Gene 26507 (Tetrahymena)
26507
Group:
Other
Family:
Ciliate-E6
Sequence
Protein domains of 26507.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 26507.AA | Ciliate-E6 | 74-221 | 38 | 1.1e-60 | 191.61 | In-house | 1-154 (154) | Show / Hide |
Range on Protein: 74-221 Range on HMM: 1-154/154 Sequence Identity: 38% (60 aa) VNRLKQCSHKNIIRYYDSFQIEDSFFIVMEKVEFSLQQWIN--DNKKNLIQKEQFLKFALQMVEAADYLHQKKYILSNISLKNIFLDRDLNIKLSTFTVQ ...||.|.|.||..|.||||||...|||||..|..||.||. .|||...|..||.||..|...|..|||.|.|.|.||.|||||||...|||.. | | IQNLKNCNHPNILKYMDSFQIENYYFIVMERCEMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFLDKNMNIKICDFGFQ QEVSVKYLLHKQIYA-LENDQLIYFPI-FLI---DKRDNQDLITLSSKQDMYTIG |.. .. . |.. | . ...|.| ... |. . . . . | . .. QCI-IPNQQTKEFMAQKNQNKYHYCPPEQFDYSKDQQSKHYKVNWTQEGDIWSVC |
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| Kinase | 26507.AA | Ciliate-A2 | 34-165 | 39 | 1.1e-31 | 107.3 | In-house | 4-144 (272) | Show / Hide |
Range on Protein: 34-165 Range on HMM: 4-144/272 Sequence Identity: 39% (55 aa) GFGKYLFAKYQ--QNSC--MIQIISVQNDEKL-SQYKKLQIAIEKVNRLKQCSHKNIIRYYDSFQIEDSFFIVMEKV-EFSLQQWIN--DNKKNLIQKEQ .||. .|.. .|. | |.|... . .||| . .. || |.|.||..|.|.||| ||.||| |.|||.|| | .. |...| CFGCVIFVEHMDNHNNEKYAIKIQSIIDGIDQKISQQKLQECKHEAQFLKNCNHPNIVKYHDEFQIGFYYFIQMEKCPECSLQDWIDKFQNQQKFIPDHQ FLKFALQMVEAADYLHQKKYILSNISLKNIFLDRDLN-IKL |..||.|. .| .|||.| |.| ..||.|| .| | . ||| FVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKL |
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| Kinase | 26507.AA | Ciliate-E2-Unclassified | 49-168 | 20 | 1.6e-09 | 29.19 | In-house | 29-191 (352) | Show / Hide |
Range on Protein: 49-168
Range on HMM: 29-191/352
Sequence Identity: 20% (33 aa)
MIQIISVQNDE-KLSQYK----KLQIAIEKVN-------------RLKQCSHKNIIRYYDSFQIEDSFFIVMEKVE-FSLQQWINDNKK-----------
| .....|.. |. ..| ...... . |... | .|..... || .. ..||||..| .|.|.|...||
MKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHN
----NLIQKEQFL-----KFALQMVEAADYLHQKK-YILSNISLKNIFLDRDL---NIKLSTF
. .. .| . ... | ... .|||.|. | .| . ||..| . .||.. |
MKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDF
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| Kinase | 26507.AA | NEK | 65-146 | 34 | 1.3e-08 | 26.92 | In-house | 45-141 (286) | Show / Hide |
Range on Protein: 65-146 Range on HMM: 45-141/286 Sequence Identity: 34% (33 aa) KKLQIAI-EKVNRLKQCSHKNIIRYYDSFQIED--SFFIVMEKVE--FSLQQW---INDNK--KNLIQKEQFLKFALQMVEAADYLHQK-----KYI |. | |. . |. ||| | ||..|||||. |. ...|||| | |.| |. .| . ... || ... ||. | .|.|.. | . KEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKIL |
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| Kinase | 26507.AA | STE | 52-146 | 17 | 1.4e-08 | 26.54 | In-house | 46-174 (359) | Show / Hide |
Range on Protein: 52-146
Range on HMM: 46-174/359
Sequence Identity: 17% (23 aa)
IISVQNDE-----------KLSQYKKLQIAIEKVNRLKQCS--HKNIIRYYDSFQIE-------DSFFIVMEKVEF-SLQQWINDN-KKNLIQK------
.....|.. . .. ...| .. .. .|.|. |.||..||... | |. .|.|| .. || . |. . ... ..
QMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQ
----EQFL-KFALQMVEA-ADYLHQKKYI
|. . ... | ... .|||....|
HRFPESQIAYICRQILKGLLYYLHSHHII
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| Kinase | 26507.AA | Jak | 72-160 | 24 | 3.6e-08 | 25.03 | In-house | 58-154 (299) | Show / Hide |
Range on Protein: 72-160 Range on HMM: 58-154/299 Sequence Identity: 24% (24 aa) EKVNRLKQCSHKNIIRYYDSF--QIEDSFFIVMEKVEF-SLQQWIN---DNKKNLIQK--EQFLKFALQMVEAADYLHQKKYILSNISLKNIFLDRD . . ...|.|||.|..|. ...|. .||| ... .| . . ...|. . . ..|| | .....||. |.|| ... .|| .||. REISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDDYLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDRE |
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| Kinase | 26507.AA | Pkinase | 77-166 | 22 | 4.7e-08 | 29.56 | Pfam | 54-154 (293) | Show / Hide |
Range on Protein: 77-166 Range on HMM: 54-154/293 Sequence Identity: 22% (24 aa) LKQCSHKNIIRYYDSFQIEDSFFIVMEKVEF-----SLQQWIN-DNKKNL-IQKEQFLKFALQMVEAADYLHQKKYILSNIS-----LKNIFLDRDLNI- .| ..|.||.|.||.|. .|. .||| .| .| .| ...... . .. ....|.... .|.|.. .| . ||..|.. .| MKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM-----GIIHRDLKPENILIDNNGHID ---KLS |.. ACVKIC |
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| Kinase | 26507.AA | STE20 | 77-103 | 45 | 7.2e-08 | 25.15 | In-house | 58-88 (288) | Show / Hide |
Range on Protein: 77-103 Range on HMM: 58-88/288 Sequence Identity: 45% (14 aa) LKQCSHKNIIRYYDSFQIE----DSFFIVME .||| |.||..||.|.. . |. .|||| MKQCKHPNIVKYYGSYLKDDTCDDELWIVME |
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| Kinase | 26507.AA | CAMKL | 77-166 | 22 | 9.3e-08 | 20.68 | In-house | 66-171 (297) | Show / Hide |
Range on Protein: 77-166 Range on HMM: 66-171/297 Sequence Identity: 22% (24 aa) LKQCS---HKNIIRYYDSFQIEDS------FFIVMEKVEFS---LQQWINDNKKNL--IQKEQFLKFALQMVEAADYLHQKKYILSNISLKNIFLDRDL- .|. . |.|||. |. .. .. ...||| .. |...| ... .. .. .. |.|.| .|.|... . | . || || . MKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGN -NIKLS |||.. NNIKII |
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| Kinase | 26507.AA | SLK | 51-170 | 21 | 2e-07 | 20.98 | In-house | 30-143 (259) | Show / Hide |
Range on Protein: 51-170 Range on HMM: 30-143/259 Sequence Identity: 21% (26 aa) QIISVQNDEKLSQYKKLQIAIEKVNRLKQCSHKNIIRYYDSFQIEDSFFIVMEKVEFSLQQWINDNKKNLIQKEQFLKFALQMVEAADYLHQKKYILSNI ..| ....|.|. | . .. | .| | ||.. |... ... ....| . | . . .. .| . .|.|| ..||..| | .. KMIEIKDEEELEDY------MVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQYVCKHMCEALNWLHSNKVIHRDL SLKNIFLDRDLNIKLSTFTV || . | ...| | | KAGNILMTMDGDVRLADFGV |
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| Kinase | 26507.AA | CMGC | 77-146 | 14 | 2.6e-07 | 19.11 | In-house | 75-206 (513) | Show / Hide |
Range on Protein: 77-146
Range on HMM: 75-206/513
Sequence Identity: 14% (19 aa)
LKQCS-----------------HKNIIRYYDSFQIED-----------------SFFIVMEKVEFSLQQWINDNKK-------NLIQKEQ----------
||. . |.||.. ||.|. .. ....|.| .. .| | | .|.. . .
LKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPP
--FLKFA------LQMVEAAD--YLHQKK--YI
.| |. .. . |.|... |
HNIKYFMIHIRYMYQILRGLKLKYCHSHWGNII
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| S_TKc | 26507.AA | S_TKc | 28-276 | 14 | 3.7e-07 | -71.92 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 28-276
Range on HMM: 1-231/231
Sequence Identity: 14% (43 aa)
IRKDKE----GFGKYLFAKYQQ--NSCMIQIISVQNDEKLSQYKKLQIAIEKVNRLKQCSHKNIIRYYDSFQIEDSFFIVMEKVEF---SLQQWINDNKK
.. .. .||| .. . | ||. . .. .. ||. |.||...||.|| |....||| .. .| . | ....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR
NL----IQKEQFLKFALQMVEAADYLHQKKYILSNISLKNIFLDRDLNIKL-----STFTVQQEVSVKYLLHKQIYALENDQLIYFPIF----LIDKRDN
. . . ... |...| .|.|... | . ||.||. .||. ... . .. | . ..
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------------TTFCGTPWYMAPEVL-----
QDLITLSS-KQDMYTIGLCLY-CLTGVS----YMEVLNYIWGDKFQVSISLGVDVNQILQLMLFRN-----QCSFVPS-------PSYF
. | |.. .| .|| .|.| ...... | .. .... .| .. . . .|
----GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 26507.AA | Jak | 279-289 | 54 | 0.373684 | 0.1 | In-house | 289-299 (299) | Show / Hide |
Range on Protein: 279-289 Range on HMM: 289-299/299 Sequence Identity: 54% (6 aa) SFQQIIESLNK ||. ||. ||. SFRTIIRDLNQ |
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| TPR_1 | 26507.AA | TPR_1 | 450-483 | 26 | 3e-06 | 25.74 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 450-483 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) DEVYNNIGDIYFNLNDYNTSKSYFKKSVEFNPRQ |...|.| .|.....|. ...| .| || AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR_2 | 26507.AA | TPR_2 | 450-483 | 26 | 3.7e-05 | 22.34 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 450-483 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) DEVYNNIGDIYFNLNDYNTSKSYFKKSVEFNPRQ |...|.|..|....|| . |..|... .|. AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR | 26507.AA | TPR | 450-483 | 26 | 4.3e-05 | 24.15 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 450-483 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) DEVYNNIGDIYFNLNDYNTSKSYFKKSVEFNPRQ |...|.| .|....||. ...|..| .| AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_1 | 26507.AA | TPR_1 | 484-517 | 23 | 0.000449 | 18.21 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 484-517 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) HIAFYNLGQVYFQQNMFQKGSYYLKKAKKIELDD |.||||..|.... ... ...|| ... .. AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR_2 | 26507.AA | TPR_2 | 484-517 | 35 | 0.000547 | 18.2 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 484-517 Range on HMM: 1-34/34 Sequence Identity: 35% (12 aa) HIAFYNLGQVYFQQNMFQKGSYYLKKAKKIELDD | |||||.|..|. ... |..|| |.. .. AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR | 26507.AA | TPR | 382-415 | 26 | 0.000644 | 20.26 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 382-415 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) DILYLFLGHLYEISQDFQQSLDSYKKAFALNDQN .. ||..|. |... .. |.|| .|. .| AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_1 | 26507.AA | TPR_1 | 382-415 | 26 | 0.000703 | 17.53 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 382-415 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) DILYLFLGHLYEISQDFQQSLDSYKKAFALNDQN . ||..|. ..... .. |.|| .|| .| AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR_2 | 26507.AA | TPR_2 | 382-415 | 26 | 0.001894 | 16.29 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 382-415 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) DILYLFLGHLYEISQDFQQSLDSYKKAFALNDQN .. || .|. .|... .. |.|| .|. .| AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR | 26507.AA | TPR | 484-517 | 23 | 0.003799 | 17.7 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 484-517 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) HIAFYNLGQVYFQQNMFQKGSYYLKKAKKIELDD |.||||..|.... ... ...|| ... .. AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_2 | 26507.AA | TPR_2 | 416-449 | 23 | 0.592765 | 7.46 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 416-449 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) DAAVFGMGLAYGELGFIQESLNCYNKYINLNTLD .| . .|..| ..| .| ...|.| . |. . AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR | 26507.AA | TPR | 416-449 | 26 | 0.977977 | 0.67 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 416-449 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) DAAVFGMGLAYGELGFIQESLNCYNKYINLNTLD | . .|..| .| ..| ..||.| . |. . AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_1 | 26507.AA | TPR_1 | 416-446 | 32 | 15.887207 | 2.33 | Pfam | 1-31 (34) | Show / Hide |
Range on Protein: 416-446 Range on HMM: 1-31/34 Sequence Identity: 32% (10 aa) DAAVFGMGLAYGELGFIQESLNCYNKYINLN | . .|..| ..| .| . ||.| . || AEAWYNLGNCYYKMGNYDEAIECYQKALELN |
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| TPR_1 | 26507.AA | TPR_1 | 523-542 | 35 | 0.525006 | 7.5 | Pfam | 7-26 (34) | Show / Hide |
Range on Protein: 523-542 Range on HMM: 7-26/34 Sequence Identity: 35% (7 aa) LGFFYKQKQDYEKSLKCYEK || | ....|.. ..||.| LGNCYYKMGNYDEAIECYQK |
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| TPR_2 | 26507.AA | TPR_2 | 522-550 | 31 | 0.551818 | 7.57 | Pfam | 6-34 (34) | Show / Hide |
Range on Protein: 522-550 Range on HMM: 6-34/34 Sequence Identity: 31% (9 aa) LLGFFYKQKQDYEKSLKCYEKLSIKTQNY .|| | ...||.. ...|||. |. NLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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