Gene 19298 (Tetrahymena)
19298
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 19298.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 19298.AA | Ciliate-E2 | 455-637 | 16 | 2.8e-20 | 66.29 | In-house | 150-365 (365) | Show / Hide |
Range on Protein: 455-637
Range on HMM: 150-365/365
Sequence Identity: 16% (44 aa)
IFYDILT---------------GLDVIHSSK-LAHNDIKPDNMLFFSSSSSAKLCDFERCNSQSFD----------LKRTDFV-----------------
|.. || .| .|| . | ||||.| || |..|| . .. | . ..
IMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQN
----------YQSPEIVQIYKEYKRTNEINTKLFHLDLLKNDIFSFGVTLFSTMFGFYPFADQFEKNNQDELYSLLISADRDQFWQEKEISSICQTIEHN
|..|||.. |... .... | ||.|.||.|. .|| .|| | . ..
MFNTICGTPGYMAPEILNGKKYDNQ------QKQKGYDYKCDIWSLGVILYEMLFGKPPF----------------------------------QQQIKQ
TNFSYLYNF----------------------KKFIED----TLEENPSNRID-TSSLMNHDFF
.... .. | .| |. .|..||. . ..|| .|
CKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
|
|||||||||
| Kinase | 19298.AA | Ciliate-A7 | 324-637 | 22 | 3.5e-18 | 62.67 | In-house | 23-360 (360) | Show / Hide |
Range on Protein: 324-637 Range on HMM: 23-360/360 Sequence Identity: 22% (86 aa) KNVVLKTYFHQNNV------EQCN---QECDKLGKEFYILQKFSGHPYIIQAYSLEHDLNLPKVNAKRINQNQYSDNPYNCSLVMEQATCDLITYFTQDV ...|. . | .. ||| |||. | .|...|.| . || ||.. . |.| ..... .. . | . |||| ||| .||.| . YQIVKVKKHHEHMMYNLEGREQCCHHCQECYMLKNEYNFLKKMD-HPHIIMLFEQFNDYN---------MDEFWHHRNC-CCILMEQAECDLFQYFSQHY YKTHPHHY--------YKFLQNKHQYSILCSNDFSTQVKNSFYNCFPGIFYDILTGLDVIHS-SKLAHNDIKPDNMLFFSSSS-----SAKLCDFERCNS . .|| | | .|. | .|. .|. ...|||||||.|.. |.. .|| || ... PHKNLHHNEKIENQCEY------------------------CVNQMRHCFRQIAQALHYLHNEKNIAHNDIKPENIFIFCNNNQQNQYCFKLADFGFAKK QSFDLKRT---------DFV---------YQSPEIVQIYKE--------YKR---TNEINTKLFHLDLLKNDIFSFGVTLFSTMFGFYPFADQFEKNNQD .|. .. |.. |..|||... .. | ... | ..| |. | |.|.|||..| |.. ||. ... . | YQFQSHFESTLRQQIIEDQYKNWKYRCKQYFAPEIINCLNKCCDKNSAKNKKFISQQIDNQCEF--DEKKCDVFAFGVSFFQILFQQNPFC-CEACHQND EL-YSLLISADRDQFWQEKEISSICQTIE-------HNTNFS--YLYNFKKFIEDTLEENPSNRIDTSSLMNHDFF . |.... ||| |... . .. || .. . . | .. .|. ||| |. .. . | .| PYKYKHYFQKTYSKFWQWMQIQWMWNHFQKEIQDMIKNTDQQQQDIDQMKDLLNKMLCPNPSQRYCIKQILQHPWF |
|||||||||
| Kinase | 19298.AA | Ciliate-E2-Unclassified | 455-637 | 21 | 9.7e-17 | 54.61 | In-house | 148-352 (352) | Show / Hide |
Range on Protein: 455-637
Range on HMM: 148-352/352
Sequence Identity: 21% (49 aa)
IFYDILTGLDVIHSSK-LAHNDIKPDNMLFFSSSS--SAKLCDFERCN-------------------SQSFDLKRT---DFV--YQSPEIVQIYKEYKRT
.|. || ||. .|... | ||||.| || .. . |..|| . .| .. . |..||. | . ....
YFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSK
NEINTKLFHLDLLKNDIFSFGVTLFSTMFGFYPFAD-QFEKNNQDE-----------LYSLLISADRDQFWQEK----EISSICQ--TIEHNTNFSYLYN
| ||.|.|| |. .|| ||| | . |...|.. ||. . . ....... ..| .. |.
