12856

Species: Tetrahymena
Alias: 95.m00102, TTHERM_00653690, 3825.m02510, PreTt12856, 12856, 170
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Uni1

Sequence

Name Sequence Type Origin Length Description Download
12856.AA Protein None 2828 None Fasta, JSON
12856.kin_dom Protein Kinase Domain None 298 None Fasta, JSON
12856.NA RNA None 8487 None Fasta, JSON

Protein domain

Protein domains of 12856.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 12856.AA CAMKK 3-11 44 0.147859 0.2 In-house 1-9 (396) Show / Hide
Range on Protein: 3-11
Range on HMM: 1-9/396
Sequence Identity: 44% (4 aa)

YELLEKLGS
|||....|.
YELMKEIGQ

S_TKc 12856.AA S_TKc 2103-2400 19 3.8e-29 104.07 SMART 1-231 (231) Show / Hide
Range on Protein: 2103-2400
Range on HMM: 1-231/231
Sequence Identity: 19% (59 aa)

YTDLQFMASGQFGSIFEAKTNLSDPQIVAIKQMDLPKSIYDRCVLHDIFNEITCLELFRFDQCVTDLYDYGLAENDYKIIMKRYPM---SLKQWRQQQKS
|. |.   .| ||. . .. .  . .|||||...            .| .|| .|.       .  |||.    ... ..|   .    .|..  .....
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

--DQFTENLPTYLNIYRDALKAVQLLHSNSVIHYDIKADNILLDFPNKSENGNPNDQSIKVVLGDFGVCKMFRNEEDEYCLVSKGTQFIQSPEMQTLAIQ
   .|  .  .   . .  ..|.. .||. .|| |.| .|||||                . ..|||... .            || .  .||.      
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------------HIKICDFGLARQL--------TTFCGTPWYMAPEVL-----

SKKEGDKYDRRKKVGTTR-SSDVWSLGCLLYEILTNEFLFYNQNETAFLFRVTSNTEQILTQENLDRVQNNMYAIDFLKYILVRDQQIRPNIDNVIK---
              | .. ..|.||.||.||| |. . .|.   . . .|..                     |.||.. .|..| . || .  . .   
--------------GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEW

-RFEHIYA
    | . 
DIKCHPWF

Kinase 12856.AA STE 2103-2387 17 7.7e-29 99.03 In-house 1-347 (359) Show / Hide
Range on Protein: 2103-2387
Range on HMM: 1-347/359
Sequence Identity: 17% (66 aa)

YTDLQFMASGQFGSIFEAKTNL-----SDPQI---------VAIKQMDLPK-------------SIYDRCVLHDIFNEITCLELFRF-DQCVTDLYDYGL
......  .| ||. . |. .      .  ..         .|||||.| .             .. .   . .| .||  .  ..   . .   |.. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

AE-------NDYKIIMKRYP-MSLKQWRQQQKSDQFTEN----------LPTYLNIYRDALKA-VQLLHSNSVIHYDIKADNILLDFPNKSENGNPNDQS
 |       ..  |.|   .  || .  .. .. ... |           .    | |. ||.  ..|||. .|| |||..||||               
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------------

IKVVLGDFGVCKMFRN---------------EEDEYCLVSKGTQFIQSPEMQTLAIQSKKEGDKYDRRKKVGTTRSSDVWSLGCLLYEILTNEFLFYNQN
  | | |||||. . .                 .. .    ||.   .||. .   |. .         . | ....|.|||||.. | .| .  . . .
--VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R---------DKGYDTKCDIWSLGCTIIEMATGKPPWHDMH

ETAFLFRVTSNT-------------EQILTQE-NLDRV--------------QNNMYAIDFLKYILVRDQQIRPN
 .  .|. . |.             ... . . .|. .              .     .||..  |..| . ||.
PMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPT

Kinase 12856.AA Ciliate-E2 2217-2393 18 3.3e-20 66.03 In-house 170-361 (365) Show / Hide
Range on Protein: 2217-2393
Range on HMM: 170-361/365
Sequence Identity: 18% (43 aa)

LKAVQLLHSNS-VIHYDIKADNILLDFPNKSENGNPNDQSIKVVLGDFGVCKMFRNEED--------EYCLVSK-----------------------GTQ
..|.. |||.  .|| ||| .|||.                 . . ||| .| . ....        . ..  |                       || 
ILALEYLHSKNNIIHRDIKPENILF-----------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTP

FIQSPEMQTLAIQSKKEGDKYDRRKKVGTTRSSDVWSLGCLLYEILTNEFLFYNQNETAFLFRVTSNTEQILTQENLDRVQNNMY---------------
  ..||.    ...||..      |. | . ..|.||||..||| |.... |                .|.  | ..|  ....                
GYMAPEI----LNGKKYDNQ---QKQKGYDYKCDIWSLGVILYEMLFGKPPF----------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKK

----AIDFLKY----ILVRDQQIRPN-IDNVIK
    ..|..|     .|..|.. |.. .. ...
WSQECKDLIKKFGKRMLQKDPEKRITGWEQILN

Kinase 12856.AA Pkinase 2217-2395 20 8.4e-20 71.09 Pfam 118-293 (293) Show / Hide
Range on Protein: 2217-2395
Range on HMM: 118-293/293
Sequence Identity: 20% (41 aa)

LKAVQLLHSNSVIHYDIKADNILLDFPNKSENGNPNDQSIKVVLGDFGVCKMFRNEEDEYCLVSKGTQFIQSPEMQTLAIQSKKEGDKYDRRKKVGTTRS
|.... .||...|| |.| .|||.|  |. ...       .| ..|||..| |..  .. . .  || .  .||     |.           .  . ...
LRGLEYCHSMGIIHRDLKPENILID--NNGHIDA------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV----IR-----------GGQYYGPK

SDVWSLGCLLYEILTNEFLFYNQ-----NETAFLFRVTSNTEQILTQENLDRVQNN---------------MYAIDFLKYILVRDQQIRPNIDNVIKR--
.|.||.||.||| |. ...|...     ..  .... .  ..     ...... .                  ..||.|..| .| . ||... . .   
VDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

F
|
F

Kinase 12856.AA Ciliate-E2-Unclassified 2217-2393 19 5.5e-17 55.48 In-house 153-348 (352) Show / Hide
Range on Protein: 2217-2393
Range on HMM: 153-348/352
Sequence Identity: 19% (43 aa)

LKAVQLLHSNS-VIHYDIKADNILLDFPNKSENGNPNDQSIKVVLGDFGVCKMFRNEEDEYCLVS-KGTQFIQSPEMQTLA--IQSK--------KEGDK
|.. . ||..  .||.||| .|||.|  .|           .. . ||| .|   . ....   .   .|.... .|.| .  .. .         .| .
LQGLEYLHHKNNIIHRDIKPENILFDNNGK---------NYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQN

YDRRKKVGTTRSSDVWSLGCLLYEILTNEFLFYNQNETA-----------FLFRVTSNTEQILTQENLDR-------------VQNNMYAIDFLK----Y
|| .|      ..|.||||..|||.|.... || .|..            .       ....| |. ...              . .  |.||..     
YDHSKA----YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNA-------YRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQK

ILVRDQQIRPNIDNVIK
.|. ..  |.... ...
MLKKNPNKRITFEQILN

Kinase 12856.AA AGC 2219-2342 20 6.1e-14 30.95 In-house 165-323 (395) Show / Hide
Range on Protein: 2219-2342
Range on HMM: 165-323/395
Sequence Identity: 20% (39 aa)

AVQLLHS-NSVIHYD-IKADNILLDFPNKSENGNPNDQSIKVVLGDFGVCKMFRNEE-------------------------------------------
|.. ||| . .|| | .| .|||||                . | ||| ||...|..                                           
ALEYLHSHMGIIHRDYLKPENILLDED------------GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQED

------DEYCLVSKG--TQFIQSPEMQTLAIQSKKEGDKYDRRKKVGTTRSSDVWS--LGCLLYEILTNEFLFYNQN------------ET
      .. .    |  |    .||.                      ... | ||  ||||.|| ||    ||..|            |.
DTTRKKRDRTWTFCGPCTPEYMAPEIL--------------------YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEM

Kinase 12856.AA CMGC 2103-2264 14 1.9e-12 36.27 In-house 232-480 (513) Show / Hide
Range on Protein: 2103-2264
Range on HMM: 232-480/513
Sequence Identity: 14% (37 aa)

YTDLQFMASGQFGSIFEAKTNLSD-------------PQIVAIKQMDLPKSIYDRCV---LHDIFN-----EITCLELFR----------------FDQC
|. ..   .| .|  .... ....              .||||| . .|.   . .    . | |.     || .|. ..                 .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VTDLYDYGLAEN-----------------DYKIIMKRYPMSLKQWRQQQKSD-------QFTENL----------PTYLNIY------RDALKAVQ--LL
.  |||.   .|                 .  ...   ...|.|  .... |        ..|            ..  ..       .  |...    .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSNS--VIHYDIKADNILLDFPNK----------SENGNPNDQSIKVVLGDFG
||.   .|| |.|  |||..  ..          . . ||.... .. ..|||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSED-W-NPCQKNGRLKICDFG

Kinase 12856.AA TKL 2200-2341 19 6.7e-12 39.15 In-house 127-294 (364) Show / Hide
Range on Protein: 2200-2341
Range on HMM: 127-294/364
Sequence Identity: 19% (34 aa)

DQFTENLPTYLNIYRDALKAVQLLHSNS--------VIHYDIKADNILLDFPNKSENGN---PNDQSIKVVLGDFGVCKMFRNEEDEYCL----------
....  ..  ... .|. .... |||.         .|| |.| .|||.|  ..  . |   .    ... ..||| .... ....  .           
HYLH--WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEH

--------VSKGTQFIQSPEM-QTLAIQSKKEG-DKYDRRKKVGTTRSSDVWSLGCLLYEILTNEFLFYNQNE
           ||    .||. .     ..| | |.  . |.   . ..||.| | .|.|||| .  .|....
QNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE--FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

Kinase 12856.AA Ciliate-E1 2109-2305 19 1.2e-11 34.61 In-house 1-202 (202) Show / Hide
Range on Protein: 2109-2305
Range on HMM: 1-202/202
Sequence Identity: 19% (41 aa)

MASGQFGSIFEAKTNLSDPQIVAIKQMDLPKSIYDRCVLHDIFNEITCLELFRFDQCVTDLYDYGLAENDYKI--IMKRYPMSLKQWRQ---------QQ
 ..| |. .|.|| . .. ... .... . . .|.   ..|. .|. ... |.. ... ...||   .. | .  |.  . .|||.  |         |.
IGNGSFSIVFKAK-QQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

KSDQFTENLPTYLNIYRDALKAVQLLHSNSVIHYDIKADNILLDFPNKSENGNPNDQSIKVVLGDFGVCKMFRNEEDEYCLVSKGTQFIQSPEMQT----
...|.  .    ..|  ....... ||.. .|| ||| .||| .  ..  .             |||..| . |.....| ..  |.  ..||  .    
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC------------DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ

--LAI-QSKKEGDKY
      . ... | |
EHNKNQKINYKSDIY

Kinase 12856.AA CAMKK 2214-2341 23 1.7e-11 32.28 In-house 183-331 (396) Show / Hide
Range on Protein: 2214-2341
Range on HMM: 183-331/396
Sequence Identity: 23% (37 aa)

RDALKAVQLLH-SNS-------------------VIHYDIKADNILLDFPNKSENGNPNDQSIKVVLGDFGVCKMFRNEEDEYCLV----------SKGT
|| .|... || ..                    .|| ||| .|||.|     |.|.      .|.. ||||...|  ....                ||
RDCIKGLEYLHNYQKACSYIIIYINEFIIDHFQDIIHRDIKPQNILID-----EEGC----GEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGT

QFIQSPEMQTL-AIQSKKEGDKYDRRKKVGTTRSSDVWSLGCLLYEILTNEFLFYNQNE
   . ||...    ...  | |  | . .   .  |.|.||. || .....  |...|.
PAFMAPELCSKENQKENYNGYK-YRFRFIYCGKAADIWALGVTLYCFVFGKCPFWHNNL

Kinase 12856.AA TyrKc 2103-2395 17 4.9e-10 -60.44 SMART 1-280 (280) Show / Hide
Range on Protein: 2103-2395
Range on HMM: 1-280/280
Sequence Identity: 17% (56 aa)

YTDLQFMASGQFGSIFEAKTNLSDPQIVAIKQMDLPKSIYDRCVLHDIFNEITCLELF--RFDQCVTDLYDYGLAE-------NDYKIIMKRYPM-SLKQ
 | ..   .|.|| ..... .    . ||.| .   .       . |. .|.  .  .  . .  |  || . . .         . |.|   |  .||.
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVR-LYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

