Gene 21075 (Tetrahymena)
21075
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 21075.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 21075.AA | Ciliate-E1 | 247-374 | 23 | 2.8e-14 | 43.25 | In-house | 1-139 (202) | Show / Hide |
Range on Protein: 247-374 Range on HMM: 1-139/202 Sequence Identity: 23% (33 aa) LGNGGQGKVAT-FLDKNNNNIIALKEFARIQEFD--------RESK-IYKFLQEHTGLHDYINLMLDEDRSQRQIKMQMGCCNLYEMYI---HMKNYNTS .|||... | . ..||.| .|.| . ... .. .| . | | .... ....|. ... |... ||.|.. .. | . IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRL-EYWQQ FPKNQICWEQDHLIKIFRQLIHGLIAFRRNKFFHGDIKPHN . .||. . ......|. |||.|||... ... |.||||.| CQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQN |
|||||||||
| Kinase | 21075.AA | Ciliate-B2 | 336-377 | 42 | 6.3e-11 | 21.83 | In-house | 96-137 (197) | Show / Hide |
Range on Protein: 336-377 Range on HMM: 96-137/197 Sequence Identity: 42% (18 aa) KNQICWEQDHLIKIFRQLIHGLIAFRRNKFFHGDIKPHNLML | |.| .. |.... ||| ||| || . | |||| | . KQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILF |
|||||||||
| Kinase | 21075.AA | S_TKc | 241-575 | 12 | 1.5e-09 | -36.79 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 241-575
Range on HMM: 1-231/231
Sequence Identity: 12% (47 aa)
YLILEILGNGGQGKVATFLDKNNNNIIALKEFARIQEFDRESKIYKFLQEHTGLHDYINLMLDEDRSQRQIKMQMGCCNL--YEMYIHMKNYNTSFPKNQ
| ||...| |. ||| .|. . | |.|. . . || .| | | . .. . | . | | .|. ... ..|.... ....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK--HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGR--HGLR
ICWEQDHLIKIFRQLIHGLIAFRRNKFFHGDIKPHNLMLFSVENVFNHYMVKYIDLGAAGFEEKEYYEFYSDQFYHPEYL-------DM-----------
| ....|.. .| .... | |.|| |..| . .| .| | | . . . |.|. .
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------HIKICDFGLARQL--------TTFCGTPWYMAPEVLGYGKCKCDWWSCGCI
---IVMKEYVLSEVEVNICEIFAIIRSIWIIICFEREDVNNFKQYPELDFGIEFIKSKYPRLASLMQKVVDFKGDLDLIEKTINEDQLNESIINPLNSLC
. . . .. ..| .|.
LYEMLCGYPPFP----QMQMMFKKIG--------------------------------------------------------------------------
LIDPFKIDEYKQKYCHFDITQNYLKLSDQMKELIQNIIQMKKEKFINEQSEDQ------LQELF
|...|..|... |. || . | . . |
--------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
|||||||||
| Kinase | 21075.AA | Ciliate-E2-Unclassified | 241-377 | 17 | 9.3e-07 | 19.49 | In-house | 1-177 (352) | Show / Hide |
Range on Protein: 241-377 Range on HMM: 1-177/352 Sequence Identity: 17% (32 aa) YLILEILGNGGQGKVATFLDKNNNNIIALKEFARIQEFDRESKIYK----------FLQEHTGLHD----------------YINLMLDEDRSQRQIKMQ | |....|.||.||| .|... . |.|. ||.... .. .| . ... .. .| |....... | . YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV MGCCNLYEMYIHMKNYNT----------------SFPKNQICWEQDHLI---KIFRQLIHGLIAFRRNK-FFHGDIKPHNLML | |. .. ..|.... |. .|.. . ..|.|.. || ... . | |||| |... MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKY-----KKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILF |
|||||||||
| Kinase | 21075.AA | CASK | 348-382 | 25 | 3e-06 | 15.93 | In-house | 118-152 (330) | Show / Hide |
Range on Protein: 348-382 Range on HMM: 118-152/330 Sequence Identity: 25% (9 aa) KIFRQLIHGLIAFRRNKFFHGDIKPHNLMLFSVEN .. ||.. | . .. |.|..||.... |..| HYMRQILEALMYCHQWDHIHRDVRPHCRVMASKDN |
|||||||||
| Kinase | 21075.AA | STE | 241-398 | 17 | 4e-06 | 17.77 | In-house | 1-195 (359) | Show / Hide |