A-----------YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN----------
FKKFIEDTLEENPSNRIDTSSLMNHDFF
... |. ||..||. . ..|| .|
--DLLQKMLKKNPNKRITFEQILNHPWF
|
|||||||||
| S_TKc | 19298.AA | S_TKc | 290-637 | 16 | 1e-11 | -5.17 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 290-637
Range on HMM: 1-231/231
Sequence Identity: 16% (59 aa)
SHNAKLIAKGSQSHIYSLAVDIPSNSHCEFQPEIKNVVLKTYFHQNNVEQCNQECDKLGKEFYILQKFSGHPYIIQAYSLEHDLNLPKVNAKRINQNQYS
. ..| ||. . | ..... . | .| ... .| ||.| .||.|.. | .|
YEILRKIGKGAFGKVY-KCRHKK---------TGRIVAIKIIK------------EHIRREIQILKK--HHPNIVKLYDVFQD-----------------
DNPYNCSLVMEQATC---DLITYFTQDVY----KTHPHHYYKFLQNKHQYSILCSNDFSTQVKNSFYNCFPGIFYDILTGLDVIHSSKLAHNDIKPDNML
. .||| . || .| . . . | .| ..| |. .|. .|| . | |.||.| |
---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF-----------------------------YMYQICCALEYCHSHGIIHRDLKPENIL
FFSSSSSAKLCDFERCNSQSFDLKRTDFV----YQSPEIVQIYKEYKRTNEINTKLFHLDLLKNDIFSFGVTLFSTMFGFYPFADQFEKNNQDELYSLLI
. . |.||| . | |. | .||.. . . | |. |.|..|. . | || ...... ..
LDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL-----------------GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG
SADRDQFWQEKEISSICQTIEHNTNFSYLYNFKKFIEDTLEENPSNRIDTSSLMN-------HDFF
.| ||. |. .|..|. ... | .|
----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
|||||||||
| Kinase | 19298.AA | Pkinase | 541-637 | 17 | 9.3e-10 | 35.59 | Pfam | 192-293 (293) | Show / Hide |
Range on Protein: 541-637 Range on HMM: 192-293/293 Sequence Identity: 17% (19 aa) KNDIFSFGVTLFSTMFGFYPFADQ---FEKNNQDELYSLLISADRDQFWQEK------EISSICQTIEHNTNFSYL--YNFKKFIEDTLEENPSNRIDTS | |..|.|..|. ..| || .. . ..|.... . ... . |... . .. . . .. | .. ..|.||.. |. .|. |. KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAE SLMNHDFF ...|..| QILQHPWF |
|||||||||
| Kinase | 19298.AA | Ciliate-E1 | 455-537 | 25 | 1.6e-09 | 27.59 | In-house | 114-202 (202) | Show / Hide |
Range on Protein: 455-537 Range on HMM: 114-202/202 Sequence Identity: 25% (23 aa) IFYDILTGLDVIHSSKLAHNDIKPDNMLFFSSSSSAKLCDFERCN------SQSFDLKRTDFVYQSPEIVQIYKEY--KRTNEINTKLFHL |..... || .|. .. | ||||.| |. .. . ..||| . |. . | |..|| ... |. .....|| |. IIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCP-EQEHNKNQKINYKSDIY |
|||||||||
| Kinase | 19298.AA | LKB | 454-495 | 35 | 2.5e-09 | 23.93 | In-house | 108-148 (265) | Show / Hide |
Range on Protein: 454-495 Range on HMM: 108-148/265 Sequence Identity: 35% (15 aa) GIFYDILTGLDVIHSSKLAHNDIKPDNMLFFSSSSSAKLCDF ..| . |.. .|| . | ||||.|.| .. |.||| FYFCQLCDGCEYLHSQRVVHKDIKPGNLL-LTHDNTLKICDF |
|||||||||
| Kinase | 19298.AA | WEE | 454-552 | 26 | 5.6e-09 | 26.33 | In-house | 115-227 (297) | Show / Hide |
Range on Protein: 454-552
Range on HMM: 115-227/297
Sequence Identity: 26% (33 aa)
GIFYDILTGLDVIHSS-KLAHNDIKPDNMLFFSSSS--------------------SAKLCDFERCNSQSF---DLKRT---DFVYQSPEIVQIYKEYKR
.|. ||..|| |||. . |.||||.| .|.|. . |. || ..... . . . |. |..|||.|
QILVDICQGLHHIHSNCGMVHMDIKPEN-IFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTDMNSNNNNPHQEQEGDSRYMAPEILQG------
TNEINTKLFHLDLLKNDIFSFGVTLF
. .|.| ||||.| |..
------YYHYTHLYKADIFSLGITIY
|
|||||||||
| Kinase | 19298.AA | CAMK | 543-637 | 17 | 9.9e-09 | 23.51 | In-house | 316-425 (425) | Show / Hide |
Range on Protein: 543-637 Range on HMM: 316-425/425 Sequence Identity: 17% (21 aa) DIFSFGVTLFSTMFGFYPFADQFEKN---------NQDELYSLLISADRDQFWQEKEISSICQTIEHNTNFSYLY------------------NFKKFIE |. | || |. |..|| . ... |. ||. .... | . . ..|. | | .| DMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCN------------YGPEWWDDISDEFHHFVSQECKDLIR DTLEENPSNRIDTSSLMNHDFF |. .|..|. . .|| .. KMLQVDPEKRMTIEQCLNHPWM |
|||||||||
| Kinase | 19298.AA | STE | 455-495 | 45 | 2.1e-08 | 25.94 | In-house | 156-191 (359) | Show / Hide |
Range on Protein: 455-495 Range on HMM: 156-191/359 Sequence Identity: 45% (19 aa) IFYDILTG-LDVIHSSKLAHNDIKPDNMLFFSSSSSAKLCDF | ..|| | |. .|| . | ||||.| |. .||||| ICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDF |
|||||||||
| Kinase | 19298.AA | CMGC | 455-495 | 26 | 1.5e-07 | 19.89 | In-house | 185-248 (513) | Show / Hide |
Range on Protein: 455-495 Range on HMM: 185-248/513 Sequence Identity: 26% (17 aa) IFYDILTGLD--VIHSSK--LAHNDIKPDNMLFFSSSSS-------------------AKLCDF ..| ||.||. .|| . | |.|| | |. . . |.||| YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDF |
|||||||||
| Kinase | 19298.AA | CAMK | 455-495 | 22 | 3.7e-07 | 18.34 | In-house | 184-240 (425) | Show / Hide |
Range on Protein: 455-495 Range on HMM: 184-240/425 Sequence Identity: 22% (13 aa) IFYDILTGLDVIHSSKLAHNDIKPDNMLFFSSS----------------SSAKLCDF .| |. ... .|| . .| |.||.| |. ... |..|| YFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDF |
|||||||||
| Kinase | 19298.AA | STE | 609-637 | 35 | 1e-06 | 19.55 | In-house | 329-359 (359) | Show / Hide |
Range on Protein: 609-637 Range on HMM: 329-359/359 Sequence Identity: 35% (11 aa) NFKKFIEDTLEENPSNRIDTSSLMN--HDFF .|| ||. |. .|..| ..| |.. | |. EFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
|||||||||
| Kinase | 19298.AA | CDKL | 455-495 | 36 | 3e-06 | 17.61 | In-house | 103-143 (286) | Show / Hide |
Range on Protein: 455-495 Range on HMM: 103-143/286 Sequence Identity: 36% (15 aa) IFYDILTGLDVIHSSKLAHNDIKPDNMLFFSSSSSAKLCDF . . || ... |. . | |||| | | ... ||||| YMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDF |
|||||||||
| Kinase | 19298.AA | CDKL | 613-637 | 32 | 0.00022 | 10.9 | In-house | 262-286 (286) | Show / Hide |
Range on Protein: 613-637 Range on HMM: 262-286/286 Sequence Identity: 32% (8 aa) FIEDTLEENPSNRIDTSSLMNHDFF |.. |. .|. |. .. ||.|..| FMKKCLHMDPDERMTCEQLMHHPYF |
|||||||||
| Kinase | 19298.AA | CMGC | 613-637 | 24 | 0.001031 | 7.05 | In-house | 489-513 (513) | Show / Hide |
Range on Protein: 613-637 Range on HMM: 489-513/513 Sequence Identity: 24% (6 aa) FIEDTLEENPSNRIDTSSLMNHDFF ... |. .|..|| . ..|..| LLKKMLQYDPDKRITAEQALQHPYF |
|||||||||
| Kinase | 19298.AA | Pkinase | 455-495 | 37 | 0.001438 | 13.7 | Pfam | 113-156 (293) | Show / Hide |
Range on Protein: 455-495 Range on HMM: 113-156/293 Sequence Identity: 37% (17 aa) IFYDILTGLDVIHSSKLAHNDIKPDNMLFFSSSSSA----KLCDF ..| || ||. .|| . | |.||.| |. . |.||| YMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDF |
|||||||||
| Kinase | 19298.AA | WEE | 610-637 | 21 | 0.026799 | 3.6 | In-house | 270-297 (297) | Show / Hide |
Range on Protein: 610-637 Range on HMM: 270-297/297 Sequence Identity: 21% (6 aa) FKKFIEDTLEENPSNRIDTSSLMNHDFF .| .| .....|..|. ...|..|. LKQLIKWMMHPDPEQRPTCQQLLQHPVL |
|||||||||
| Kinase | 19298.AA | LKB | 541-561 | 57 | 0.05102 | 1.85 | In-house | 189-209 (265) | Show / Hide |
Range on Protein: 541-561 Range on HMM: 189-209/265 Sequence Identity: 57% (12 aa) KNDIFSFGVTLFSTMFGFYPF | || | ||||. | ||| KVDIWSMGVTLYNMTTGKYPF |
|||||||||
| Kinase | 19298.AA | Pkinase | 350-400 | 19 | 0.350538 | 5.26 | Pfam | 50-80 (293) | Show / Hide |
Range on Protein: 350-400 Range on HMM: 50-80/293 Sequence Identity: 19% (10 aa) EFYILQKFSGHPYIIQAYSLEHDLNLPKVNAKRINQNQYSDNPYNCSLVME | .|.... .||.|.. | .| . .. .||| EIQIMKRL-NHPNIVRLYDWFED-------------------KDHIYMVME |
|||||||||