Gene 18785 (Tetrahymena)

18785

Species: Tetrahymena
Alias: 1055, TTHERM_00237410, 3706.m00016, PreTt18785, 18785, 20.m00249
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
18785.AA Protein None 508 None Fasta, JSON
18785.kin_dom Protein Kinase Domain None 268 None Fasta, JSON
18785.NA RNA None 1527 None Fasta, JSON

Protein domain

Protein domains of 18785.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 18785.AA Ciliate-E2 136-403 24 4.9e-81 275.53 In-house 1-365 (365) Show / Hide 
Range on Protein: 136-403
Range on HMM: 1-365/365
Sequence Identity: 24% (93 aa)

YELGRKIGEGGNSVVKEC------------FIKHVNLDESQ----KAK---YAVKIVKFSDTEQLFNIIEEQR-------------IMNMLKHQNIVELI
|.. .|||.|. ..|..|            .|.  ..  .|    |.|   ||.||.| .. ||....| . |             |.  |.| ||....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

DFFIDKNKHSVQLVMEYCEGKSLTKLIQKR-----------HPFSQEEVKYITRTLLK---------------SLHYIHLKG-ICHRDLSNNNVIFDVNT
..|..|..... ||||||.|..| ..|...           ..|. .|.|||.. .|.                |.|.| |. |.|||.  .|..|    
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

RKVKLIDFSVSKEYRNK--------HRKMWTKTG------------------------TLQFVAPESIMEENDG-------YNPKIDIWSIGVIMFSLLT
  .|.|||  ||.| ..        ..|...  .                        |. ..||| .. ....       |. |.||||.|||.. .|.
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GDLPFIDPNDSELGLIDLIIHSEPDYEKYM-------------ANNQISPEAYNLLTK----LLEKDPKNRIT-LRDALQHEWL
| .||          .. |.  . |. ..               ....|.|. .|. |    .|.|||..|||   ..|.|.|.
GKPPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 18785.AA S_TKc 136-403 29 4.4e-74 253.35 SMART 1-231 (231) Show / Hide 
Range on Protein: 136-403
Range on HMM: 1-231/231
Sequence Identity: 29% (85 aa)

YELGRKIGEGGNSVVKECFIKHVNLDESQKAKYAVKIVKFSDTEQLFNIIEEQRIMNMLKHQNIVELIDFFIDKNKHSVQLVMEYCEG--KSLTKLIQKR
||..||||.|. ..|. |  |.       . ..|.||.|        .|. | .|. . .| ||| |.|.| |   ... .|||||.|   .| ..|.||
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKR

HP------FSQEEVKYITRTLLKSLHYIHLKGICHRDLSNNNVIFDVNTRKVKLIDFSVSKEYRNKHRKMWTKTGTLQFVAPESIMEENDGYNP-KIDIW
 .      |.  ....... ... | |.| .||.||||   |. .|     .|..|| .....        |  ||. ..||| .     ||.. |.|.|
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL-----GYGKCKCDWW

SIGVIMFSLLTGDLPFIDPNDSELGLIDLIIHSEPDYEKYMANNQISPEAYNLLTKLLEKDPKNRITLRDALQ-------HEWL
|.|.|.. .|.|  ||      .  ....|                |||| ... |.|.|||..|.|  .|||       |.|.
SCGCILYEMLCGYPPFP----QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 18785.AA CAMK 141-403 19 1.4e-72 232.96 In-house 1-425 (425) Show / Hide 
Range on Protein: 141-403
Range on HMM: 1-425/425
Sequence Identity: 19% (84 aa)

KIGEGGNSVVKECFIKHVN-------LDESQKAKYAVKIVKFS----------------------------DTEQLFNIIEEQRIMNM-------LKHQN
..|.|. ..||.|. |. .       . .  . |.|.||.. .                            . . . |.  | .||..       |.| |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

IVELIDFFID-----------KNKH-------SVQLVM---EYCEGK----SLTKLIQKRHP---------------FSQEEVKYITRTLLKSLHYIHLK
|. |.... |             ..        . .||   |||.|      |   |... .               |. .|.... | ..  .||.| .
IIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

