Gene 3335 (Tetrahymena)
3335
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 3335.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 3335.AA | Pkinase | 95-162 | 37 | 6.1e-16 | 57.44 | Pfam | 126-202 (293) | Show / Hide |
Range on Protein: 95-162 Range on HMM: 126-202/293 Sequence Identity: 37% (30 aa) SMKIIHCDLKASNILIS-NDQI----KLADFGLSI---LNNSTYSDFYCGQPTLCSPEK---SSYFSFEADLFSLGIII ||.|||.||| .||||. |..| |..||||. . |.. . .|| | ..|| ..| . ..| .|.|.|. SMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCIL |
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| Kinase | 3335.AA | ULK | 93-162 | 27 | 1.1e-15 | 51.28 | In-house | 146-246 (329) | Show / Hide |
Range on Protein: 93-162 Range on HMM: 146-246/329 Sequence Identity: 27% (28 aa) LQSMKIIHCDLKASNILISNDQ-------------IKLADFGLSIL-NNS------TYSDF----YCGQPTLCSPE-------KSSYFSFEADLFSLGII |....|||.|.| .||||.|.| .|.||||.. .|. ... .|| | .|. . | ....|..|||.| LHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCI I . F |
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| Kinase | 3335.AA | ULK | 93-162 | 27 | 1e-14 | 48.66 | In-house | 142-242 (324) | Show / Hide |
Range on Protein: 93-162 Range on HMM: 142-242/324 Sequence Identity: 27% (28 aa) LQSMKIIHCDLKASNILISNDQ-------------IKLADFGLSIL-NNSTYSDFYC----------GQPTLCSPE-------KSSYFSFEADLFSLGII |....|||.|.| .||||.|.| .|.||||.. .| . ... | | | .|. . | ....|..|||.| LHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCI I . F |
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| Kinase | 3335.AA | MARK | 93-161 | 35 | 2.9e-13 | 39.86 | In-house | 120-195 (262) | Show / Hide |
Range on Protein: 93-161 Range on HMM: 120-195/262 Sequence Identity: 35% (27 aa) LQSMKIIHCDLKASNILISND---QIKLADFGLSILN-NSTYSDFYCGQPTLCSPE---KSSYFSFEADLFSLGII . |. |.|.|.|. |||| . .||..|||.|| . . . || | ..|| | | ...| |||.. CHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVV |
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| Kinase | 3335.AA | CMGC | 31-94 | 18 | 3.4e-13 | 38.78 | In-house | 1-104 (513) | Show / Hide |
Range on Protein: 31-94 Range on HMM: 1-104/513 Sequence Identity: 18% (19 aa) YQIITLIGQGYFGQIFKAIN--------------KENQNEVALKIIE-DDGNKWGKQ----------IIENEKRVFKLIQ----------------NAEN |.|| ||.| .|. .|... .|....||.|.| . ...... .. | . | .. . .| YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN IVNLQ ||.|. IVKLY |
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| Kinase | 3335.AA | CAMK | 95-161 | 18 | 1.1e-12 | 36.48 | In-house | 197-323 (425) | Show / Hide |
Range on Protein: 95-161
Range on HMM: 197-323/425
Sequence Identity: 18% (24 aa)
SMKIIHCDLKASNILISND------------------QIKLADFGLSILNNSTYSDF-------------------------YCGQPTLCS-PEKSSY--
|..|.|.||| |||.... .||..|||... .. ..| .|| | .. || ..
SHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKG
--------------FSFEADLFSLGII
....| |.|.|
HCNMQNATDEEKPYYGPKCDMWSCGVI
|
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| Kinase | 3335.AA | CMGC | 95-123 | 30 | 5.4e-12 | 34.76 | In-house | 200-251 (513) | Show / Hide |
Range on Protein: 95-123 Range on HMM: 200-251/513 Sequence Identity: 30% (16 aa) SMK--IIHCDLKASNILISND---------------------QIKLADFGLS |.. |||.||| .||||... ..|..||||. SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA |
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| Kinase | 3335.AA | CDK | 93-123 | 45 | 8.1e-12 | 33.93 | In-house | 124-160 (284) | Show / Hide |
Range on Protein: 93-123 Range on HMM: 124-160/284 Sequence Identity: 45% (17 aa) LQSMKIIHCDLKASNILISNDQ------IKLADFGLS . | .|.| ||| .||||.|. .|.|||||. CHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLA |
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| Kinase | 3335.AA | CDK | 31-66 | 30 | 2.4e-11 | 32.37 | In-house | 1-50 (284) | Show / Hide |
Range on Protein: 31-66 Range on HMM: 1-50/284 Sequence Identity: 30% (15 aa) YQIITLIGQGYFGQIFKAINKENQ-----NEVALKII---------EDDG |... ||.| .|. .||..|... . |||| | |..| YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEG |
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| Kinase | 3335.AA | CAMK | 36-93 | 17 | 2.8e-11 | 31.87 | In-house | 1-103 (425) | Show / Hide |
Range on Protein: 36-93 Range on HMM: 1-103/425 Sequence Identity: 17% (18 aa) LIGQGYFGQIFKAINKENQ------------NEVALKI-------------------IEDDGNKW--------GKQIIENEKRVFKLIQ------NAENI .|.| ||. ...|.|... .|| || |.. ..|. .. ...| .. |..| . .|| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VNL ..| IKL |
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| Kinase | 3335.AA | MST | 31-62 | 37 | 4.2e-11 | 31.47 | In-house | 1-32 (254) | Show / Hide |
Range on Protein: 31-62 Range on HMM: 1-32/254 Sequence Identity: 37% (12 aa) YQIITLIGQGYFGQIFKAINKENQNEVALKII . |. ..||| .|. .|||.|.. ..|| |.. FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMV |
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| Kinase | 3335.AA | DYRK | 31-63 | 42 | 3.9e-10 | 34.33 | In-house | 1-33 (320) | Show / Hide |
Range on Protein: 31-63 Range on HMM: 1-33/320 Sequence Identity: 42% (14 aa) YQIITLIGQGYFGQIFKAINKENQNEVALKIIE |.|. ||.|.||| .|. .. .. ||.|||. YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIR |
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| Kinase | 3335.AA | STE20 | 95-138 | 38 | 4.1e-10 | 33.45 | In-house | 135-186 (288) | Show / Hide |
Range on Protein: 95-138 Range on HMM: 135-186/288 Sequence Identity: 38% (20 aa) SMKIIHCDLKASNILISND-QIKLADFGLSILNNS----TYS---DFYCGQP |..||| |.|| |||.. | ..||||||.. .. | . . .| | SNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTP |
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| Kinase | 3335.AA | STE20 | 31-63 | 32 | 1.3e-09 | 31.61 | In-house | 1-37 (288) | Show / Hide |
Range on Protein: 31-63 Range on HMM: 1-37/288 Sequence Identity: 32% (12 aa) YQIITLIGQGYFGQIFKAINKENQNE----VALKIIE |... |||| .|...||..|..... || |... YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMN |
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| Kinase | 3335.AA | Pkinase | 31-93 | 34 | 3.7e-09 | 33.47 | Pfam | 1-65 (293) | Show / Hide |
Range on Protein: 31-93 Range on HMM: 1-65/293 Sequence Identity: 34% (23 aa) YQIITLIGQGYFGQIFKAINKENQNEVALKIIEDDGNKWGKQIIE---NEKRVFKLIQNAENIVNL |.|. ||.| ||. .|...| .. .||.|||. ...|..|... .| .. | . | .||| | YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRL |
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| Kinase | 3335.AA | STE | 95-123 | 48 | 4.2e-09 | 28.41 | In-house | 170-194 (359) | Show / Hide |
Range on Protein: 95-123 Range on HMM: 170-194/359 Sequence Identity: 48% (14 aa) SMKIIHCDLKASNILISNDQIKLADFGLS |..||| |.|..|||. .||.|||.. SHHIIHRDIKPANILL----VKLCDFGVC |
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| Kinase | 3335.AA | ULK | 31-63 | 32 | 9.4e-09 | 27.25 | In-house | 1-37 (324) | Show / Hide |
Range on Protein: 31-63 Range on HMM: 1-37/324 Sequence Identity: 32% (12 aa) YQIITLIGQGYFG-QIFKAINKEN---QNEVALKIIE |... .|.| || . .|..||.. . || |.|. YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMID |
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| Kinase | 3335.AA | S_TKc | 31-174 | 19 | 1.7e-08 | -52.24 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 31-174
Range on HMM: 1-231/231
Sequence Identity: 19% (48 aa)
YQIITLIGQGYFGQIFKAINKENQNEVALKIIEDDGNKWGKQIIENEKRVFKLIQNAENIVNL-----------------Q-------------------
|.|. .||.| ||. .|...|. . .||.||| . |..| .. | . .|||.| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF
---------------------SMKIIHCDLKASNILISNDQIKLADFGLSILNNSTYSDFYCGQPTLCSPEKSSYFSF-EADLFSLGIII----------
|..|||.||| .|||... .||..||||. . . .|| | ..|| ... ..| |.|.|.
PFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-----TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPF
---------------------LMVDNPI-----TFLK----------I
... .| |. .
PQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
|
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| Kinase | 3335.AA | STE | 31-92 | 20 | 1.9e-08 | 26.11 | In-house | 1-94 (359) | Show / Hide |
Range on Protein: 31-92 Range on HMM: 1-94/359 Sequence Identity: 20% (19 aa) YQIITLIGQGYFGQIFKAINK------ENQNE---------VALKIIE----------------DDGNKWGKQIIENEKRVFKLIQN-AENIVN ...| ||.| ||. .||.|. ..... .| |... .. |. .| |..| .. | .. .|||. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVK |
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| Kinase | 3335.AA | MST | 95-123 | 53 | 1.4e-07 | 20.07 | In-house | 115-144 (254) | Show / Hide |
Range on Protein: 95-123 Range on HMM: 115-144/254 Sequence Identity: 53% (16 aa) SMKIIHCDLKASNILISND-QIKLADFGLS ..|.|| |.|| |||.... |||||| | DNKKIHRDIKAGNILLNHEGECKLADFGVS |
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| Kinase | 3335.AA | MARK | 31-63 | 33 | 3.1e-07 | 19.9 | In-house | 1-33 (262) | Show / Hide |
Range on Protein: 31-63 Range on HMM: 1-33/262 Sequence Identity: 33% (11 aa) YQIITLIGQGYFGQIFKAINKENQNEVALKIIE | ... ||.| ... .|..| . .||.||.| YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYE |
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| Kinase | 3335.AA | DYRK | 93-123 | 44 | 4e-06 | 19.05 | In-house | 119-154 (320) | Show / Hide |
Range on Protein: 93-123 Range on HMM: 119-154/320 Sequence Identity: 44% (16 aa) LQSM-KIIHCDLKASNILISND----QIKLADFGLS |.. .||||||| ||.. . .||..|||.| LHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSS |
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| Kinase | 3335.AA | TyrKc | 31-186 | 14 | 1.7e-05 | -133.58 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 31-186
Range on HMM: 1-280/280
Sequence Identity: 14% (43 aa)
YQIITLIGQGYFGQIFKAINKENQNEVALKIIEDDGNKWGKQIIENEKRVFKLI-QNAENIVNL-----Q------------------------------
. . .| | ||...|.. | .|| | . .| .. . .| |. . . . .|||.| |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH
------------------------SMKIIHCDLKASNILISNDQ-IKLADFGLSILNNST-----YSDFYCG----QPT--L----CSPE--KSSYFSFE
|...|| || | |.|..... .| .||||| . .| | . | ..|| . . |...
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK
ADLFSLGIII------------------LMVDNPITFLKININMSSRKK-----------------------------------NSI
| .| |. . . . | ..| | . .
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
|
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| Kinase | 3335.AA | ULK | 31-91 | 22 | 3.6e-05 | 14.08 | In-house | 1-81 (329) | Show / Hide |
Range on Protein: 31-91 Range on HMM: 1-81/329 Sequence Identity: 22% (18 aa) YQIITLIGQGYFGQIFKAINKEN----QNEVALKIIEDDGNKWGKQI---------IENEKRVFKLIQ---NAEN----IV |... .|.| ||. .|..||.. . || |.|. . . .. ..|| .. | . . .| || YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIV |
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| Kinase | 3335.AA | Pkinase_Tyr | 95-125 | 43 | 6.7e-05 | 17.21 | Pfam | 129-160 (270) | Show / Hide |
Range on Protein: 95-125 Range on HMM: 129-160/270 Sequence Identity: 43% (14 aa) SMKIIHCDLKASNILIS-NDQIKLADFGLSIL |...|| || | |.|.. | ..| .||||. . SKNCIHRDLAARNCLVTENNVVKICDFGLARD |
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| Kinase | 3335.AA | Pkinase_Tyr | 31-65 | 23 | 0.003649 | 11.34 | Pfam | 1-39 (270) | Show / Hide |
Range on Protein: 31-65 Range on HMM: 1-39/270 Sequence Identity: 23% (9 aa) YQIITLIGQGYFGQIFKAINK----ENQNEVALKIIEDD ... .|.| ||...|.. | ... .|| |.. .. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG |
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