Gene 27894 (Tetrahymena)
27894
Group:
Other
Family:
Ciliate-E7
Sequence
Protein domains of 27894.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 27894.AA | Ciliate-E7 | 59-342 | 63 | 3.3e-216 | 724.58 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 59-342 Range on HMM: 1-290/290 Sequence Identity: 63% (184 aa) YVLKEEISYSSYEYKCKAYDNKSHQDVQINYYFFYSQYQLKEILKAIEIQKFLNHENIEKIYNFNFTSYPEINEMYVVSDFMQTSLNYIIQSEQQLTEDH |..|.||.|..|.|.||||.....|..|..||.||.|..||.|.|||||||||||||.||||||||.||.|||.||||||||||.|.||.||.||||..| YQIKREIWYDTYIYFCKAYIDREYQQKQFIYYIFYEQCYLKYIIKAIEIQKFLNHENHEKIYNFNFHSYMEINNMYVVSDFMQTNLKYITQSRQQLTDEH IKYFMYQILRALHYIHSAKIVFVQLEPKLIKINSDCSIKISDFIWCIGNQNQEIETNYVNQYYYMSPEYIVEQMGTE-KSDIWSAGCIFAELISRRKLFT ||.||||||||||||||.||...||.|..|.||..|.||||||||||||...||...|.|..|||||.||||||.|. |.|||..||||.|||.|.|.|. IKWFMYQILRALHYIHSQKIYHTQLTPRFIQINQNCDIKISDFIWCIGNFPHEINKKYINKNYYMSPYYIVEQMETFSKTDIWHVGCIFLELIQRYKFFS G---YEYPQAITQILKFCGKQNEE--DLKYYKIINRERLLKSMPKEKQISSLQAYFPNANPLALDLLGKMLTFNLDKRFNALECLQHEYL . ..|...|||...|||.|||| ||||||..||......|||.....|.|..|||||||..|||.|||.||.|||||..|||||.|. DFCCHDYNGVITQYFYFCGSQNEEDLDLKYYKQYNRQYNQLKMPKQYCKQSWQVQFPNANPLLCDLLDKMLVFNEDKRFNVKECLQHPYF |
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| Kinase | 27894.AA | MAPK | 105-342 | 33 | 1.4e-61 | 210.9 | In-house | 55-328 (328) | Show / Hide |
Range on Protein: 105-342 Range on HMM: 55-328/328 Sequence Identity: 33% (93 aa) IEIQKFL-NHENIEKIYNFNFTS-----YP--EINEMYVVSDFMQTSLNYIIQSEQQLTEDHIKYFMYQILRA--LHYIHSAKIVFVQLEPKLIKINSDC | ..... .|||| |... . .. | |. |.|...|.| |. ||.|.|.|..|||.||||||||. | ||||| .. | | | .|..| IKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENC SIKISDF----IWCIG---NQNQEIE--------TNYVNQYYYMSPEYIVE---QMGTEKSDIWSAGCIFAELIS-RRKLFTGYEYPQAITQILKFCGKQ || || ... ...| . | || . .| .|| . . |.. |.||.||||||... |. || | | ...|....|. DLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTP NEEDLKYYK-IINRERLLKSM--PKEKQISSLQAYFPN----ANPLALDLLGKMLTFNLDKRFNALECLQHEYL ||.... . . ...|. .. .. ... ||| |||.|.||| |||.|. ||| .. |.|||.|. SEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF |
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| Kinase | 27894.AA | ERK | 105-342 | 38 | 5.7e-61 | 208.87 | In-house | 54-307 (307) | Show / Hide |
Range on Protein: 105-342 Range on HMM: 54-307/307 Sequence Identity: 38% (99 aa) IEIQKFLN-HENIEKIYNFNFTSYP-EINEMYVVSDFMQTSLNYIIQSEQQLTEDHIKYFMYQILRALHYIHSAKIVFVQLEPKLIKINSDCSIKISDFI | ...... |||| .... ..| ..|. |.|...|.| | ||.|.|.|..||..|||||||..| |||||... .| |. | .||.| ||.||. IKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIINSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFG W-CIGNQ--------NQEIETNYVNQYYYMSPEYIVEQMG-TEKSDIWSAGCIFAELISRRKLFTGYEYPQAITQILKFCGKQ-NEEDLKYYKIINRERL .. . ||.. |.|| .| .|| . |.. ||||.||||||.. |. || | | |..|.. |. ||||.| . .| . LARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKY LKSMPK-EKQISSLQAYFPNAN--PLALDLLGKMLTFNLDKRFNALECLQHEYL .|..|. .. ... ||||| |.|.||| |||.|. ||| .. |||.|.|. IKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF |
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| Kinase | 27894.AA | p38 | 109-342 | 37 | 3.4e-54 | 183.53 | In-house | 56-289 (289) | Show / Hide |
