Gene 27040 (Tetrahymena)
27040
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 27040.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 27040.AA | CMGC | 520-700 | 16 | 2.8e-25 | 79.21 | In-house | 1-287 (513) | Show / Hide |
Range on Protein: 520-700 Range on HMM: 1-287/513 Sequence Identity: 16% (49 aa) YIDLQLIHKATYSVLLEVYS--------------QKQNKKVCLKISEESELDYQ-------------MVINEFQILNRMQ-NISQLSF----KQDNLKNN | .. | . ||.| . . . |..| .|. . . . . . | .|| ... | . . || . | YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN NIVQVFEFLDYSK---------------FITCIIVQELCQQNLEEEITNLK------------------------QQNKFFTNEDINTIFIHMINAIN-- |||. .... ... | .| |.....| . | | . .. |.|.. .| .. ...... NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK HIHSHK--IIHCDIKPSNILKSQQSIY--------------------KICDFDLSSQLDQFQ----------------DSTSIMKGYTKYQC ..|||. |||.|.||.||| ... . ||||| |. .... . |. .... || | . YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDD-KPNRPYTHYVV |
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| Kinase | 27040.AA | Ciliate-E1 | 526-706 | 26 | 1.5e-24 | 77.04 | In-house | 1-183 (202) | Show / Hide |
Range on Protein: 526-706
Range on HMM: 1-183/202
Sequence Identity: 26% (51 aa)
IHKATYSVLLEVYSQKQN-KKVCLKISEESELDYQMVINEFQILNRMQNISQLSFKQDNLKNNNIVQVFEFLDYSKFITCIIVQELCQQNLEEEIT----
| . .|. .. ..|..| ..|..|| .. .... |.|| ... .. . || |. .|.|...... . ..|||..|.|...|.....
IGNGSFSIVFKAKQQNNNYNQVAQKII---NCCFNYNQNHFQDEIKEYYKIMK-FK----KECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNR
-----NLKQQNKFFTNEDINTIFIHMINAINHIHSHKIIHCDIKPSNILKSQQSIYKICDFDLSSQLDQFQDSTSIMKGYTKYQCLQNKMN
..|... || . . |....| ... .|...|||.||||.|||...|..|..||| .|..| |.... ||||.| . ....|
LEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYN
|
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| Kinase | 27040.AA | Ciliate-B2 | 585-680 | 30 | 5.6e-20 | 43.58 | In-house | 58-152 (197) | Show / Hide |
Range on Protein: 585-680 Range on HMM: 58-152/197 Sequence Identity: 30% (29 aa) KNNNIVQVFEFLDYSKFITCIIVQELCQQNLEEEITNLKQQNKFFTNEDINTIFIHMINAINHIHSHKIIHCDIKPSNILKSQQSIYKICDFDLSS .| |.|.. ... .. | ... | |. |..|. ...| | |.|. . .. .|.. ... |.| ||||.|||..|. |. ||| || YNINVVKYIDHIQINETID-VLIMEKCECSLKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISS |
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| Kinase | 27040.AA | CAMK | 525-684 | 16 | 3.7e-18 | 54.43 | In-house | 1-248 (425) | Show / Hide |
Range on Protein: 525-684 Range on HMM: 1-248/425 Sequence Identity: 16% (41 aa) LIHKATYSVLLEVYSQKQN------------KKVCLKI-----------------------------SEESELDYQMVINEFQILNRMQNISQLSFKQDN . . .... ... . . .|| || ..... | ..| .| .|....|.|. . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGN------K LKNNNIVQVFEFLDYSK--------------FIT----CIIVQ---ELCQQN-----LEEEITNL------------KQQNKFFTNEDINTIFIHMINAI |. ||.. .|. . .. | | ...| |.|. | . |. ... || .. ..| .. |. LDHPNIIKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAV NHIHSHKIIHCDIKPSNILKSQQS-----------------IYKICDFDLSSQLDQ ...|||.|.|.|.|| ||| .. . ||.|| .. ..|. HYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDP |
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| Kinase | 27040.AA | LKB | 635-687 | 35 | 1.4e-16 | 45.83 | In-house | 107-159 (265) | Show / Hide |
Range on Protein: 635-687 Range on HMM: 107-159/265 Sequence Identity: 35% (19 aa) NTIFIHMINAINHIHSHKIIHCDIKPSNILKSQQSIYKICDFDLSSQLDQFQD . .|. . . . .|| ...| ||||.|.| . . ||||| ||..||. HFYFCQLCDGCEYLHSQRVVHKDIKPGNLLLTHDNTLKICDFGVAEQLHHFQR |
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| Kinase | 27040.AA | C8 | 520-698 | 25 | 1.5e-16 | 54.03 | In-house | 1-197 (226) | Show / Hide |
Range on Protein: 520-698 Range on HMM: 1-197/226 Sequence Identity: 25% (50 aa) YIDLQLIHKATYSVLLEVYSQKQNKKVCLKISE-ESELDYQMVINEFQILNRMQNISQLSFKQDN-LKNNNIVQVFEFLDYS-------KFITCIIVQ-E . |.. . |.. |. . |.|... ||. . ... | | .. . . | ..| | . .||| . | . | . . | FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME LCQQNLEEEITNLKQQNKFFTNEDINTIFIHMINAINHIHSHKIIHCDIKPSNIL--KSQQSI--YKICDFDLSSQLDQFQDSTSIMK----GYTKY ||.|||.. ...... |..|. | | || .| ||...|.| ||||.|.| .|... |.|||...||. . ... . | | .| LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAY |
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| Kinase | 27040.AA | Pkinase | 543-696 | 22 | 2.8e-15 | 55.09 | Pfam | 24-172 (293) | Show / Hide |
Range on Protein: 543-696 Range on HMM: 24-172/293 Sequence Identity: 22% (38 aa) NKKVCLKISEESELDYQMVIN-----EFQILNRMQNISQLSFKQDNLKNNNIVQVFEFLDYSKFITCIIVQELCQQNLEEEITNL----KQQNKFF--TN .|.|..|| . .. . .. .. | ||..|.. |||. ... ... | .|.|.|. |. . .... | . GKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-------------HPNIVRLYDWFEDKDHIY--MVMEYCEGGLY-VMDLFDYISTWRHGCFYFSE EDINTIFIHMINAINHIHSHKIIHCDIKPSNILKSQQSIY----KICDFDLSSQLDQFQDSTSIMKGYT ... .. .. .....||..|||.|.||.||| ... ||||| |. |.| . | |.... WECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFC |
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| Kinase | 27040.AA | Ciliate-C8 | 608-682 | 32 | 1.3e-14 | 49.03 | In-house | 93-179 (238) | Show / Hide |
Range on Protein: 608-682 Range on HMM: 93-179/238 Sequence Identity: 32% (28 aa) QELCQQN--LEEEITNLKQQNKFFTNEDINTIFIHMINAINHIHSHKIIHCDIKPSNIL----KSQQSIYKICD------FDLSSQL .|.|||| |.. ......... ..... | | || .| .| . |.| ||||.|.| ...| . |.|| |...||| MEKCQQNCNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQL |
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| Kinase | 27040.AA | ULK | 580-676 | 28 | 8.2e-14 | 45.45 | In-house | 66-182 (324) | Show / Hide |
Range on Protein: 580-676
Range on HMM: 66-182/324
Sequence Identity: 28% (33 aa)
KQDNLKNNN--IVQVFEFLDYSKFITCIIVQELCQQ-NLEEEITNLKQ-----QNKFFTNEDINTIFIHMINAINHIHSHKIIHCDIKPSNILKSQQS--
| ..||..| ||. .... | . . |..|.|.. .||. | . | .|... . . .|.. .|. ..|.|.|||.||||.||| .
KLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPK
----------IYKICDF
..||.||
TDSKKVHPNGVLKIADF
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| Kinase | 27040.AA | Ciliate-A1 | 520-687 | 30 | 9.4e-13 | 39.69 | In-house | 1-156 (301) | Show / Hide |
Range on Protein: 520-687
Range on HMM: 1-156/301
Sequence Identity: 30% (52 aa)
YIDLQLIHKATYSVLLEVY-SQKQNKKVCLKISEESELD-YQMVINEFQILNRMQNISQLSFKQDNLKNNNIVQVFEFLDYSKF--ITCIIVQELCQQNL
| ||| | ..| . .| .| | |..|.|| .. . |. |.|.... . || . ... | | |. | || ..
YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFEQYKNNIQEYRKCKQ-------------INHNNVIKNYQQLYYNTNNKECMFIIMEYCQYGN
EEEITNLKQQNKFFTNEDINTIFIHMINAINHIHSHKIIHCDIKPSNILKSQQSIYKICDFDLSSQLDQFQD
|. ||.. |.| | ..| . ||.| |.| |.|| ||| .||||. .| || | ||
---LFNYCYQNDYMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQD
|
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| Kinase | 27040.AA | ULK | 544-676 | 21 | 1.9e-12 | 39.84 | In-house | 34-186 (329) | Show / Hide |
Range on Protein: 544-676 Range on HMM: 34-186/329 Sequence Identity: 21% (36 aa) KKVCLK-ISEESELDY-----QMVINEFQILNRM------QNISQLSFKQDNLKNNNIVQVFEFLDYSKFITCIIVQELCQQ-NLEEEITNLKQ------ |..... ..... ... |...|| .|. .. .| .. |||. .... |.. . |..|.|.. .||. | . | KMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKN-----------HHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTE QNKFFTNEDINTIFIHMINAINHIHSHKIIHCDIKPSNILKSQQS------------IYKICDF .|... . . .|.. .|. ..|.|.|||.||||.||| . ..||.|| EKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADF |
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| Kinase | 27040.AA | S_TKc | 520-715 | 19 | 1e-09 | -34.32 | SMART | 1-220 (231) | Show / Hide |
Range on Protein: 520-715
Range on HMM: 1-220/231
Sequence Identity: 19% (50 aa)
YIDLQLIHKATYSVLLEVYSQKQNKKVCLKISEESELDYQMVINEFQILNRMQNISQLSFKQDNLKNNNIVQVFEFLDYSKFITCIIVQELCQQ---NLE
| |..| | .... .. | ...| .|| .....| ||| . . |||. ... . .| |.| . .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--------------HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLF
EEITNLKQQNKF--FTNEDINTIFIHMINAINHIHSHKIIHCDIKPSNILKSQQSIYKICDFDLSSQLDQFQDSTS----------IMKGYTK-------
. | . . . . |. .. .. ...|....|||.|||.|.||.||| .. ||||| |. || .| .. ||.|
DYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL-GYGKCKCDWWS
-----YQCLQNKM---------------------NGIIIKN--------HLS
| .| . ... |. |
CGCILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQ
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