Gene 22063 (Tetrahymena)

22063

Species: Tetrahymena
Alias: 83.m00132, 635, TTHERM_00599970, PreTt22063, 22063, 3685.m00024
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
22063.AA Protein None 648 None Fasta, JSON
22063.kin_dom Protein Kinase Domain None 128 None Fasta, JSON
22063.NA RNA None 1947 None Fasta, JSON

Protein domain

Protein domains of 22063.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 22063.AA S_TKc 26-296 11 2.2e-08 -54.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 26-296
Range on HMM: 1-231/231
Sequence Identity: 11% (35 aa)

CVKLENCGEGGFGTVDAYYDNNLQKVIAVKTVSRKTTYLQEKRRLINLKKQQLDFVNNLIGFCD-QERILVFELGEATLLEIDDMFQDDGY-----TWRE
  .|.  |.|.||.|   .... ... |.| ..   . ..| . | .    . ... .|..... ..  .|.|. .  | .  |. .. |.        |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK----HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

IDLIYIAWNLLVGLKYLREIKSFHGDISPNNIMFFMEKVKYIDLGSSEINKNNQYLQQYKIEFVNHEIRKNKANFKYSDEQI--------------T-QN
 .  .... .. .|.|. . .  | |. | ||..    .| .| |.. .                             . ..              .   
-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL----------------------------TTFCGTPWYMAPEVLGYGKCKC

EIFALGKTLLYLAL----YNDNDKNHFIMDVDKKSQKQLIEMQKAHFYELVANDSLSNSYPQLKNLIIKMMYPFDIDLNDIDQNLS-QSEDKEDSIK
 . ..| .|  ..     .      . .... .                           |..|..| |..     .   . . |  ... | .   
DWWSCGCILYEMLCGYPPFP---QMQMMFKKIG--------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 22063.AA Ciliate-E2-Unclassified 27-174 17 1e-06 18.91 In-house 2-203 (352) Show / Hide 
Range on Protein: 27-174
Range on HMM: 2-203/352
Sequence Identity: 17% (36 aa)

VKLENCGEGGFGTVDAYYDNN---------LQKVIAVKTVSRKTTYLQEKRRLINLKKQQLDFVNN-------------------LIGFCDQER---ILV
 ... .|.||||.|   ....         . |.. .|  . ..   .... .. .....  ....                      .|.| .   ..|
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

FELGEATLLEI----------------DDMFQDDGYTWREIDLI---YIAWNLLVGLKYLREIK-SFHGDISPNNIMFFME----KVKYIDLGSS-EINK
 |. |   |.                 ..| |.   | ...  .   .... .|.||.|| . .   | || |.||.|  .    ..| ||.|.| ....
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

NNQY
||..
NNNC
Kinase 22063.AA Ciliate-E1 32-207 17 3e-06 16.85 In-house 1-202 (202) Show / Hide 
Range on Protein: 32-207
Range on HMM: 1-202/202
Sequence Identity: 17% (36 aa)

CGEGGFGTVDAYYDNNLQ-KVIAVKTVSRKTTYLQE----KRRLINLKKQQLDFVNNLIGFCDQER-------ILVFELGEATLLEIDD---------MF
 |.|.|. |   . .| . ...|.| . ..  | |.    . . ... .. . .  ..| ..|. .       |..||. . .|..  .         ..
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

QDDGYTWREIDLIYIAWNLLVGLKYLREIKSFHGDISPNNIMFFM-EKVKYIDLGSSEI-NKNNQYLQQYKIEFVNHEIRKNKA----NFKYSDEQITQN
| .   . .  ...|. .|. || .|.  .  |.|| | || .   .. .| |.| | . ..|... .||| .  .      .     . .....   . 
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKS

EIF
.|.
DIY
Kinase 22063.AA Ciliate-E2 119-174 26 7e-06 16.06 In-house 144-211 (365) Show / Hide 
Range on Protein: 119-174
Range on HMM: 144-211/365
Sequence Identity: 26% (19 aa)

EIDLIYIAWNLLV---------------GLKYLREIK-SFHGDISPNNIMFFMEKVKYIDLGSSEINKNNQY
|   .|| . .|                .|.|| . .  .| || |.||.|    .| ||.| | .......
EKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IKIIDFGLSKKYDDDNQ
Kinase 22063.AA STE 122-166 36 0.000232 11.45 In-house 153-194 (359) Show / Hide 
Range on Protein: 122-166
Range on HMM: 153-194/359
Sequence Identity: 36% (17 aa)

LIYIAWNLLVG-LKYLREIKSFHGDISPNNIMFFMEKVKYIDLGSS
..||.  .| | |.|| . .  | || | ||..    || .| | .
IAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVC
Kinase 22063.AA YSK 27-57 41 0.000236 8.62 In-house 2-32 (257) Show / Hide 
Range on Protein: 27-57
Range on HMM: 2-32/257
Sequence Identity: 41% (13 aa)

VKLENCGEGGFGTVDAYYDNNLQKVIAVKTV
.|.|  | | || |   .||  |.|.|.|..
TKQECIGRGSFGEVYKGIDNRTQRVVAIKII
Kinase 22063.AA CMGC 26-166 15 0.000378 8.51 In-house 1-251 (513) Show / Hide 
Range on Protein: 26-166
Range on HMM: 1-251/513
Sequence Identity: 15% (39 aa)

CVKLENCGEGGFGTVDAYYD--------------NNLQKVIAVKTVSRKTTYL-QEK----------RRLINLKK-QQL----------------DFVNN
  ... .||| .|.|   .|              .. ....|.| ....  |  |.|          | |  .|  ..|                .  ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LIG---FCDQER-------------------ILVFELGEATLLEIDDMFQDD-----GYTWREID------------LIYIA------WNLLVGLK--YL
...   ..  .                     ||||. . .|... .. |.|     .    |                |.       . .| |||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

REIK--SFHGDISPNNIMFFMEK---------------------VKYIDLGSS
   .   .| |. | ||..  ..                     .| .| |..
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA