Gene 17985 (Tetrahymena)
17985
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 17985.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 17985.AA | Ciliate-E2 | 207-461 | 14 | 1.3e-26 | 88.36 | In-house | 142-365 (365) | Show / Hide |
Range on Protein: 207-461
Range on HMM: 142-365/365
Sequence Identity: 14% (48 aa)
LSLNSIKTIMQKAFK---------------IVENLYNLS-IIHLNLTPQTINYYFTKQTINICISDFEHSQQIETSYT-------CNFDNFEY-------
.... ||.||.. .. .| | . ||| .. |. | . |.|.|| |... ... |. |
FTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTP
----------------GDLRYQAPEIILGIE---------YTTKSDVWSLGCIMYELLTGETLFKTQDKKEIIFIVNIQKRLNLSKNSIKIVFTMITFII
| . |.||||. | . |..|.|.||||.|.||.|.|.. |
GYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------------------------------------
KKIKKVFENEDDEDGCLNNDGSILNNKYIESFQTSVFMDQNNLSRDMQLSSSNHSATKKIHELNEKILEIKQNF-------------NLLRESSLLYDFL
. . .. ... ... . . | |..
-----------------------------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLI
RY----LLSPNPEQRPS-LEEALQHVWI
. .| .||.|.. |..|.| |.
KKFGKRMLQKDPEKRITGWEQILNHPWF
|
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| Kinase | 17985.AA | CAMK | 281-461 | 16 | 1.4e-20 | 62.41 | In-house | 285-425 (425) | Show / Hide |
Range on Protein: 281-461
Range on HMM: 285-425/425
Sequence Identity: 16% (36 aa)
YQA-PEIILG-------------IEY-TTKSDVWSLGCIMYELLTGETLFKTQDKKEIIFIVNIQKRLNLSKNSIKIVFTMITFIIKKIKKVFENEDDED
| | ||...| ..| . |.|.||.|.|.| .|.|. | . .||. . .
YMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICE-D--E-W---------------------------------
GCLNNDGSILNNKYIESFQTSVFMDQNNLSRDMQLSSSNHSATKKIHELNEKILEIKQNFNLLRESS-----------------------LLYDFLRYLL
... ..|| |||.. | .| | |..| .|
-----------------------------------------IGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKML
SPNPEQRPSLEEALQHVWI
..||.|...|..|.| |.
QVDPEKRMTIEQCLNHPWM
|
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| Kinase | 17985.AA | CLK | 281-322 | 57 | 1.3e-19 | 54.81 | In-house | 213-254 (350) | Show / Hide |
Range on Protein: 281-322 Range on HMM: 213-254/350 Sequence Identity: 57% (24 aa) YQAPEIILGIEYTTKSDVWSLGCIMYELLTGETLFKTQDKKE | |||.||| . ...|||| ||| .|| ||.||| | |..| YRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNRE |
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| Kinase | 17985.AA | CMGC | 281-319 | 36 | 3.5e-17 | 52.15 | In-house | 291-347 (513) | Show / Hide |
Range on Protein: 281-319 Range on HMM: 291-347/513 Sequence Identity: 36% (21 aa) YQAPEIILGIE----------YTTKSDVWSLGCIMYELLTG--------ETLFKTQD | ||||.|| . |||. |.||.|||..|..|| ..||.... YRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHS |
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| Kinase | 17985.AA | Ciliate-E2-Unclassified | 227-356 | 22 | 8.6e-17 | 54.79 | In-house | 161-335 (352) | Show / Hide |
Range on Protein: 227-356 Range on HMM: 161-335/352 Sequence Identity: 22% (39 aa) YNLSIIHLNLTPQTINYYFTKQTI--NICISDFEHSQQIETSYTC-------------NFDNFEYGDLRYQ----APEIILGIEYT----TKSDVWSLGC ... ||| ...|. | |... .|.|.|| | ...... | . . | ..|. |||.. | .| |.|.||||. HKNNIIHRDIKPENI--LFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGV IMYELLTGETLFKTQDKKE---------------IIFIVNIQKRLNLSKNSI-----KIVFTMITFII----KKIKK |.||.|.|. |. ..... ... .|| .. .| . .. .. . || |..|| ILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKK |
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| Kinase | 17985.AA | Pkinase | 277-325 | 39 | 2.6e-16 | 58.76 | Pfam | 173-228 (293) | Show / Hide |
Range on Protein: 277-325 Range on HMM: 173-228/293 Sequence Identity: 39% (22 aa) GDLRYQAPEIIL-GIEYTTKSDVWSLGCIMYELLTGETLFKTQ------DKKEIIF | ..| |||.|. | .|..|.|.||.|||.||.|.|...|. . |....|. GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMIC |
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| Kinase | 17985.AA | Ciliate-E2a | 283-324 | 41 | 5.9e-16 | 43.47 | In-house | 178-225 (275) | Show / Hide |
Range on Protein: 283-324 Range on HMM: 178-225/275 Sequence Identity: 41% (20 aa) APEIILGIE------YTTKSDVWSLGCIMYELLTGETLFKTQDKKEII |||.. | |.|| |.||.|.|.| ||.|...|| .. .||. APEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEIL |
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| Kinase | 17985.AA | DYRK | 281-315 | 60 | 2.2e-15 | 54.21 | In-house | 170-204 (320) | Show / Hide |
Range on Protein: 281-315 Range on HMM: 170-204/320 Sequence Identity: 60% (21 aa) YQAPEIILGIEYTTKSDVWSLGCIMYELLTGETLF | |||.|||. | .. |.||||||..||.||. || YRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLF |
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| Kinase | 17985.AA | JNK | 281-320 | 42 | 4.7e-14 | 48.65 | In-house | 171-212 (309) | Show / Hide |
Range on Protein: 281-320 Range on HMM: 171-212/309 Sequence Identity: 42% (18 aa) YQAPEIILGIE--YTTKSDVWSLGCIMYELLTGETLFKTQDK | |||.|.| |... |.||.|||| |..... ||. .|. YRAPEVICGMMDNYKENVDIWSVGCIMAEMIRHHVLFPGKDH |
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| Kinase | 17985.AA | STE | 254-312 | 27 | 1.9e-13 | 43.98 | In-house | 188-265 (359) | Show / Hide |
Range on Protein: 254-312 Range on HMM: 188-265/359 Sequence Identity: 27% (22 aa) ISDFEHSQQIETSYT--------------CNFDNFEYGDLRYQAPEIILG------IEYTTKSDVWSLGCIMYELLTGE ..|| .. |.. |.. | | . |||.|.. .|.||.|.||||| . |..||. LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK |
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| Kinase | 17985.AA | MARK | 281-323 | 45 | 8.2e-13 | 38.38 | In-house | 171-216 (262) | Show / Hide |
Range on Protein: 281-323 Range on HMM: 171-216/262 Sequence Identity: 45% (21 aa) YQAPEIILGIEYT-TKSDVWSLGCIMYELLTGETLFK--TQDKKEI | ||||.|. .|. .| |.|||| ..| ...| |. ||| ||. YMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKEL |
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| S_TKc | 17985.AA | S_TKc | 75-461 | 13 | 3.2e-11 | -12.3 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 75-461
Range on HMM: 1-231/231
Sequence Identity: 13% (55 aa)
YQQL-----------FQASSQQEQRQSFKQSQNKIPLKASEQLPKKEQKITNFKGNRENFSKVNEMDPSMEENQLVNTFNTECPLSSERFIQNSCSSHNY
|. | ... .. . .| . . .|. | . | .
YEILRKIGKGAFGKVYKCRHKK--------TGRIVAIKIIK-----------------------------------------EHIRREIQILKK--HHPN
QKIFIPVILENKFNSSQVKAGSYISKFSYSNQ----WKNILNINKRF-----LSLNSIKTIMQKAFKIVENLYNLSIIHLNLTPQTINYYFTKQTINICI
.. |. . ... . | .. . .. ..| .. .. .|. .. .| . .. ||| | |. | .| |
IVKLYDVFQD----------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKI
SDFEHSQQIETSYTCNFDNFEYGDLRYQAPEIILGIEYTT-KSDVWSLGCIMYELLTGETLFKTQDKKEIIFIVNIQKRLNLSKNSIKIVFTMITFIIKK
.|| . |. . | . | |||.. |.. |.|.||.|||.||.|.|...| . .... ..
CDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------------------
IKKVFENEDDEDGCLNNDGSILNNKYIESFQTSVFMDQNNLSRDMQLSSSNHSATKKIHELNEKILEIKQNFNLLRESSLLYDFLRYLLSPNPEQRPSLE
|. . ||.| .| .||.||.
-----------------------------------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-
EALQ-------HVWI
|||| | |.
EALQDEWDIKCHPWF
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| Kinase | 17985.AA | Ciliate-E2a | 435-461 | 29 | 5.9e-09 | 22.53 | In-house | 249-275 (275) | Show / Hide |
Range on Protein: 435-461 Range on HMM: 249-275/275 Sequence Identity: 29% (8 aa) YDFLRYLLSPNPEQRPSLEEALQHVWI .|... .| ..|..|.. ..||.| | KDLMKKMLEKDPKKRITAQQALNHPWF |
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| Kinase | 17985.AA | MARK | 431-461 | 38 | 9.4e-09 | 24.92 | In-house | 232-262 (262) | Show / Hide |
Range on Protein: 431-461 Range on HMM: 232-262/262 Sequence Identity: 38% (12 aa) SSLLYDFLRYLLSPNPEQRPSLEEALQHVWI | . .... || .|||.||..|| ..| |. SKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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| Kinase | 17985.AA | Pkinase | 429-461 | 36 | 1.8e-08 | 31.06 | Pfam | 261-293 (293) | Show / Hide |
Range on Protein: 429-461 Range on HMM: 261-293/293 Sequence Identity: 36% (12 aa) RESSLLYDFLRYLLSPNPEQRPSLEEALQHVWI . |. . ||....| ..|..||. |..||| |. NWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 17985.AA | Ciliate-E2-Unclassified | 436-461 | 38 | 8.6e-08 | 23.13 | In-house | 327-352 (352) | Show / Hide |
Range on Protein: 436-461 Range on HMM: 327-352/352 Sequence Identity: 38% (10 aa) DFLRYLLSPNPEQRPSLEEALQHVWI |.|. .| ||..|...|..|.| |. DLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | 17985.AA | CMGC | 428-461 | 29 | 3.1e-07 | 18.85 | In-house | 480-513 (513) | Show / Hide |
Range on Protein: 428-461 Range on HMM: 480-513/513 Sequence Identity: 29% (10 aa) LRESSLLYDFLRYLLSPNPEQRPSLEEALQHVWI ....... |.| .| .|..|.. |.|||| .. KCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF |
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| Kinase | 17985.AA | STE | 436-461 | 32 | 1e-06 | 19.77 | In-house | 332-359 (359) | Show / Hide |
Range on Protein: 436-461 Range on HMM: 332-359/359 Sequence Identity: 32% (9 aa) DFLRYLLSPNPEQRPSLEEALQ--HVWI ||.. | .|..||. .. |. | .| DFINKCLQKDPNKRPTASQLLKSEHPFI |
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| Kinase | 17985.AA | Pkinase_Tyr | 283-313 | 56 | 2e-06 | 22.51 | Pfam | 182-213 (270) | Show / Hide |
Range on Protein: 283-313 Range on HMM: 182-213/270 Sequence Identity: 56% (18 aa) APEIILGIEYTTKSDVWSLGCIMYELLT-GET ||| | ..|||||||| | |.|..| ||. APECINYGKFTTKSDVWSFGVLMWEIFTYGEQ |
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| Kinase | 17985.AA | CLK | 430-461 | 34 | 7e-06 | 12.79 | In-house | 319-350 (350) | Show / Hide |
Range on Protein: 430-461 Range on HMM: 319-350/350 Sequence Identity: 34% (11 aa) ESSLLYDFLRYLLSPNPEQRPSLEEALQHVWI | | | .| .| | .|... .|||| . EHRQLFDLIRKMLEYDPSKRITCKDALQHPFF |
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| Kinase | 17985.AA | DYRK | 429-461 | 30 | 9e-06 | 17.93 | In-house | 288-320 (320) | Show / Hide |
Range on Protein: 429-461 Range on HMM: 288-320/320 Sequence Identity: 30% (10 aa) RESSLLYDFLRYLLSPNPEQRPSLEEALQHVWI .. ... ||.. .| .|..|.. ..|||| |. CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF |
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| Kinase | 17985.AA | JNK | 445-461 | 52 | 0.002212 | 8.57 | In-house | 293-309 (309) | Show / Hide |
Range on Protein: 445-461 Range on HMM: 293-309/309 Sequence Identity: 52% (9 aa) NPEQRPSLEEALQHVWI ||..| | ..|||| | NPDDRISVDDALQHPYI |
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