Gene 13389 (Tetrahymena)
13389
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 13389.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 13389.AA | Pkinase | 81-285 | 20 | 2.7e-15 | 55.15 | Pfam | 57-293 (293) | Show / Hide |
Range on Protein: 81-285
Range on HMM: 57-293/293
Sequence Identity: 20% (51 aa)
LKHPNFVHFQRYFIRNHMFFFLMDYYPV-----TLRSLLY--ESKSI--TQEHKYRYALELVQGINFVHSQGHTHRELKTQNIMISPEDRI----IICEF
|.||| | . ..| .. . |.| . | ... ..... . .. .|......|... ||.| || || .||.|. .. | || |
LNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF
GL--EFDSDIHKKKQETSSLSDKWYLAPEINQNTESI-YYQQSKQTDIWAIGVIIAEIFG----FKYA----SALSSNEELERIKA-SLSSQEYAKCLGE
|| || . .. |. ||.|||. . .. |.|..|.|..| . |. . . .. .. ..||. |..... .| .
GLAKQFD--Y-NNS-MTTFCGTPWYMAPEV-----IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSIS
---------------MDQSVQSKVVQMLNLNPDKRGDIADYLPF--F
.... .. . .|...| || ... | |
YFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
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| Kinase | 13389.AA | Ciliate-E2 | 77-219 | 18 | 1.4e-14 | 46.43 | In-house | 85-286 (365) | Show / Hide |
Range on Protein: 77-219 Range on HMM: 85-286/365 Sequence Identity: 18% (39 aa) ILCDLKHPNFVHFQRYFI--RNHMFFFLMDYYPV-TLRSLLYES-----------KSITQEHKYRYALELVQ---------------GINFVHSQG-HTH || |.||| . . .|. .. ... |.|. .|....... |..| .. .. ...| .... ||.. | ILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIH RELKTQNIMISPEDRIIICEFGL--EFDSD--------IHKKKQETS------------SLSDKW---------YLAPEINQNTE----SIYYQQSKQTD | .| .||.. | |. ||| ..| | ..|.... . ... . |.|||| .. . . . ... | RDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCD IWAIGVII ||..|||. IWSLGVIL |
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| S_TKc | 13389.AA | S_TKc | 31-285 | 19 | 5.1e-14 | 28.67 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 31-285 Range on HMM: 1-231/231 Sequence Identity: 19% (55 aa) IKDGKTTDKIIPNKVVIVSKDN--KKYAFKIRYFQNELDSQGISAQVGILCDLKHPNFVHFQRYFIRNHMFFFLMDYYPV---TLRSLLYESKS------ . ... | || . . . ...| || . | . || .||| |.. .| . ... |.| . .|.... . .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP ITQEHKYRYALELVQGINFVHSQGHTHRELKTQNIMISPEDRIIICEFGL--EFDSDIHKKKQETSSLSDKWYLAPEINQNTESIYYQQSK-QTDIWAIG .. | .|. ........ ||.| || || .||... .| || ||| .. |. ||.|||. . .| |.|..| FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL--------GYGKCKCDWWSCG VIIAEIFG----FKYASALSSNEELERIKASLSSQEYAKCLGEMDQSVQSKVVQMLNLNPDKRGDIADYL---------PFF .|..| . | .. ...|. .... . . ..|. .|.|| . . | |.| CILYEMLCGYPPFP-----QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 13389.AA | TKL | 77-223 | 18 | 6.4e-13 | 42.87 | In-house | 78-283 (364) | Show / Hide |
Range on Protein: 77-223 Range on HMM: 78-283/364 Sequence Identity: 18% (40 aa) ILCDLKHPNFVHFQRYFIRNHM-------------FFFLMDYYPV-TLRSLLYESKSITQEHKYRYALELVQGINFVHSQG--------HTHRELKTQNI .. |.||| |.| | ... ... |.|.| .|...| ... | ||. .|.|. ||.. || ||..|| MMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNI MISPEDR--------------IIICEFGLEFDSDIHKKKQETS---------------SLSDK---WYLAPEI---NQNTESIY--------YQQSKQTD .. . . || ||| . . ..... |. . . ..|||. ..|... . .. |...| LVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCD IWAIGVIIAEIF ... |... ||. VYSFGIVLWEIL |
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| Kinase | 13389.AA | C8 | 120-219 | 25 | 1.1e-12 | 40.44 | In-house | 120-226 (226) | Show / Hide |
Range on Protein: 120-219 Range on HMM: 120-226/226 Sequence Identity: 25% (28 aa) ITQEHKYRYALELVQGINFVHSQGHTHRELKTQNIMISPEDRII----ICEFGLEFDSDIHKKKQETSSLS-----DKWYLAPEINQNTESIYYQQSKQT ...| | |. .. |.|..|. ||..| .|... .. . .| || | | . | |.. | . |.|||| . . | | ..| FSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFG--FASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQS DIWAIGVII |.. .|.. DLFSVGLVL |
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| Kinase | 13389.AA | CMGC | 77-169 | 14 | 3.9e-11 | 31.91 | In-house | 74-250 (513) | Show / Hide |
Range on Protein: 77-169 Range on HMM: 74-250/513 Sequence Identity: 14% (26 aa) ILCDLK-----------------HPNFVHFQRYFIRNH-----------------MFFFLMDYYPVTLRSLLYESK---------SITQEH--------- || |. |.| |. . .| ... ... ..| . .| .... . .. | ILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRP ---KYRYA------LELVQGIN--FVHSQG--HTHRELKTQNIMISPE--------------------DRIIICEFGL . . . .|.. . ||.. || || .||.|... .|. || ||| PHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGL |
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| Kinase | 13389.AA | Ciliate-E2-Unclassified | 77-219 | 20 | 4.5e-10 | 31.16 | In-house | 74-260 (352) | Show / Hide |
Range on Protein: 77-219 Range on HMM: 74-260/352 Sequence Identity: 20% (38 aa) ILCDLKHPNFVHFQRYFIRNHMFFFLMDYYP-VTLRSLLYESKS-----------------ITQEHKY-----RYALELVQGINFVHSQG-HTHRELKTQ || ...||. |.. .| ... |.| . .|. . ..|. .| .. .|. ...||... |... || .| . ILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPE NIMISPED---RIIICEFGL--EFDSDIHK-----------KKQETSSLS-DKWYL----APEINQNTESIYYQQS-KQTDIWAIGVII ||... . .| |. ||. . .... . |.|.... . |. |||. |. . |.... .. |||. |||. NILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQN--YDHSKAYKCDIWSLGVIL |
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| Kinase | 13389.AA | STE-Unique | 127-169 | 30 | 1.9e-09 | 29.13 | In-house | 407-456 (616) | Show / Hide |
Range on Protein: 127-169 Range on HMM: 407-456/616 Sequence Identity: 30% (15 aa) RYALELVQGINFVHSQG--HTHRELKTQNIMISPED-----RIIICEFGL .|..... | .. |||. || || ||... .. .. || ||. WYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGH |
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| Kinase | 13389.AA | PLK1 | 71-285 | 23 | 2.4e-09 | 26.6 | In-house | 46-253 (253) | Show / Hide |
Range on Protein: 71-285
Range on HMM: 46-253/253
Sequence Identity: 23% (52 aa)
ISAQVGILCDLKHPNFVHFQRYFIRNHMFFFLMDYYP-VTLRSLLYESKSITQEHKYRYALELVQGINFVHSQGHTHRELKTQNIMISPEDRIIICEFGL
.. . | .|.|.. |.| .| .. ..... | | |.|| | .|.|. ..| . ||.|| |. . . .. | .|||
MTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPECRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGL
EFDSDIHKKKQETSSLSDKWYLAPEINQNTESIYYQQSKQTDIWAIGVII-AEIFGFKYASALSSNEELERIKASLSSQEYAKCLGEMDQSVQSKVVQML
. . .. | |.|||. ... . |||.|| |. .|| . . .| ||| || .. | .. ...||
ATKCEYDGERKKTLCGTPN-YIAPEVLNKKGHSF-----EVDIWSIGCIMYILLFGQPPFETKCLKETYSRIKK----NEYR-IPSHISQPAAQLIRKML
NLNPDKRGDIADYLP--FF
. .|..| | | ||
DPDPTRRPTIEQVLNDEFF
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| Kinase | 13389.AA | AGC | 100-219 | 19 | 2.9e-09 | 18.58 | In-house | 109-295 (395) | Show / Hide |
Range on Protein: 100-219
Range on HMM: 109-295/395
Sequence Identity: 19% (38 aa)
FFLMDYYP----------V-TLRSLLY---ESKSITQEHKYRYALE-------LVQGINFVHS-QGHTHRE-LKTQNIMISPEDRIIICEFGL--EFDSD
.|.|.|.| | . |. ... . |. || | .| .. . || .| || || ||.. . | .. ||| |. .|
YFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMND
-----------------------------------------------IHKKKQETSSLS---DKWYLAPEINQNTESIYYQQSKQTDIWA--IGVII
. ||.. |... |.|||| .|. |.|. |...
GEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTR-KKRDRTWTFCGPCTPEYMAPEIL---------YGKACDWWSFGLGCLM
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| Kinase | 13389.AA | nmo | 132-224 | 30 | 6.4e-09 | 22.93 | In-house | 111-199 (292) | Show / Hide |
Range on Protein: 132-224 Range on HMM: 111-199/292 Sequence Identity: 30% (28 aa) LVQGINFVHSQGHTHRELKTQNIMISPEDRIIICEFGLEFDSDIHKKKQETSSLSDKWYLAPEINQNTESIYYQQSKQTDIWAIGVIIAEIFG .. |. ..|| . ||..| |... . . ||.||| . ..|. | ..| |||| . | . |||..| | ||. | ILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEI--LMGARHY--TSAVDIWSVGCIFAELLG |
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| Kinase | 13389.AA | CDC2 | 77-169 | 28 | 1.3e-08 | 22.09 | In-house | 53-149 (301) | Show / Hide |
Range on Protein: 77-169 Range on HMM: 53-149/301 Sequence Identity: 28% (28 aa) ILCDLK-HPNFVHFQRYFIRNHMFFFLMDYYPVTLRSLLY----ESKSITQEHKYRYALELVQGINFVHSQGHTHRELKTQNIMISPEDRIIICEFGL .| .|| ||| | . .. . . .|. |. .. |..... |. ..||..| |... || || ||| |. . .| | ||| CLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGL |
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| TyrKc | 13389.AA | TyrKc | 26-285 | 15 | 2.1e-07 | -102.91 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 26-285 Range on HMM: 1-280/280 Sequence Identity: 15% (49 aa) YTIL---------EIKDGKTTDKIIPNKVVIVSKDNKKYAFKIRYFQNELDSQGISAQVGILCDL--KHPNFVHFQRYFIRN-------HMFFFLMDYYP | . |. |. . . | |..| . . |.| | .||| | . . . . . .| | | ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMP V-TLRSLLYESKS-ITQEHKYRYALELVQGINFVHSQGHTHRELKTQNIMISPEDRIIICEFGLEFDSDIHKKK-------QETSSLS--DKW------Y |.. | ... .. ... ... .| .. ||.. || | . |.... . .. |. ||| | .. . . .. . .. HGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGL---SRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW LAPEINQNTESIYYQQSKQTDIWAIGVIIAEIF--GFKYASA-----LSSNEELERIKASLSSQEYAKCLGE-----MDQSVQSKVVQMLNLNPDKRGDI .||| .... . ..|.|. || . ||| | . . .| | .|..|. . . . . . . . | . .|..| MAPECI--NYGKF---TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTF ADYLPFF .. .| SEIHECF |
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| Kinase | 13389.AA | CMGC | 207-223 | 35 | 0.005085 | 4.73 | In-house | 313-329 (513) | Show / Hide |
Range on Protein: 207-223 Range on HMM: 313-329/513 Sequence Identity: 35% (6 aa) SKQTDIWAIGVIIAEIF ... |.|..| |.||.. TTPIDMWSVGCIFAEMY |
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