Gene 23282 (Tetrahymena)

23282

Species: Tetrahymena
Alias: PreTt23282, 23282, 184.m00057, TTHERM_00985120, 853
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C7

Sequence

Name Sequence Type Origin Length Description Download
23282.AA Protein None 1132 None Fasta, JSON
23282.kin_dom Protein Kinase Domain None 210 None Fasta, JSON
23282.NA RNA None 3399 None Fasta, JSON

Protein domain

Protein domains of 23282.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 23282.AA Ciliate-C7 83-242 29 4.1e-23 71.37 In-house 2-164 (164) Show / Hide 
Range on Protein: 83-242
Range on HMM: 2-164/164
Sequence Identity: 29% (48 aa)

QLIGFGCQSYVFSSVDHNMN-RYAVKCFNICKNDSEEIDSEKLKKAEFEAQVLLNNRNQ-NVVYCFKSVKGNKFYLIQLEQCV-GTLSELKEQ--IGHLG
  .| | |. |.   | . | |||.| ... .... .|| . ..... |...| . . . .||  ...  |..|. ..|..|  |||... |.     | 
RFLGQGQQGLVLLAKDQKTNMRYAIKGVQV-RDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN

ENQFIQYFIDLMKGLKFTQNNKMINRDLKPDNILIGFDGRLKLSDFGLSYQLQSFSNKYASSIEG
|  .| |  |   || .   .... .||| ||||| . |  ...||||  .|   | ||. .  .
EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKS-KYQINQYM
Kinase 23282.AA Ciliate-E1 85-277 21 2e-15 47.07 In-house 1-202 (202) Show / Hide 
Range on Protein: 85-277
Range on HMM: 1-202/202
Sequence Identity: 21% (46 aa)

IGFGCQSYVFSS--VDHNMNRYAVKCFNICKNDSEEIDSEKLKKAEFEAQVLLNNRNQNVVYCFKSV-KGNKFYLIQLEQCVGTLSELKE----------
|| |..| ||      .| | .|.| .|.| |. .... ....| ... .  ...  . . ..     . |....| .| |  .| .  .          
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNY-NQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQ

---QIGHLGENQFIQYFIDLMKGLKFTQNNKMINRDLKPDNILIGFDGRLKLSDFGLSYQLQSFSNKYA-SSIEGNCYHFAPELMDENIKKMIKKQTQFE
   . . . . |..| ...| .||   .... | ||.||.||||  .|.....|||.| .|.. .|..   . . ..|   .......  ...|.|    
CQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQ----

SKQSFKTDSF
 | ..|.| .
-KINYKSDIY
Pkinase 23282.AA Pkinase 79-347 19 8.3e-15 53.44 Pfam 1-293 (293) Show / Hide 
Range on Protein: 79-347
Range on HMM: 1-293/293
Sequence Identity: 19% (61 aa)

LKNSQLIGFGCQSYVFSSVDHNMNR-YAVKCFNICKNDSEEIDSEKLKKAEFEAQVLLNNRNQNVVYCFKSVKGNKFYLIQLEQCVGT--LSELK-----
..  . || |  . |.  .... .. .|||... ....|..  .  .     |.|.... .  |.| .. ..  .. . . .| | |.  . .|.     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL---SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

EQIGHL--GENQFIQYFIDLMKGLKFTQNNKMINRDLKPDNILIGFDGRL----KLSDFGLSYQLQSFSNKYASSIEGNCYHFAPELMDENIKKMIKKQT
.. | .   |.. . |.  . .||..  ... | |||||.||||  .| .    |..||||. |..  .|  .... |  .  |||.    |.       
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV----IR-------

QFESKQSFKTDSFAAGLILLNLICDNSNFNYYHLLFSDE-----------YVQNMQFSWLDHFKLK---------------------NPIVQMLKSLLAF
 . .. . | | ...|.||  ..| .       ..|...           ....|.  .  ..  .                      .  . .|..|..
-GGQYYGPKVDMWSCGCILYEMLCGR-------PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK

YPWQRADPDQILQQ--F
 | .|  ..||||   |
DPKKRPTAEQILQHPWF
Kinase 23282.AA S_TKc 79-351 17 1.1e-14 38.62 SMART 1-231 (231) Show / Hide 
Range on Protein: 79-351
Range on HMM: 1-231/231
Sequence Identity: 17% (51 aa)

LKNSQLIGFGCQSYVFSSVDHN-MNRYAVKCFNICKNDSEEIDSEKLKKAEFEAQVLLNNRNQNVVYCFKSVKGNKFYLIQLEQCVG---TLSELKEQIG
 .  ..|| |  . |.  ....   ..|.|. .              .... | |.| . .  |.| .. .    ... . .| | |   .| .. .. |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

H------LGENQFIQYFIDLMKGLKFTQNNKMINRDLKPDNILIGFDGRLKLSDFGLSYQLQSFSNKYASSIEGNCYHFAPELMDENIKKMIKKQTQFES
.      . | .   |.  . ..|..  ... | |||||.|||.    ..|..||||. ||        ... |  .  |||..                
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----------------

KQSF-KTDSFAAGLILLNLICDNSNFNYYHLLFSDEYVQNMQFSWLDHFKLKNPIVQMLKSLLAFYPWQRADPDQILQQF-----EDLI
. .. | |  . | ||  ..|    |        ..  ...            .  .... .| . | .|    ..||          .
GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 23282.AA STE 79-255 17 1.4e-14 48.05 In-house 1-237 (359) Show / Hide 
Range on Protein: 79-255
Range on HMM: 1-237/359
Sequence Identity: 17% (43 aa)

LKNSQLIGFGCQSYVFSSVDHN----------------MNRYAVKCFNICKNDS----------EEIDSEKLKKAEFEAQVLLNNR--NQNVVYCFKSVK
... . || |    |.  ..|.                 ...|.|  |......          | ...|.... . | ... . .   .|.| .. .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

GN-------KFYLIQLEQCV-GTLSELKEQI-GHLG-------------ENQFIQYFIDLMKG-LKFTQNNKMINRDLKPDNILIGFDGRLKLSDFGLSY
 .           | .| .  |.|... ..  |...             |.| . .  .. || |..  ... | ||.||.|||.      ||.|||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLQS-------------------FSNKYASSIEGNCYHFAPELMDEN
||..                    .|  . .      . ||| .. |
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-----WMAPEVIQQN
Kinase 23282.AA CAMKK 184-255 26 2.4e-14 41.5 In-house 181-286 (396) Show / Hide 
Range on Protein: 184-255
Range on HMM: 181-286/396
Sequence Identity: 26% (28 aa)

YFIDLMKGLKFTQ-NNK-------------------MINRDLKPDNILIGFDG---RLKLSDFGLSYQL-QSFSNKYA---------SSIEGNCYHFAPE
|| |  |||..   ..|                   .|.||.||.||||. .|   ..|..||| | .. .. ...           ....|  . .|||
YFRDCIKGLEYLHNYQKACSYIIIYINEFIIDHFQDIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPE

LMDE-N
| .. |
LCSKEN
Kinase 23282.AA AGC 203-229 57 2.5e-14 31.99 In-house 178-205 (395) Show / Hide 
Range on Protein: 203-229
Range on HMM: 178-205/395
Sequence Identity: 57% (16 aa)

RD-LKPDNILIGFDGRLKLSDFGLSYQL
|| |||.|||.  || .||.||||. ..
RDYLKPENILLDEDGHIKLTDFGLCKEG
Kinase 23282.AA ULK 164-226 28 1e-13 44.34 In-house 105-189 (329) Show / Hide 
Range on Protein: 164-226
Range on HMM: 105-189/329
Sequence Identity: 28% (24 aa)

GTLSELKEQIGHLGENQ----------FIQYFIDLMKGLKFTQNNKMINRDLKPDNILIGFD------------GRLKLSDFGLS
|.|... .. ..|.|..           ||.|.... |.|. . .. | ||.||.||||  .            |.||..|||..
GDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA
Kinase 23282.AA CAMKK-Unclassified 184-226 28 1.6e-13 40.1 In-house 183-251 (392) Show / Hide 
Range on Protein: 184-226
Range on HMM: 183-251/392
Sequence Identity: 28% (20 aa)

YFIDLMKGLKFTQNNK---------------------MINRDLKPDNILIGFDGR-----LKLSDFGLS
|| .  |||.   |..                     .|.||.||.||||. ...     .|..|||.|
YFRQCCKGLQYMHNFNQACSYIIIYINEFDKIDHFQDIIHRDIKPQNILIDHEDNDKGEHFKIADFGIS
Kinase 23282.AA WEE 155-261 22 1.3e-12 38.74 In-house 80-216 (297) Show / Hide 
Range on Protein: 155-261
Range on HMM: 80-216/297
Sequence Identity: 22% (31 aa)

YLIQLEQCVG-------TLSELKEQIGHLGENQFIQYFIDLMKGLKFTQNN-KMINRDLKPDNILIGFDG--------------------RLKLSDFGLS
..|| | | |        ... .    .| |..  |.. |. .||..  .|  |.  |.||.||.|....                    ..|. |||..
MYIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHV

YQLQSFSNKYASSIEGNCYHFAPELMDE--NIKKMIK
  . | .|.. .  ||..   |||.  .  .  . .|
TDMNSNNNNPHQEQEGDSRYMAPEILQGYYHYTHLYK
Kinase 23282.AA CDC2 183-226 40 3.5e-12 33.22 In-house 107-150 (301) Show / Hide 
Range on Protein: 183-226
Range on HMM: 107-150/301
Sequence Identity: 40% (18 aa)

QYFIDLMKGLKFTQNNKMINRDLKPDNILIGFDGRLKLSDFGLS
.|.. . .|. |   .. . |||||.||||  .|..|..||||.
SYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLA
Kinase 23282.AA IRE 130-226 24 3.7e-12 38.01 In-house 40-171 (292) Show / Hide 
Range on Protein: 130-226
Range on HMM: 40-171/292
Sequence Identity: 24% (32 aa)

EAQVLL---NNRNQNVVYCFKSVKGNKFYLIQLEQCVGTLSELKEQ-----------------------IGHLG-ENQFIQYFIDLMKGLKFTQNNKMIN
| |.|    ... .||.  . . .. .| .. || |.|.|... ||                       . ... ... .| . ..|.|| .    . . 
EIQMLIKLESDNHPNVIRYYCQEEDDQFVYLALELCQGSLQDYVEQKKRNNFINSSNNSNNNNKNNNNNNNQWQIHIRMWQLIKQCMNGLQHLHSQNIVH

RDLKPDNILIGF--------DGRLKLSDFGLS
||||| ||||           .|...|||||.
RDLKPHNILIHMNRPNQHGENNRFMISDFGLC
Kinase 23282.AA TyrKc 79-347 11 3e-06 -122.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 79-347
Range on HMM: 1-280/280
Sequence Identity: 11% (40 aa)

LKNSQLIGFGCQSYVFSSVDHNMNRYAVKCFNICKNDSEEIDSEKLKKAEF--EAQVLLNN--RNQNVVYCFKSVKGN-------KFYLIQLEQCVG--T
..  . .| |.   |.  .       |||. . ..            ...|  ||... .   ...|.| ..  .          . ..| .| . .   
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

LSELKEQIGHLGENQFIQYFIDLMKGLKFTQNNKMINRDLKPDNILIGFDGRLKLSDFGLSYQLQSF-------SNKYA----SSI--------------
.. |..  ..|   ..... ..  .|  .   .. | |||   |.|.| ... | ||||||  . .        . . .    ..               
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

EG--------------------NCYHFAPE-----LMDENIKKMIKKQTQFESKQS----FKTDSFAAGLILLNLICDNSNFNYYHLLFSDEYVQNMQFS
.|                    ..    |.     . .. . . .|.    .  ..                                          | 
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------------------F-

WLDHFKLKNPIVQMLKSLLAFYPWQRADPDQILQQF
          . |. |.  .. | .|    .| ..|
----VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF