Gene 26940 (Tetrahymena)

26940

Species: Tetrahymena
Alias: 26940, PreTt26940, 986, 3816.m00146, TTHERM_01094780, 231.m00024
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: CDK

Sequence

Name Sequence Type Origin Length Description Download
26940.AA Protein None 325 None Fasta, JSON
26940.kin_dom Protein Kinase Domain None 292 None Fasta, JSON
26940.NA RNA None 975 None Fasta, JSON

Protein domain

Protein domains of 26940.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 26940.AA CDK 1-292 36 1.3e-118 381.21 In-house 7-284 (284) Show / Hide 
Range on Protein: 1-292
Range on HMM: 7-284/284
Sequence Identity: 36% (120 aa)

LGEGTFGKVYKAQDKKNN-----EIVAVKQVKTQN-YHESRNDFKIYFIQLKEIKLLSELQNHPNIVQFKEVVVGQN---------QNSIFLIFEYCQMD
.||||.|.||||.||...     .||| |.....|   ... .  . .  . ||.|| ||  |||||. ..|... |         .|.....|||. .|
IGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEG-REEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHD

IANLIFRMDQEREYFSESEIKCIILQLLNGVQHMHKQYQMHRDIKLSNVLINDKGV-----VKIADFGLAREYNK------PNKPYTPKVVTLWYRSPEL
 . ..              |||...|||.|. ..|..  ||||.| .| |||..|.     .|||||||||...       ||..||..|||||||.|||
LKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPEL

LLEMEQYT--TSIDIWSVGCVLAELLN--KGQPIFPGDTEMKQFQLICELIGYPTRYEWN-----EYYSQVKKEVRKELEKFSGFKTNNLQKQLKCSENC
||  ..|.  |.||.|||||..||...   ..|.||||.|  |  .|....| ||   |       .|                                
LLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------------

LKLLQKMLAWDPKKRISAEKAMSHPYF
  ||.|||. ||||||||| |..||||
-DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 26940.AA CMGC 1-292 23 1.3e-116 384.97 In-house 7-513 (513) Show / Hide 
Range on Protein: 1-292
Range on HMM: 7-513/513
Sequence Identity: 23% (121 aa)

LGEGTFGKVYKAQD--------------KKNNEIVAVKQVK-TQNYHESRN----DFKIYFIQLKEIKLLSELQ----------------NHPNIVQFKE
.||||.|.|||..|              ...|||||.| .|  . |.|          . .. | |||.| .|.                .|.|||. ..
IGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYD

VVVGQN---------------QNSIFLIFEYCQMDIANLIFRMDQ-----EREYFSESE------------IKCII------LQLLNGVQ--HMHKQY--
...  |                |...|.|||...| ...| .. .      . ..|| .            ||...       |.|.|.   ..|..   
IFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGN

QMHRDIKLSNVLINDK--------------------GVVKIADFGLAREYNKP---------------------NKPYTPKVVTLWYRSPELLLEMEQYT
 .|||.| .|.|||..                    |..||.|||||| |...                     |.|||. |||.|||.||.|| ...||
IIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYT

---------TSIDIWSVGCVLAELLNK-------GQPIFPGDTE-----------MKQFQLICELIGYPT---------------RYEWNEYYS------
         |.||.|||||..||....       |.|.|||..|             | ..|....| ||                 || .. .      
NHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNK

------------QVKKEVRKELEK---FSGFKTNNLQKQLK------------------------------------CSENCLKLLQKMLAWDPKKRISA
            . .. .|. ...   |  .. ...... .                                    |.. .. ||.||| .||.|||.|
FPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITA

EKAMSHPYF
| |..||||
EQALQHPYF
Kinase 26940.AA PITSLRE 45-292 44 3.7e-102 345.7 In-house 48-295 (295) Show / Hide 
Range on Protein: 45-292
Range on HMM: 48-295/295
Sequence Identity: 44% (113 aa)

LKEIK-LLSELQNHPNIVQFKEVVVGQNQNSIFLIFEYCQMDIANLIFRMDQEREYFSESEIKCIILQLLNGVQHMHKQYQMHRDIKLSNVLINDKGVVK
| ||. .| .|| |||||. ||.|.| | ..|....||   |.. |.  | . .  |...|||| ..|||.||.|||.   |||| | || |.. ||. |
LREINMILMALQ-HPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILK

IADFGLAREYNKPNKPYTPKVVTLWYRSPELLLEMEQYTTSIDIWSVGCVLAELLNKGQPIFPGDTEMKQFQLICELIGYPTRYEWNEYYSQVKKEVRKE
|.||||||||  | ||||| |||||||.|||||. . |.| .|.|||||..||.. . .|.|.|. |. | . |  . | ||   |  . .     . | 
ICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEFITM-KPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTEL---PHWKM

LEKFSGFKTNNLQKQLK----CSENCLKLLQKMLAWDPKKRISAEKAMSHPYF
.. |.  . ||| |  .     |.. ..||..||  .||.||.|..|. ||.|
MNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase 26940.AA CDC2 1-292 36 2.4e-101 312.25 In-house 7-301 (301) Show / Hide 
Range on Protein: 1-292
Range on HMM: 7-301/301
Sequence Identity: 36% (112 aa)

LGEGTFGKVYKAQDKKNNEIVAVKQVKTQNYHESRNDFKIYFIQLKEIKLLSELQNHPNIVQFKEVVVGQNQNSIFLIFEYCQMDIANLIFRMDQEREYF
.||||.|.|||..|.. |.|||.|....   .|.  |  .    ..|| .| ||..|||||. ..|..    |.....|||. ||  ..  .  . ....
IGEGTYGVVYKCKDMQTNQIVALKKIRLE--QEDEGD-GVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKNKHM

SESEIKCIILQLLNGVQHMHKQYQMHRDIKLSNVLINDKGVVKIADFGLAREYNKPNKPYTPK--VVTLWYRSPELLLEMEQYTTSIDIWSVGCVLAEL-
... .| .. |.|.|| . | .  ||||.| .| ||..||..|||||||||  . | ..||.   |||||||.||.||  ..|.|..|.||.||..||. 
PPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMF

LN-KGQPIFPGDTEMKQFQLICELIGYPTRYEWNEYYSQV--KKEVRKELEKFSGFKTNNLQKQLK----------CSENCLKLLQKMLAWDPKKRISAE
..    |.|.|| |  |   | . .| |.  .|.. ..    |       ..|  .|...|.|...          . .... ||..||. || |||||.
MDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYK-------NTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAK

KAMSHPYF
.|..||||
EALQHPYF
Kinase 26940.AA CDK7 1-292 34 2.4e-97 259.78 In-house 7-288 (288) Show / Hide 
Range on Protein: 1-292
Range on HMM: 7-288/288
Sequence Identity: 34% (103 aa)

LGEGTFGKVYKAQDKKNNEIVAVKQVKTQNYHESRNDFK--IYFIQLKEIKLLSELQNHPNIVQFKEVVVGQNQNSIFLIFEYCQMDIANLIFRMDQERE
.|||.|. ||||.|.. ..|||.| .|      .|...|  | .  . |||.| |.| |.|..    .     . .| |.|.. . |    |   |..  
IGEGQFATVYKACDHQTGQIVAIKKIKK---LGHRSEAKDGINRTAIREIKILQEMQ-HDNVIGLIDIFM--HKSNIQLVFDFMDWDLEVVI--KDKSI-

YFSESEIKCIILQLLNGVQHMHKQYQMHRDIKLSNVLINDKGVVKIADFGLAREYNKPNKPYTPKVVTLWYRSPELLLEMEQYTTSIDIWSVGCVLAELL
 .  ..|| . ...| |. ..|. .  |||.|  | |.|  |..||||||||| |  ||. ||..||| |||.||||    .|.|..|.|||||..|||.
ILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELM

NKGQPIFPGDTEMKQFQLICELIGYPTRYEWNEYYSQVKKEVRKELEKFSGFKTNNLQKQLK-CSENCLKLLQKMLAWDPKKRISAEKAMSHPYF
    |..||| .. | . |.. .| ||  || .  .. .  .  .. .| |.    |..     |.  | |...|.. .| ||...  . ..|||
LR-VPYLPGDSDIDQLTRIFQTLGTPTEEEWPN-MCCMMDYI--KFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase 26940.AA CDK10 1-292 43 3.8e-91 309.12 In-house 7-285 (285) Show / Hide 
Range on Protein: 1-292
Range on HMM: 7-285/285
Sequence Identity: 43% (126 aa)

LGEGTFGKVYKAQDKKNNEIVAVKQVKTQNYHESRNDFKIYFIQLKEIKLLSELQNHPNIVQFKEVVVGQNQNSIFLIFEYCQMDIANLIFRMDQEREYF
.||||.| ||.| | . .||||.|.|. .   .      .    |.||.|| ... |.|||. .||||||  .||||. .||  |.| |.  | |    |
VGEGTYGIVYRARDMRSDEIVALKKVRMDKEKDG-----LPISGLREIMLLIQCR-HENIVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNMPQP---F

SESEIKCIILQLLNGVQHMHKQYQMHRDIKLSNVLINDKGVVKIADFGLAREYNKPNKPYTPKVVTLWYRSPELLLEMEQYTTSIDIWSVGCVLAELLNK
.|...|||.||.| |.. .|... .|||.| ||.|. ||| .|.||||||| |  | || |||.|||||| |||||   . ||.||.| |||.|.|||  
TETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCILGELL-V

GQPIFPGDTEMKQFQLICELIGYPTRYEWNEYYSQVKKEVRKELEKFSGFKTNNLQKQLKC-SENCLKLLQKMLAWDPKKRISAEKAMSHPYF
..|..||  |..| ..| .|.| |    |   .|..    .  |.|      |||... .  |.  ..||. .. ..||||  || ..   ||
HKPLMPGNSEIHQIDMIIDLLGTPSENIWPG-FSDLPMVQNFTLKKQP---YNNLKHKFHWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase 26940.AA S_TKc 1-292 27 3.1e-89 303.66 SMART 7-231 (231) Show / Hide 
Range on Protein: 1-292
Range on HMM: 7-231/231
Sequence Identity: 27% (83 aa)

LGEGTFGKVYKAQDKKNNEIVAVKQVKTQNYHESRNDFKIYFIQLKEIKLLSELQNHPNIVQFKEVVVGQNQNSIFLIFEYCQM---DIANLIFRMDQER
.|.|.||||||...|| ..|||.|..|                 ..||..|..  .|||||....| .    .......|||     |   .| ..  ..
IGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

--EYFSESEIKCIILQLLNGVQHMHKQYQMHRDIKLSNVLINDKGVVKIADFGLAREYNKPNKPYTPKVVTLWYRSPELLLEMEQYTT-SIDIWSVGCVL
   .|.| ...... |........|..  .|||.| .|.|...  ..||.||||||..       |  ..|.||..||.|    .|.. ..|.||.||.|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL

AELLNKGQPIFPGDTEMKQFQLICELIGYPTRYEWNEYYSQVKKEVRKELEKFSGFKTNNLQKQLKCSENCLKLLQKMLAWDPKKRISAEKAMS------
.|.|  |.| ||      | |.. ..||                                       |. .. ...|.| .||.||..| .|.       
YEMLC-GYPPFP------QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

-HPYF
 ||.|
CHPWF
Kinase 26940.AA CRK7 2-292 37 7.7e-89 301.46 In-house 8-343 (343) Show / Hide 
Range on Protein: 2-292
Range on HMM: 8-343/343
Sequence Identity: 37% (131 aa)

GEGTFGKVYKAQDKKNNEIVAVKQVKTQNYHESRNDFKIYFIQLKEIKLLSELQNHPNIVQFKEVVVGQ-------NQN-SIFLIFEYCQMDIANLIFRM
||||.|.||||..|...|.|| | |...|    .  | |  |   |||.| .| ||.|||. ||.|.         ..  |....|||   | . |    
GEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAI--REIKILRQL-NHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGLL--E

DQEREYFSESEIKCIILQLLNGVQHMHKQYQMHRDIKLSNVLINDKGVVKIADFGLAREYNKPN--KPYTPKVVTLWYRSPELLLEMEQY----------
  |  .||....||.  ||| |.. .||.  .||||| ||.|.| .| |||||||||| ||. .  .||| .|.||||| |||||  |.|          
SKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKELI

----------------------------TTSIDIWSVGCVLAELLNKGQPIFPGDTEMKQFQLICELIGYPTRYEWNE-----YYSQVKKEV---RKELE
                            ...||.||.|| |.||..| .|||.|  ||.|  .| .. | |.   | |     ..   |      |. .|
RNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTK-KPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRLRE

KFS-GFKTNNLQKQLKCSENCLKLLQKMLAWDPKKRISAEKAMSHPYF
 |.  .|  .. |.      || || |||. |||||..|| .  |..|
EFYHHKKPVFMPKE------CLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase 26940.AA Pkinase 1-292 30 2.3e-87 301.33 Pfam 7-293 (293) Show / Hide 
Range on Protein: 1-292
Range on HMM: 7-293/293
Sequence Identity: 30% (96 aa)

LGEGTFGKVYKAQDKKNNEIVAVKQVKTQNYHESRN--DFKIYFIQLKEIKLLSELQNHPNIVQFKEVVVGQNQNSIFLIFEYCQM-----DIANLIFRM
.|.|.||.|||...|....|||||..| .. ... .  ....      ||... .| ||||||......     ..| ...|||..     | . .| . 
IGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----SEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-

DQEREYF--SESEIKCIILQLLNGVQHMHKQYQMHRDIKLSNVLINDKGVV----KIADFGLAREY-NKPNKPYTPKVVTLWYRSPELLLEMEQYTTSID
 ...  |  || |.|....|.| |....|..  .|||.|..|.||...|..    ||.|||||. . . .|  .|  ..|.||..||.... . |....|
-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

IWSVGCVLAELLNKGQPIFPGD----TEMKQFQLICELIGYPTRYEWNEYYS--------QVKKEVRKELEKFSGFKTNNLQKQLKCSENCLKLLQKMLA
.||.||.|.|.|. |.|.|||.    . . | |.||.  | |....| . .|        . .              . .  .  . ||.|.... ..|.
MWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHW-H--------------F-HWTF-HNWSEECKDFIKWCLC

WDPKKRISAEKAMSHPYF
.|||||..|| .. ||.|
KDPKKRPTAEQILQHPWF
Kinase 26940.AA RCK 1-292 38 6.3e-84 266.15 In-house 7-298 (298) Show / Hide 
Range on Protein: 1-292
Range on HMM: 7-298/298
Sequence Identity: 38% (117 aa)

LGEGTFGKVYKAQDKKNNEIVAVKQVKTQNYHESRNDFKIYFIQLKEIKLLSELQNHPNIVQFKEVVVGQNQNSIFLIFEYCQMDIANLIFRMDQEREY-
||.||.| | |||.|...|||| |. |  .  .| ..     ..|.||| |  |  ||||.. |||.  ..  . ...|||..|..  ..    . |.  
LGDGTYGCVMKAQNKETGEIVAIKKMK--QKFYSWEE----CMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKE-RRKY

FSESE--IKCIILQLLNGVQHMHKQYQMHRDIKLSNVLIND---------KGVVKIADFGLARE-YNKPNKPYTPKVVTLWYRSPELLLEMEQYTTSIDI
..|..  || |. |.| |  ||||.  .|||.|  | ....          ...|||||||.|| ..||  |||  | | |||.||.||   .|.. .||
LPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKP--PYTDYVSTRWYRAPECLLRCTYYNSPMDI

WSVGCVLAELLNKGQPIFPGDTEMKQFQLICELIGYPTRYEWNEYYSQVKKEVRKELEKFSGFKTNNLQKQL-KCSENCLKLLQKMLAWDPKKRISAEKA
|.|||. .||  . .| |||  |. | . ||. .| |.  .|.. | .. .   ... .|   | ..|.. .  || .|..|..|||.|||.|||.|..|
WAVGCIMYELYML-RPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQ---MNF-NFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQA

MSHPYF
  ||||
LQHPYF
Kinase 26940.AA CDK5 1-292 37 1.7e-80 254.01 In-house 7-287 (287) Show / Hide 
Range on Protein: 1-292
Range on HMM: 7-287/287
Sequence Identity: 37% (110 aa)

LGEGTFGKVYKAQDKKNNEIVAVKQVKTQNYHESRNDFKIYFIQLKEIKLLSELQNHPNIVQFKEVVVGQNQNSIFLIFEYCQMDIANLIFRMDQEREYF
.||||.| ||||..|.  |||| |.|.  .  |      .    . || || ||. |.|||    |.   .   . |.||.|  |.      ||.  .. 
IGEGTYGTVYKARNKETHEIVALKRVRLDSEDEG-----VPSTAIREICLLKELK-HKNIVRLHDVIHSEKK--LTLVFEFCDQDLKKY---MDSCNGEM

SESEIKCIILQLLNGVQHMHKQYQMHRDIKLSNVLINDKGVVKIADFGLAREYNKPNKPYTPKVVTLWYRSPELLLEMEQYTTSIDIWSVGCVLAELLNK
.   || ...||| |..  |..  .||| |  | ||| .|  | ||||||| .  | . |.  ||||||| |  |.   .|.||||.||.||..||. | 
DMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANA

GQPIFPGDTEMKQFQLICELIGYPTRYEWNEYYSQVKKE-VRKELEKFSGFK-TNNLQKQLKCSENCLKLLQKMLAWDPKKRISAEKAMSHPYF
|.| |||  .  |  .| ...| |.  .|       .     ...... . .   .. ..|  .|. . ||||||  .|..||||..|. ||||
GRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKL--DEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 26940.AA MAPK 47-292 30 7.9e-73 248.27 In-house 54-328 (328) Show / Hide 
Range on Protein: 47-292
Range on HMM: 54-328/328
Sequence Identity: 30% (85 aa)

