Gene 22159 (Tetrahymena)
22159
Group:
Other
Family:
Ciliate-E1
Sequence
Protein domains of 22159.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 22159.AA | Ciliate-E1 | 6-160 | 22 | 2.7e-29 | 92.64 | In-house | 32-202 (202) | Show / Hide |
Range on Protein: 6-160 Range on HMM: 32-202/202 Sequence Identity: 22% (40 aa) QFSSKKKLQNLEEDI-LKDFLKKNKYE-YLIKSFKDDSNGLVALAMEFCDGNLTDVLS--------------QNDLDILQIQAMTYQILQGLLKIYKQGN .... .......|.. ... .||..| ..|. .|.|.| . .. .|.|. .|.| |. ||.....|. ....|...|| .. ... NYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNI IHGNIKPSNILYSKFKNQFLIADLGLSKNDEELNIQQSVNNIYQTYDY-NMPIK--EVAGSEESNSIKVSLQIY ||..|||.|||.... ......|.|.||. . ..||.. . |..| | .. .. |. .... |. . || IHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKINYKSDIY |
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| Kinase | 22159.AA | Ciliate-A8 | 32-109 | 40 | 1.5e-24 | 82.04 | In-house | 64-151 (151) | Show / Hide |
Range on Protein: 32-109 Range on HMM: 64-151/151 Sequence Identity: 40% (36 aa) YLIKSFKDDSNGLVALAMEFCDG--------NLTDVLS--QNDLDILQIQAMTYQILQGLLKIYKQGNIHGNIKPSNILYSKFKNQFL ..| . |. |..| .|||| ||. .|. | ... || |.||| | .|| ...| ||..||| |||||. ||||. QIIECIQDKEQGFIAIVTEFCDCFDFYKKKENLASILENNLNKFTFEQIVALTYQLLKCLLVFQEKGIIHCDIKPQNILYSWSKNQFI |
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| Kinase | 22159.AA | Ciliate-A1 | 47-117 | 38 | 1.8e-14 | 45.66 | In-house | 78-149 (301) | Show / Hide |
Range on Protein: 47-117 Range on HMM: 78-149/301 Sequence Identity: 38% (28 aa) LAMEFCD-GNLTDVLSQND-LDILQIQAMTYQILQGLLKIYKQGNIHGNIKPSNILYSKFKNQFLIADLGLSK ..||.| ||| . ||| . .|. . ||| .|.. | .. .| .|| ||| |.... |.|||.|| IIMEYCQYGNLFNYCYQNDYMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILI-HFDDKWKICDLGMSK |
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| Kinase | 22159.AA | CMGC | 33-117 | 17 | 7.2e-12 | 34.34 | In-house | 103-252 (513) | Show / Hide |
Range on Protein: 33-117 Range on HMM: 103-252/513 Sequence Identity: 17% (26 aa) LIKSFKDDS---------------NGLVALAMEFCDGNLTDVLSQND----------LDILQ------------IQAMT------YQILQGLL--KIYKQ |. .|... . . | .|..| .| ... .| |. . |. .. ||||.|| . .. LYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSH G--NIHGNIKPSNILYSKFKNQF-------------------LIADLGLSK . || .||.||| .. . . |.| ||.. WGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLAR |
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| Kinase | 22159.AA | Ciliate-E2 | 9-140 | 20 | 9.8e-12 | 36.54 | In-house | 58-256 (365) | Show / Hide |
Range on Protein: 9-140
Range on HMM: 58-256/365
Sequence Identity: 20% (41 aa)
SKKKLQNLEEDIL------------KDFLKKNKYEYLIKSF---KDDSNGLVALAMEFCDG-NLTDVLSQN------------DLDILQIQAMTYQILQ-
.... .. |..|. | |.... ..|| . .. .. . | ||.|.| .| | . .| ... .|. ...||||
NQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQG
--------------GLLKIYKQG-NIHGNIKPSNILYSKFKNQFLIADLGLSKNDEELNI-----------------------------QQSVNNIYQTY
.| . ... || .|||.|||. |.|.||||. . |. |. .|.|. |.
FKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTP
DYNMP
| .|
GYMAP
|
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| Kinase | 22159.AA | CDK | 47-117 | 25 | 5.9e-10 | 27.87 | In-house | 95-161 (284) | Show / Hide |
Range on Protein: 47-117 Range on HMM: 95-161/284 Sequence Identity: 25% (19 aa) LAMEFCDGNLTDVLSQNDLDILQIQAMTYQILQGLLKIYKQGNIHGNIKPSNILYSKFKN----QFLIADLGLSK . .|..| | ... |. ...|.|.|| . ... .| .||.|||... . . ||| ||.. MVFEYMDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLAR |
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| Kinase | 22159.AA | Ciliate-E2-Unclassified | 9-137 | 20 | 1.5e-09 | 29.28 | In-house | 52-228 (352) | Show / Hide |
Range on Protein: 9-137 Range on HMM: 52-228/352 Sequence Identity: 20% (37 aa) SKKKLQNLE-------EDILKDFLKKNKYEYLIKSFKDD-SNGLVALAMEFC-DGNLTDVLSQ------------------NDLDILQIQ-----AMTYQ ..| ..|.. ..|... |. .. ....| | . . . . ||.| .|.| . ... . .. |.. ...| EMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQ ILQGLLKIYKQGNI-HGNIKPSNILYSKFKN--QFLIADLGLSKNDEELNI-------------QQSVNNIYQTYDY ||||| .. ...|| | .|||.|||... .. . |.|.|.||. .. | || . . .|. | ILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNY |
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| Kinase | 22159.AA | STE | 47-118 | 26 | 1.5e-09 | 30.05 | In-house | 114-196 (359) | Show / Hide |
Range on Protein: 47-118 Range on HMM: 114-196/359 Sequence Identity: 26% (24 aa) LAMEFCD-GNLTDVLS-----QNDLD----------ILQIQAMTYQILQG-LLKIYKQGNIHGNIKPSNILYSKFKNQFLIADLGLSKN ..||..| | |.|.. ...|. || ....|||.| | . ... || |||.||| ..| |.... ICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVCGQ |
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| Kinase | 22159.AA | S_TKc | 6-242 | 17 | 2.4e-09 | -39.78 | SMART | 11-231 (231) | Show / Hide |
Range on Protein: 6-242 Range on HMM: 11-231/231 Sequence Identity: 17% (48 aa) QFSSKKKLQNLE-----------------EDILKDFLKKNKYEYLIKSFKDDSNGLVALAMEFCDG---NLTDVLSQND-------LDILQIQAMTYQIL |.. .| .. . .||| . |. .| | . . . ||.||| .| |.. .. .. ... ..|||. AFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQIC QGLLKIYKQGNIHGNIKPSNILYSKFKNQFLIADLGLSKNDEELNIQQSVNNIYQTYDYNMPIKEVAGSEESNSIKVSLQIY---LVNIRNIINLTQQKG ..| . ..| || .||.||| .. . |.| ||.. ... ... .. . | CALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------------------------------TTFCGTPWYMAPEVL------GYGKCKC DVFSLGLLLIEVFLKRPLTQQEQIDLNVKNIFSVLPTLKNSRHIKFIQKIIS------PMVDPCRQ----TKIEPTL |. |.| .|.| . .|. . |... |.| . . ||.|. | . . | |. | . DWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 22159.AA | ULK | 49-128 | 25 | 2.2e-08 | 25.47 | In-house | 99-203 (329) | Show / Hide |
Range on Protein: 49-128 Range on HMM: 99-203/329 Sequence Identity: 25% (27 aa) MEFCDG-NLTDVLSQN-----------DLDILQIQAMTYQILQGLLKIYKQGNIHGNIKPSNILYSKFK-----------NQFLIADLGLSKN-DEE-LN ||.|.| .| . ...| | ... .|||.|. ..|.. || |||.||| .. . ... ||| |..| |.. .. MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME IQQSV .|. . QQMMM |
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| Kinase | 22159.AA | ULK | 47-117 | 25 | 3.1e-08 | 25.39 | In-house | 94-186 (324) | Show / Hide |
Range on Protein: 47-117 Range on HMM: 94-186/324 Sequence Identity: 25% (24 aa) LAMEFCDG-NLTDVLSQN----------DLDILQIQAMTYQILQGLLKIYKQGNIHGNIKPSNILYSKFK-----------NQFLIADLGLSK . ||.|.| .| . . .| | ... .||..|. ..|.. || |||.||| .. . ... ||| |..| IIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAK |
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| Kinase | 22159.AA | Pkinase | 33-117 | 29 | 2.9e-07 | 26.78 | Pfam | 65-160 (293) | Show / Hide |
Range on Protein: 33-117 Range on HMM: 65-160/293 Sequence Identity: 29% (29 aa) LIKSFKDDSNGLVALAMEFCDG-----NLTDVLS---QNDL--DILQIQAMTYQILQGLLKIYKQGNIHGNIKPSNILYSKFKNQF----LIADLGLSK |. .| | .. . . ||.|.| | |..| .. . . ... . ||||.|| ....| || .||.|||.. ... |.| ||.| LYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAK |
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| Kinase | 22159.AA | Pkinase | 173-193 | 38 | 1.25616 | 3.3 | Pfam | 191-211 (293) | Show / Hide |
Range on Protein: 173-193 Range on HMM: 191-211/293 Sequence Identity: 38% (8 aa) QKGDVFSLGLLLIEVFLKRPL .| |..|.|..|.|....||. PKVDMWSCGCILYEMLCGRPP |
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| LRR_RI | 22159.AA | LRR_RI | 312-339 | 35 | 0.003642 | 15.75 | SMART | 1-28 (28) | Show / Hide |
Range on Protein: 312-339 Range on HMM: 1-28/28 Sequence Identity: 35% (10 aa) NISQLTLNLSYNSINEEGAKYICTGISK | | ..|.||.| . .||.. .| |.. NCSLRELWLSNNKLGDEGCRQLCEGLKH |
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| LRR_RI | 22159.AA | LRR_RI | 402-429 | 28 | 0.072793 | 6.57 | SMART | 1-28 (28) | Show / Hide |
Range on Protein: 402-429 Range on HMM: 1-28/28 Sequence Identity: 28% (8 aa) NISTLNLNFNNNNIKAEGAKKILNSLQK | | . |. .||.. .||.. . ..|. NCSLRELWLSNNKLGDEGCRQLCEGLKH |
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| LRR_RI | 22159.AA | LRR_RI | 462-489 | 32 | 0.07115 | 6.64 | SMART | 1-28 (28) | Show / Hide |
Range on Protein: 462-489 Range on HMM: 1-28/28 Sequence Identity: 32% (9 aa) NLSYLSLNLDQNSLLADGARIIGESVEK | | . |.| .| | ..|.| . |. . NCSLRELWLSNNKLGDEGCRQLCEGLKH |
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