WRQQQKSDQFTENLPTYLNIYRDALKAVQLLHSNSVIHYDIKADNILLDFPNKSENGNPNDQSIKVVLGDFGVCKMFRNE------EDEYCL----VSK-
  .  . .    .... |..  .. .  . |||. .|| |. | |.|.. ..             |  .||| ..   ..      .| |       .| 
YLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

-GTQFIQSPEMQTLAIQSKKEGDKYDRRKKVGTTRSSDVWSLGCLLYEILTNEFLFYNQNET--AFLFRVTSNTEQILTQENLDR--------VQNNMYA
       .||     . . |                ||||| | ...||.|.    |   .      ..|  . .|    .  .             || 
MLPIRWMAPECINYGKFTTK----------------SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ

IDFLKYILVRDQQIRPNIDNVIKRF
    |    .|   ||.  .....|
--IMKQCWHEDPEDRPTFSEIHECF

Kinase 12856.AA STE20 2103-2154 27 1.3e-07 24.17 In-house 1-55 (288) Show / Hide
Range on Protein: 2103-2154
Range on HMM: 1-55/288
Sequence Identity: 27% (16 aa)

YTDLQFMASGQFGSIFEAKTNLSDPQI----VAIKQMDLPKS---IYDRCVLHDIFNEI
|..|.   .| .|... | .. .  ..    ||||.|.| |        . ..||..||
YELLEKIGQGSYGKVYKA-YHKPTGEYCNQRVAIKKMNLEKCDNEQ---DEWEDIQKEI

Kinase 12856.AA STE11-Unclassified 2223-2242 65 1.9e-07 22.49 In-house 123-142 (308) Show / Hide
Range on Protein: 2223-2242
Range on HMM: 123-142/308
Sequence Identity: 65% (13 aa)

LHSNSVIHYDIKADNILLDF
|||...|| |||..|||.||
LHSHGIIHRDIKGANILIDF

Kinase 12856.AA STE20 2212-2241 60 2e-06 20.08 In-house 122-151 (288) Show / Hide
Range on Protein: 2212-2241
Range on HMM: 122-151/288
Sequence Identity: 60% (18 aa)

IYRDALKAVQLLHSNSVIHYDIKADNILLD
| |..|.. . |||| .|| |||||||||.
ICREVLQGLDYLHSNHIIHRDIKADNILLT

Kinase 12856.AA CMGC 2318-2341 31 4e-06 14.96 In-house 317-348 (513) Show / Hide
Range on Protein: 2318-2341
Range on HMM: 317-348/513
Sequence Identity: 31% (10 aa)

DVWSLGCLLYEILTN--------EFLFYNQNE
|.||.|| ..|..|.        . ||  ..|
DMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSE

Kinase 12856.AA STE11-Unclassified 2312-2328 58 2.8e-05 14.71 In-house 214-230 (308) Show / Hide
Range on Protein: 2312-2328
Range on HMM: 214-230/308
Sequence Identity: 58% (10 aa)

GTTRSSDVWSLGCLLYE
|..|.||.|||||. .|
GHCRKSDIWSLGCTVIE

Kinase 12856.AA Ciliate-E2-Unclassified 2103-2135 24 0.002922 7.19 In-house 295-326 (352) Show / Hide
Range on Protein: 2103-2135
Range on HMM: 295-326/352
Sequence Identity: 24% (8 aa)

YTDLQFMASGQFGSIFEAKTNLSDPQIVAIKQM
|. ..   .|.||...... .  . |. |.|.|
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYM

Kinase 12856.AA Pkinase 2103-2139 24 0.003486 12.34 Pfam 1-36 (293) Show / Hide
Range on Protein: 2103-2139
Range on HMM: 1-36/293
Sequence Identity: 24% (9 aa)

YTDLQFMASGQFGSIFEAKTNLSDPQIVAIKQMDLPK
|. ..   || ||. .... . ....|||.|......
YHIGRKIGSGSFGCVYKCH-HKGTGKIVAVKIIKKRH

Kinase 12856.AA Ciliate-E2 2103-2135 18 0.147876 1.09 In-house 1-55 (365) Show / Hide
Range on Protein: 2103-2135
Range on HMM: 1-55/365
Sequence Identity: 18% (10 aa)

YTDLQFMASGQFGSIFEAKTNLSDP----------------------QIVAIKQM
|  ..   .|.|||....|  . .                       .|.|.|.|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIM