Gene 6910 (Tetrahymena)

6910

Species: Tetrahymena
Alias: 3715.m00055, PreTt06910, 6910, 1117, 62.m00194, TTHERM_00497440
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
6910.AA Protein None 1691 None Fasta, JSON
6910.kin_dom Protein Kinase Domain None 57 None Fasta, JSON
6910.NA RNA None 5076 None Fasta, JSON

Protein domain

Protein domains of 6910.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 6910.AA TKL 1132-1324 15 1.6e-08 26.81 In-house 123-345 (364) Show / Hide 
Range on Protein: 1132-1324
Range on HMM: 123-345/364
Sequence Identity: 15% (37 aa)

GNLEDFLEKYEVQESERIKLCYQIALGIQDIHLHN--------YIHTQISPQNIMITENFM--------------PLITSLKESSSLSEQKLEKDQNSK-
|.|...|       . |......||.|..  | .|         ||  . ..||.. ||.               . |. .  | ..|. .  .|. .. 
GSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTM

-------DNKQDKSNLPLTYQW----ILTKGNTWNQKNQ-FTNQDATGSYDFSFDIFSLGLIIYHILTQKEIPSEFNESSFTNFDDLKQKLANLDDLPME
       .|.. ...   |..|    .| . .  ..|.  .  ..  ..|. . |..| |.... ||| ..            ..|..     . | | .
MESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE-FCKGFEYSEKCDVYSFGIVLWEILTRCR-----------PYYDYPYMPMIFQD-P-F

QQIIIKLCLEKQTSIQG--------------ILYRLKQLIEK
...... |....                   .. ..|.|...
EEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQD
Kinase 6910.AA ULK 1132-1183 33 1.8e-08 26.23 In-house 102-163 (324) Show / Hide 
Range on Protein: 1132-1183
Range on HMM: 102-163/324
Sequence Identity: 33% (21 aa)

GNLEDFLEKYE----------VQESERIKLCYQIALGIQDIHLHNYIHTQISPQNIMITENF
|.||....|.             |.| |. ..||. | ...| ||.||  | ||||.|....
GDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQ
Kinase 6910.AA ULK 1132-1183 33 2.3e-08 25.37 In-house 105-167 (329) Show / Hide 
Range on Protein: 1132-1183
Range on HMM: 105-167/329
Sequence Identity: 33% (21 aa)

GNLEDFLEKYE-----------VQESERIKLCYQIALGIQDIHLHNYIHTQISPQNIMITENF
|.||....|.              |.| |. ..||. | ...| ||.||  | ||||.|....
GDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQ
S_TKc 6910.AA S_TKc 1056-1322 15 3.6e-08 -57.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 1056-1322
Range on HMM: 1-231/231
Sequence Identity: 15% (47 aa)

FQIGNK-------EAYKAIIKRTSQSCTLISFPLETSFHIEMLLKEIELINIIQSHYTLKPLCSYIDREEQKYYLNIIYIPL-IGNLEDFLEKYE-----
..|..|       . ||.. |.| . . .   .       |....||..    .  .  | . .. |   ...|.   |..   |.| |...|.      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--VQESERIKLCYQIALGIQDIHLHNYIHTQISPQNIMITENFMPLIT----SLKESSSLSEQKLEKDQNSKDNKQDKSNLPLTYQW----ILTKGNTWN
    | .  ...|||..... .| |. ||  . |.||...|     |.    . .                       . .  |  .    .|       
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------------TTFCGTPWYMAPEVL-------

QKNQFTNQDATGSYDF-SFDIFSLGLIIYHILTQKEIPSEFNESSFTNFDDLKQKLANLDDLPMEQQIIIKLCLEKQTS----IQGILY-----RLKQLI
            .|.. . |. |.| |.|  |.  . | .       . . . .|.      . |   .|. ||.|  .    .  .|      .. . .
------------GYGKCKCDWWSCGCILYEMLC-GYPPFP-------QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 6910.AA Ciliate-A1 1132-1179 40 7.1e-08 22.82 In-house 86-134 (301) Show / Hide 
Range on Protein: 1132-1179
Range on HMM: 86-134/301
Sequence Identity: 40% (20 aa)

GNLEDFLEKYE-VQESERIKLCYQIALGIQDIHLHNYIHTQISPQNIMI
||| ..    .   . | . .||||  |. ||| || .|  . ||||.|
GNLFNYCYQNDYMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILI
TyrKc 6910.AA TyrKc 1050-1315 15 9e-06 -128.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 1050-1315
Range on HMM: 1-280/280
Sequence Identity: 15% (49 aa)

FEFINQFQIGN---------KEAYKAIIKRTSQSCTLISFPLETSFHIEMLLKEIELINII--QSHYTLKPLCSYIDREE-----QKYYLNIIYIPLIGN
 ... .   |.         |  ..  .|    ..            .|....|...   .  .    .. .   .. ..     . ...   | |. |.
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GD

LEDFLEKYE--VQESERIKLCYQIALGIQDIHLHNYIHTQISPQNIMITENFMPLITSLKES-SSLSEQKLEKDQN--SKDNKQDKS--NLP--LTYQW-
| |.| |..  .. .. .. |.||| | . .| .|.||  .   |....||.       | |   ||    ..||.  ||| .  |.  .    | . | 
LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

---ILTKGNTWNQKNQFTNQDATGSYDFSFDIFSLGLIIYHILTQKEIPSE------FNESSFTNFDDLKQKLANLDD--------LPMEQQIIIKLCLE
    .                 .| . .  |..| |  .. |.|  . | .       . .   .. .    .   ..         | |   |.| | .
APECI----------------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWH

KQ-------TSIQGIL
 .       . |  ..
EDPEDRPTFSEIHECF
Kinase 6910.AA CMGC 1133-1182 18 1e-05 13.78 In-house 140-220 (513) Show / Hide 
Range on Protein: 1133-1182
Range on HMM: 140-220/513
Sequence Identity: 18% (15 aa)

NLEDFLEKYE----------VQESE------------RIKLC------YQIALGIQ--DIHLHN--YIHTQISPQNIMITEN
.| ......             | .              ..       |||  |.    .| |.   ||. . |.||.|..|
DLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHN
Kinase 6910.AA Fer 1132-1169 39 1.2e-05 15.37 In-house 94-134 (283) Show / Hide 
Range on Protein: 1132-1169
Range on HMM: 94-134/283
Sequence Identity: 39% (16 aa)

GNLEDFLEKYE---VQESERIKLCYQIALGIQDIHLHNYIH
|.|...| |..   | . |.|. |||.| |.. .| .| ||
GSLDSYLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIH
Kinase 6910.AA Ciliate-E2-Unclassified 1132-1266 18 1.9e-05 14.92 In-house 106-267 (352) Show / Hide 
Range on Protein: 1132-1266
Range on HMM: 106-267/352
Sequence Identity: 18% (32 aa)

GNLEDFLEK------------------YEVQESERI-----KLCYQIALGIQDIHLHN-YIHTQISPQNIMITEN---FMPLITSLKESSSLSEQKLEKD
|.|.....|                   ...| . .     ....|| .|.. .|  |  ||  | |.||....|   . . |. .  |. . ..  .. 
GDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-

QNS-------KDNKQDKSNLPLTYQ------WILTKGNTWNQKNQFTNQDATGSYDFSFDIFSLGLIIYHILTQK
 |.       |.....     . |.       .| . |  ..|             .. ||.||| |.| .|...
TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA------------YKCDIWSLGVILYEMLFGY
Kinase 6910.AA RTKC 1132-1169 33 2.2e-05 13.58 In-house 86-124 (261) Show / Hide 
Range on Protein: 1132-1169
Range on HMM: 86-124/261
Sequence Identity: 33% (13 aa)

GNLEDFLEKY-EVQESERIKLCYQIALGIQDIHLHNYIH
| | ..|..  .. |. ..  |||.|.|   ||  . ||
GSLKSYLMNNPDCTEHQKVRFCYQCASGMEHIHSFGFIH
Kinase 6910.AA Ciliate-D1 1251-1269 36 3.2e-05 18.26 In-house 1-19 (19) Show / Hide 
Range on Protein: 1251-1269
Range on HMM: 1-19/19
Sequence Identity: 36% (7 aa)

DIFSLGLIIYHILTQKEIP
||.|.|.|.|..|... ..
DIWSFGCILYEMLFGQPPF
Kinase 6910.AA Ciliate-B1 1245-1319 25 0.000347 10.69 In-house 205-290 (290) Show / Hide 
Range on Protein: 1245-1319
Range on HMM: 205-290/290
Sequence Identity: 25% (22 aa)

SYDFSFDIFSLGLIIYHILTQKEIPS--EFNESSFTN----FDDLKQKLANLDDLPMEQQI-IIKLCLEKQTS----IQGILYRLK
.||.. || |.|.|.| |.|..       ...    |    |. . ..  ...... | |  |.|.||.....    |. |. || 
QYDKKVDIWSFGCIMYEIITNEQLFCSLGNTQQEVANQIRNFQCCDYQCHFQNNIYQEIQQLIQKYCLQPDPENRITIDQIIDRLM
Kinase 6910.AA Ciliate-A1 1251-1267 52 0.126624 1.22 In-house 210-225 (301) Show / Hide 
Range on Protein: 1251-1267
Range on HMM: 210-225/301
Sequence Identity: 52% (9 aa)

DIFSLGLIIYHILTQKE
|..|||.||.  |. ||
DMYSLGCIICF-LCYKE