GICHRDLSNNNVIFDVNT----------------RKVKLIDFSVSKEYRNKHR-----------------------KMWTKTGTLQFVA-PESIMEE---
.|.||||   |. .| |                  ..|.|||  ..... ..                        ||.|  ||. ..| || .  .   
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

---------NDGYNPKIDIWSIGVIMFSLLTGDLPFIDPND-----------SELGLIDLIIHSEPD-YEKYMA-------------------NNQISPE
         ...|.||.|.||.|||.. .|.| .|| ...|           ..  |   |.  . | ...|.                    . ..|.|
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVSQE

AYNLLTKLLEKDPKNRITLRDALQHEWL
. .|. |.|..||..|.|. ..|.|.|.
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 18785.AA Ciliate-E2-Unclassified 136-403 26 4.6e-72 245.73 In-house 1-352 (352) Show / Hide 
Range on Protein: 136-403
Range on HMM: 1-352/352
Sequence Identity: 26% (94 aa)

YELGRKIGEGGNSVVKECFIKHVNLD-----ESQKAKYAVKIVKFSDTEQLFNIIEEQR---------------IMNMLKHQNIVELIDFFIDKNKHSVQ
|.....||.||...|..|  |  ..       ... .|..|.....| | .....|...               |. ...| .|| ... | ||..  . 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQN--IY

LVMEYCEGKSLTKLIQKR-----------------HPFSQEEVK-----YITRTLLKSLHYIHLKG-ICHRDLSNNNVIFDVNTR--KVKLIDFSVSKEY
.|||||||..| . |.||                 . |. ...|     .... .|. | |.| |. |.|||.  .|..|| | .  ..|.|||. ||.|
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

---------------RNKHRKMWTKTGTLQFV----APESIMEENDGYN--PKIDIWSIGVIMFSLLTGDLPFIDPNDSE--------------LGLIDL
               ..|. .|||..||...     ||| ....| .     |.|||| |||.. .|.| .|| |.|. .              . |.. 
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

IIHSEPDYEKYM---ANNQISPEAYNLLT----KLLEKDPKNRITLRDALQHEWL
|.  .... |.    .  ..|||| ....    |.|.|.|..|||. ..|.| |.
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 18785.AA Pkinase 136-403 30 6.2e-65 226.84 Pfam 1-293 (293) Show / Hide 
Range on Protein: 136-403
Range on HMM: 1-293/293
Sequence Identity: 30% (94 aa)

YELGRKIGEGGNSVVKECFIKHVNLDESQKAKYAVKIVKFSDTEQLFNIIE----EQRIMNMLKHQNIVELIDFFIDKNKHSVQLVMEYCEGK----SLT
|..|||||.|. ..|..|  |  .       ..||||.| ....  ....     | .||..|.| |||.|.|.| | ..|   .|||||||     .| 
YHIGRKIGSGSFGCVYKCHHKGTGK------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIY-MVMEYCEGGLYVMDLF

KLIQ--KRHPF--SQEEVKYITRTLLKSLHYIHLKGICHRDLSNNNVIFDVNTRKV----KLIDFSVSKEY-RNKHRKMWTKTGTLQFVAPESIMEENDG
 .|.  .. .|  | .|.| . . .|. | |.| .||.||||   |. .| |.  .    |..|| ..| .   . . |.| .||. ..||| |. .. .
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQY

YNPKIDIWSIGVIMFSLLTGDLPFIDP----NDSELGLIDLIIHSEPDYEKYMANN----------------QISPEAYNLLTKLLEKDPKNRITLRDAL
| ||.|.||.|.|.. .|.| .|| .     |.... .|..| . ..... .  ..                 .|.|.  .....|.|||| |.| ...|
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL

QHEWL
||.|.
QHPWF
Kinase 18785.AA CAMK-Unique 136-403 22 3.9e-61 200.5 In-house 1-363 (363) Show / Hide 
Range on Protein: 136-403
Range on HMM: 1-363/363
Sequence Identity: 22% (85 aa)

YELGRKIGEGGNSVVKECFIKHVNLDESQKAKYAVKIVKFSDTEQLFNII--------------------EEQRIMNMLKHQNIVELIDF----FIDKNK
|...| ||.|. ..|.||.      | . . |.|.|.||. . .   ...                    .| .|. |..|.||..| |.    | |...
YKMHRIIGHGNFGHVYECM------DRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKY

--------------HSVQLVMEYCEGKSLTKLIQK--------------------RHPFSQ--EEVKYITRTLLKSLHYIHLKGICHRDLSNNNVIFDVN
              . . .|||||.|. | ..|||                    . .||    ..  | . ||  . | | ..| ||||   |. .  .
PLCDLIIKTPRALPYMY-IVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYS

---------------TRKVKLIDFSVSKEYRNKHRK--MWTKTGTLQFVAP--------------ESIMEENDGYNPKI----DIWSIGVIMFSLLTGDL
                 ..||.||  ...|....    | |  ||. ..||              | |..  ..|  .     ||||.||||...|.| .
FKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINM--QCYDQQCSPASDIWSLGVIMYYMLCGCP

PFIDPNDSE------LGLIDLIIHSEP-DYEKYMANNQ--ISPEAYNLLTKLLEKDPKNRITLRDALQHEWL
||  ...         .... |   .. .... | .    ||.||......... ||. |...  .|.|.|.
PFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 18785.AA CAMKL 136-403 27 1.5e-59 188.66 In-house 1-297 (297) Show / Hide 
Range on Protein: 136-403
Range on HMM: 1-297/297
Sequence Identity: 27% (84 aa)

YELGRKIGEGGNSVVKECFIKHVNLDESQKAKYAVKIVK----FSDTEQLFN-----------IIEEQRIMNMLK---HQNIVELIDFFIDKNK----HS
|..|. .|.|. ..|| .  .  .     . |.|.||..      |.  . |           |  | .|| ||.   |.||. | . . ....      
YRIGKTLGKGSFGKVKLATHIRTT-----GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKK

VQLVMEYCEGKS--LTKLIQKR----HPFSQEEVKYITRTLLKSLHYIHLKGICHRDLSNNNVIFDVNTR-KVKLIDFSVSKEYRN----KHRKMWTKTG
..||||||.| .  |   |.|.     ... .| . . | ..  ..|.| .||.|||.   |. .| | . ..|.|||  | .||.    . .|. |  |
IYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCG

TLQFVAPESIMEENDGYN-PKIDIWSIGVIMFSLLTGDLPFIDPND-----SELGLIDLIIHSEPDYEKYMANNQISPEAYNLLTKLLEKDPKNRITLRD
.. . ||| .   |. |. ||.||||.|||.. ...| ||| |...     .   .  ..| .   |  .   ...| .. .|. |.|...|. |.|. .
SPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YY--PPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQ

ALQHEWL
 ..|.|.
IMNHPWM
Kinase 18785.AA Ciliate-E2a 136-403 32 1.4e-54 159.07 In-house 1-275 (275) Show / Hide 
Range on Protein: 136-403
Range on HMM: 1-275/275
Sequence Identity: 32% (91 aa)

YELGRKIGEGGNSVVKECFIKHVNLDESQKAKYAVKIVKFSDTEQ--LFNIIEEQRIMNMLKHQNIVELIDFFIDKNKHSVQLVMEYCEGKSLTKLIQKR
|.. .|||.|   .|     ..... .  | . ..|. |.   .    .... |  || .|.| ||  |.....|.|  .  ||||||||..| . |.. 
YKFIKKIGKGNFGSV-----YLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDEN--NYYLVMEYCEGGELYDKIKQC

HPFSQE--EVKYITRTLL-KSLHYIHLKGICHRDLSNNNVIFD---VNT---RKVKLIDFSVSKEYR-NKHRKMWTKTGTLQFVAPESIMEEND----GY
. | .|  |.. | . || . |||.| ..| ||||   |..|.    |     ..|.|||  .. .  .. ..| .| ||  .|||| .  . .     |
KRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQY

NPKIDIWSIGVIMFSLLTGDLPFIDPNDSELGLIDLIIHSEPDYEKYMANNQISPEAYNLLTKLLEKDPKNRITLRDALQHEWL
  | |.||.|||.. ||.| .||   . .|   . ..   . |..     ...| |...|. |.||||||.|||  .||.| | 
DTKCDMWSCGVIFYILLCGKPPFKGKTYNE--ILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 18785.AA STE 136-403 22 1.3e-52 181.1 In-house 1-359 (359) Show / Hide 
Range on Protein: 136-403
Range on HMM: 1-359/359
Sequence Identity: 22% (84 aa)

YELGRKIGEGGNS-VVKECFIKHVNLDESQKAK---------YAVKIVKFSDT-----------------EQLFNIIEEQRIMNMLK--HQNIVELIDFF
.|. .|||.|.   |.| . .|  |.. . . .         .|.|......                  |.. .|..| .||. ..  |.|||. .. .
WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

I-----DKNKHSVQLVMEYCEGKSLTKLIQ---KR-----------HPFSQEEVKYITRTLLKS-LHYIHLKGICHRDLSNNNVIFDVNTRKVKLIDFSV
.     .||.... ..|||..| ||...|.   ..           |.|. ....||.| .||  |.|.| ..| |||.   |. .      |||.|| |
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGV

SKEYRNKHR----------------KMWTKTGTLQFVAPESIMEE----NDGYNPKIDIWSIGVIMFSLLTGDLPFID-PNDSELGLIDLIIHSEP----
..   ....                |  | .||  . ||| |. .    ..||. | ||||.|  .  ..||  |. | .. . . .|   .|...    
CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQ

------DYEKYMA-----------------NNQISPEAYNLLTKLLEKDPKNRITLRDALQ--HEWL
      .  .                      . |||  . . | |.|||..| |  . |.  |...
LCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 18785.AA RSK 135-403 27 3.2e-50 173.17 In-house 1-278 (278) Show / Hide 
Range on Protein: 135-403
Range on HMM: 1-278/278
Sequence Identity: 27% (80 aa)

IYELGRKIGEGGNSVVKECFIKHVNLDESQKAKYAVKIVKFSDTEQ----LFNIIEEQRIMNMLK-HQNIVELIDFFIDKNKHSVQLVMEYCEGKSLTKL
. .|| ..| |  .....|       .. ..  ||.|..| .   |    .    .|..|. . . |..||.| . | .. |  . |.||||.|  |.. 
LKVLG-QGGYGKVFLCRKC------THHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGK--LYLIMEYCRGGELFTH

IQKRHP---FSQEEVKYITRTLLKSLHYIHLKGICHRDLSNNNVIFDV--NTRKVKLIDFSVSKEYRNK-HRKMWTKTGTLQFVAPESIMEEN-DG-YNP
.||.     || .|.... ... . . ..| .|| ||||   |...|   | . .||.||  .|. |..   .. |  .|....||| ... | .| .. 
LQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDK

KIDIWSIGVIMFSLLTGDLPFIDPND-SELGLIDLIIHSE--PDYEKYMANNQISPEAYNLLTKLLEKDPKNRIT-----LRDALQHEWL
  |.|| ||.|. .||| .||  ||| .   ... | . .  .   . .... .|.|| .|..|.|..||..|..     . . .||.|.
ACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSL---TMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 18785.AA MSK 136-403 30 6.2e-47 156.68 In-house 1-277 (277) Show / Hide 
Range on Protein: 136-403
Range on HMM: 1-277/277
Sequence Identity: 30% (90 aa)

YELGRKIGEGGNSVVKECFIKHVNLDESQKAKYAVKIVK----------FSDTEQLFNIIEEQRIMNMLKHQNIVELIDFFIDKNKHSVQLVMEYCEGKS
 ... ..|.|  .... |       . .. . ||.||..           . | ..  . |  .     .| |||.| . | |. .    |||||| |  
LKVLGTGGYGKFFICRKC------VHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQ-----QHPNIVNLHYAFQDQCH--TYLVMEYCNGGE

LTKLIQKRHPFSQEEVKYITRTLLKSLHYIHLKGICHRDLSNNNVIFDVN--TRKVKLIDFSVSKEYRNK-HRKMWTKTGTLQFVAPESIME--ENDG-Y
|.  | ||  |. .|. .| | |   . ..| ||| ||||   |. || .   ..||||||  ...  .    .| .  .||.. ||| . .  ..|| |
LFTHIRKREHFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGY

NPKIDIWSIGVIMFSLLTGDLPFI----DPN---DSELGLIDLIIHSEPDYEKYMANNQISPEAYNLLTKLLEKDPKNRITLRDALQHEWL
.. .|.|| |||.. .|||  ||     |      |   .   | ..|. ..  || ...||.| .|...||.|||| | .. | ..|||.
DEACDWWSLGVILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPG-MAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase 18785.AA CMGC 136-357 19 3.1e-38 122.6 In-house 1-367 (513) Show / Hide 
Range on Protein: 136-357
Range on HMM: 1-367/513
Sequence Identity: 19% (71 aa)

YELGRKIGEGGNSVVKECFIKHVNLD--------ESQKAKYAVKIVK--FSDTEQLF----------NIIEEQRIMNMLK-----------------HQN
||  .|||||  .|| .|. |. |             . ..|.|..|  | ..||             .. | .|. .|.                 | |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVELIDFFIDKN---------------KHSVQLVMEYCEGKSLTKLIQKRH---------PFSQEE------------VKYIT------RTLLKSLH--Y
|| |.|.| .||                 .. ||.||.. ..| ..|.. .         |.|. .            .||..      . .|..|.  |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMD-HDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

IHLKG--ICHRDLSNNNVIFDVNTRK-------------------VKLIDFSVSKEYRNK---------------------HRKMWTKTGTLQFVAPESI
.| ..  |.||||   |. .. |..                    .|..||  .. | .                       | . .   |.   ||| .
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

MEEN--------DGYNPKIDIWSIGVIMFSLLTG-------DLPFIDPNDSE----------LGLIDLII
.           ..|...||.||.| |.. ..||         |.  .....          .  ...|.
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIF
Kinase 18785.AA CMGC 368-403 41 4.4e-13 38.4 In-house 478-513 (513) Show / Hide 
Range on Protein: 368-403
Range on HMM: 478-513/513
Sequence Identity: 41% (15 aa)

ANNQISPEAYNLLTKLLEKDPKNRITLRDALQHEWL
......|.| .|| |.|. ||..|||  .||||...
KRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 18785.AA TyrKc 136-403 24 6.6e-13 -14.0 SMART 1-280 (280) Show / Hide 
Range on Protein: 136-403
Range on HMM: 1-280/280
Sequence Identity: 24% (74 aa)

YELGRKIGEGGNSVVKECFIKHVNLDESQKAKYAVKIVKFSDTEQLFNIIEEQRIMNML--KHQNIVELIDFFIDKNK-----HSVQLVMEYCEGKSLTK
 .||.|.|||   .| ..  |          . ||| .| .    .  ...| ||| .|  .|.||| |.   ...       . . .||||... .| .
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

LIQKRHP-FSQEEVKYITRTLLKSLHYIHLKGICHRDLSNNNVIFDVNTRKVKLIDFSVSKEYRNK---------HRKM---WTKT-GTLQFVAPESIME
 ..|..| .. ..  ..     .   |.| |.. ||||   |.  . |   ||  ||  |..  ..          ||.    .||   .   |||.|  
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

ENDG-YNPKIDIWSIGVIMFSLLT-GDLPFIDP--NDSELGLIDLIIHSEPDYEKYMANN-------QISPEAYNLLTKLLEKDPKNRITLRDALQHEWL
 |.| ...| |.|| || |. ..| |. |  ..  .   .  ...| . .  |      |         ..| |.. ..  . ||..| | ..   || .
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 18785.AA Pkinase_Tyr 136-223 27 9.5e-09 30.25 Pfam 1-91 (270) Show / Hide 
Range on Protein: 136-223
Range on HMM: 1-91/270
Sequence Identity: 27% (26 aa)

YELGRKIGEGGNSVVKECFIKHVNLDESQKAKYAVKIVKFSDTEQ---LFNIIEEQRIMNML-KHQNIVELIDFFIDKNKH-SVQLVMEYCEG
 ..|.|.|||   .|...  |   .....| . |||..| . ...   .   ..| .||  | .|.||| |.   .|. .. .. .||||...
ITFGKKLGEGAFGEVYKGTWKG--DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPH