Gene 6000 (Tetrahymena)

6000

Species: Tetrahymena
Alias: 3689.m00035, 6000, 34.m00237, TTHERM_00334560, PreTt06000, 1005
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E1

Sequence

Name Sequence Type Origin Length Description Download
6000.AA Protein None 792 None Fasta, JSON
6000.kin_dom Protein Kinase Domain None 221 None Fasta, JSON
6000.NA RNA None 2379 None Fasta, JSON

Protein domain

Protein domains of 6000.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 6000.AA Ciliate-E1 153-350 11 3.3e-34 108.82 In-house 1-202 (202) Show / Hide 
Range on Protein: 153-350
Range on HMM: 1-202/202
Sequence Identity: 11% (24 aa)

VSNGLPHPNIIQIKDAYIIESKEKTKKARSLIIVMEYFDSNLHDIIQFRKKHKWEFSTKELCSFLRDISSALATILRQGVSHRDIRPTN------IWHIC
..||  .  ...... ........    .  ......|..... .... | .|.|... ... .... .. . .|. . ..... . ..      .|..|
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

MRNQGVRHEDGEGYNTVRGVPQFAAPEILNLMHMNAN-QKVLNYNPFSQDIYS-LGLTLILMKNLYDEVDFDTLLSKVKQSGSANINIDLGSMELNQLVD
..||.  ...   . ... . .... ...|..|.. . |..| .|  .. .|. .|. ..|..| .......  .......   |.. .. ... || ..
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCP-EQ-EHNKNQKIN

QMVNKY
.... |
YKSDIY
S_TKc 6000.AA S_TKc 103-367 18 5.7e-14 27.97 SMART 1-231 (231) Show / Hide 
Range on Protein: 103-367
Range on HMM: 1-231/231
Sequence Identity: 18% (56 aa)

FNDGNKI-------IARAQDKRTNERFTLQTIPFDDYEDYEFKAALYQIYIQRNLQTVSNGLPHPNIIQIKDAYIIESKEKTKKARSLIIVMEYFDS---
.  ..||         ....|.|.... .  |.               . |.| .|  ..   ||||....|..            .| .|||| |    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------EHIRREIQILKK--HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLG

NLHDIIQFRKKHKWE--FSTKELCSFLRDISSALATILRQGVSHRDIRPTNI----------WHICMRNQGVRHEDGEGYNTVRGVPQFAAPEILNLMHM
.|.|.|. |..|..   |.  . ..... | .||. . ..|. |||. | ||            .. .            .|. | | . |||.|     
DLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL-----------TTFCGTPWYMAPEVL-----

NANQKVLNYNPFSQDIYSLGLTLILM---KNLYDEVDFDTLLSKVKQSGSANINIDLGSMELNQLVDQMVNKYPQRRINAIQLEQ-Y-----SQRV
        |.... |..|.| .|. |   . ...  . .... |..            | |. ...... .| |..|. | .. |        . .
-------GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 6000.AA CMGC 159-242 17 1.9e-11 32.92 In-house 97-215 (513) Show / Hide 
Range on Protein: 159-242
Range on HMM: 97-215/513
Sequence Identity: 17% (21 aa)

HPNIIQIKDAYIIESKEKTKKA---------RSLIIVMEYFDSNLHDIIQFRKK-----HKWEFSTKE------------LCSFL------RDISSALA-
|.||....| .  .  ... .          ..| .|.|| | .|...|.  ..      . ..|  .             ..|.      . |  .|. 
HNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKL

-TILRQG--VSHRDIRPTNI
  . ...  . |||. | ||
KYCHSHWGNIIHRDLKPENI
Kinase 6000.AA Ciliate-C6 181-242 27 9.6e-09 27.12 In-house 87-167 (306) Show / Hide 
Range on Protein: 181-242
Range on HMM: 87-167/306
Sequence Identity: 27% (22 aa)

RSLIIVMEYFDSNLHDIIQFRKKH------------------KWEFSTKELCSFLRDISSALATILR-QGVSHRDIRPTNI
|...|| .   |.| |.|| . .                   .  |. .|   |. .|   || |   ... |||| | ||
RQTYIVLDLAESTLQDCIQMKQANVNNFYFKQEINIFSFNYKYEHFDENEIVQFCKQIGKTLADIYNECNIAHRDIKPSNI
Kinase 6000.AA CDK 157-242 22 1.2e-08 23.59 In-house 65-139 (284) Show / Hide 
Range on Protein: 157-242
Range on HMM: 65-139/284
Sequence Identity: 22% (20 aa)

LPHPNIIQIKDAYIIESKEKTKKAR---SLIIVMEYFDSNLHDIIQFRKKHKWEFSTKELCSFLRDISSALATILRQGVSHRDIRPTNI
| ||||....| .. ...... | .   .| .|.|| |  |  ..                .... . ..|. . .... |||. | ||
L-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNI
Kinase 6000.AA Pkinase 144-242 26 2.1e-08 30.83 Pfam 51-139 (293) Show / Hide 
Range on Protein: 144-242
Range on HMM: 51-139/293
Sequence Identity: 26% (28 aa)

IYIQRNLQTVSNGLPHPNIIQIKDAYIIESKEKTKKARSLIIVMEYFDS-----NLHDIIQ-FRKKHKWEFSTKELCSFLRDISSALATILRQGVSHRDI
|.| ..|.       ||||....|..           ... .|||| .       |.|.|.  |..    || .|...... | ..|. . ..|. |||.
IQIMKRLN-------HPNIVRLYDWFED--------KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDL

RPTNI
 | ||
KPENI
Kinase 6000.AA CAMK 144-242 26 9e-08 20.37 In-house 82-210 (425) Show / Hide 
Range on Protein: 144-242
Range on HMM: 82-210/425
Sequence Identity: 26% (35 aa)

IYIQRNLQTVSNGLPHPNIIQIKDAYI------------IESK-EKTKKARSLIIVM---EYFDSN-----LHDIIQFRKKHKWE-----------FSTK
| | ..|| ..| | |||||.. ..|               ||    .| . ...||   || .       | | |. ...   |           |. .
IEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTER

ELCSFLRDISSALATILRQGVSHRDIRPTNI
| . . | | ||.. .  ... |||. | ||
EARRYFRQICSAVHYCHSHNIVHRDLKPENI
Kinase 6000.AA MOK 143-242 25 9.8e-07 16.59 In-house 41-131 (283) Show / Hide 
Range on Protein: 143-242
Range on HMM: 41-131/283
Sequence Identity: 25% (25 aa)

QIYIQRNLQTVSNGLPHPNIIQIKDAYIIESKEKTKKARSLIIVMEYFDSNLHDIIQFRKKHKWEFSTKELCSFLRDISSALATILRQGVSHRDIRPTNI
|.   | .| .    |||||.....  . .     .|. .| .. |  | |. ..|  |   ..  . | .  ..  .  .|  . | |. |||..| ||
QVNNLREIQAMRRLNPHPNILMLHEV-VFD-----RKTGNLALICELMDMNIYELIRGR---RHYLPQKKIMHYMYQLCKSLDHMHRNGIFHRDVKPENI
Kinase 6000.AA Ciliate-E2 159-242 25 1e-06 19.09 In-house 91-192 (365) Show / Hide 
Range on Protein: 159-242
Range on HMM: 91-192/365
Sequence Identity: 25% (28 aa)

HPNIIQIKDAYIIESKEKTKKARSLIIVMEYFDS-NLHDIIQFR---KKHKWE----FSTKELCSFLRDISS---------------ALATILRQG-VSH
|||||.......      .|.  .. .||||..  .| |.|. .   ..|. |    |. || . . . | .               ||  .  .. . |
HPNIIKMYECFQ------EKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIH

RDIRPTNI
||| | ||
RDIKPENI
Kinase 6000.AA NZAK 185-242 25 1e-06 17.78 In-house 79-136 (329) Show / Hide 
Range on Protein: 185-242
Range on HMM: 79-136/329
Sequence Identity: 25% (15 aa)

