Gene 13028 (Tetrahymena)

13028

Species: Tetrahymena
Alias: 4.m00427, PreTt13028, 460, TTHERM_00058430, 3707.m00072, 13028
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E5

Sequence

Name Sequence Type Origin Length Description Download
13028.AA Protein None 938 None Fasta, JSON
13028.kin_dom Protein Kinase Domain None 277 None Fasta, JSON
13028.NA RNA None 2817 None Fasta, JSON

Protein domain

Protein domains of 13028.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 13028.AA Ciliate-E5 65-253 40 1e-111 364.94 In-house 1-257 (271) Show / Hide 
Range on Protein: 65-253
Range on HMM: 1-257/271
Sequence Identity: 40% (105 aa)

IIENGLLGSGAGGFILKACSEWNDHLAVKFM-KYSNLEQFKINKREYDILKKLSSRYVTKVYSYFIESYESNGYQFIVMERCLYDLKNYIAKKITSKKFL
||||..||.| .|...|.||||||....... |..|..|.. |.||..|||.. | ...||| .....||.. ||||.||||..||..|..|.|...|..
IIENQILGKGGSGMVMKGCSEWNDKPIAIKIMKCKNQKQCEDNQREFNILKQFNSPHIIKVYQIYQYQYENMNYQFIIMERCKCDLHTYLNKIIYQMKWQ

SHQHLYYLCLQLSKGLQELHQKNIIHLDIKPANLLLGLDLKWKYADLGIS---------KVVSEQKQ---------------------------------
.|| .|..||||.||||..||||||||||||||.|||.|.||||.|.|||         |.|||| |                                 
KHQDIYQICLQLVKGLQDIHQKNIIHLDIKPANILLGYDNKWKYIDMGISRKFKHVVRDKQVSEQRQNSSETIEENMIKFIKIIPYFFQREYPKLHNKNR

--------HTNNLIGLTAVYSSPEQYQLAT-----------------TSANRKVTKS
        ||.||.|.|. ||||||||. .                 .|.. |.||.
KKLRYQIPHTCNLKGFTQCYSSPEQYQCYHNQMFYILIRNLPDIKYIQSFKKKITKQ
Kinase 13028.AA Ciliate-A1 65-241 30 1.1e-34 115.53 In-house 1-193 (301) Show / Hide 
Range on Protein: 65-241
Range on HMM: 1-193/301
Sequence Identity: 30% (60 aa)

IIENGLLGSGAGGFILKACSEWNDH--LAVKFMKYSNLEQFKINKREYDILKKLSSRYVTKVYSYFIESYESN--GYQFIVMERCLYD-LKNYIAKKITS
  .  |...|  | ...|    |    |..| .. .| ||.| |  || ..| . . .| |.|      |. |    .||.|| |.|  | ||.      
YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFEQYKNNIQEYRKCKQINHNNVIKNYQQL--YYNTNNKECMFIIMEYCQYGNLFNYCYQ----

KKFLSHQHLYYLCLQLSKGLQELHQKNIIHLDIKPANLLLGLDLKWKYADLGISKVVSEQK----------------QHTNNLI-GLTAVYSSPEQYQL
.....    | .|.|. .|.  .| .||.|.|.|| | |.. | ||| .|||.||.   ..                .| .    |..  | ||||||.
NDYMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQM
Kinase 13028.AA Ciliate-E1 71-240 29 1.7e-25 80.12 In-house 1-183 (202) Show / Hide 
Range on Protein: 71-240
Range on HMM: 1-183/202
Sequence Identity: 29% (54 aa)

LGSGAGGFILKACSEWND--HLAVKFMKYS---NLEQFKINKREYD-ILKKLS-SRYVTKVYSYFIESYESNGYQFIVMERCLYDLKNYIA--------K
.|.|  ....|| ...|   . |.|. ..    | ..|  ...||. |.| .    |. ... |..   ..|  . |..| | . ||.|.         .
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIK--IDQNYICIIIFECCCCSLKDYLQNHNRLEYWQ

KITSKKFLSH-QHLYYLCLQLSKGLQELHQKNIIHLDIKPANLLLGLDLKWKYADLGISKVVSEQKQHTNNLIGLTAVYSSPEQYQ
.. ....  . |.. ..  || .||.||||.||||.||||.|.|   . . .|.|.||||.  ...... .  | |  |..||||.
QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYN
Kinase 13028.AA Ciliate-B2 138-238 35 8.5e-25 55.16 In-house 76-174 (197) Show / Hide 
Range on Protein: 138-238
Range on HMM: 76-174/197
Sequence Identity: 35% (36 aa)

QFIVMERCLYDLKNYIAKKITSKKFLSHQHLYYLCLQLSKGLQELHQKNIIHLDIKPANLLLGLDLKWKYADLGISKVVSEQKQHTNNLIGLTAVYSSPE
. ..||.| ..||. . |    .|    | || .  ||  || ... .||.||||||.| |.    . .| | ||| . .  ..   .  |.|  | |||
DVLIMEKCECSLKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISSIKK--DNQQIKIKGFTKKYASPE

Q
|
Q
Kinase 13028.AA STE 66-237 22 9.3e-19 62.95 In-house 1-232 (359) Show / Hide 
Range on Protein: 66-237
Range on HMM: 1-232/359
Sequence Identity: 22% (54 aa)

IEN-GLLGSGAGGFILKACSEWND--H--------------LAVKFMKYSNL-----------------EQFKINKREYDILKKLS--SRYVTKVYSYFI
 |. . .|.||.|   ||.   |.  |               |.| |...|                  |...  ..| .|.||..  . .. | | ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ESYES---NGYQFIVMERCL-YDLKNYIA-KKITSK---------KFLSHQHLYYLCLQLSKG-LQELHQKNIIHLDIKPANLLLGLDLKWKYADLGISK
   .    ... .|.|| .    |   |  |... |         .... . . | | |. || |. ||...||| |||||| ||      | .| |...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

VVSE----------------QKQHTNNLIGLTAVYSSPE
 ...                ..|..| ..|    . .||
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--WMAPE
Kinase 13028.AA Ciliate-E2 65-240 20 2.3e-18 59.62 In-house 1-260 (365) Show / Hide 
Range on Protein: 65-240
Range on HMM: 1-260/365
Sequence Identity: 20% (54 aa)

IIENGLLGSGAGGFILKACS------------------------EWNDHLAVKFMKYSNLEQFKINKREYD-------------ILKKLSSRYVTKVYSY
.. . ..|.|. | . |..                           .   |.| || ...||.|  ....              ||..|.. .. | | .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FIESYESNGYQFIVMERCLY-DLKNYIAKKITSKKFL-------SHQHLYYLCLQLSK---------------GLQELHQKN-IIHLDIKPANLLLGLDL
|.|  ... . ..||| | . ||. || .. .....        ....  |.  |. .               .|..||.|| ||| |||| |.|.    
FQE--KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

KWKYADLGISKVVSEQ------------------------------KQHTNNLIGLTAVYSSPEQYQ
  | .|.|.|| ....                              .|.. | |  |. | .|| ..
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILN
Kinase 13028.AA CMGC 65-199 19 1.2e-17 53.67 In-house 1-217 (513) Show / Hide 
Range on Protein: 65-199
Range on HMM: 1-217/513
Sequence Identity: 19% (42 aa)

IIENGLLGSGAGGFILKACS---------------EWNDHLAVKFMK---YSNLEQ-------FK-INKREYDILKKLS-----------------SRYV
    . .|.|. |   |.                 |.| . |.| .|   | . ..       |. .  ||  |||.|.                   ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

TKVYSYFIESYES-------------NGYQFIVMERCLYDLKNYIAKKIT-----SKKFLSHQH------------LYYLC------LQLSKGLQ--ELH
 | | .|  . .              . . ..|.| . .||..|| .. .      .. ||. |              |.        |. .||    .|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

QKN--IIHLDIKPANLLL
...  ||| |.||.|.|.
SHWGNIIHRDLKPENILI
Kinase 13028.AA Pkinase 65-237 23 1.5e-17 63.16 Pfam 1-181 (293) Show / Hide 
Range on Protein: 65-237
Range on HMM: 1-181/293
Sequence Identity: 23% (45 aa)

IIENGLLGSGAGGFILKACSEWNDH-LAVKFMKYSNLEQ--FKINKR--EYDILKKLSSRYVTKVYSYFIESYESNGYQFIVMERCLY-----DLKNYIA
.   . .|||. |   |..   . .  ||| .|... .    ... |  |  |.|.|.. .. . | .| .    ...  .||| |       ||. || 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

KKITSKKFL--SHQHLYYLCLQLSKGLQELHQKNIIHLDIKPANLLLGLDLKW----KYADLGISKVVSEQKQHTNNLIGLTAVYSSPE
    ... .  | ...   ..|. .||. .|...||| |.||.|.|.  .       | .| |..|.... ... .. .  |  | .||
T--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPE
Kinase 13028.AA Ciliate-E2-Unclassified 65-240 20 3.9e-16 52.49 In-house 1-239 (352) Show / Hide 
Range on Protein: 65-240
Range on HMM: 1-239/352
Sequence Identity: 20% (50 aa)

IIENGLLGSGAGGFILKA-CSEWNDHL-----AVKFMKYSNLEQ---FKINKREYDILKKLSSRYVTK------------------VYSYFIESYESNGY
 . .  .|.|. | . |. ... .  .     . |...|. . .     . ..| ........ |. .                  |. ....  ..  .
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCF--QDKQN

QFIVMERCLY-DLKNYIAKKIT-------------SKKFLSHQHLY-----YLCLQLSKGLQELHQKN-IIHLDIKPANLLLGLDL---KWKYADLGISK
 .|||| | . ||..|| |. .             ..| .. |.       ... |. .||. ||.|| ||| |||| |.|.  .    . | .|.||||
IYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISK

VVSEQ--------------KQHTNNLIGLTAVYS----SPEQYQ
   ..              ||.  . .  |  |     .|| .|
KYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ
Kinase 13028.AA ULK 65-223 27 8.1e-16 52.65 In-house 1-200 (324) Show / Hide 
Range on Protein: 65-223
Range on HMM: 1-200/324
Sequence Identity: 27% (56 aa)

IIENGLLGSGAGG-FILKACSEWN----DHLAVKFMKYSNLEQFKIN----------KREYDILKKLS---SRY--VTKVYSYFIESYESNGYQFIVMER
.. |  ||.|. |    |.  . .     . |.| .  ... ..| .          |.|  |.|||    . .  . | | .| .| .   . .|.|| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNH--NNIYIIMEY

CLY-DLKNYIAKKIT-----SKKFLSHQHLYYLCLQLSKGLQELHQKNIIHLDIKPANLLLGLDLKWK-------------YADLGISKVVSE-----QK
|   ||..|| |. .      ||.|| |     . |.  |..|||..|||| ||||.|.|.  . ..|              || | .|.| .     |.
CNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILI-HNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQM

QHT
 .|
CQT
Kinase 13028.AA ULK 65-228 26 1.9e-15 50.46 In-house 1-213 (329) Show / Hide 
Range on Protein: 65-228
Range on HMM: 1-213/329
Sequence Identity: 26% (57 aa)

IIENGLLGSGAGGFILKACSEWN-----DHLAVKFMKYSNLEQFKIN----------KREYDILKKLS----SRY----VTKVYSYFIESYESNGYQFIV
.. |  ||.|. |   |.  . .        |.| .  . . |.. .          |.| .|.|||     . .    . | | .| .| . | . .|.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH-N-NIYII

MERCLY-DLKNYIAKKIT------SKKFLSHQHLYYLCLQLSKGLQELHQKNIIHLDIKPANLLLGLDLK------------WKYADLGISKVVSEQ---
|| |   ||..|| |. .       ||.|| |     . |.  |..|||..|||| ||||.| |.  .               | || | .|.|..    
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

KQHTNNLI------G
.| .          |
QQMMMTCVNEKRLCG
Kinase 13028.AA S_TKc 65-315 20 3e-15 46.78 SMART 1-231 (231) Show / Hide 
Range on Protein: 65-315
Range on HMM: 1-231/231
Sequence Identity: 20% (57 aa)

IIENGLLGSGAGGFILKACSEW-NDHLAVKFMKYSNLEQFKINKREYDILKKLSSRYVTKVYSYFIESYESNGYQFIVMERCLY---DLKNYIAKKITSK
     ..|.|| |   |.     . . |.| .|       .  .|| .||||    .. | | .| .     .. ..||| |     ||. || |. . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHG

KF--LSHQHLYYLCLQLSKGLQELHQKNIIHLDIKPANLLLGLDLKWKYADLGISKVVSEQKQHTNNLIGLTAVYSSPEQYQLATTSANRKVTK------
.   ..  |  ... |. ..|. .|...||| |.||.|.||      | .| |.....       . ..| |  | .||           . .|      
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCG-TPWYMAPEVL---------GYGKCKCDWW

--------SLT------GVDVTQKWIIKEKISTRNYDRCLNPYYEEFNNCIIKKMMQYQANERLQIEEVID-----VLKRLL
         |.       .... | |                  .|. . .|.|..|.  ..|. . |.        .   .
SCGCILYEMLCGYPPFPQMQMMFKKIG----------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 13028.AA TyrKc 65-311 20 5.8e-08 -93.94 SMART 1-280 (280) Show / Hide 
Range on Protein: 65-311
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

IIENGLLGSGAGGFILKACSEWNDHLAVKFMK-YSNLEQFKINKREYDILKKL--SSRYVTKVYSYFIES---YESNGYQFIVMERCLY-DLKNYIAKKI
|  .  ||.|| | . |.        ||| .| .. .| |    ||  |..||  .   . . | . ...   . . .  .|||| . . |||.|. |. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-REDF---MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

TSKKFLSHQHLYYLCLQLSKGLQELHQKNIIHLDIKPANLLLGLDLKWKYADLGISKVVSEQ-------KQHTN----NLIG-LTAVYSSPEQYQLATTS
     |....| . |.| ..| . ||.||.|| |.   | |.| ..  | .| | |. . .        .  .     .  . |     .||  .  . .
PK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

ANRKVTKS------------LTGVDVTQKW---------IIKEKISTRNYDRCLNP--------YYEEFNNCIIKKMMQYQANERLQIEEVIDVL
     |||            .|  .               . |.. .... ..             .|  . |.|.  ......|   .|... .
-----TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase 13028.AA Ciliate-A1 279-314 41 6.5e-08 22.95 In-house 267-301 (301) Show / Hide 
Range on Protein: 279-314
Range on HMM: 267-301/301
Sequence Identity: 41% (15 aa)

NPYYEEFNNCIIKKMMQYQANERLQIEEVIDVLKRL
.| .|| .| .|.|||||  | |.. ...|| |. .
EPRFEELQN-LIFKMMQYEPNNRCSLQQCIDCLYIF
Kinase 13028.AA Ciliate-E2-Unclassified 261-308 18 0.090191 1.95 In-house 295-347 (352) Show / Hide 
Range on Protein: 261-308
Range on HMM: 295-347/352
Sequence Identity: 18% (10 aa)

QKWIIKEKISTRNYD-----RCLNPYYEEFNNCIIKKMMQYQANERLQIEEVI
...|.. .|. ....       ..| ...| | ...||.... |.|...|...
YQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQIL
Kinase 13028.AA ULK 289-309 33 0.12876 1.52 In-house 305-325 (329) Show / Hide 
Range on Protein: 289-309
Range on HMM: 305-325/329
Sequence Identity: 33% (7 aa)

IIKKMMQYQANERLQIEEVID
.|..|.||. ..|  .||...
LIRRMLQYDEKDRISWEELFN
Kinase 13028.AA ULK 289-309 33 0.133161 1.53 In-house 300-320 (324) Show / Hide 
Range on Protein: 289-309
Range on HMM: 300-320/324
Sequence Identity: 33% (7 aa)

IIKKMMQYQANERLQIEEVID
.|..|.||. ..|  .||...
LIRRMLQYDEKDRISWEEIFN
Kinase 13028.AA Ciliate-E2 289-309 26 0.181504 0.78 In-house 336-361 (365) Show / Hide 
Range on Protein: 289-309
Range on HMM: 336-361/365
Sequence Identity: 26% (7 aa)

IIKK----MMQYQANERLQ-IEEVID
.|||    |.|.. ..|.. .|....
LIKKFGKRMLQKDPEKRITGWEQILN
Kinase 13028.AA Ciliate-E5 433-654 43 8.49999999999e-143 467.74 In-house 1-271 (271) Show / Hide 
Range on Protein: 433-654
Range on HMM: 1-271/271
Sequence Identity: 43% (119 aa)

FIENGLMGQGGSAFILKAFSEWNLSLAVKFIKLNQNQQNQEDYKREYEILKIFNSPYILKVFTFYNKSNSKNLSYQIIVMERCKYDLRRYINKVIYPQQS
.|||...|.|||....|..|||| ......|....||...||..||..|||.||||.|.||...|.... .|..||.|.|||||.||..|.||.||....
IIENQILGKGGSGMVMKGCSEWNDKPIAIKIMKCKNQKQCEDNQREFNILKQFNSPHIIKVYQIYQYQY-ENMNYQFIIMERCKCDLHTYLNKIIYQMKW

DNLLNIYLLSLQLAKGLQVLHQNNIIHLDIKPGNILYGYDQSWKFADFGIA---------KVVSDDRT--------------------------------
.....|| ..|||.||||..||.|||||||||.|||.|||..||..|.||.         |.||..|.                                
QKHQDIYQICLQLVKGLQDIHQKNIIHLDIKPANILLGYDNKWKYIDMGISRKFKHVVRDKQVSEQRQNSSETIEENMIKFIKIIPYFFQREYPKLHNKN

---------FTNQLVFISRAVSFSNGSSFYHNQGFYILIRNLPDIKYIQSFYTTQPKQSDVYSLGIIFLELT
         .|..|.......|.......||||.|||||||||||||||||.....||||.|||||.|||||
RKKLRYQIPHTCNLKGFTQCYSSPEQYQCYHNQMFYILIRNLPDIKYIQSFKKKITKQSDIYSLGIVFLELT
Kinase 13028.AA Ciliate-E1 439-584 29 1.6e-22 70.38 In-house 1-157 (202) Show / Hide 
Range on Protein: 439-584
Range on HMM: 1-157/202
Sequence Identity: 29% (48 aa)

MGQGGSAFILKAFSEWNL--SLAVKFIKLN--QNQQNQEDYKREYE-ILKIFN-SPYILKVFTFYNKSNSKNLSYQIIVMERCKYDLRRYIN--------
 |.|......||....|   . |.|.|...  .||....|...||  |.| |.   ||.... .. . ....   .||..| |.. | .|..        
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYI---CIIIFECCCCSLKDYLQNHNRLEYW

-KVIYPQQSDNLLNIYLLSLQLAKGLQVLHQNNIIHLDIKPGNILYGYDQSWKFADFGIAK
 .  . |.. . ...  .  || .||. |||.||||.|||| |||.  .   ...||||.|
QQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISK
Kinase 13028.AA Ciliate-B2 458-589 30 1e-21 47.77 In-house 30-157 (197) Show / Hide 
Range on Protein: 458-589
Range on HMM: 30-157/197
Sequence Identity: 30% (40 aa)

LAVKFIKLNQNQQNQEDYKREYEILKIFN-SPYILKVFTFYNKSNSKNLSYQIIVMERCKYDLRRYINKVIYPQQSDNLLNIYLLSLQLAKGLQVLHQNN
||.| |  |. . ..|.   |..|.|.|. . .. |.  .       | . ....||.|...|.  ..|.   |.  |  ..| .  ||  ||  .. .|
LAFK-IYFNKQDCDKEEIQHEIKIMKMFEYNINVVKYIDHIQ----INETIDVLIMEKCECSLKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYN

IIHLDIKPGNILYGYDQSWKFADFGIAKVVSDD
|.|||||| |||  .    .. ||||  . .|.
ILHLDIKPQNILFMQNGNYVYCDFGISSIKKDN
Kinase 13028.AA Ciliate-A1 433-585 28 5.3e-20 64.73 In-house 1-150 (301) Show / Hide 
Range on Protein: 433-585
Range on HMM: 1-150/301
Sequence Identity: 28% (45 aa)

FIENGLMGQGGSAFILKAFSEWNLS--LAVKFIKLNQNQQNQEDYKREYEILKIFNSPYILKVF-TFYNKSNSKNLSYQIIVMERCKYDLRRYINKVIYP
. .  |.. |.   ...|.   |    |..| |.   . | ..    || ..|  |... .|..   | . | |   .  |.|| |.|      |   | 
YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFEQYKNNIQ-EYRKCKQINHNNVIKNYQQLYYNTNNKECMF--IIMEYCQYG-----NLFNYC

QQSD--NLLNIYLLSLQLAKGLQVLHQNNIIHLDIKPGNILYGYDQSWKFADFGIAKV
 | |      || . .|. .|.  .|  ||.|.|.||.||| . |  ||..|.|. |.
YQNDYMKKEEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQ
Kinase 13028.AA CMGC 433-597 17 1.7e-18 56.55 In-house 1-287 (513) Show / Hide 
Range on Protein: 433-597
Range on HMM: 1-287/513
Sequence Identity: 17% (50 aa)

FIENGLMGQGGSAFILKAFS---------------EWNLSLAVKFIKLNQNQQNQED-----------YKREYEILKIFN-----------------SPY
.   .  |.|  .   |..                |.|   |.| ||...  ..|.              || .||| .|                  ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

ILKVFTFYNKSNSKNLS------------YQIIVMERCKYDLRRYINKVI------YPQQSDNLL-----------NIYLLS------LQLAKGLQ--VL
|.| . ..  .||..              .  .|.| . .|| .|| .        .|.  .              ||  ..       |. .||    .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HQNN--IIHLDIKPGNILYGYDQSW--------------------KFADFGIAKVVSDD----------------------RTFTNQLV
|...  ||| |.|| |||   .                       | .||| |. ...                       |..|.. |
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVV
Kinase 13028.AA STE 459-584 25 1.8e-18 61.96 In-house 43-195 (359) Show / Hide 
Range on Protein: 459-584
Range on HMM: 43-195/359
Sequence Identity: 25% (41 aa)

AVKFIKLNQNQ----------------QNQEDYKREYEILKIFN--SPYILKVFTFYNKSN--SKNLSYQIIVMERCK-YDLRRYINKVIYPQQSDN---
|.| ..|....                ........| .|.| .|  .|.| | .  | | .  .|| ..  |.|| .    |.  |...  .....|   
AIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNR

-------LLNIYLLSLQLAKG-LQVLHQNNIIHLDIKPGNILYGYDQSWKFADFGIAK
          |     |. || |. ||...||| ||||.|||       | .|||...
QHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG
Kinase 13028.AA Ciliate-A1 639-713 29 1.1e-16 53.24 In-house 207-301 (301) Show / Hide 
Range on Protein: 639-713
Range on HMM: 207-301/301
Sequence Identity: 29% (28 aa)

KQSDVYSLGIIFLELTG-----------VDITQQWIVEQK----------SCALDFDEYLNPQFERFNSMIVKKMIQFKPENRISLQEVIQILSAF
||||.||||.|...|..           | |    ... .          .    |    .|.||  .  ...||.|  |.||.|||..|. |  |
KQSDMYSLGCIICFLCYKEDSHPYVGTIVNIFGNNMQNDQSIHFCKSVNAIKKIIFPPMQEPRFEELQ-NLIFKMMQYEPNNRCSLQQCIDCLYIF
Kinase 13028.AA Ciliate-E2 433-584 21 2.4e-16 52.58 In-house 1-204 (365) Show / Hide 
Range on Protein: 433-584
Range on HMM: 1-204/365
Sequence Identity: 21% (46 aa)

FIENGLMGQGGSA--FILKAFSEWNLS-----------------LAVKFIKLNQNQQNQEDYK-REYEIL--------KIFN---------SPYILKVFT
.. . . |||. .  .  |  .. ...                  ..|.. ......||  .. .|  |.        || |         .|.|.| . 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYE

FYNKSNSKNLSYQIIVMERCKY-DLRRYIN--KVIYPQQSD-----NLLNIYLLSLQLAK---------------GLQVLHQNN-IIHLDIKPGNILYGY
..   . .|.    .||| |.. ||. ||.  |   ... .     ..  |  .. |...               .|. ||..| ||| |||| |||.  
CFQEKDDNNI---YLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

DQSWKFADFGIAK
    | .|||..|
---IKIIDFGLSK
Kinase 13028.AA S_TKc 433-714 17 3.4e-16 60.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 433-714
Range on HMM: 1-231/231
Sequence Identity: 17% (55 aa)

FIENGLMGQGGSAFILKAFSEW-NLSLAVKFIKLNQNQQNQEDYKREYEILKIFNSPYILKVFTFYNKSNSKNLSYQIIVMERCKY---DLRRYINKVIY
.    . |.|. .   |.     .   |.| ||        |. .|| .|||  . |.| | . ..        ..  .||| |     ||..|| |  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGR

--PQQSDNLLNIYLLSLQLAKGLQVLHQNNIIHLDIKPGNILYGYDQSWKFADFGIAKVVSDDRTFTNQLVFISRAVSFSNGSSFYHNQGFYILIRNLPD
  ...  .   .  .  |....|. .|...||| |.|| |||       | .|||.|...                                        
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------------------------------

IKYIQSFY-------TTQPKQSDVYSLGIIFLELTG-------VDITQQWIVEQKSCALDFDEYLNPQFERFNSMIVKKMIQFKPENRISLQEVIQ----
  .. . .          .. .|..|.|.|. |.         .. . . |.                 . . . ...|. |. ||.|..  |. |    
TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG----------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWD

-ILSAFI
  .  ..
IKCHPWF
Kinase 13028.AA Pkinase 433-593 24 6.6e-15 53.78 Pfam 1-169 (293) Show / Hide 
Range on Protein: 433-593
Range on HMM: 1-169/293
Sequence Identity: 24% (44 aa)

FIENGLMGQGGSAFILKAFSEWNLS-LAVKFIKLNQNQQNQEDYKR---EYEILKIFNSPYILKVFTFYNKSNSKNLSYQIIVMERCKY-----DLRRYI
.   .  |.|...   |.    .    ||| ||.  .  ... ..|   | .|.| .|.|.|.. . ..    ....    .||| |       || .||
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIY---MVMEYCEGGLYVMDLFDYI

N---KVIYPQQSDNLLNIYLLSLQLAKGLQVLHQNNIIHLDIKPGNILYGYDQSW----KFADFGIAKV--VSDDRTFT
    .  .   |..   .    .|...||. .|...||| |.|| |||.  .       | .|||.||.     .. .|
STWRHGCFY-FSEWE--CKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MT
Kinase 13028.AA Ciliate-E2-Unclassified 433-594 19 2e-14 46.43 In-house 1-222 (352) Show / Hide 
Range on Protein: 433-594
Range on HMM: 1-222/352
Sequence Identity: 19% (44 aa)

FIENGLMGQGGSAFILKAFSEWNLSLA------VKFIKLNQNQQNQE-DYKREYEILKIFNSPYILK---------------VFTFYNKSNSKNLSYQII
.. .   |||| . . |.  . .  ..       |... .|.|.... ....| ..... .. |. .                |  .     ..  . .|
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VMERCKY-DLRRYINK----------VIYPQQSDNLLNIYLLS--------LQLAKGLQVLHQNN-IIHLDIKPGNILYGYDQ---SWKFADFGIAK---
||| |.. ||. ||.|              ..... .  .  .         |. .||. ||..| ||| |||| |||.  ..     | .||||.|   
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

--------------VVSDDRTFTN
              . ..... |.
QNNNCDTNQQQKMQIWKQQMMWTF
Kinase 13028.AA ULK 544-589 43 8.3e-14 44.65 In-house 138-195 (329) Show / Hide 
Range on Protein: 544-589
Range on HMM: 138-195/329
Sequence Identity: 43% (25 aa)

QLAKGLQVLHQNNIIHLDIKPGNILYGYDQ------------SWKFADFGIAKVVSDD
|.. |.. ||..|||| |||| |||   .|              | |||| ||.|..|
QILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDND
Kinase 13028.AA ULK 544-589 41 3.9e-13 43.01 In-house 134-191 (324) Show / Hide 
Range on Protein: 544-589
Range on HMM: 134-191/324
Sequence Identity: 41% (24 aa)

QLAKGLQVLHQNNIIHLDIKPGNILYGYDQ------------SWKFADFGIAKVVSDD
|.. |.. ||..|||| |||| |||   .|              | |||| ||.| ..
QICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNN
Kinase 13028.AA ULK 433-525 24 1e-06 19.37 In-house 1-110 (324) Show / Hide 
Range on Protein: 433-525
Range on HMM: 1-110/324
Sequence Identity: 24% (28 aa)

FIENGLMGQGGSA-FILKAFSEWN----LSLAVKFIK---LNQNQQNQE------DYKREYEILKIFN---SPY--ILKVFTFYNKSNSKNLSYQIIVME
.. |   |.|  .    |.. . .       |.| |    .|.....||        |.| .|.|...   .|.  | | . ... ||.    .  |.||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNH---NNIYIIME

RCKY-DLRRYINK
 |   ||. ||.|
YCNGGDLEQYIKK
Kinase 13028.AA Ciliate-B2 640-647 75 5.3e-05 7.6 In-house 190-197 (197) Show / Hide 
Range on Protein: 640-647
Range on HMM: 190-197/197
Sequence Identity: 75% (6 aa)

QSDVYSLG
|||.||.|
QSDIYSMG
Kinase 13028.AA ULK 433-525 22 0.000146 11.94 In-house 1-113 (329) Show / Hide 
Range on Protein: 433-525
Range on HMM: 1-113/329
Sequence Identity: 22% (26 aa)

FIENGLMGQGGSAFILKAFSEWNL--SLAVKFIKLNQ----NQQNQEDY--------KREYEILKIFN----SPY----ILKVFTFYNKSNSKNLSYQII
.. |   |.|  .   |.. . .   .  . ..|  .    ||.|.|..        |.| .|.|  .    ...    | | . ... ||.    .  |
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH---NNIYI

VMERCKY-DLRRYINK
.|| |   ||. ||.|
IMEYCNGGDLEQYIKK
Kinase 13028.AA Ciliate-E2 639-708 19 0.00037 10.15 In-house 275-361 (365) Show / Hide 
Range on Protein: 639-708
Range on HMM: 275-361/365
Sequence Identity: 19% (18 aa)

KQSDVYSLGIIFLELTGVDITQQW--IVEQKSCALDFDEYLNP-----------QFERFNSM---IVKK----MIQFKPENRIS-LQEVIQ
...|..|||.|. |.    .. ..  . ..| | .||... .             ..        . ||    |.| .||.||.  .....
YKCDIWSLGVILYEM----LFGKPPFQQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 13028.AA ULK 688-709 27 0.013897 5.06 In-house 300-321 (324) Show / Hide 
Range on Protein: 688-709
Range on HMM: 300-321/324
Sequence Identity: 27% (6 aa)

IVKKMIQFKPENRISLQEVIQI
. ..|.|.... ||| .|....
LIRRMLQYDEKDRISWEEIFNH
Kinase 13028.AA ULK 688-709 27 0.018047 4.54 In-house 305-326 (329) Show / Hide 
Range on Protein: 688-709
Range on HMM: 305-326/329
Sequence Identity: 27% (6 aa)

IVKKMIQFKPENRISLQEVIQI
. ..|.|.... ||| .|....
LIRRMLQYDEKDRISWEELFNH
Kinase 13028.AA Ciliate-E2-Unclassified 639-708 14 0.027407 3.77 In-house 249-348 (352) Show / Hide 
Range on Protein: 639-708
Range on HMM: 249-348/352
Sequence Identity: 14% (15 aa)

KQSDVYSLGIIFLELTGVDITQQWIVEQKSCAL----------------DFDEYLN--PQFERFNS----MIVK------------KMIQFKPENRISLQ
...|..|||.|. |.    .....  ....|                   ... ..  .||  |.     ...             ||.. .|..||...
YKCDIWSLGVILYEM----LFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFE

EVIQ
....
QILN
Kinase 13028.AA STE 640-653 35 0.321454 0.21 In-house 248-261 (359) Show / Hide 
Range on Protein: 640-653
Range on HMM: 248-261/359
Sequence Identity: 35% (5 aa)

QSDVYSLGIIFLEL
..|..|||.  .|.
KCDIWSLGCTIIEM
Kinase 13028.AA Pkinase 638-653 31 3.379813 1.78 Pfam 190-205 (293) Show / Hide 
Range on Protein: 638-653
Range on HMM: 190-205/293
Sequence Identity: 31% (5 aa)

PKQSDVYSLGIIFLEL
.. .|..|.|.|. |.
GPKVDMWSCGCILYEM
Kinase 13028.AA Pkinase 688-710 16 5.027856 1.17 Pfam 269-293 (293) Show / Hide 
Range on Protein: 688-710
Range on HMM: 269-293/293
Sequence Identity: 16% (4 aa)

IVKKMIQFKPENRISLQEVIQI--L
..|......|. |.. ... |   .
FIKWCLCKDPKKRPTAEQILQHPWF