Gene 24353 (Tetrahymena)
24353
Group:
Other
Family:
Ciliate-E4
Sequence
Protein domains of 24353.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 24353.AA | Ciliate-E4 | 71-217 | 49 | 7.8e-90 | 297.84 | In-house | 3-150 (150) | Show / Hide |
Range on Protein: 71-217 Range on HMM: 3-150/150 Sequence Identity: 49% (73 aa) KGEA-EDKWYGDVQILEHKIQKEIVVLKIVESSSETEAEQVQQQFIRRIKLNHEHIVRLRYIVHKAVDAFCSVIYKSYLFFDYLLTDLATDLKNRNKKGL | |. | |||.||.||||||.|.|.||.....||.|.|.||||.||..||||.|.......||..|.|||.||..|.|..||..||....|.....|. KIESVKDIHYGDIQIMEHKIQKQIIVMKIRKFQNETKARQQQQQFRRRQDLNHENIIMVYEYFHKKEDQFCSSIYRLYWFMEYLQKDLQQHIKQHKQQGQ YFSEDEIWNMAYCLINGMKYLYSVNITHGCVRSKNVYITQYGSFKVAD .|.|.|||..|.|.||.|.||..|||||| .. |. ..|| |.|| HFDESEIWQIAFCCINAMYYLQQVNITHGDLKPSNIFFDQYFMVKIAD |
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| Kinase | 24353.AA | Ciliate-A5 | 78-339 | 27 | 4.9e-39 | 132.93 | In-house | 1-275 (275) | Show / Hide |
Range on Protein: 78-339 Range on HMM: 1-275/275 Sequence Identity: 27% (75 aa) WYGDVQILEHKIQKEIVVLKIVESSSETEAEQVQQQFIRRIKLNHEHIVRLRYIVHKAVDAFCSVIYKSYLFFDYLLTDLATDLKNRNKKG--LYFSEDE || . | | |... | . .|. .. || | | .|.| || | .. . . ||| ||. ... | .| ... .| .. ...|.| FYGCMKIWKNQHQQEYYICKQKQIQDEDRQKHFQQYFEQRMQLQHPNIVKLIDFHTHKKEEFCSQFYKVNCYYEYHDNNLEQEMQMRKQCQKDIFYNEQE IWNMAYCLINGMKYLYSVNITHGCVRSKNVYITQYGSFKVADPG-------LFNYEVNYDIVFNNQDNNHKGIILSPAQVHGLERH----IETPIHDQQK .| .. |||. || . || || | .|. .|| |..|..| . . | . . . . | . ||| | .. | |.|. .| LWYIMDCLISVCMYLQQNNICHGDIRPQNICLTQDGQVKLMDMNESKDFFYQINWSSYKQYQHHMSTEN--KQYLSPMQWYQMMHRDEQNIQRPEHNWYK SDVFCIGMVILEAASLLSA-DSCFDYYHAWVLEDKIQDRLNEIKS-KYHDSLYYMLKEMLTINEIQRPNFQTLFEKN |||||.||..|| ... .. || . . . | . |. || .... .|.|| ..| .||.| . . SDVFCLGMICLEMCTMRDCTQFYYDYETFQIQNNQLIKQLIQMKEKKYSEQFINFIKQMLQFEENKRPDFHQIYQYL |
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| S_TKc | 24353.AA | S_TKc | 68-345 | 15 | 1.7e-09 | -37.57 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 68-345
Range on HMM: 1-231/231
Sequence Identity: 15% (46 aa)
FDFKGEAEDKWYGDVQILEHKIQKEIVVLKIVESSSETEAEQVQQ--QFIRRIKLNHEHIVRLRYIVHKAVDAFCSVIYKSYLFFDYLLT---DLATDLK
... . .| | || ..|| .||. |.... | .. .|..||.| .. . . |....|. . || . .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK---HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDYIK
NRNKKGLY--FSEDEIWNMAYCLINGMKYLYSVNITHGCVRSKNVYITQYGSFKVADPGLFNYEVNYDIVFNNQDNNHKGIILSPA-----QVHGLERHI
.|...||. |.| ... ..| ......|. | .| | . |. ... |..| || . .. .| .
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL-------
ETPIHDQQKSDVFCIGMVILEAAS---LLSADSCFDYYHAWVLEDKIQDRLNEIKSKYHDSLYYMLKEMLTINEIQRPNFQTLFE---KNQRNPKF
.. |.|. .| .. | .. . . . .. .|| ... ... .|. . .|| ... . | |
---GYGKCKCDWWSCGCILYEMLCGYPPFP--------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
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| Kinase | 24353.AA | Ciliate-E1 | 85-237 | 11 | 2.1e-07 | 20.63 | In-house | 1-175 (202) | Show / Hide |
Range on Protein: 85-237 Range on HMM: 1-175/202 Sequence Identity: 11% (20 aa) LEHKIQKEIVVLKIVESSSETEAEQVQQQFIRRI-----KLNHEHI-VRLRYIVHKAVDAFCSVIY-KSYLFFDYLLTDLATDLKNRNK----------- ... . .. |. ... . |..... . . ....| . . .. .. . .. .|. ....... ... . ||. .. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC --KGLYFSEDEIWNMAYCLINGMKYLYSVNITHGCVRSKNVYITQYGSFKVADPGLF---NYEVNYDIVFNNQDNN . .|..... .... || | .|.. ||.|.. .|. |...| .. .| |. ... |........ .. QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHY |
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| Kinase | 24353.AA | CMGC | 86-197 | 16 | 2.4e-07 | 19.24 | In-house | 33-207 (513) | Show / Hide |
Range on Protein: 86-197 Range on HMM: 33-207/513 Sequence Identity: 16% (29 aa) EHKIQKEIVVLKIVESSSETEAEQ-------------VQQQFIRRIK---------------LNHEHIVRLRYIVHKAVDA-----FCSV----IYKSYL .|. .||| .|.. . ..| .. .. .... .|..||.|..|.. .. . . .. || HHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYL FFDYLLTDLATDLKNRNK-----KGLYFSEDE------------IWNMA------YCLINGMK--YLYSVN--ITH |.|. .||. .|| .. .....|| . | .. | ...|.| |. | . | | VFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIH |
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| Kinase | 24353.AA | Pkinase | 79-197 | 23 | 9.2e-07 | 25.0 | Pfam | 12-131 (293) | Show / Hide |
Range on Protein: 79-197 Range on HMM: 12-131/293 Sequence Identity: 23% (32 aa) YGDVQILEHKIQKEIVVLKIVESSSETEAEQVQ------QQFIRRIKLNHEHIVRLRYIVHKAVDAFCSVIYKSYLFFDYLLT-----DLA----TDLKN .| | . || .||..||.. ..| . .... | .|.. |..||||..... . |. ..|. ||. | FGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--HPNIVRLYDWFED--------KDHIYMVMEYCEGGLYVMDLFDYIST---- RNKKGLYFSEDEIWNMAYCLINGMKYLYSVNITH ......||||.|. ...| .. |..|..| .| | WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIH |
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| Kinase | 24353.AA | CDK10 | 118-220 | 31 | 1.6e-05 | 14.88 | In-house | 53-146 (285) | Show / Hide |
Range on Protein: 118-220 Range on HMM: 53-146/285 Sequence Identity: 31% (32 aa) IKLNHEHIVRLRYIVHKAVDAFCSVIYKSYLFFDYLLTDLATDLKNRNKKGLYFSEDEIWNMAYCLINGMKYLYSVNITHGCVRSKNVYITQYGSFKVAD |.. || ||.|. .| | | .| .| ||| | | . |.| .. .. .. |.||| . . | .. |. .| | |||| IQCRHENIVELHEVV---VGQHLDSI---FLVMQYCEQDLASLLDNMPQP---FTETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVAD PGL || FGL |
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| Kinase | 24353.AA | Jak | 183-219 | 28 | 7.5e-05 | 13.25 | In-house | 127-171 (299) | Show / Hide |
Range on Protein: 183-219 Range on HMM: 127-171/299 Sequence Identity: 28% (13 aa) LINGMKYLYSVNITHGCVRSKNVYITQYGS--------FKVADPG ...||.||..... || |. .|.... .| ||..||. ICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKIPFFKLMDPW |
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| Kinase | 24353.AA | TAO | 158-219 | 30 | 0.000138 | 10.58 | In-house | 85-144 (254) | Show / Hide |
Range on Protein: 158-219 Range on HMM: 85-144/254 Sequence Identity: 30% (19 aa) ATDLKNRNKKGLYFSEDEIWNMAYCLINGMKYLYSVNITHGCVRSKNVYITQYGSFKVADPG |.|. . ||.. |.|| .. ..|..|| | . | .. |. .|. | |.|| | ASDILDVHKKPM--QEVEIAAICHGALQGLRYLHSHKMIHRDIKAGNILLTEHGQVKLADFG |
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| Kinase | 24353.AA | CDK9 | 144-220 | 40 | 0.000143 | 11.39 | In-house | 88-165 (340) | Show / Hide |
Range on Protein: 144-220 Range on HMM: 88-165/340 Sequence Identity: 40% (33 aa) YKS----YLFFDYLLTDLATDLKNRNKKGLYFSEDEIWNMAYCLINGMKYLYSVNITHGCVRSKNVYITQYGSFKVADPGL ||. || ||. ||| | | | | || .| | |.||. |. . | | . || ||. | | || || YKDRATFYLVFDFCEHDLAGLLSNMNVK---FSLGHIKKMMQHLMNGLYYIHRNKILHRDMKAANVLITKDGILKLADFGL |
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| Kinase | 24353.AA | TK-Unique | 185-217 | 34 | 0.000168 | 11.58 | In-house | 142-176 (294) | Show / Hide |
Range on Protein: 185-217 Range on HMM: 142-176/294 Sequence Identity: 34% (12 aa) NGMKYLYS--VNITHGCVRSKNVYITQYGSFKVAD .||.|| | .|.|. . ..|| .| .. |..| CGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICD |
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| Kinase | 24353.AA | CDC2 | 119-190 | 21 | 0.000205 | 8.9 | In-house | 56-119 (301) | Show / Hide |
Range on Protein: 119-190 Range on HMM: 56-119/301 Sequence Identity: 21% (16 aa) KLN-HEHIVRLRYIVHKAVDAFCSVIYKSYLFFDYLLTDLATDLKNRNKKGLYFSEDEIWNMAYCLINGMKYL .|. |. ||.|. ..|. .| |..|.|| || ... ..|. ..... . . .| ...|. .. ELKDHPNIVKLHDVIHQ---------NKLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFC |
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| TyrKc | 24353.AA | TyrKc | 62-349 | 14 | 0.000343 | -154.87 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 62-349 Range on HMM: 1-280/280 Sequence Identity: 14% (48 aa) MIVLKEFD-------FKGEAEDKWYGDVQILEHKIQKEIVVLKIVESSSETEAEQVQQQFIRRIK----L--NHEHIVRLRYIVHKA-------VDAFCS .|. .||.. . | | . ... .. |.| .. | .|..|||| .. . . ITLGKKLGEGAFGEVYKGTWK----------------IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIV VIYKSYLFFDYLLTDLATDLKNRNKKGLYFSEDEIWNMAYCLINGMKYLYSVNITHGCVRSKNVYITQYGSFKVADPGLFNYEVNY-------DIVFNNQ . | .. . | . . .. .. .... .|| || | |. | |. .. . |..| || . .. | . MEYMPHGDLKDYLRKHRPK----------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKE DNNHK--GII--LSPAQVHGLERHIETPIHD--QQKSDVFCIGMVILEAASLLSADSCFDYYHA---------WVLEDKIQDRLNEIKSK--------YH . | | ..| |. . ||||. | .. | .. . | |.|. | . .. . HKGGKTMLPIRWMAP----------ECINYGKFTTKSDVWSFGVCMWEIFTY-----GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCP DSLYYMLKEMLTINEIQRPNFQTLFEKNQRNPKFKTIL | .| . |. . .||.|... . .. DEMYQIMKQCWHEDPEDRPTFSEI----------HECF |
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| MORN | 24353.AA | MORN | 531-553 | 56 | 5.4e-10 | 41.05 | Pfam | 1-23 (23) | Show / Hide |
Range on Protein: 531-553 Range on HMM: 1-23/23 Sequence Identity: 56% (13 aa) YEGSWKDGKMNGQGTLYFPDGST |||.||.|||.|.|....|||.. YEGEWKNGKMHGHGVYTWPDGDR |
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| MORN | 24353.AA | MORN | 529-550 | 36 | 4.3e-07 | 30.8 | SMART | 1-22 (22) | Show / Hide |
Range on Protein: 529-550 Range on HMM: 1-22/22 Sequence Identity: 36% (8 aa) GYYEGSWKDGKMNGQGTLYFPD |||.|..||. |.|...... DRYEGEWHNGKRHGHGVYWWAN |
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| MORN | 24353.AA | MORN | 508-530 | 43 | 6e-06 | 26.31 | Pfam | 1-23 (23) | Show / Hide |
Range on Protein: 508-530 Range on HMM: 1-23/23 Sequence Identity: 43% (10 aa) YEGEVRNGVRDGKGKYYYNNGGY |||| .||...|.|.|.. .|.. YEGEWKNGKMHGHGVYTWPDGDR |
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| MORN | 24353.AA | MORN | 506-527 | 54 | 2.2e-05 | 25.11 | SMART | 1-22 (22) | Show / Hide |
Range on Protein: 506-527 Range on HMM: 1-22/22 Sequence Identity: 54% (12 aa) SRYEGEVRNGVRDGKGKYYYNN .||||| .|| |.|.|.|.. | DRYEGEWHNGKRHGHGVYWWAN |
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| MORN | 24353.AA | MORN | 553-574 | 27 | 2.3e-05 | 25.08 | SMART | 1-22 (22) | Show / Hide |
Range on Protein: 553-574 Range on HMM: 1-22/22 Sequence Identity: 27% (6 aa) TAYDGSWRDDQFHGYGTLYNNS |.|.|.....||.|... . DRYEGEWHNGKRHGHGVYWWAN |
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| MORN | 24353.AA | MORN | 555-571 | 35 | 0.000262 | 20.4 | Pfam | 1-17 (23) | Show / Hide |
Range on Protein: 555-571 Range on HMM: 1-17/23 Sequence Identity: 35% (6 aa) YDGSWRDDQFHGYGTLY |.|.|.....||.|... YEGEWKNGKMHGHGVYT |
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| MORN | 24353.AA | MORN | 597-619 | 34 | 0.000224 | 20.65 | Pfam | 1-23 (23) | Show / Hide |
Range on Protein: 597-619 Range on HMM: 1-23/23 Sequence Identity: 34% (8 aa) YEGDFKSDQKEGFGTLFVSNGER |||..| ....|.|.. ..| | YEGEWKNGKMHGHGVYTWPDGDR |
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| MORN | 24353.AA | MORN | 620-642 | 30 | 0.000305 | 20.16 | Pfam | 1-23 (23) | Show / Hide |
Range on Protein: 620-642 Range on HMM: 1-23/23 Sequence Identity: 30% (7 aa) YVGGFKQDKIHGQGTFYTQSNQV | | .|..|.||.|... . . YEGEWKNGKMHGHGVYTWPDGDR |
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| MORN | 24353.AA | MORN | 618-639 | 31 | 0.00115 | 16.37 | SMART | 1-22 (22) | Show / Hide |
Range on Protein: 618-639 Range on HMM: 1-22/22 Sequence Identity: 31% (7 aa) ERYVGGFKQDKIHGQGTFYTQS || | .. .| ||.|... . DRYEGEWHNGKRHGHGVYWWAN |
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| MORN | 24353.AA | MORN | 595-616 | 27 | 0.00154 | 15.42 | SMART | 1-22 (22) | Show / Hide |
Range on Protein: 595-616 Range on HMM: 1-22/22 Sequence Identity: 27% (6 aa) LKYEGDFKSDQKEGFGTLFVSN .|||... ... |.|.. .| DRYEGEWHNGKRHGHGVYWWAN |
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