EIKLLSELQNHPNIVQFKEVVVG-----QNQ----NSIFLIFEYCQMDIANLIFRMDQEREYFSESEIKCIILQLLNG--VQHMHKQYQMHRDIKLSNVL
||||| .. .|.||.  ...        ||     | | ...|... |  ..| ...      |.  |. .. |.|.|  ....|     |||.| ||.|
EIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQIIKSQQ----PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNIL

INDKGVVKIADFGLAREYNK-PNKPY-------------TPKVVTLWYRSPELLLE--MEQYTTSIDIWSVGCVLAELLNKGQPIFPGDTEMKQFQLICE
.|  . .||.||||||      ....             |. |.| |||.||..|   .  ||...|.||||| .||.|. ..|.|||.  . |..|| |
VNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIME

LIGYPTRYEWNEYYSQVKKEVRKELEKF--SGFKTN-NLQKQLK-----CSENCLKLLQKMLAWDPKKRISAEKAMSHPYF
..| |..  ..       ...|. .. .     ..  ...| ..     ..  .. ||.|||..||.|||..| |..||||
VLGTPSEEFIQCICM--SEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 26940.AA TyrKc 1-292 23 1.1e-15 30.9 SMART 7-280 (280) Show / Hide 
Range on Protein: 1-292
Range on HMM: 7-280/280
Sequence Identity: 23% (75 aa)

LGEGTFGKVYKAQDKKNNEIVAVKQVKTQNYHESRNDFKIYFIQLKEIKLLSEL-QNHPNIVQFKEVVVGQ-----NQNSIFLIFEYCQMDIANLIFRMD
|||| ||.|||.. |   . |||| .|       | ||      ..|......|  .|||||..  |.. |         .....||.    . . .  .
LGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDF------MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRK

QEREYFSESEIKCIILQLLNGVQHMHKQYQMHRDIKLSNVLINDKGVVKIADFGLAREYNKP-----NKPYTPK----VVT--LWYR--SPELLLEMEQY
 ... .. ..   . .|  .| .. |..   |||.   |.|......|||.||||.|.         .| |  |         | .|  .|| . . . .
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK-F

TTSIDIWSVGCVLAELLNKGQPIFPGDTE-MKQFQLICELIGYPTRYEWNEYY---SQVKKEVRKELEKFSGFKTNNLQKQLKCSENCLKLLQKMLAWDP
||  |.|| | .. |..  ||.  ||... |.  | . |..    | .  ...   |               |          |..   .. ..  . ||
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------F--------VCCPDEMYQIMKQCWHEDP

KKRISAEKAMSHPYF
..| . .    | .|
EDRPTFSEI--HECF
Kinase 26940.AA Pkinase_Tyr 1-83 32 6.3e-12 41.02 Pfam 7-90 (270) Show / Hide 
Range on Protein: 1-83
Range on HMM: 7-90/270
Sequence Identity: 32% (30 aa)

LGEGTFGKVYKAQDK----KNNEIVAVKQVKTQNYHES---RNDFKIYFIQLKEIKLLSELQNHPNIVQFKEVVVGQNQN-SIFLIFEYCQ
|||| ||.|||.  |    ...  |||| .  ......   | ||      ..|.|....| .|||||..  |.. | .  .|....||..
LGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDF------MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMP
Kinase 26940.AA PITSLRE 2-27 57 9.6e-09 28.17 In-house 8-33 (295) Show / Hide 
Range on Protein: 2-27
Range on HMM: 8-33/295
Sequence Identity: 57% (15 aa)

GEGTFGKVYKAQDKKNNEIVAVKQVK
.|||.| ||.|.||. .|||| | .|
HEGTYGVVYRAKDKRTDEIVALKRLK
Kinase 26940.AA Pkinase_Tyr 133-202 32 1.3e-07 26.39 Pfam 141-212 (270) Show / Hide 
Range on Protein: 133-202
Range on HMM: 141-212/270
Sequence Identity: 32% (25 aa)

NVLINDKGVVKIADFGLAREYNKPNKPYTPKVVTL-------WYRSPELLLEMEQYTTSIDIWSVGCVLAELLNKGQ
|.|.....||||.||||||     |. |   ...        |. .|| . ... .||  |.|| | .. |..  |.
NCLVTENNVVKICDFGLARDI--YNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSDVWSFGVLMWEIFTYGE
Kinase 26940.AA MAPK 1-24 33 0.000296 10.36 In-house 7-36 (328) Show / Hide 
Range on Protein: 1-24
Range on HMM: 7-36/328
Sequence Identity: 33% (10 aa)

LGEGTFGKVYKAQDKK------NNEIVAVK
.|.| .| | .| ||.      ....||.|
IGQGAYGVVCSAIDKRTNQKTKCGKKVAIK