Gene 15587 (Tetrahymena)

15587

Species: Tetrahymena
Alias: 590, TTHERM_00294770, 3692.m00050, PreTt15587, 15587, 27.m00247
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
15587.AA Protein None 304 None Fasta, JSON
15587.kin_dom Protein Kinase Domain None 253 None Fasta, JSON
15587.NA RNA None 915 None Fasta, JSON

Protein domain

Protein domains of 15587.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 15587.AA Pkinase 64-301 24 5.4e-32 114.22 Pfam 49-293 (293) Show / Hide 
Range on Protein: 64-301
Range on HMM: 49-293/293
Sequence Identity: 24% (66 aa)

NEINILKELNNDYIIKAIGLHETQQSKMLVLESYYC-----DLSDFIA-QNSTPLPTFSLFDLRYMISDIAKGLEYLHSKQISHNDIKPSNILLDESCNV
.|| |.|.|| ..|.. ..  |. ..  .|.|   .     ||.|.|  ......  ||  ... ..  |..||||.||. | | |.||.|||.|. ...
SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHI

----VLSDFGTASMSEGQSSEHLNYITSIMNKTYLAPEINGLAEQKII--HFNPFKSDIFSFGLTIFSLMFGGQLPYES------DQYRNYDKKFK----
     ..||| |   .        . |      |.|||.       |      . |.|..|.|.... ...|  . ...      ||.  .... .    
DACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEV-------IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLH

----LLHSNPDLFFARQEYEQYIQYWKQQKEFKY---SLFVEFIQSILNPDPLKRMTASQVLDHQWL
     ..|... |  |. .       .  ..| .   . . .|| ..|..|| || || |.| | |.
FDWPWWCSISYFF-FRH-W-H-----F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
S_TKc 15587.AA S_TKc 20-301 21 1.8e-31 111.76 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-301
Range on HMM: 1-231/231
Sequence Identity: 21% (67 aa)

YE------------VYLSKSSQSTNQNNKFFLNAQEGYYIGKSISKSCNFSLKLLDNEINILKELNNDYIIKAIGLHETQQSKMLVLESYYC---DLSDF
||            ||. .                  ..  | |.       . . .||.|||. . ..|.| ..  .. ..  .|.|       || |.
YEILRKIGKGAFGKVYKCRHKK------------TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDY

IAQNSTPLPT--FSLFDLRYMISDIAKGLEYLHSKQISHNDIKPSNILLDESCNVVLSDFGTASMSEGQSSEHLNYITSIMNKTYLAPEINGLAEQKIIH
| .. .. .   |.  . |...  |...|||.||..| | |.||.||||||  .. ..||| |              | .    |.|||.         .
IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL--------G

FNPFKSDIFSFGLTIFSLMFGGQLPYESDQYRNYDKKFKLLHSNPDLFFARQEYEQYIQYWKQQKEFKYSLFVEFIQSILNPDPLKRMTASQVLD-----
....|.|. |.| ... ..  |. |..     .... ||..                            . . .||. .|. || ||.|| ..|      
YGKCKCDWWSCGCILYEMLC-GYPPFP-----QMQMMFKKIG--------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI

--HQWL
  |.|.
KCHPWF
Kinase 15587.AA Ciliate-E2 49-301 20 1e-29 99.17 In-house 53-365 (365) Show / Hide 
Range on Protein: 49-301
Range on HMM: 53-365/365
Sequence Identity: 20% (69 aa)

KSISKSCNFSLKLLDNEIN-------------ILKELNNDYIIKAIGLHE--TQQSKMLVLESYYC-DLSDFIAQN---STPLPT----FSLFDLRYMIS
|...|.  ...|  .....             ||..||...||| .   .  ....  ||.| .   || |.| .|   ..  ..    |...  .|.. 
KIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMK

DIAK---------------GLEYLHSKQ-ISHNDIKPSNILLDESCNVVLSDFGTASMSEGQSSEHL-----NYITSIM---------------------
 |..               .|||||||  | | ||||.|||.     . ..|||..     .. ...     . ..                        
QILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNT

---NKTYLAPEINGLAE---QKIIHFNPFKSDIFSFGLTIFSLMFGGQLPYESDQYRNYDKKFKLLHSNPDLFFARQEYEQYIQYWKQQ-----------
   .  |.|||| .  .   |.  .   .|.||.|.| ... ..|| ..|.                        .|  .. |.. ...           
ICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG-KPPF-----------------------QQQIKQCKIDFPCPEWQKDTQCIQCK

--KEFKYSLF-VEFIQS----ILNPDPLKRMT-ASQVLDHQWL
  . .| |.    .|.     .|. || ||.| ..|.|.|.|.
WKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 15587.AA CAMK 49-301 17 3.4e-26 80.82 In-house 37-425 (425) Show / Hide 
Range on Protein: 49-301
Range on HMM: 37-425/425
Sequence Identity: 17% (71 aa)

KSISKSCNF----------------------------SLKLLDNEINILKE-------LNNDYIIKAIGLHE------------TQQS--------KMLV
| |.|.                               ..| . .||.|.|        |.   ||| .   |            | .           .|
KIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMV

L---ESYYC-----DLSDFIAQNSTPL-----------PTFSLFDLRYMISDIAKGLEYLHSKQISHNDIKPSNILLDES-----------------CNV
.   |         || |.| ... .              |.  . |...  |. ...|.||. | | |.|| |||||..                 .|.
MEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNI

VLSDFGTASMSEGQSSEHLN--------------------YITSIMNKTYLA-PEINGL--AEQKI------IHFNPFKSDIFSFGLTIFSLMFGGQLPY
 ..||| | . .. .... .                    . |.     | | ||.       ..       .   ..|.|. | |   . .  |  .|.
KIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCG-YPPF

ESD---QYRNYDKKFKLLHSNPDLFFA--RQEYEQYIQYWKQ-----------------QKEFKYSLFVEFIQSILNPDPLKRMTASQVLDHQWL
..|   . .. | . ..  . ..||    . .|. .  |..                  .. |       .|...|..|| ||||..|.|.|.|.
YGDCDNEICE-D-E-WIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 15587.AA Ciliate-E2-Unclassified 60-301 21 3.9e-26 87.66 In-house 69-352 (352) Show / Hide 
Range on Protein: 60-301
Range on HMM: 69-352/352
Sequence Identity: 21% (63 aa)

KLLDNEINILKELNNDYIIKAIGLHETQQSKMLVLESYYC---DLSDFIAQNST----------PLPT---FSLFDLR-----YMISDIAKGLEYLHSKQ
|....   ||. ... .|.| .   ...|   .|.|  ||   ||...| ....           . .   |. .  .     ...  | .||||||.|.
KIMQQ---ILLNHPHPFIVKMFYCFQDKQNIYIVME--YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN

-ISHNDIKPSNILLDESC---NVVLSDFGTASMSEGQSSEHLN-------------YITSIMNKTYL----APEINGLAEQKIIHFNPFKSDIFSFGLTI
 | | ||||.|||.|...   .. ..||| .. .. .. .  .             . | . .  |.    |||. .  ..    .  .|.||.|.|  .
NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA--YKCDIWSLGVIL

FSLMFGGQLPYES-DQYRNY-DKKFKLLHSNPDLFFARQEYEQYIQ--------YWK----QQKEFKYSLFVE-FIQSILNPDPLKRMTASQVLDHQWL
. ..||  .|... ... .. ... .. . |    . |....| |.        ...    ..  ...  |.. ..|..|. .| ||.|..|.| |.|.
YEMLFGY-YPFYDNNCEQHQQLITQWI-N-N----AYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 15587.AA Ciliate-A7 62-301 22 2.8e-25 88.8 In-house 55-360 (360) Show / Hide 
Range on Protein: 62-301
Range on HMM: 55-360/360
Sequence Identity: 22% (69 aa)

LDNEINILKELNNDYIIKAIG---------LHETQQSKMLVLESYYCDLSDFIAQNSTPLPTFSLF------------DLRYMISDIAKGLEYLHS-KQI
| || |.||...   ||...          . .   .... .|.  ||| .. .|.. |   ...              .|.. . ||..| |||. |.|
LKNEYNFLKKMDHPHIIMLFEQFNDYNMDEFWHHRNCCCILMEQAECDLFQYFSQHY-PHKNLHHNEKIENQCEYCVNQMRHCFRQIAQALHYLHNEKNI

SHNDIKPSNILLDESCN------VVLSDFGTASMSEGQSSE------------HLNYITSIMNKTYLAPEINGLAEQ----------KIIHFNPF-----
.|||||| ||.. .. |        |.|||.|. .. ||.               |.   . .| |.||||  . ..          | | .. .     
AHNDIKPENIFIFCNNNQQNQYCFKLADFGFAKKYQFQSHFESTLRQQIIEDQYKNW--KYRCKQYFAPEIINCLNKCCDKNSAKNKKFISQQIDNQCEF

---KSDIFSFGLTIFSLMFGGQLPYESDQYRNYDKK-FKLLHSNPDL-FFARQEYEQYIQYWK----------QQKEFKYSLFVEFIQSILNPDPLKRMT
   |.|.|.||...| . | .|.|...    ..|   .|... ..   |.  .  ..  ....          .|.. .. . .  .   |.|.| .| .
DEKKCDVFAFGVSFFQILF-QQNPFCCEACHQNDPYKYKHYFQKTYSKFWQWMQIQWMWNHFQKEIQDMIKNTDQQQQDIDQMKDLLNKMLCPNPSQRYC

ASQVLDHQWL
..|.| | |.
IKQILQHPWF
Kinase 15587.AA STE 53-301 22 2.4e-21 72.21 In-house 50-359 (359) Show / Hide 
Range on Protein: 53-301
Range on HMM: 50-359/359
Sequence Identity: 22% (74 aa)

KSCN----------------FSLKLLDNEINILKELN--NDYIIKAIGLHETQ-------QSKMLVLESYYCD---LSDFIAQNSTPLPTFS--------
..||                  .. . .||.|.|..|   ..|.| .| ..         ..  ...|  |.|   |.|.| ..  .. ...        
ENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICME--YMDGGSLDDIIKHKYGCGKPLNHNRQHQHR

--LFDLRYMISDIAKG-LEYLHSKQISHNDIKPSNILLDESCNVVLSDFGTASMSEG---------------QSSEHLNYITSIMNKTYLAPEINGLAEQ
     ..|.. .| || |.||||..| | ||||.||||     | |.|||...  .                 .... | ..      . |||.    .|
FPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP---WMAPEVIQQNGQ

K-IIHFNPFKSDIFSFGLTIFSLMFGGQLPYESDQYRNYDKKFKLLH--------------SNPDLFFARQEYEQYIQYWKQQKEFKY------------
.   . . .|.|| |.|.||   |  |. |.   ..      .   .                | |    .. |. |.         |            
GRDKGYD-TKCDIWSLGCTII-EMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEM-IS---------YGGSGTTYPHKWS

SLFVEFIQSILNPDPLKRMTASQVLD--HQWL
. | .||.  |. || || |||| |   | ..
PEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 15587.AA TKL 123-218 23 5e-19 65.16 In-house 137-280 (364) Show / Hide 
Range on Protein: 123-218
Range on HMM: 137-280/364
Sequence Identity: 23% (34 aa)

MISDIAKGLEYLHS--------KQISHNDIKPSNILLDESCN--------------VVLSDFGTAS-MSEGQSSEHL---------------NYITSIMN
.. |||.|..||||        ..| | |.|..|||.||  .              . ..|||..  ||. .....                . .| . .
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

KTYLAPEI----------NGLAEQKIIHFNPF-KSDIFSFGLTIF
. ..|||.          .|..| .. .|  . |.|..|||. ..
PRWMAPEVLRGQMNYTEKVGIDE-FCKGFEYSEKCDVYSFGIVLW
Kinase 15587.AA STE-Unique 122-223 22 1.6e-18 61.9 In-house 407-549 (616) Show / Hide 
Range on Protein: 122-223
Range on HMM: 407-549/616
Sequence Identity: 22% (32 aa)

YMISDIAKGLEYLHSKQ--ISHNDIKPSNILLDE-S----CNVVLSDFGTA-SMSEG----------------------------------QSSEHLNYI
...  |..|||||||..  | | |.||.||...       |.|...|||.| .....                                   . . .. .
WYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMK

TSIMNKTYLAPEINGLAEQKIIHFNPFKSDIFSFGLTIFSLMFG
. . . .| .||.   ..|   ...  |.||.|.| ..| . .|
YCCGTPCYMCPEVINCRNQINNPYD-TKVDIWSLGCMCFHMCCG
Kinase 15587.AA CMGC 65-165 20 1.6e-17 53.23 In-house 71-251 (513) Show / Hide 
Range on Protein: 65-165
Range on HMM: 71-251/513
Sequence Identity: 20% (37 aa)

EINILKELN----------------NDY-IIKAIGLHETQQ-----------------SKMLVLESYYCDLSDFIAQNSTP-----LPTFSLFD------
|| |||.||                ..  |.| .    . .                 .  || |   .|| ..| .|...        .|         
EIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPH

------LRYMI------SDIAKGLE--YLHSKQ--ISHNDIKPSNILLDESCNV--------------------VLSDFGTA
       .|..        | .||.  |.||.   | | |.||.|||... | .                     . ||| |
RRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 15587.AA CAMKK 126-171 37 5.5e-17 50.03 In-house 254-322 (396) Show / Hide 
Range on Protein: 126-171
Range on HMM: 254-322/396
Sequence Identity: 37% (26 aa)

DIAKGLEYLH-SKQ-------------------ISHNDIKPSNILLDESC---NVVLSDFGTASMSEGQ
|..||||||| ...                   | | ||||.|||.||     .|...|||.. . |||
DCIKGLEYLHNYQKACSYIIIYINEFIIDHFQDIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQ
Kinase 15587.AA CAMKL 127-163 51 2e-14 42.32 In-house 136-174 (297) Show / Hide 
Range on Protein: 127-163
Range on HMM: 136-174/297
Sequence Identity: 51% (20 aa)

IAKGLEYLHSKQISHNDIKPSNILLDESC--NVVLSDFG
|  ...|.||. | | |||| ||||||.   |. ..|||
IVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFG
TyrKc 15587.AA TyrKc 37-301 19 3.4e-11 -41.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 37-301
Range on HMM: 1-280/280
Sequence Identity: 19% (62 aa)

FFLNAQ----------EGYYI----GKSISKSCNFSLKLLDNEINILKEL--NNDYIIKAIGLHETQ-------QSKMLVLESY-YCDLSDFIAQNSTPL
  |. .          .| ..     |.. ...   .. . .|..|...|  ... |.. .|   .|       .  |.|.|   . || |..  .    
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

PTFSLFDLRYMISDIAKGLEYLHSKQISHNDIKPSNILLDESCNVVLSDFGTASMSEGQSSE------HLNYIT-----SI--MNKTYLAPEINGLAEQK
  ... || ..  .||.| ||||||.. | |.   |.|..|   |  ||||   .|    ..      .  | .     .   .    .|||       .
--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG---LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----N

IIHFNPFKSDIFSFGLTIFSLMFGGQLPYES--------DQYRNYDKKFKLLHSNPD----LFFARQEYEQYIQYWKQQKEF--KYSLFVEFIQSILNPD
   |. .|||..||| ... ..  || ||.         .. ..| |. . .   |.                        |    .   . ...  . |
YGKFT-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------FVCCPDEMYQIMKQCWHED

PLKRMTASQVLDHQWL
| .| | |..  |. .
PEDRPTFSEI--HECF
Kinase 15587.AA CAMKL 277-301 36 6e-09 24.54 In-house 273-297 (297) Show / Hide 
Range on Protein: 277-301
Range on HMM: 273-297/297
Sequence Identity: 36% (9 aa)

FIQSILNPDPLKRMTASQVLDHQWL
.|...|...| ||.|. |.. | |.
LIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 15587.AA CMGC 256-301 17 2.8e-08 22.33 In-house 422-513 (513) Show / Hide 
Range on Protein: 256-301
Range on HMM: 422-513/513
Sequence Identity: 17% (16 aa)

YEQYIQY-----WKQQKEFKY-----------------------------------------SLFVEFIQSILNPDPLKRMTASQVLDHQWL
. .|||      |.. | .|                                          ........ .|  || ||.||.| |.| ..
ARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 15587.AA CAMKK 278-301 37 4e-06 15.01 In-house 373-396 (396) Show / Hide 
Range on Protein: 278-301
Range on HMM: 373-396/396
Sequence Identity: 37% (9 aa)

IQSILNPDPLKRMTASQVLDHQWL
|.  |. .| ||.|..|.. |.|.
IKRMLEKNPTKRITIPQIKVHPWV
Kinase 15587.AA Pkinase_Tyr 64-163 30 1.1e-05 19.85 Pfam 52-156 (270) Show / Hide 
Range on Protein: 64-163
Range on HMM: 52-156/270
Sequence Identity: 30% (32 aa)

NEINILKEL-NNDYIIKAIGLHE-TQQS--KMLVLESYYC-DLSDFIAQNSTPLPTFSLFDLRYMISDIAKGLEYLHSKQISHNDIKPSNILLDESCNVV
.|..|.|.| ... |.. .|     ...   ..|.|   . || |.  ..... . ... ||  |  .||||.|||.||.. | |.   |.|..|.  | 
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVK

LSDFG
 .|||
ICDFG
Kinase 15587.AA STE-Unique 273-301 37 2.5e-05 14.25 In-house 588-616 (616) Show / Hide 
Range on Protein: 273-301
Range on HMM: 588-616/616
Sequence Identity: 37% (11 aa)

LFVEFIQSILNPDPLKRMTASQVLDHQWL
....||.. |...| .| .|.| | | ||
EQQQFIEKCLERNPHHRPSAHQLLHHFWL