Range on Protein: 241-398 Range on HMM: 1-195/359 Sequence Identity: 17% (37 aa) YLILEILGNGGQGKVATFLDKN---------------NNNIIALKEFA----------------------RIQEFDRESKIYKFLQE-HTGLHDYINLML . ..|..|.|. |.| . .... ...|.| |. .|.. .| || | .. | |. . WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF DED--RSQR-QIKMQMGCCN---LYEMYIHMKNYNTSFPKNQ---ICWEQDHLIKIFRQLIHG-LIAFRRNKFFHGDIKPHNLMLFSVENVFNHYMVKYI .|. ... .. . | .. | ... | . . ....|. . . . ...| ||...| | ... | |||| | .| || . KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----------VKLC DLGAAG | | .| DFGVCG |
|||||||||
| Kinase | 21075.AA | CMGC | 241-291 | 18 | 4e-06 | 15.24 | In-house | 1-96 (513) | Show / Hide |
Range on Protein: 241-291 Range on HMM: 1-96/513 Sequence Identity: 18% (18 aa) YLILEILGNGGQGKVATFLD--------------KNNNNIIALKEFARIQEFD-----------------RESKIYKFLQ---------------EH | |.. .| | |.| | ...|.|.|.| . . . .. || || | |. .| YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKH |
|||||||||
| Kinase | 21075.AA | Ciliate-E3 | 241-270 | 40 | 1.7e-05 | 13.42 | In-house | 1-30 (202) | Show / Hide |
Range on Protein: 241-270 Range on HMM: 1-30/202 Sequence Identity: 40% (12 aa) YLILEILGNGGQGKVATFLDKNNNNIIALK |... |||.|. | | .| .||...| | YTVQQILGCGQFGRVYKAFDFQNNQDVAIK |
|||||||||
| Kinase | 21075.AA | Ciliate-E3 | 343-374 | 40 | 2.7e-05 | 12.78 | In-house | 102-133 (202) | Show / Hide |
Range on Protein: 343-374 Range on HMM: 102-133/202 Sequence Identity: 40% (13 aa) QDHLIKIFRQLIHGLIAFRRNKFFHGDIKPHN | ...|. |.| |.|| . |.|||| | QNIIYDICIQIIQGMIAIHEKNIIHSDIKPDN |
|||||||||
| Kinase | 21075.AA | DYRK2 | 241-270 | 36 | 9.1e-05 | 11.07 | In-house | 1-30 (318) | Show / Hide |
Range on Protein: 241-270 Range on HMM: 1-30/318 Sequence Identity: 36% (11 aa) YLILEILGNGGQGKVATFLDKNNNNIIALK | |||..| | | |. .|. .. .|.| YEILEVIGKGSFGQVVKCYDHKTKQHVAIK |
|||||||||
| Kinase | 21075.AA | Ciliate-E2 | 349-406 | 20 | 0.000152 | 11.5 | In-house | 165-212 (365) | Show / Hide |
Range on Protein: 349-406 Range on HMM: 165-212/365 Sequence Identity: 20% (12 aa) IFRQLIHGLIAFRRNK-FFHGDIKPHNLMLFSVENVFNHYMVKYIDLGAAGFEEKEYYE .....|..| .. .| |||| |... .| ||.| . . ..... YIACIILALEYLHSKNNIIHRDIKPENILF-----------IKIIDFGLSKKYDDDNQN |
|||||||||
| Kinase | 21075.AA | HIPK | 349-397 | 36 | 0.000273 | 8.87 | In-house | 106-152 (329) | Show / Hide |
Range on Protein: 349-397 Range on HMM: 106-152/329 Sequence Identity: 36% (18 aa) IFRQLIHGLIAFRRNKFFHGDIKPHNLMLFSVENVFNHYMVKYIDLGAA | | . |. . | |.|| |.|| |. . | || || | | ILQQVLTALMKLKELGLIHADLKPENIML--VDPTRCPYRVKVIDFGSA |
|||||||||
| Kinase | 21075.AA | DYRK2 | 347-377 | 25 | 0.002428 | 6.35 | In-house | 105-135 (318) | Show / Hide |
Range on Protein: 347-377 Range on HMM: 105-135/318 Sequence Identity: 25% (8 aa) IKIFRQLIHGLIAFRRNKFFHGDIKPHNLML .. ......| . ..|. |.| || | .| RRFAHSILQCLRFLHKNNIIHCDLKPENILL |
|||||||||
| Kinase | 21075.AA | HIPK | 241-270 | 36 | 0.003031 | 5.52 | In-house | 1-30 (329) | Show / Hide |
Range on Protein: 241-270 Range on HMM: 1-30/329 Sequence Identity: 36% (11 aa) YLILEILGNGGQGKVATFLDKNNNNIIALK | .||.|| | |.|. . | ..|.| YEVLEFLGRGTFGQVVKCWKRGTNEMVAIK |
|||||||||
| Kinase | 21075.AA | Ciliate-E2 | 241-290 | 15 | 0.003577 | 6.72 | In-house | 1-82 (365) | Show / Hide |
Range on Protein: 241-290 Range on HMM: 1-82/365 Sequence Identity: 15% (13 aa) YLILEILGNGGQG---KVATFLD--------------------KNNNNIIALKEF--ARIQEFDRESKIYK-------FLQE | .....|.|..| |. .. |....|.|.| . |... .| .|.. ...| YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINE |
|||||||||
| Kinase | 21075.AA | CMGC | 318-377 | 13 | 0.052729 | 1.33 | In-house | 139-217 (513) | Show / Hide |
Range on Protein: 318-377 Range on HMM: 139-217/513 Sequence Identity: 13% (11 aa) CNLYEMYIHMKN-----YNTSFPKNQ-------------ICWEQDHLIKIFRQLIHGLI--AFRRNK--FFHGDIKPHNLML ..||.. .... .. .. . . | ...|.. || ... ..| |.|| |... HDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILI |
|||||||||
| Kinase | 21075.AA | Ciliate-B2 | 241-253 | 30 | 0.06483 | 0.17 | In-house | 1-13 (197) | Show / Hide |
Range on Protein: 241-253 Range on HMM: 1-13/197 Sequence Identity: 30% (4 aa) YLILEILGNGGQG | . .....||.| YYLCKYINKGGCG |
|||||||||
| Kinase | 21075.AA | Ciliate-E2 | 521-561 | 22 | 0.107673 | 1.57 | In-house | 295-351 (365) | Show / Hide |
Range on Protein: 521-561 Range on HMM: 295-351/365 Sequence Identity: 22% (13 aa) PFKIDEYKQKYCHFDITQ-------------NYLKLSDQMKELIQN----IIQMKKEK || ... ||. . |. . ...|.|...| ||.. ..| . || PF-QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEK |
|||||||||
| TPR | 21075.AA | TPR | 725-758 | 14 | 0.807785 | 1.4 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 725-758 Range on HMM: 1-34/34 Sequence Identity: 14% (5 aa) GYICQVIGRLYVEINSYSNGLKYLKQALQIFECL .. .| .| . | ......||.. . AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
|||||||||
| TPR_2 | 21075.AA | TPR_2 | 725-756 | 18 | 18.042251 | 2.21 | Pfam | 1-32 (34) | Show / Hide |
Range on Protein: 725-756 Range on HMM: 1-32/34 Sequence Identity: 18% (6 aa) GYICQVIGRLYVEINSYSNGLKYLKQALQIFE ... .|..| . . | ..|...||.... AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDP |
|||||||||
| TPR_1 | 21075.AA | TPR_1 | 725-754 | 16 | 69.016535 | 0.1 | Pfam | 1-30 (34) | Show / Hide |
Range on Protein: 725-754 Range on HMM: 1-30/34 Sequence Identity: 16% (5 aa) GYICQVIGRLYVEINSYSNGLKYLKQALQI .. .| .| . . | ......||.. AEAWYNLGNCYYKMGNYDEAIECYQKALEL |
|||||||||
| TPR_2 | 21075.AA | TPR_2 | 786-819 | 17 | 17.127669 | 2.29 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 786-819 Range on HMM: 1-34/34 Sequence Identity: 17% (6 aa) QLTLIKLSQASLFLRHNNKALEYIDAAIQKGKQM . | |. . ... .|.|| ..|.. . AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| TPR_2 | 21075.AA | TPR_2 | 829-862 | 17 | 8.002133 | 3.46 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 829-862 Range on HMM: 1-34/34 Sequence Identity: 17% (6 aa) ASCLNIKSHILKQQNQDLQALELQNKCLEIRLKI | ... .. .|.. .|.|. .|.|.. . AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| TPR | 21075.AA | TPR | 917-950 | 32 | 1e-06 | 29.16 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 917-950 Range on HMM: 1-34/34 Sequence Identity: 32% (11 aa) ISCLRNFGIIYLKKGDYEKSESYFLQALELADKS . .. | | .|.|.|||.. . .. .||||. . AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
|||||||||
| TPR_2 | 21075.AA | TPR_2 | 917-950 | 32 | 2.3e-05 | 23.05 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 917-950 Range on HMM: 1-34/34 Sequence Identity: 32% (11 aa) ISCLRNFGIIYLKKGDYEKSESYFLQALELADKS ...| | .|.|.|||.. . |. .||.|. . AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
|||||||||
| TPR_1 | 21075.AA | TPR_1 | 917-950 | 29 | 0.000188 | 19.53 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 917-950 Range on HMM: 1-34/34 Sequence Identity: 29% (10 aa) ISCLRNFGIIYLKKGDYEKSESYFLQALELADKS . | | .|.|.|.|.. . .. .|||| . AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
|||||||||