|.|| || ||||    .   .||  .|||||  | |  |
MVFEHCDWDLHTYLDKCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMA-LTPVVVTLWYRAPEVLL-Q

TNYSKAVDIWSLGCVFGEMVRLVPLFRGQTELEQALKIIQSLGLPTEFQ-------DFDSFHERVSDQAFSYEKNFPYLSEDGIDLLKGMLNINPSKRLT
  |   ||.||.||.| || .  |||.|| | .|  ||    |||.| .         |.|. |   .. . ..  | ... |.|||. ||  |..||..
SYYNTPVDMWSVGCIFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLPWDHFPQR---HPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMS

AKQCKEHRFF
| || .| .|
AYQCLQHPYF
Kinase 12538.AA Ciliate-E2 1-200 21 1.9e-42 143.55 In-house 111-365 (365) Show / Hide 
Range on Protein: 1-200
Range on HMM: 111-365/365
Sequence Identity: 21% (60 aa)

MVFDYIDQ-NLQTFIKEF---------------ENKKCYIPLIQIK------------IVLGIYEMHVNG-FMHRDIKPANILITQQGQVKVADLGLARQ
.|..|... .|. .||..               |.. .||   ...            |.|.. ..| ..  .|||||| |||.     .|..|.||...
LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKK

VTQKRQ-----------------TFTPGWI--------------TLWYRPLEMLCNQTN--------YSKAVDIWSLGCVFGEMVRLVPLFRGQTELEQA
.....|                 . ||| .              |. | . |.| .. .        |....||||||... ||.   | |         
YDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---------

LKIIQSLGLPTEFQDF---DSFHERVSDQAFSYEKNFPYLSEDGIDLLKG----MLNINPSKRLT-AKQCKEHRFF
  ..| .  . .|. .   .  .     | ... |.. ..|....||.|     ||. .|.||.| ..|...| .|
--QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKW-KSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 12538.AA ERK7 38-200 36 3.8e-41 138.29 In-house 116-292 (292) Show / Hide 
Range on Protein: 38-200
Range on HMM: 116-292/292
Sequence Identity: 36% (64 aa)

MHVNGFMHRDIKPANILITQQGQVKVADLGLARQVTQKR------QTFTPGWITLWYRPLEMLCNQTNYSKAVDIWSLGCVFGEMVRLVPLFRGQTELEQ
||    .|||.||.|||.  .  |||.| |||| ..|..      .  |    | |||  | |   ..| |.|| ||.||. |||.|  |.| |   ..|
MHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEMLRGKPMFPGTSTMNQ

ALKIIQSLGLPT--EFQDFDS------FHERVSDQAFSYEKNFPYLSEDGIDLLKGMLNINPSKRLTAKQCKEHRFF
  ||..... ||  . .. .|       ..  ...  . .. .|  ..|.||||| .|  || |||||.|. .|.. 
IEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 12538.AA MAPK 42-144 35 3.5e-34 115.46 In-house 137-256 (328) Show / Hide 
Range on Protein: 42-144
Range on HMM: 137-256/328
Sequence Identity: 35% (43 aa)

GFMHRDIKPANILITQQGQVKVADLGLARQVTQKR------QTF--------TPGWITLWYRPLEMLCN--QTNYSKAVDIWSLGCVFGEMVR-LVPLFR
.  |||.||.|||... ...|..| ||||.. ..       ...        |.   | |||  | ..|   ..|.||||.||.|| |.||..   |||.
NVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFP

GQTELEQALKIIQSLGLPTE
|.  ..|  .|.. || |.|
GKDYIDQWNLIMEVLGTPSE
Kinase 12538.AA S_TKc 1-200 19 1.7e-18 68.68 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-200
Range on HMM: 1-231/231
Sequence Identity: 19% (54 aa)

M---------------------------------------------------------------VFDYIDQ---NLQTFIKEFENKK--CYIPLIQIK--
                                                                |..|.|.   .| ..||.   ..  ...|  ...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

---IVLGIYEMHVNGFMHRDIKPANILITQQGQVKVADLGLARQVTQKRQTFTPGWITLWYRPLEMLCNQTNYSK-AVDIWSLGCVFGEMVRLVPLFRGQ
   |....  .| .|..|||.||.|||...  ..|..| |||||.       |    |.||.. |.|     |.| ..|.||.||.. ||.   |.|.  
MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP--

TELEQALKIIQSLGLPTEFQDFDSFHERVSDQAFSYEKNFPYLSEDGIDLLKGMLNINPSKRLTAKQCKE-------HRFF
 .... .|.|                                 |....|.....|. .|.||.|| .. .       | .|
-QMQMMFKKIG--------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 12538.AA CDC2 163-200 44 4.6e-12 32.84 In-house 264-301 (301) Show / Hide 
Range on Protein: 163-200
Range on HMM: 264-301/301
Sequence Identity: 44% (17 aa)

EKNFPYLSEDGIDLLKGMLNINPSKRLTAKQCKEHRFF
.||.  | ..|||||. || ..|.||..||.  .|..|
KKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase 12538.AA MAPK 166-200 35 2.8e-11 35.02 In-house 290-328 (328) Show / Hide 
Range on Protein: 166-200
Range on HMM: 290-328/328
Sequence Identity: 35% (14 aa)

FPY----LSEDGIDLLKGMLNINPSKRLTAKQCKEHRFF
||      . . ||||. || ..|.||.|.... .| .|
FPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 12538.AA TyrKc 1-200 11 7.2e-05 -143.93 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-200
Range on HMM: 1-280/280
Sequence Identity: 11% (35 aa)

MVFD------------------------------------------Y--------------IDQ--------------------NLQTFIKEFENKKCYI
 ...                                          .              ..|                    .|. .... ..|    
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK----

PLIQIKIVLGIYE--------MHVNGFMHRDIKPANILITQQGQVKVADLGLARQVTQK-------RQTFT----PGW--ITLWYRPLEMLCNQTNYSKA
  .. |  | .           | ... |||.   |.|.. ...||..| ||.| .. .           .     |   . .   ..| . |   .. .
--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTK

VDIWSLGCV------FGEMVRLVPLF--RGQTELEQALKIIQSLGLPTE----FQDFDSFHERVSDQAFSYEKNFPYLSEDGIDLLKGMLNINPSKRLTA
 |.|| | .      .|..    . .     .|. . .|    .  | .                         |.  ...  .. |   . .|..| | 
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------FVCCPDEMYQIMKQCWHEDPEDRPTF

KQCKEHRFF
...  |..|
SEI--HECF
Kinase 12538.AA Pkinase_Tyr 52-81 29 0.000145 16.08 Pfam 141-177 (270) Show / Hide 
Range on Protein: 52-81
Range on HMM: 141-177/270
Sequence Identity: 29% (11 aa)

NILITQQGQVKVADLGLARQV-------TQKRQTFTP
|.|.| ...||..| |||| .       ...  .  |
NCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLP