Gene 28415 (Tetrahymena)

28415

Species: Tetrahymena
Alias: PreTt28415, TTHERM_00158250, 13.m00374, 3829.m01228, 28415, 130
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
28415.AA Protein None 493 None Fasta, JSON
28415.kin_dom Protein Kinase Domain None 254 None Fasta, JSON
28415.NA RNA None 1482 None Fasta, JSON

Protein domain

Protein domains of 28415.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 28415.AA Ciliate-E2 36-289 21 4.8e-32 107.27 In-house 1-352 (365) Show / Hide 
Range on Protein: 36-289
Range on HMM: 1-352/365
Sequence Identity: 21% (77 aa)

YNIERQIGEGNFGVVYEASV-QQDSIKNQQLIEKDLK-------KVAVKL--MKIENEYTKIQVLNEIEIQKKIQLKG----------------YALQIY
|.. ..||.||||.||...| ...  .. ..|. ...       ||..|.  ||| ... ..|...|| | ..|.  .                . ...|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMY

QVVQ--TTNVIAIVMELAQC-SLKQFLNEK-QY------------IQVIIDLMLQLLE---------------GIKTLEENR-IIHFDIRPDNILLDCNL
 . |  ..| | .|||..|  .|....... .             .. |...| |.|.               ... | ..  ||| || |.|||.    
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

KAKFSDFNLST----------------LLDVDKSYISQCNG---------------GTFKYISPESLLSDR-----NVHKITNKTDIYSLGIVFLELLGI
  | .|| ||.                ..   |...| . |               ||  | .|| | .       . .  . | ||.|||... |.|  
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

QISFDEASDYRRNRQKKLDLSFF--------------NKDILRYQLYDLIIN---NMINSNPDQR
.  |     .. . |.|.|....              ... .  .  ||| .    |.. .|..|
KPPF-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKR
Kinase 28415.AA S_TKc 36-298 21 5.3e-29 103.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 36-298
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)

YNIERQIGEGNFGVVYEASVQQDSIKNQQLIEKDLKKVAVKLMKIENEYTKIQVLNEIEIQKKIQLKGYALQIYQVVQTTNVIAIVMELAQC---SLKQF
| | |.||.| ||.|| .               . ..||.| .|       .....||.| ||     .  ..| | |. . . .|||..     .|...
YEILRKIGKGAFGKVYKCRHKK-----------TGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDY

LNEKQY--------IQVIIDLMLQLLEGIKTLEENRIIHFDIRPDNILLDCNLKAKFSDFNLSTLLDVDKSYISQCNGGTFKYISPESLLSDRNVHKITN
. ....          ..  .| |...... . ...||| |. |.|||||     | .|| |...|       ..|  ||  |..|| |       . . 
IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFC--GTPWYMAPEVL-------GYGK

-KTDIYSLGIVFLELLGIQISFDEASDYRRNRQKKLDLSFFNKDILRYQLYDLIINNMINSNPDQR-NINQVYE---------FI
 | |..|.|... |.|  .  |.   .. .  .| .            .. | .|... . .|..|  . .. .         ..
CKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 28415.AA CAMK 41-234 15 4.2e-27 83.77 In-house 1-323 (425) Show / Hide 
Range on Protein: 41-234
Range on HMM: 1-323/425
Sequence Identity: 15% (53 aa)

QIGEGNFGVVYEASVQQDSIKNQQLIEK-DL------------KKVAVKLMKIE----------------------------NEYTKIQVLNEIEIQKKI
..|.|.||.|.              |.| .             .|||.| .. .                            ..... .|..|||| ||.
TLGRGSFGKVK------------LCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKL

QLKG------YALQIYQVVQTTNV-------------------IAIVM---ELAQC-----SLKQFLNEKQY-----------------IQVIIDLMLQL
| .|        ...|.| .....                   . .||   |...       | ... |. .                  .    .. |.
QGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQI

LEGIKTLEENRIIHFDIRPDNILLDCN-----------------LKAKFSDFNLSTLLDVDKSYI----------------------SQCNGGTFKYIS-
..... . .. |.| |. |.||||| |                  . | .|| ... .| ....                        .   ||  |.. 
CSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAA

PESLLS----------DRNVHKITNKTDIYSLGIV
|| |..          | .   .. |.|. |.|..
PEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVI
Kinase 28415.AA Pkinase 36-239 25 3.4e-25 90.17 Pfam 1-206 (293) Show / Hide 
Range on Protein: 36-239
Range on HMM: 1-206/293
Sequence Identity: 25% (56 aa)

YNIERQIGEGNFGVVYEASVQQDSIKNQQLIEKDLKKVAVKLMKIENEYTKIQVLN----EIEIQKKIQLKGYALQIYQVVQTTNVIAIVMELAQC----
| |.|.||.|.||.||..  . ...           .|||| .| ..|  . .. .    ||.| |...   . ...| .... . | .|||....    
YHIGRKIGSGSFGCVYKCHHKGTGK-----------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-HPNIVRLYDWFEDKDHIYMVMEYCEGGLYV

-SLKQFLN---EKQY---IQVIIDLMLQLLEGIKTLEENRIIHFDIRPDNILLDCNLKA----KFSDFNLSTLLDVDKSYISQCNGGTFKYISPESLLSD
 .|. ..    .. .    ..... |.|.|.|.. . ...||| |. |.|||.| |       | .|| |. ..|  ..   .   ||  |..|| ..  
MDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR--

RNVHKITNKTDIYSLGIVFLELL
    ... | |..|.|... |.|
-GGQYYGPKVDMWSCGCILYEML
Kinase 28415.AA TKL 42-239 18 3.4e-25 87.66 In-house 1-283 (364) Show / Hide 
Range on Protein: 42-239
Range on HMM: 1-283/364
Sequence Identity: 18% (54 aa)

IGEGNFGVVYEASVQ-QDSIKNQQLIEKDLKK------VAVKLMKIEN----------------------EYTKIQVLNEIEIQKKIQLKG----YALQI
||.| ||.|| .  . ... |          .      |||| .|..|                      . .... ... |..   ...       .|.
IGSGGFGEVYKGKWRGWGG-KC---------PSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQF

YQVVQTTNV-------------IAIVMELAQC-S-LKQFLNEKQYIQVIIDLMLQLLEGIKTLEENR--------IIHFDIRPDNILLDCNLK-------
. ...  .              ..||||.... | | ...     ........|.   |.  |  ..        ||| |. ..|||.| |..       
MGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMY

-------AKFSDFNLSTLLDVDKSYISQC------------------NGGTFKYISPESLLSDRNVH------------KITNKTDIYSLGIVFLELL
       .| .|| ||. .. ...   .                    .||. . .|| |  . |              . . |.|.|| |||. |.|
NPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEIL
Kinase 28415.AA ULK 36-239 23 9.2e-25 83.42 In-house 1-250 (329) Show / Hide 
Range on Protein: 36-239
Range on HMM: 1-250/329
Sequence Identity: 23% (59 aa)

YNIERQIGEGNFGVVYEASVQQDSIKNQQLIEKDLKKVAVKLMKIEN-----EYTKIQVLNEIEIQKKIQLKG-------YALQIYQVVQTT--NVIAIV
|.. ...|.| ||.||..  ...  . .. .    |..  . |...|     .| . .. |||.|.||.  .        .  . | . .|.  | | |.
YCLNHCLGKGSFGKVYKGRNKKTK-D-YVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII

MELAQC-SLKQFLNEKQY--IQV----------IIDLMLQLLEGIKTLEENRIIHFDIRPDNILLDCNLK------------AKFSDFNLSTLLDVD---
||. .   |.|.......   ..          .|  . |.|.| | | ...||| || |.|||.. .              .| .|| ..  .| |   
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

-KSYISQC-NG---GTFKYISPESLLSDRNVHKITNK-TDIYSLGIVFLELL
 . . ..       ||  | .|. | .     . ... .||.|||..| |.|
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEML
Kinase 28415.AA CMGC 36-239 17 2.9e-24 75.83 In-house 1-329 (513) Show / Hide 
Range on Protein: 36-239
Range on HMM: 1-329/513
Sequence Identity: 17% (59 aa)

YNIERQIGEGNFGVVYEASVQQDSIK----NQQLIEKDLKKVAVKLMKIENEYTKIQV------------LNEIEIQKKIQ---------------LKGY
| | ..|||| .||||..  ..   |      .   .. ..||.| .| .  |.  .             | ||.| |...                .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQ-AHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHN

-ALQIYQVVQTTN-----------------VIAIVMELAQCSLKQFLNEKQ-------YIQV---------------IIDLM------LQLLEGIK--TL
  ...| .... |                  . .|.|. ...|.|.. ..|        .                 |  .|       |.|.|.|   .
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

EENR--IIHFDIRPDNILLDCN--------------------LKAKFSDFNLSTLLDVDK--------------------SYISQCNGGTFKYISPESLL
  ..  ||| |. | |||.. |                     . |  || |.. ... .                    .     .  |  | .|| ||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

SDRNV------HKITNKTDIYSLGIVFLELL
....       .. | . |. |.| .| |..
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMY
Kinase 28415.AA Ciliate-E2-Unclassified 36-239 22 5.6e-24 80.08 In-house 1-264 (352) Show / Hide 
Range on Protein: 36-239
Range on HMM: 1-264/352
Sequence Identity: 22% (60 aa)

YNIERQIGEGNFGVVYEASVQQDSIKNQQLIEKDLKKVAVKLMKIENEYTKIQVLNEIEIQK--------KIQLKG--------YALQIYQVVQTTNVIA
|.| .|||.|.||.||..   ..  .. . . |. .....|... ..   ... ..|....|        || ..         . .  . . |... | 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD--EIMNEMKEMNNKKKYHQRKYNKI-MQQILLNHPHPFIVKMFYCFQDKQNIY

IVMELA-QCSLKQFLNEK-----------------QYI--QVII-----DLMLQLLEGI-KTLEENRIIHFDIRPDNILLDCNL---KAKFSDFNLSTLL
||||.. . .|.|.....                 . .  | ..     ... |.|.|. .  ..| ||| || |.|||.| |    . | .|| .|  .
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

DVD--------------KSYISQCNGGTFKYI----SPESLLSDRNVHKITNKTDIYSLGIVFLELL
. .              |. ... . ||  |.    .|| | .  . |.   | ||.|||... |.|
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEML
Kinase 28415.AA STE 36-239 21 1.5e-23 80.12 In-house 1-262 (359) Show / Hide 
Range on Protein: 36-239
Range on HMM: 1-262/359
Sequence Identity: 21% (58 aa)

YNIERQIGEGNFGVVYEASVQQDSIKNQQLIEK-----DLKKVAVKLMKIENE-----------------YTKIQVLNEIEIQKKI--------QLKGYA
. . ..||.|.||.|| |    ... . .  |.       . .|.| |..||.                   . |.|.||.| ||         .  |. 
WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

LQIYQVVQTTNVIAIVMELAQC-SLKQFLNEKQYI----------------QVIIDLMLQLLEG-IKTLEENRIIHFDIRPDNILLDCNLKAKFSDFNLS
..     .  . . |.||.    || .....|  .                ..|.    |.|.|  . |....||| || |.||||     .| .|| ..
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

TLLDVD-------------KSYISQC--NGGTFKYISPESLLS-DRN-VHKITNKTDIYSLGIVFLELL
. |. .             ..  ...    ||  . .|| ..  ... ... . | ||.|||.. .|..
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA
Kinase 28415.AA ULK 36-239 24 2.2e-23 79.85 In-house 1-246 (324) Show / Hide 
Range on Protein: 36-239
Range on HMM: 1-246/324
Sequence Identity: 24% (61 aa)

YNIERQIGEGNFG-VVYEA--SVQQDSIKNQQLIEKDLKKVAVKLMKIEN--EYTKIQVLNEIEIQKKIQL-----KGYALQIYQVVQTT--NVIAIVME
|.. ...|.| || .||..    ...  .||.   |   |   .  | |.  .| . .  |||.|.||.         .  . | . .|.  | | |.||
YCLNHCLGKGSFGVKVYKGRNKKTNT--QNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIME

LAQC-SLKQFLNEKQY--IQV----------IIDLMLQLLEGIKTLEENRIIHFDIRPDNILLDCNLK------------AKFSDFNLSTLLD---VDKS
. ..  |.|.......    .          .|  . |...| | | .. ||| || |.|||.  .              .| .|| ..  .|    .. 
YCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQ

YISQCNG-----GTFKYISPESLLSDRNVHKITNK-TDIYSLGIVFLELL
 . .| .     ||  | .|. | .     . ... .||.|||..| |.|
MCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEML
Kinase 28415.AA Ciliate-E1 42-229 24 3.2e-23 72.69 In-house 1-202 (202) Show / Hide 
Range on Protein: 42-229
Range on HMM: 1-202/202
Sequence Identity: 24% (52 aa)

IGEGNFGVVYEASVQQDSIKNQQLIEKDLKKVAVKLMKIENEYTKIQVLNEIE-IQKKIQLKGYALQIYQVVQ-TTN-VIAIVMELAQCSLKQFLN----
||.| |..|..|       |.|. ...  ... ...  ..|. .. ....|.  |.| .. . | .||... .   | ...|..|. .||||. |.    
IGNGSFSIVFKA-------KQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNR

---------EKQYIQVI--IDLMLQLLEGIKTLEENRIIHFDIRPDNILLDCNLKAKFSDFNLSTLLDVDKSYISQCNGGTFKYISPESLL----SDRNV
         .... .    . .. ||..|.  |. ..|||.|| |.||| . . . ...|| .| .|   . . .| .| | .| .|| .     .  . 
LEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKN

HKITNKTDIY
 ||. |.|||
QKINYKSDIY
Kinase 28415.AA Ciliate-E3 111-239 31 3.2e-19 56.85 In-house 72-202 (202) Show / Hide 
Range on Protein: 111-239
Range on HMM: 72-202/202
Sequence Identity: 31% (43 aa)

VVQTTNVIAIVMELAQC-SLKQFLNEKQYIQV--IIDLMLQLLEGIKTLEENRIIHFDIRPDNILLDCNL---KAKFSDFNLSTLLDVDKSYISQC-NGG
. | . .| ||.|.    .|. ..  .|  .   |.|.. |...|.  . |  ||| || |||||.| |.    .|..|| .| .|  .| ...   .| 
YDQQNKMIFIVQEYCSNGDLYHYIK-QQNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGW

TFKYISPESLLSDRNVHKITNKTDIYSLGIVFLELL
|  | .|| .       .| .  |.||.| ||..| 
TPFYAAPEQNDQ----QQISKESDYYSVGAVFCQLC
Kinase 28415.AA TyrKc 36-298 19 1.6e-12 -20.37 SMART 1-280 (280) Show / Hide 
Range on Protein: 36-298
Range on HMM: 1-280/280
Sequence Identity: 19% (62 aa)

YNIERQIGEGNFGVVYEASVQQDSIKNQQLIEKDLKKVAVKLMKIENEYTKIQVLNEIEIQKKI--------QLKGYALQ-----IYQVVQTTNVIAIVM
   ....|||.||.||..                  .|||| .| .    .   ..|..| .|.        .| |...|     .|        . |||
ITLGKKLGEGAFGEVYKGTWK--------------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMY-----IEPLMIVM

ELAQC-SLKQFLNEKQY---IQVIIDLMLQLLEGIKTLEENRIIHFDIRPDNILLDCNLKAKFSDFNLSTLLDVD------KSYIS-----QCNG-GTFK
|..   .||..| ...     .  .. ..|  .|   |.....|| |.   |.|.. |. .| ||| ||  .. |      |.|..     ....    .
EYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

YISPESLLSDRNVHKITNKTDIYSLGIV-----------FLE-----LLGIQISFDEASDYRRNRQKK--LDLSFFNKDILRYQLYDLIINNMINSNPDQ
  .||..    | .| | |.|..| |..             .     .  ...  .  . ||. . .     .||    .    .|. |.    . .|..
WMAPECI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSF---VCCPDEMYQ-IMKQCWHEDPED

R-NINQVYEFI
| . ....|..
RPTFSEIHECF
Kinase 28415.AA Pkinase_Tyr 36-79 27 4e-05 17.98 Pfam 1-37 (270) Show / Hide 
Range on Protein: 36-79
Range on HMM: 1-37/270
Sequence Identity: 27% (12 aa)

YNIERQIGEGNFGVVYEASVQQDSIKNQQLIEKDLKKVAVKLMK
  . ...|||.||.||..           . ...  .|||| .|
ITFGKKLGEGAFGEVYKGTWKG-------DPDNTKIPVAVKMLK
Kinase 28415.AA Ciliate-E3 36-53 44 8.7e-05 11.19 In-house 1-18 (202) Show / Hide 
Range on Protein: 36-53
Range on HMM: 1-18/202
Sequence Identity: 44% (8 aa)

YNIERQIGEGNFGVVYEA
| . ...| | ||.|| |
YTVQQILGCGQFGRVYKA
Kinase 28415.AA Pkinase_Tyr 156-234 28 0.011912 9.6 Pfam 127-203 (270) Show / Hide 
Range on Protein: 156-234
Range on HMM: 127-203/270
Sequence Identity: 28% (23 aa)

LEENRIIHFDIRPDNILLDCNLKAKFSDFNLSTLLDVDKSY-ISQCNGGT-FKYISPESLLSDRNVHKITNKTDIYSLGIV
||....|| |..  |.|...|...| .|| |. ..  |  |  .. .|    |  .||..   .     | |.|..| |..
LESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK----FTTKSDVWSFGVL