Range on Protein: 109-342 Range on HMM: 56-289/289 Sequence Identity: 37% (89 aa) KFLNHENIEKIYN-FNF--TSYPEINEMYVVSDFMQTSLNYIIQSEQQLTEDHIKYFMYQILRALHYIHSAKIVFVQLEPKLIKINSDCSIKISDFIWCI | ..|||. .. . | .| .... |.|. ||...|| |. ... |..|||.. |||||.| ||||| |. | | | .| || ..| || KHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKCQR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR GNQNQEIETNYVNQYYYMSPEYIVEQMG-TEKSDIWSAGCIFAELISRRKLFTGYEYPQAITQILKFCGKQNEEDLKYYKIINRERLLKSMPKEKQISSL . .|. | || | .|| . | |.. |||| ||| ||||..| || | .. . ...|.| ||. || .. . . ..|.|. .. . -HCDDEM-TGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPR-RDF QAYFPNANPLALDLLGKMLTFNLDKRFNALECLQHEYL . |..|||.|.||| ||| ||| | | .||.|. HHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF |
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| Kinase | 27894.AA | nmo | 99-342 | 34 | 4.9e-50 | 151.71 | In-house | 43-292 (292) | Show / Hide |
Range on Protein: 99-342 Range on HMM: 43-292/292 Sequence Identity: 34% (86 aa) KEILKAIEIQKFLNHENIEKIYNFNFTSYPEI---NEMYVVSDFMQTSLNYIIQSEQQLTEDHIKYFMYQILRALHYIHSAKIVFVQLEPKLIKINSDCS | . . . . | .|.| . . |.. .|.||| . || | || | |.|. ||.| |.||||| | |.|||.|. . | . .||.| KRVFRELKMLCFFKHDN--VLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSSDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCV IKISDFIWCIGNQNQEIE--TNYVNQYYYMSPEYIV-EQMGTEKSDIWSAGCIFAELISRRKLFTGYEYPQAITQILKFCGKQNEEDLKYYKIINRERLL .|| || . .. |. | || || .. . |. |||| |||||||. || || . | . | | ||.|| . .| LKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGRRILFQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHML KSMPKEKQISSLQAYFP--NANPLALDLLGKMLTFNLDKRFNALECLQHEYL . .|. ... | .|. | .|| .|| |. ||| . . |.| || RMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL |
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| Kinase | 27894.AA | ERK1 | 59-342 | 36 | 7.2e-49 | 168.68 | In-house | 1-289 (289) | Show / Hide |
Range on Protein: 59-342 Range on HMM: 1-289/289 Sequence Identity: 36% (108 aa) YVLKEEISYSSYEYKCKAYDNKSHQDVQINYYF-FYSQYQLKEILKAIEIQKFLNHENIEKIYN-FNFTSYPEINEMYVVSDFMQTSLNYIIQSEQQLTE |. . |. | | |||. .| | | | | . |. |.| . .|||| .| . . .. ..|.| . | | | | . |.| YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKISPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDL-YKLLKTQHLSN DHIKYFMYQILRALHYIHSAKIVFVQLEPKLIKINSDCSIKISDF----IWCIGNQNQEIETNYVNQYYYMSPEYIVEQMGTEKS-DIWSAGCIFAELIS ||| ||.||||| | ||||| .. | | . .| | .|| || | . | || .| || .. | || |||| ||| ||..| DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS RRKLFTGYEYPQAITQILKFCGKQNEEDLKYYKIINRE--RLLKSMPKEKQISSLQAYFPNANPLALDLLGKMLTFNLDKRFNALECLQHEYL | .| | | . || | ..||. |||. |.|.| ... ... ||.| . |||||.|||||| .|| . | | | || NRPIFPGKHYLDQLNHILGVLGSPSQDDLNC--IINEKARNYLQSLPHKPKV-PWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL |
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| Kinase | 27894.AA | CMGC | 105-342 | 20 | 2.2e-46 | 149.89 | In-house | 72-513 (513) | Show / Hide |
Range on Protein: 105-342
Range on HMM: 72-513/513
Sequence Identity: 20% (89 aa)
IEIQKFLN-----------------HENIEKIYNFNFTSYPE-------------INEMYVVSDFMQTSLNYIIQSEQ---------QLTEDH-------
|.| | || |.|| |.|.. .. .. |..| | ..|...| .|.. | |.| |
IKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHR
-----IKYFM------YQILRALH--YIHSAK--IVFVQLEPKLIKINSDCS--------------------IKISDF---IWCIGNQNQ----------
||||| |||||.|. |.||.. |. | | | ||..| .|| || | ....
RPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFK
---------EIETNYVNQYYYMSPEYIVEQ---------MG-TEKSDIWSAGCIFAELISR--------RKLFT-----------GYEYPQAITQILKFC
. |.|| .| .|| .. |. |.. |.||.||||||.. . . || | . . .| | .
NVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVL
GKQN---------------EEDLKYYKIINRERL-------------LKSM----------PKEKQISSLQAYFPN------------------------
|. . ||. ... . . ... .... ... ||.
GTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKS
-----------ANPLALDLLGKMLTFNLDKRFNALECLQHEYL
..|.|.||| |||... ||| | ..|||.|.
HKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
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| Kinase | 27894.AA | ERK7 | 107-342 | 30 | 2.8e-43 | 145.7 | In-house | 52-292 (292) | Show / Hide |
Range on Protein: 107-342 Range on HMM: 52-292/292 Sequence Identity: 30% (75 aa) IQKFLNHENIEKIYNFNFTSYPEINEMYVVSDFMQTSLNYIIQSEQQLTEDHIKYFMYQILRALHYIHSAKIVFVQLEPKLIKINSDCSIKISDF--IWC .| | .|.|| ...| . .|.| .|| | |. .|. . | . | .| |||.|||. |.||.... | | | ..|.| .|. || LQEFHCHPNIIRLINVIRAD--NDRDIYLVFEFMETDLHAVIRKGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARS IGNQN-----QEIETNYVNQYYYMSPEYIVE-QMGTEKSDIWSAGCIFAELISRRKLFTGYEYPQAITQILKFCGKQNEEDLKYYKIINRERLLKSMPKE |..|. . . |.|| | .|| . . | | || ||| .|.. . .| | | .||. .| .||.. . . .|..|. . IAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMN-Q KQISSLQAYFPNANPLALDLLGKMLTFNLDKRFNALECLQHEYL .. .|.. .|.. . |.||| ..| || .|| | ..||| | QKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV |
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| Kinase | 27894.AA | ERK5 | 59-342 | 31 | 1.4e-42 | 147.75 | In-house | 1-295 (295) | Show / Hide |
Range on Protein: 59-342 Range on HMM: 1-295/295 Sequence Identity: 31% (94 aa) YVLKEEISYSSYEYKCKAYDNKSHQDVQINYY--FFYSQYQLKEILKAIEIQKFLNHENIEKIYNFNFTSYP--EINEMYVVSDFMQTSLNYIIQSEQQL | |.| | | | | | | | | . | .. . | . |.|| | . | |. ..||| | | | || |.| . YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF TEDHIKYFMYQILRALHYIHSAKIVFVQLEPKLIKINSDCSIKISDFIWCIGNQN------QEIETNYVNQYYYMSPEYIVEQMG-TEKSDIWSAGCIFA | .||.||.||||| | |.|||... | | . .| | .|| || | | |.|| .| || .. | |.|| |||| TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG ELISRRKLFTGYEYPQAITQILKFCGKQNEEDLKYYKIINRERLLKSMPK---EKQISSLQAYFPNANPLALDLLGKMLTFNLDKRFNALECLQHEYL |.|.||..| | | . . |.. | . . . ... . | ..| .. .| | . |||||..|| | .| . . ||| .| EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMI---QAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL |
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| S_TKc | 27894.AA | S_TKc | 23-342 | 18 | 1.2e-24 | 89.11 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 23-342
Range on HMM: 1-231/231
Sequence Identity: 18% (63 aa)
ENFDKQLELYKFKNVKQSRNITYQYFKRSKLIIDQRYVLKEEISYSSYEYKCKAYDNKSHQDVQINYYFFYSQYQLKEILKAIEIQKFLNHENIEKIYNF
. ... | |.. |.. .... .|. . |.. |.| | .|.|| |.| .
YEILRKIGKGAFGKVYKCRHKK----------TGRIVAIKIIK---------------------------------EHIRREIQILKK-HHPNIVKLYDV
NFTSYPEINEMYVVSDFMQT---SLNYIIQSEQQ------LTEDHIKYFMYQILRALHYIHSAKIV---------FVQLEPKLIKINSDCSIKISDFIWC
. ...|.| ... . .| .|.. . ..| |....||||..|| |.|| .|. .. |||.|| .
FQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----------HIKICDFGLA
IGNQNQEIETNYVNQYYYMSPEYIVEQMGTEKSDIWSAGCIFAELISRRKLFTGYEYPQAITQILKFCGKQNEEDLKYYKIINRERLLKSMPKEKQISSL
| .. .||.|| . . |..|.|.|| |||..|..... .| . ...| .|
RQL------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------
QAYFPNANPLALDLLGKMLTFNLDKRFNALECLQ-------HEYL
| |.|.. |.|... .|| | |.|| |...
-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 27894.AA | MAPK-Unclassified | 234-342 | 23 | 1.6e-19 | 66.9 | In-house | 427-575 (575) | Show / Hide |
Range on Protein: 234-342 Range on HMM: 427-575/575 Sequence Identity: 23% (35 aa) TEKSDIWSAGCIFAELISR-----------RKLFTGYE--------------------YPQAITQILKFCGKQNEEDLKYYKIINRERLLKSMPKEKQIS . ..||||.||||||.... | ||.| . | |. | .|||. . . ...| . ... DTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDCNFITCDSARKYIQSFKCKTPVH SLQAYFPNAN---------PLALDLLGKMLTFNLDKRFNALECLQHEYL ...|..| ....|.. ||| || ||..| . |.|.| FTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF |
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| Kinase | 27894.AA | MAPK-Unclassified | 59-201 | 37 | 1.8e-18 | 62.99 | In-house | 1-153 (575) | Show / Hide |
Range on Protein: 59-201 Range on HMM: 1-153/575 Sequence Identity: 37% (57 aa) YVLKEEISYSSYEYKCKAYDNKS-HQDVQINYYF--FYSQYQLKEILKAIEIQKFLNHENIEKIYNFNFTSYPEI---NEMYVVSDFMQT---SLNYIIQ | ... | .| |.| |.|. | | | | . | .| | |. |||.|| .| . . .. |.| |.||| | .||. YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK SEQ-QLTEDHIKYFMYQILRALHYIHSAKIVFVQLEPKLIKINSDCSIKISDF | | . . ||.||.||||| | |.||| |. | | . || |||..| || SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDF |
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| Kinase | 27894.AA | Pkinase | 220-342 | 22 | 5.1e-18 | 64.8 | Pfam | 175-293 (293) | Show / Hide |
Range on Protein: 220-342 Range on HMM: 175-293/293 Sequence Identity: 22% (28 aa) YYYMSPEYIV-EQMGTEKSDIWSAGCIFAELISRRKLFTGY-EYPQAITQILKFCGKQNEEDLKYYKIINRERLLKSMPKEKQISSLQAYFPNANPLALD ..||.|| | |. . |.|.||.|||..|....| .| | . ..|. ..| . . . ..... . . . .. .|... ..| PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKD LLGKMLTFNLDKRFNALECLQHEYL .. ..|... || .| ..|||... FIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 27894.AA | Pkinase | 105-179 | 30 | 2.5e-11 | 41.16 | Pfam | 51-130 (293) | Show / Hide |
Range on Protein: 105-179 Range on HMM: 51-130/293 Sequence Identity: 30% (26 aa) IEIQKFLNHENIEKIYNFNFTSYPEINEMYVVSDFMQT-----SLNYIIQ--SEQQL--TEDHIKYFMYQILRALHYIHSAKIV |.| | |||.|| ..| . . ...|.| .... .| .|. .. . .|...| .||||||.| |.|| .|. IQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGII |
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| Kinase | 27894.AA | TyrKc | 67-342 | 14 | 0.000136 | -148.38 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 67-342 Range on HMM: 1-280/280 Sequence Identity: 14% (47 aa) YSSYE----------YKCKAYDNKSHQDV-----QINYYFFYSQYQLKEILKAIEIQKFL--NHENIEKIYNFNFTS---YPEINEMYVVSDFMQTS--L . . ||.... ..| . . ...... ..| . | .|.|| ..| .. . .| ...| .| . ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK NYIIQSEQQLTEDHIKYFMYQILRALHYIHSAKIV---------FVQLEPKLIKINSDCSIKISDFIWCIGNQNQ--------EIETNY---VNQ---YY .|. .. .|. .. .|..|| . |.|| ... | . .||||| . . . . . . DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR YMSPEYIVEQMGTEKSDIWSAGCIFAELISRRKLFTGYEYPQAITQILKFCGKQNEEDLKYYKIINRERLLKSMPKEKQISSLQAYFPNANPLALDLLGK |.|| | . . |.|||.|| | |. .. | . . ..| . . ... . .. ...|. . . .| |. . . .. . WMAPECINYGKFTTKSDVWSFGVCMWEIFTY-----GQQPYPGMIQQ-----MMSNQEV-IEYVKQGYRMPQPPNDY-PMS-----FVCCPDEMYQIMKQ MLTFNLDKRFNALECLQHEYL .. ..| . |. ||.. CWHEDPEDRPTFSEI--HECF |
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