IVMEYFD-SNLHDIIQFRKKHKWEFSTKELCSFLRDISSALATILRQGVSHRDIRPTNI
|.||. .  || ...   ||   .|   .  . . ||   .    .... ||||.. |.
IYMEWMEGGNLTQFLMNDKKQ-LRFKEHRIIKMIADIAETMSYLHKHHIIHRDIKSNNV
Kinase 6000.AA Ciliate-E2-Unclassified 159-242 24 2e-06 18.36 In-house 78-175 (352) Show / Hide 
Range on Protein: 159-242
Range on HMM: 78-175/352
Sequence Identity: 24% (25 aa)

HPNIIQIKDAYIIESKEKTKKARSLIIVMEYF-DSNLHDIIQFRKK-------------HKWEFSTKELC-----SFLRDISSALATILRQG-VSHRDIR
||... .|. |. ..|..      ..|||||. . .|...|. |||             .. .|. .. .      ... | ..|  . ... . |||| 
HPHPFIVKMFYCFQDKQN------IYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIK

PTNI
| ||
PENI
Kinase 6000.AA Ciliate-B2 268-300 36 0.000102 6.91 In-house 168-197 (197) Show / Hide 
Range on Protein: 268-300
Range on HMM: 168-197/197
Sequence Identity: 36% (12 aa)

QFAAPEILNLMHMNANQKVLNYNPFSQDIYSLG
..| || ..  |   .  |.| . |  ||||.|
KYASPEQMECDHN--QTFVTNID-FQSDIYSMG
Kinase 6000.AA Ciliate-B2 184-242 23 0.001404 4.17 In-house 77-135 (197) Show / Hide 
Range on Protein: 184-242
Range on HMM: 77-135/197
Sequence Identity: 23% (14 aa)

IIVMEYFDSNLHDIIQFRKKHKWEFSTKELCSFLRDISSALATILRQGVSHRDIRPTNI
...|| .   | . .|  .| . .|  . |.    .   .|  .    . | ||.|.||
VLIMEKCECSLKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNI
Kinase 6000.AA Ciliate-E2 260-303 36 0.049356 2.75 In-house 244-286 (365) Show / Hide 
Range on Protein: 260-303
Range on HMM: 244-286/365
Sequence Identity: 36% (16 aa)

YNTVRGVPQFAAPEILNLMHMNANQKVLNYNPFSQDIYSLGLTL
.||. | | . ||||||    . . .  ..  .. ||.||| .|
FNTICGTPGYMAPEILNGKKYDNQ-QKQKGYDYKCDIWSLGVIL
Kinase 6000.AA CAMK 255-300 26 0.057394 1.32 In-house 271-321 (425) Show / Hide 
Range on Protein: 255-300
Range on HMM: 271-321/425
Sequence Identity: 26% (14 aa)

EDGEGYNTVRGVPQFAA-PEILNLMHMNANQKV-----LNYNPFSQDIYSLG
..|. ..|. | | ..| ||.||  .. ..|         | ... |. |.|
TEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQ-NATDEEKPYYGPKCDMWSCG
Kinase 6000.AA Pkinase 254-304 21 7.382503 0.58 Pfam 164-203 (293) Show / Hide 
Range on Protein: 254-304
Range on HMM: 164-203/293
Sequence Identity: 21% (11 aa)

HEDGEGYNTVRGVPQFAAPEILNLMHMNANQKVLNYNPFSQDIYSLGLTLI
.  .. ..|. | | ..|||...           .| . . |..|.|..|.
Y-NNS-MTTFCGTPWYMAPEVIR---------GGQYYGPKVDMWSCGCILY
TPR 6000.AA TPR 465-498 20 0.074448 10.5 SMART 1-34 (34) Show / Hide 
Range on Protein: 465-498
Range on HMM: 1-34/34
Sequence Identity: 20% (7 aa)

SVIFNEEGHECRKRSQLEGAIRYYEIAIECVRKG
. ...  |. ..|. ... || .|. |.|  .. 
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_1 6000.AA TPR_1 465-493 24 0.358098 8.08 Pfam 1-29 (34) Show / Hide 
Range on Protein: 465-493
Range on HMM: 1-29/34
Sequence Identity: 24% (7 aa)

SVIFNEEGHECRKRSQLEGAIRYYEIAIE
. ...  |. ..|. ... || .|. |.|
AEAWYNLGNCYYKMGNYDEAIECYQKALE
TPR_2 6000.AA TPR_2 438-464 33 1.975579 5.61 Pfam 1-27 (34) Show / Hide 
Range on Protein: 438-464
Range on HMM: 1-27/34
Sequence Identity: 33% (9 aa)

AETLQKIGEGYLILNDVYRAKDYFMKA
|| .  .|. |. ..|  .|..|. ||
AEAWYNLGQCYYKQGDYDEAIEYYEKA
TPR_1 6000.AA TPR_1 438-464 25 3.723808 4.53 Pfam 1-27 (34) Show / Hide 
Range on Protein: 438-464
Range on HMM: 1-27/34
Sequence Identity: 25% (7 aa)

AETLQKIGEGYLILNDVYRAKDYFMKA
||..  .|  |. ...   | ... ||
AEAWYNLGNCYYKMGNYDEAIECYQKA
TPR_2 6000.AA TPR_2 465-493 27 10.653879 3.02 Pfam 1-29 (34) Show / Hide 
Range on Protein: 465-493
Range on HMM: 1-29/34
Sequence Identity: 27% (8 aa)

SVIFNEEGHECRKRSQLEGAIRYYEIAIE
  . .  |  ..|. ... ||.||| |..
AEAWYNLGQCYYKQGDYDEAIEYYEKALK
TPR_2 6000.AA TPR_2 508-537 33 0.000344 18.91 Pfam 1-30 (34) Show / Hide 
Range on Protein: 508-537
Range on HMM: 1-30/34
Sequence Identity: 33% (10 aa)

ALLLENIGNIYKMKGDFPKARAFQEEALQI
| .. |.|..|  .||. .|... |.||..
AEAWYNLGQCYYKQGDYDEAIEYYEKALKL
TPR_1 6000.AA TPR_1 508-537 30 0.01432 12.96 Pfam 1-30 (34) Show / Hide 
Range on Protein: 508-537
Range on HMM: 1-30/34
Sequence Identity: 30% (9 aa)

ALLLENIGNIYKMKGDFPKARAFQEEALQI
|  . |.||.|  .|.. .| .. ..||..
AEAWYNLGNCYYKMGNYDEAIECYQKALEL
TPR 6000.AA TPR 508-541 29 0.092778 9.66 SMART 1-34 (34) Show / Hide 
Range on Protein: 508-541
Range on HMM: 1-34/34
Sequence Identity: 29% (10 aa)

ALLLENIGNIYKMKGDFPKARAFQEEALQIILIQ
|  . |.||.|  .||. .| .. ..||..    
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR 6000.AA TPR 550-583 38 5e-06 27.23 SMART 1-34 (34) Show / Hide 
Range on Protein: 550-583
Range on HMM: 1-34/34
Sequence Identity: 38% (13 aa)

ARLYNNLGNLYASLGLYKKADKRLKKALKIVDNL
|. ..||||.| ..| |..| . ..|||..  | 
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_2 6000.AA TPR_2 550-583 38 2.8e-05 22.79 Pfam 1-34 (34) Show / Hide 
Range on Protein: 550-583
Range on HMM: 1-34/34
Sequence Identity: 38% (13 aa)

ARLYNNLGNLYASLGLYKKADKRLKKALKIVDNL
|....|||..|. .| |..| . ..||||.  | 
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR_1 6000.AA TPR_1 550-583 38 7.9e-05 20.85 Pfam 1-34 (34) Show / Hide 
Range on Protein: 550-583
Range on HMM: 1-34/34
Sequence Identity: 38% (13 aa)

ARLYNNLGNLYASLGLYKKADKRLKKALKIVDNL
|. ..||||.| ..| |..| . ..|||..  | 
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN
TPR 6000.AA TPR 595-628 23 9e-06 26.37 SMART 1-34 (34) Show / Hide 
Range on Protein: 595-628
Range on HMM: 1-34/34
Sequence Identity: 23% (8 aa)

ALCLCSLGEIHRLRGNLENSLEFLEEALEIREQV
| ... ||......|...  .|....|||. .. 
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_1 6000.AA TPR_1 595-628 26 2.3e-05 22.73 Pfam 1-34 (34) Show / Hide 
Range on Protein: 595-628
Range on HMM: 1-34/34
Sequence Identity: 26% (9 aa)

ALCLCSLGEIHRLRGNLENSLEFLEEALEIREQV
|  .. || ... .||..  .|....|||.... 
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN
TPR_2 6000.AA TPR_2 595-628 23 0.000101 20.79 Pfam 1-34 (34) Show / Hide 
Range on Protein: 595-628
Range on HMM: 1-34/34
Sequence Identity: 23% (8 aa)

ALCLCSLGEIHRLRGNLENSLEFLEEALEIREQV
| ... ||.... .|...  .|..|.||.. .. 
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR_1 6000.AA TPR_1 642-670 34 1e-06 26.9 Pfam 6-34 (34) Show / Hide 
Range on Protein: 642-670
Range on HMM: 6-34/34
Sequence Identity: 34% (10 aa)

NLGNVYFDLGDFHKAKKFYERALVIKKSS
||||.|. .|.. .| ..|..|| .  . 
NLGNCYYKMGNYDEAIECYQKALELNPNN
TPR_2 6000.AA TPR_2 637-670 35 2e-06 26.51 Pfam 1-34 (34) Show / Hide 
Range on Protein: 637-670
Range on HMM: 1-34/34
Sequence Identity: 35% (12 aa)

ASNCENLGNVYFDLGDFHKAKKFYERALVIKKSS
|  . |||..|. .||. .|...||.|| .    
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR 6000.AA TPR 637-670 35 9e-06 26.49 SMART 1-34 (34) Show / Hide 
Range on Protein: 637-670
Range on HMM: 1-34/34
Sequence Identity: 35% (12 aa)

ASNCENLGNVYFDLGDFHKAKKFYERALVIKKSS
|  . ||||.|. .||. .| ..|..|| .  . 
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_1 6000.AA TPR_1 679-708 30 8.1e-07 27.79 Pfam 1-30 (34) Show / Hide 
Range on Protein: 679-708
Range on HMM: 1-30/34
Sequence Identity: 30% (9 aa)

ALTLNNLGNVCKSQKEIEKAKKCYEECLQI
| ...||||.. .... ..| .||...|..
AEAWYNLGNCYYKMGNYDEAIECYQKALEL
TPR 6000.AA TPR 679-712 26 5e-06 27.25 SMART 1-34 (34) Show / Hide 
Range on Protein: 679-712
Range on HMM: 1-34/34
Sequence Identity: 26% (9 aa)

ALTLNNLGNVCKSQKEIEKAKKCYEECLQILYTK
| ...||||.. .......| .||...|..  . 
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_2 6000.AA TPR_2 679-712 26 1.7e-05 23.56 Pfam 1-34 (34) Show / Hide 
Range on Protein: 679-712
Range on HMM: 1-34/34
Sequence Identity: 26% (9 aa)

ALTLNNLGNVCKSQKEIEKAKKCYEECLQILYTK
|  ..|||...  |.. ..|...||..|..  . 
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR_1 6000.AA TPR_1 723-756 32 0.00312 15.27 Pfam 1-34 (34) Show / Hide 
Range on Protein: 723-756
Range on HMM: 1-34/34
Sequence Identity: 32% (11 aa)

ATSLGNLGLVYKELGSLVAAQSNLQKCLEILAKS
|  . |||..| ..| . .|   .||.||.  . 
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN
TPR 6000.AA TPR 723-756 32 0.035003 13.38 SMART 1-34 (34) Show / Hide 
Range on Protein: 723-756
Range on HMM: 1-34/34
Sequence Identity: 32% (11 aa)

ATSLGNLGLVYKELGSLVAAQSNLQKCLEILAKS
|  . |||..|  .| .  |   .||.||.  . 
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_2 6000.AA TPR_2 723-756 26 0.115752 9.97 Pfam 1-34 (34) Show / Hide 
Range on Protein: 723-756
Range on HMM: 1-34/34
Sequence Identity: 26% (9 aa)

ATSLGNLGLVYKELGSLVAAQSNLQKCLEILAKS
|  . |||..| ..| .  |   ..|.|..  . 
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN