Gene 6373 (Tetrahymena)

6373

Species: Tetrahymena
Alias: 3722.m00030, PreTt06373, TTHERM_00526350, 66.m00172, 6373, 360
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
6373.AA Protein None 408 None Fasta, JSON
6373.kin_dom Protein Kinase Domain None 214 None Fasta, JSON
6373.NA RNA None 1227 None Fasta, JSON

Protein domain

Protein domains of 6373.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase 6373.AA Pkinase 121-307 29 5.5e-31 110.65 Pfam 9-172 (293) Show / Hide 
Range on Protein: 121-307
Range on HMM: 9-172/293
Sequence Identity: 29% (59 aa)

KGAFGEIFLVQNKVDGNIYVIKKRKEDNVPKKATLKTIQNLKYMREAANMMRLSHPNIVRAYDWWLEKSDNSCNQFNLYIQMEYVGE-INKAHNLF----
.|.||. .. ..| .| |...|. | .   |.  ..|  .|   .|.. | ||.|||||| |||. .         ..|. |||..        ||    
SGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRL---SEIQIMKRLNHPNIVRLYDWFED-------KDHIYMVMEYCEGGLY-VMDLFDYIS

SFTKQILKNMTDLPN--KRIIIHHFFKQILSGLLYIHENGYVHRDLKPENIFVDPVRQIC---KIGDFGFSKQIQIENKVGELQFRKVPSSTYGTVC
         . . .       . ....|||.|| |.|..| .|||||||||..|   .|.   ||.|||..||..             ..| . |.|
T--------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----------Y-NNS-MTTFC
Kinase 6373.AA Ciliate-E2 121-312 21 2.7e-29 97.71 In-house 9-257 (365) Show / Hide 
Range on Protein: 121-312
Range on HMM: 9-257/365
Sequence Identity: 21% (57 aa)

KGAFGEIFLVQNKVDGNIYVIKKRKEDNVPKK------AT-----LKTI--QNLKYMREAANMM-----------------RLSHPNIVRAYDWWLEKSD
.|.|| ....... ... . ||. . ... .       ..     .|..  ......    ..|                 .|.||||.. |... ||.|
QGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDD

NSCNQFNLYIQMEYVGEINKAHNLFSFTKQILKNMTDLPN-----KRIIIHHFFKQILS---------------GLLYIHENG-YVHRDLKPENIFVDPV
|     |.|. |||.   .    ||.. |.  |. .  ..     .   | ...||||.               .| |.|...  .|||.|||||..   
N-----NIYLVMEYCQGGD----LFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

RQICKIGDFGFSKQIQIENKV-------GELQFRK-----------------VPSSTYGTVCYQPPE
   .|| |||.||.....|.        ....| |                 .  ...||  |..||
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPE
S_TKc 6373.AA S_TKc 113-396 22 1.1e-26 95.86 SMART 1-231 (231) Show / Hide 
Range on Protein: 113-396
Range on HMM: 1-231/231
Sequence Identity: 22% (66 aa)

MIPQEREMKGAFGEIFLVQNKVDGNIYVIKKRKEDNVPKKATLKTIQNLKYMREAANMMRLSHPNIVRAYDWWLEKSDNSCNQFNLYIQMEYVGEINKAH
    .   |||||. .....| .| |. ||. |                . .|| . ...  |||||. ||.. .         .||. |||..      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------EHIRREIQILKK-HHPNIVKLYDVFQD--------DHLYMVMEYCDG-----

NLFSFTKQILKNMTDLPN---KRIIIHHFFKQILSGLLYIHENGYVHRDLKPENIFVDPVRQICKIGDFGFSKQIQIENKVGELQFRKVPSSTYGTVCYQ
.| .  . | |. .  ..       . ....||...| |.|..| .|||||||||..|      ||.|||...|.               ..  ||  | 
DLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL---------------TTFCGTPWYM

PPELRSQFDS-CGDLYNLGLILLDMCNNMENRKTDHYNATYKQDEQKFPQGFRENYQHESKLIEILCACDPQQRQEYQGELENY-----DEFI
.||.  ...    | . .| ||  |.         ......|.             .    .|. ..  ||..|      |..      ....
APEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 6373.AA GCN2 197-334 26 2.3e-25 85.46 In-house 281-447 (511) Show / Hide 
Range on Protein: 197-334
Range on HMM: 281-447/511
Sequence Identity: 26% (49 aa)

NLYIQMEYVG-----EINKAHNLFSFTKQILKNMTDLPNKRIIIHHFFKQILSGLLYIHENGYVHRDLKPENIFVDPVRQICKIGDFGFSKQ--------
.|||||||..     .. . |.......               .   | |||.|| |||..| .|||||| |||.|  ... |||||| ..         
YLYIQMEYCEGKTLRQYIDNHGWCMDHD--------------ELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNV-KIGDFGLATNNKMESQIN

-------------------IQIENKVGELQFRKVPSS--------TY--GTVCYQPPEL-RSQFDSCGDLYNL-GLILLDMC
                   |. ..  ...| .. ...        |.  ||  | .||.  |  ....|.| | |.|.. |.
RKQQKQQQQASSHWAIQNEICQDDQFNQQQSQFSQWDQQDEQVHHTGKVGTPFYMCPEQQKSHYNQKVDMYSLGGIIFFEMW
Kinase 6373.AA PEK 195-334 21 3.9e-25 83.9 In-house 355-588 (655) Show / Hide 
Range on Protein: 195-334
Range on HMM: 355-588/655
Sequence Identity: 21% (51 aa)

QFNLYIQMEYVGEINKAH---NLF----------------SFTKQILK------------------NMTDLPNKRIIIHHFFKQILSGLLYIHENGYVHR
.. |||||||..  .  .   | .                .  . | .                  |.  .. ...   ..|.|||.|| |||..| .||
CHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNY-IMNQCCFQSTWSMNMRQWDENNCMFWDKDQCW--RIFRQILEGLNYIHSQGMIHR

DLKPENIFVDPVRQ----ICKIGDFGFSKQIQ--------------------IENKVGELQFRKVPSST-----------------------------YG
|||| |||.|   |    . |||||| ....                     ....  ........|.|                              |
DLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVG

TVCYQPPELRS-------QFDSCGDLYNLGLILLDMC
|. | .||. |       ...  .|.| ||.|.. |.
TCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMW
Kinase 6373.AA CMGC 121-287 17 2.5e-24 76.05 In-house 9-257 (513) Show / Hide 
Range on Protein: 121-287
Range on HMM: 9-257/513
Sequence Identity: 17% (46 aa)

KGAFGEIFLVQN--------------KVDGNIYVIKKRKEDNVPKKATL----------KTIQNLKYMREAA-----------NMMRLSHPNIVRAYDWW
.|..|. .  ..              . ...|. ||| |..   .   .          ...  .|....             . .   |.|||. ||. 
EGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIF

LEKSDNSCNQF----------NLYIQMEYVGEINKAHNLFSFTKQILK-----NMTDLPNKR----------IIIHHFF------KQILSGLL--YIHEN
  | ... ..           .||. .||..     |.|. . |.  .     .   |.               | .|.      .||| ||   |.| .
YHKNSDGNEYEDKHIISQHFNHLYLVFEYMD-----HDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSH

G--YVHRDLKPENIFVDP-------------------VRQICKIGDFGFSKQIQIE
.   .||||||||| ...                   .. . ||.|||..... ..
WGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPH
Kinase 6373.AA CAMK 236-313 25 1.8e-23 71.86 In-house 182-291 (425) Show / Hide 
Range on Protein: 236-313
Range on HMM: 182-291/425
Sequence Identity: 25% (29 aa)

HHFFKQILSGLLYIHENGYVHRDLKPENIFVDPVR----------------QICKIGDFGFSKQIQIEN-------KVGELQFRKV----------PSST
...|.||.|.. |.|... |||||||||| .|                      || ||||.....  .       . |.  . .            .  
RRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTF

YGTVCYQP-PEL
 || .| . ||.
CGTPEYMAAPEV
Kinase 6373.AA WEE 121-289 28 1.2e-21 69.39 In-house 9-187 (297) Show / Hide 
Range on Protein: 121-289
Range on HMM: 9-187/297
Sequence Identity: 28% (57 aa)

KGAFGEIFLVQNKVDGNIYVIKKRKEDNVPKKATLKTIQNLKYMREAANMMRLS-------HPNIVRAYDWWLEKSDNSCNQFNLYIQMEYVGEI-NKAH
.| ||| . .....||.|| ||| |   . .    | .      ||. . | |.       ||.||| |  | |..        .||||||  .  | ..
EGSFGEVYKCRCRIDGCIYAIKKSK-QPFRGYSERKRA-----LREVYAHMVLGQIMDCDHHPHIVRYYSAWEEDD-------HMYIQMEYCNGGSNLLQ

NLFSFTKQILKNMTDLPNKRIIIHHFFKQILSGLLYIHEN-GYVHRDLKPENIFVDPVRQ-------------------ICKIGDFGFSKQIQIENK
....  ..  . ...     . | ... .|. || .||.| | || |.||||||. .  .                   .||||||| .. .  .|.
FWIQQCHNWNHWLPE-----WMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTDMNSNNN
Kinase 6373.AA Ciliate-E2-Unclassified 121-313 20 1.5e-21 71.51 In-house 9-237 (352) Show / Hide 
Range on Protein: 121-313
Range on HMM: 9-237/352
Sequence Identity: 20% (52 aa)

KGAFGEIFLVQNKVDGNIYVIKKRKEDNVPKKATLKTIQNLKYMREAANMMRLS-----------------HPNIVRAYDWWLEKSDNSCNQFNLYIQME
.|.||.....|.| ..  | ..| . ..  .|  ..  ..  .|.|.  |....                 ||.... .. . ..     ...|.|| ||
QGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQ-----DKQNIYIVME

YV--GEINKAHNLFSF-------------------TKQIL---KNMTDLPNKRIIIHHFFKQILSGLLYIHENG-YVHRDLKPENIFVDPVRQ--ICKIG
|.  |.  . .. ...                    .|..   .             ..|.|||.|| |.|...  .|||.|||||..|   .   .|| 
YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKA------------KFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKII

DFGFSKQIQIENKVGELQF--------RKVPSSTYGTVCYQ----PPEL
|||.||..|  |.    .         ..  ... || .|.    .||.
DFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEV
Kinase 6373.AA Ciliate-E2a 235-290 33 8.2e-20 55.02 In-house 103-167 (275) Show / Hide 
Range on Protein: 235-290
Range on HMM: 103-167/275
Sequence Identity: 33% (22 aa)

IHHFFKQILS-GLLYIHENGYVHRDLKPENIFVD---PVR---QICKIGDFGFSKQI--QIENKV
| .. .|.|. ||.|.| ....|||||||||. .   .     . .|| |||....|   .....
ICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYM
Kinase 6373.AA CAMKL 236-289 41 1.9e-19 58.56 In-house 130-189 (297) Show / Hide 
Range on Protein: 236-289
Range on HMM: 130-189/297
Sequence Identity: 41% (25 aa)

HHFFKQILSGLLYIHENGYVHRDLKPENIFVDPVRQ-ICKIGDFGFSKQIQ-I----ENK
...|.||.|.. |.|..| ||||.||||| .|       || ||||| ... .    ..|
RRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQK
Kinase 6373.AA STE 240-312 27 2.9e-17 57.63 In-house 158-232 (359) Show / Hide 
Range on Protein: 240-312
Range on HMM: 158-232/359
Sequence Identity: 27% (23 aa)

KQILSG-LLYIHENGYVHRDLKPENIFVDPVRQICKIGDFGFSKQIQI---ENKVGE-------LQFRKVPSSTYGTVCYQPPE
.||| | | |.|.....|||.|| ||..      .|. |||...|..    ..   .       .   .   .  ||  .  ||
RQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVCGQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPE
Kinase 6373.AA PEK 121-188 34 3.2e-10 31.03 In-house 9-86 (655) Show / Hide 
Range on Protein: 121-188
Range on HMM: 9-86/655
Sequence Identity: 34% (28 aa)

KGAF-GEIFLVQNKVDGNIYVIKKRKEDNVPKKATLK-------------TIQNLKYMREAANMMRLSHPNIVRAYDWWLEK
||.| |  . ||||.||. | ||.     . .... |               .. |..||.  ..||.|||||| .  |.||
KGGFGGQVYKVQNKLDGCYYAIKR----IKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEK
Kinase 6373.AA GCN2 121-190 39 6e-09 27.04 In-house 9-75 (511) Show / Hide 
Range on Protein: 121-190
Range on HMM: 9-75/511
Sequence Identity: 39% (28 aa)

KGAFGEIFL-VQNKVDGNIYVIKKRKEDNVPKKATLKTIQNLKYMREAANMMRLSHPNIVRAYDWWLEKSD
||.||..   |.|..||..| ||| .  . .|.  | ..  .|.|||..  .|| |...|| |  |.|| |
KGGFGQVVKNVRNMHDGRYYAIKKWP--INWKQRKLPCK--HKIMREVKLLCRLHHQHVVRYYQAWIEKCD
Kinase 6373.AA CAMK 121-205 14 1.2e-08 23.25 In-house 4-142 (425) Show / Hide 
Range on Protein: 121-205
Range on HMM: 4-142/425
Sequence Identity: 14% (21 aa)

KGAFGEIFLVQNKVDG------------NIYVIKKRKEDNVP------------KKATLKT------IQNLKY--MREAANMMRLS-------HPNIVRA
.|.||. .|...| ..              . ||  . . ..            .. . .        .. .   .|| . |..|.       ||||.. 
RGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKL

YDWWLEKSDNSCNQF--------------NLYIQM---EYV
|...  .. .. | .              ..|. |   ||.
YEVYEDPHYFK-N-TNDYETSKQVFTKDKHMYMVMEIMEYC
Kinase 6373.AA TyrKc 121-389 21 1.3e-08 -83.64 SMART 9-280 (280) Show / Hide 
Range on Protein: 121-389
Range on HMM: 9-280/280
Sequence Identity: 21% (69 aa)

KGAFGEIFLVQNKVDGNIYVIKKRKEDNVPKKATLKTIQNLKYMREAANMMRL--SHPNIVRAYDWWLEKSDNSCNQF----NLYIQMEYVGEINKAHNL
 |||||... . |       .|. |||                ||||  |..|  .|||||| |   .... |    |     |.| |||.   .     
EGAFGEVYKGTWK---IQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----FMYIEPLMIVMEYMPHGD-----

FSFTKQILKNMTD-LPNKRIIIHHFFKQILSGLLYIHENGYVHRDLKPENIFVDPVRQICKIGDFGFSKQIQIE------NKVGELQF---RK--VP---
    |. |..  . |..|  .  .|  || .|  |.|.....||||   |. |.  . ..||.||| |. |  .       ..   .    .|  .|   
---LKDYLRKHRPKLCMKDLL--SFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

----SSTYG-------------------TVCYQPPEL---RSQFDSCGDLYNLGLILLDMCNNMEN----RKTDHYNATYKQDEQKFPQGFRENYQHESK
    .  ||                   | . ||..    .  . |  ..... .   ..   ..|                        |       ..
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEY-VKQGYRMPQPPNDYPMS-------------------F---VCCPDE

LIEILCAC---DPQQR---QEYQGEL
. .|   |   || .|   .|   ..
MYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 6373.AA STE 121-206 24 1.6e-07 22.72 In-house 9-120 (359) Show / Hide 
Range on Protein: 121-206
Range on HMM: 9-120/359
Sequence Identity: 24% (28 aa)

KGAFGEIFLVQNKV---------------DGNIYVIKKRKEDNV-PKKAT------LKTI---QNLKYMREAANMMRLS--HPNIVRAYDWWLEKSDNSC
|||||. ..  |.                 |.|. ||. . .|  .|. .      |...   .  ....|   |....  |||||. |.  . ...|. 
KGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHK

NQFNLYIQMEYVG
|  .|.| |||..
NDDELWICMEYMD
Kinase 6373.AA CAMKL 165-206 26 7e-06 14.56 In-house 61-104 (297) Show / Hide 
Range on Protein: 165-206
Range on HMM: 61-104/297
Sequence Identity: 26% (14 aa)

REAANMMRLS---HPNIVRAYDWW--LEKSDNSCNQFN-----LYIQMEYVG
||.. |..|.   ||||.. |. .   |.        .     .|. |||..
REIQIMKMLNIGKHPNIIKLYEVIETPEH--------DIETKKIYLVMEYCS
Kinase 6373.AA Ciliate-E2a 121-185 32 1.4e-05 12.39 In-house 9-68 (275) Show / Hide 
Range on Protein: 121-185
Range on HMM: 9-68/275
Sequence Identity: 32% (21 aa)

KGAFGEIFLVQNKVDGNIYVIKKRKEDNVPKKATLKTIQNLKYMREAANMMRLSHPNIVRAYDWW
||.||  .|.| | .|  ...||     . ||.  ..... . |.| . | .|.|||| . |. .
KGNFGSVYLAQHKQTGKQFAMKK-----FIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVY
Kinase 6373.AA Pkinase_Tyr 164-180 66 0.003341 11.47 Pfam 51-68 (270) Show / Hide 
Range on Protein: 164-180
Range on HMM: 51-68/270
Sequence Identity: 66% (12 aa)

MREAANMMRL-SHPNIVR
||||. |. | .||||||
MREAKIMKQLGHHPNIVR
Kinase 6373.AA Pkinase_Tyr 244-284 34 0.013928 9.37 Pfam 122-161 (270) Show / Hide 
Range on Protein: 244-284
Range on HMM: 122-161/270
Sequence Identity: 34% (14 aa)

SGLLYIHENGYVHRDLKPENIFVDPVRQICKIGDFGFSKQI
.|. | ......||||   |. |.  . ..||.||| .. |
KGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFGLARDI
Kinase 6373.AA GCN2 354-383 29 0.107783 1.2 In-house 467-500 (511) Show / Hide 
Range on Protein: 354-383
Range on HMM: 467-500/511
Sequence Identity: 29% (10 aa)

QKFPQGFR---ENYQH-ESKLIEILCACDPQQRQ
..|||.|    .| .  . ..|. .  .|||.|.
CEFPQDFDKKVDNHHKDQQDMIRWCLNHDPQKRP