Gene 18670 (Tetrahymena)

18670

Species: Tetrahymena
Alias: TTHERM_00467680, 55.m00225, 18670, PreTt18670, 3710.m00074, 423
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: GCN2

Sequence

Name Sequence Type Origin Length Description Download
18670.AA Protein None 1494 None Fasta, JSON
18670.kin_dom Protein Kinase Domain None 456 None Fasta, JSON
18670.NA RNA None 4485 None Fasta, JSON

Protein domain

Protein domains of 18670.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 18670.AA GCN2 428-882 32 2.5e-212 711.7 In-house 1-508 (511) Show / Hide 
Range on Protein: 428-882
Range on HMM: 1-508/511
Sequence Identity: 32% (174 aa)

FEEVEQIGKGGFGQVYK-VKNRLDSLNYAVKKIKLDINQKELTKK--TLKEVKLLSILQHNHIVRYYQAWLEKPDEKTLQEFENSEEEDELREDSKEEEC
|||....||||||||.| |.|..|. .||.||......|..|..|  ...|||||..|.|.|.|||||||.||.||.......|............|.||
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDEPMVTDTNNDDDTNNNYHSDDESEC

SSENDSAPSKASKESSMCFEFIESSEESSLPFEFENYSDNGIVFEDSD----------------------------------------------------
.|.....|........||..........|......|..|||..|...|                                                    
FSGQYEMPKSVNQSEEMCNKEESMEWSMSNERNNSNWHDNGNFFSEWDNPFDQPFGPKCAFRMGQKRTFDLTDDHYSYCHSDCEFDDDVFDIDWDIESNN

------GDEEQKQKNQNSSTANNKQETHK------------------RKESQIQDIDETDFFTKEDKKKHHKKKKSKDFRLLHIQMEFCGGSTLREMIDN
      .|.|..|..||......|||.|.                  .|.||.||.............|....||.|....|.||||.|.|.|||..|||
VRDMESDDNEWEQEQQNNQSFQPKQEDHQNQYYDQEDLNNAESEDQNKKKSQQQDKMCQNQHKNKVHYKCMNCKKPKEVHYLYIQMEYCEGKTLRQYIDN

HFFCAEKEKRISSKQKKSLLAQILEALKYLHEKELIHRDLKPQNILLDQSGQIKLVDFGLATTLKKERQIERKAVLNLKRASSVQSNFYNASSLPGEIDY
|..|....      .......||||.|.|.|... |||||||.||.||..|..| .||||||..|.|.||.||.......|||.......... . ....
HGWCMDHD------ELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQKQQQQASSHWAIQNEICQDDQFNQQ

KDKKSENSNNYFPSEITRGVGTGVYRAPEQENTSSYCTKADMFSLGILNQAKQYFNNLIFKINKIGVIIFEMWYP-LPTFMEKYQTLKEIREKNQLPQDF
....|...........|..|||..|..|||. .|.|..|.||.|||                   |.|.|||||| ..|.||..|.||..| ....||||
QSQFSQWDQQDEQVHHTGKVGTPFYMCPEQQ-KSHYNQKVDMYSLG-------------------GIIFFEMWYPPFCTQMERVQILKQLR-SCEFPQDF

NLKVGNDAKEIRDILTKLLDPDPSKRYSAEELLKT
..||.|..|...|.....|..||.||.||..||..
DKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQH
Kinase 18670.AA PEK 428-885 25 5.6e-176 590.93 In-house 1-655 (655) Show / Hide 
Range on Protein: 428-885
Range on HMM: 1-655/655
Sequence Identity: 25% (173 aa)

FEEVEQIGKGGF-GQVYKVKNRLDSLNYAVKKIKLDINQ---------------KELTKKTLKEVKLLSILQHNHIVRYYQAWLEKPDEKTLQEFENSEE
|||.. .||||| ||||||.|.||. .||.|.|||...|               |.. .|.|.|||.|..|.| .||||..||.|||.||..|.......
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

EDELREDSKEE--------------------------------------ECSSENDSAPSKASKESSMCFEFIESSEESS--------------------
.|. .......                                      .|.||..|..||...|.||.....| |..||                    
LDSSTDWPNGKHKSKDYNFHPFEKEWDDEEAQESNVMSECEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFSINFGTENENES

-----------------------------------------------------------LPFEFENYSDNGIVFEDSDGDEEQKQKNQNSSTANNKQETH
                                                           .||......||.. .|.||.|.|..|....|.....|...|
HISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDSKNQSH

KR----------------------KESQIQDIDETDFFTKEDKKKHHKKKKSKDFRLLHIQMEFCGGSTLREMIDNHFFCAE------------------
|.                      ..||.|. .|........|.|.....|......|.||||.|...||| .|||.. | .                  
KKCMEMTWIQDQEDNKNNCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNG-C-PVQFNYWRRNSCKNHYNNY

---------------------KEKRISSKQKKSLLAQILEALKYLHEKELIHRDLKPQNILLDQSGQ-----IKLVDFGLATTLKKERQIERKAVLN---
                     . . ....| .....||||.|.|.|.. .|||||||.||.||..||     .|  ||||||......| ..|. .|   
IMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQ-SQKN-YNQQD

-----LKRASSVQSNFYNASSLPGEIDYKDKKSEN-------SNNYFPSEITRGVGTGVYRAPEQENTS-----SYCTKADMFSLGILNQAKQYFNNLIF
     .. ... |....|....|...|.... |.|       .........|.||||  |..|||.. .      |..|.||.||               
QSYWKYVANDNCQWWNTNQQNSPTGQDTHMW-SNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSL---------------

KINKIGVIIFEMWYPLPTFM-EKYQTLKEIR-EKNQLPQDFN-LKVGNDAKEIRDILTKLLDPDPSKRYSAEELLKTLED
     |.|.||||||  | | |...||. .| |..|.|.||.  .. |.... .|.. ..|..||..|.||...|...  
-----GIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase 18670.AA CMGC 428-794 15 7e-45 144.85 In-house 1-322 (513) Show / Hide 
Range on Protein: 428-794
Range on HMM: 1-322/513
Sequence Identity: 15% (75 aa)

FEEVEQIGKGGFGQVYKVKNRLDSLN--------------YAVKKIKLDINQKELTK----------KTLKEVKLLSILQ-----------------HNH
.| ...||.| .|.||| ....   .              .|.||||..   .|  |          ..| |.|.|  |.                 ||.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVRYYQAWLEKPDEKTLQEFENSEEEDELREDSKEEECSSENDSAPSKASKESSMCFEFIESSEESSLPFEFENYSDNGIVFEDSDGDEEQKQKNQNSST
||. |     | ......|. ..                                                                             
IVKLYDIFYHKNSDGNEYEDKHI-----------------------------------------------------------------------------

ANNKQETHKRKESQIQDIDETDFFTKEDKKKHHKKKKSKDFRLLHIQMEFCGGSTLREMIDNHFF-CAE-KEKRISSKQ------------KKSLL----
                 |                     .|. |.. .|.. . .| ..|.|. |   . . .  |  .            .|...    
-----------------I-S-----------------Q-HFNHLYLVFEYM-DHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIR

--AQILEALK--YLHEKE--LIHRDLKPQNILLDQS--------------------GQIKLVDFGLATTLKKERQIERKAVLNLKRASSVQSNFYNASSL
   |||..||  |.| .    |||||||.|||...                     |..|. |||||. . ..   . . . ..  .             
YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQS--F-------------

PGEIDYKDKKSENSNNYFPSE-----------ITRGVGTGVYRAP-----EQENT-----SSYCTKADMFSLG
                                .|  | |  ||||      .. |       |.|. || |.|
--------------------KNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVG
Kinase 18670.AA STE 428-881 16 2.3e-44 153.72 In-house 1-353 (359) Show / Hide 
Range on Protein: 428-881
Range on HMM: 1-353/359
Sequence Identity: 16% (92 aa)

FEEVEQIGKGGFGQVYKVKNRLDS-LN--------------YAVKKIKLDINQK---------------ELTKKTLKEVKLLSILQ--HNHIVRYYQAWL
.| .|.||||.||.||| .|. .. ..              .|.|...|. ...               |  .. |||.|... ..  | .||.|| . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EKPDEKTLQEFENSEEEDELREDSKEEECSSENDSAPSKASKESSMCFEFIESSEESSLPFEFENYSDNGIVFEDSDGDEEQKQKNQNSSTANNKQETHK
 . ..                                                                                               
KEGHN-----------------------------------------------------------------------------------------------

RKESQIQDIDETDFFTKEDKKKHHKKKKSKDFRL---LHIQMEFCGGSTLREMIDNHFFCAEKEK-------RISSKQKKSLLAQILEA-LKYLHEKELI
                                     |.| ||...| .|...|.. . | .  .       |.. .| .  . |||.. |.|||..  |
-------------------------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHII

HRDLKPQNILLDQSGQIKLVDFGLATTLKKERQ-------IERKAVLNLKRASSVQSNFYNASSLPGEIDYKDKKSENSNNYFPSEI--TRG------VG
|||.||.||||     .||.|||... | ..         |                                            .   |..      ||
HRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNII--------------------------------------------DCIETMQQKRNTFVG

TGVYRAPEQENT------SSYCTKADMFSLGILN---------QAKQYFNNLIFKINKIGVII--FEMWYPLPTFME-KYQTLKEIREKNQLPQDFNLKV
|  . |||  .       . | ||.|. |||..           .. .    .| |.. ...   ||.   |   .. .  .|..  ..|....      
TP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQ---L-CIVNGPPPPLPDHLSQNEMIS------

GNDA------------KEIRDILTKLLDPDPSKRYSAEELLK
   .            .| .| . | |. ||.|| .|..|||
---YGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLK
Kinase 18670.AA S_TKc 428-889 16 6.7e-39 136.48 SMART 1-231 (231) Show / Hide 
Range on Protein: 428-889
Range on HMM: 1-231/231
Sequence Identity: 16% (77 aa)

FEEVEQIGKGGFGQVYKVKNRLDSLNYAVKKIKLDINQKELTKKTLKEVKLLSILQHNHIVRYYQAWLEKPDEKTLQEFENSEEEDELREDSKEEECSSE
.| ...||||.||.|||.... .   .|.|.||                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

NDSAPSKASKESSMCFEFIESSEESSLPFEFENYSDNGIVFEDSDGDEEQKQKNQNSSTANNKQETHKRKESQIQDIDETDFFTKEDKKKHHKKKKSKDF
                                                                         .. . | .   |    .|    | .|.
-------------------------------------------------------------------------EHIRREIQILKK----HHPNIVKLYDV

RL---LHIQMEFCGG--STLREMIDNHFF---CAEKEKRISSKQKKSLLAQILEALKYLHEKELIHRDLKPQNILLDQSGQIKLVDFGLATTLKKERQIE
     |.. ||.|.|   .|...|...     .    ....  . .....||..||.|.|..  |||||||.|||||.  .||. |||||. |       
FQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLR----FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------

RKAVLNLKRASSVQSNFYNASSLPGEIDYKDKKSENSNNYFPSEITRGVGTGVYRAPEQENTSSYCT-KADMFSLGI----LNQAKQYFNNLIFKINKIG
                                             |  .||  |.|||     .| . |.|. |.|.    .   .  |   .... |. 
---------------------------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKI

VIIFEMWYPLPTFMEKYQTLKEIREKNQLPQDFNLKVGNDAKEIRDILTKLLDPDPSKRYSAEELLK---TLEDEQYL
.                                        .| .|.. |.|. ||.||..| |.|.        ...
G---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 18670.AA Ciliate-E2 632-796 24 1.8e-29 98.33 In-house 111-285 (365) Show / Hide 
Range on Protein: 632-796
Range on HMM: 111-285/365
Sequence Identity: 24% (52 aa)

IQMEFCGGSTLREMIDNHFFCAEKE----KRISSKQKKSLLAQILE---------------ALKYLHEKE-LIHRDLKPQNILLDQSGQIKLVDFGLATT
. ||.| | .|.. | |.  .  .|    |... |. | . .|||.               ||.|||.|   ||||.||.|||.     ||..||||.. 
LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKK

LKKERQIER-----KAVLNLKRASSVQSNFYNASSLPGEIDYKDKKSENSNNYFPSEITRGV-----------GTGVYRAPEQENTSS---------YCT
.....| ..     |  .. |   |...  .                                          ||  | |||  |  .         | .
YDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD-----------------------------QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDY

KADMFSLGIL
|.|..|||..
KCDIWSLGVI
Kinase 18670.AA PEK 428-530 28 7.3e-28 89.17 In-house 571-702 (758) Show / Hide 
Range on Protein: 428-530
Range on HMM: 571-702/758
Sequence Identity: 28% (38 aa)

FEEVEQIGKGGFGQVYKVKNRLDSLNYAVKKIKLDI-------NQKELTKKTLKEVKLLSILQHNHIVRYYQAWLEKP------------------DEKT
||... .|.|||| |...|| .|  |||.|.| ...       | ..   | . ||. | .| |  ||||. |||| |                      
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLETPELLPPNNKMRSTSFSTVNGKQI

LQEFENSEEEDELRED----SKEEECSSENDS
  . .| . .. . .|      |.| . || .
DSNNDNDIYNNHFFFDGNWGQDEDEDEYENED
Kinase 18670.AA WEE 428-497 42 2.3e-26 85.51 In-house 1-77 (297) Show / Hide 
Range on Protein: 428-497
Range on HMM: 1-77/297
Sequence Identity: 42% (33 aa)

FEEVEQIGKGGFGQVYKVKNRLDSLNYAVKKIKLDINQKELTKKTLKEVKLLSILQ-------HNHIVRYYQAWLEK
|.||..||.| ||.|||...|.|.  ||.||.|  ...    |  |.||. .. |        |.||||||.|| |.
FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWEED
Kinase 18670.AA STE-Unique 620-796 29 4.9e-24 81.88 In-house 359-542 (616) Show / Hide 
Range on Protein: 620-796
Range on HMM: 359-542/616
Sequence Identity: 29% (59 aa)

KKKKSKDFRLLHIQMEFCGGSTLREMIDNHFFCA---------EKEKRISSKQKKSLLAQILEALKYLHEKE--LIHRDLKPQNILLDQSG-----QIKL
.||  |.   ..|.||.| ..||.. |..   ..           | ..     . .. ||||.| ||| .    ||||||| ||...|.|      .|.
RKKPPKEQNWVWIFMEYCEHGTLQQIIKR--CGCPGNPNNLQLFPETEV-----IWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKI

VDFGLATTLKKERQIERKAVLNLKRASSVQSNFYNASSLPGEIDYKDKKSENSNNYFPSEITRGVGTGVYRAPEQENTS-----SYCTKADMFSLGIL
.|||.||..     ..    .|.|   .   |  | ||             | |||..   ....||  | .||  |.      .| ||.|..|||..
CDFGHATCCQ---PDHFEKDNNSKNSNTWI-NINNNSSTNSTAQQTPMWDLNINNYTM---KYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCM
Kinase 18670.AA Pkinase 630-709 36 2.8e-23 83.38 Pfam 75-159 (293) Show / Hide 
Range on Protein: 630-709
Range on HMM: 75-159/293
Sequence Identity: 36% (33 aa)

LHIQMEFCGGS----TLREMIDNHFFCAEKEKRI--SSKQKKSLLAQILEALKYLHEKELIHRDLKPQNILLDQSGQI----KLVDFGLA
... ||.|.|      | ..|       ......  | .. |. . |||..|.|.|..  |||||||.|||.|. |.|    |. |||||
IYMVMEYCEGGLYVMDLFDYIST-----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA
Kinase 18670.AA NEK 428-497 32 1.9e-20 69.01 In-house 1-76 (286) Show / Hide 
Range on Protein: 428-497
Range on HMM: 1-76/286
Sequence Identity: 32% (25 aa)

FEEVEQIGKGGFGQVYKVKNRLDSLN-----YAVKKIKLDINQKELTKKTL-KEVKLLSILQHNHIVRYYQAWLEK
.|....||.| ||.||||. . |.       |. |||...  . . ..... .||..|. |.| .||.|| ...|.
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEE
Kinase 18670.AA PEK-Unclassified 428-496 37 6.7e-20 65.63 In-house 1-74 (835) Show / Hide 
Range on Protein: 428-496
Range on HMM: 1-74/835
Sequence Identity: 37% (28 aa)

FEEVEQIGKGGFGQVYKVKNRLDSLNYAVKKIKLDIN------QKELTKKTLKEVKLLSILQHNHIVRYYQAWLE
| .|  ||.|||. ||.. . .|   ||||.|.. |       ||  .|  ..||  .  . |  |.|||  | |
FNQVQKIGQGGFAIVYQCCHKFDQMEYAVKQIHVNIKDIKEDLQKHYEKE-IMEVRYMAQVNHPNIIRYYHSWIE
Kinase 18670.AA STE-Unique 429-497 30 1.3e-18 62.23 In-house 1-73 (616) Show / Hide 
Range on Protein: 429-497
Range on HMM: 1-73/616
Sequence Identity: 30% (22 aa)

EEVEQIGKGGFGQVYKVKNRLDSLNYAVKKIKLDINQKE----LTKKTLKEVKLLSILQHNHIVRYYQAWLEK
.. . ||.|.|| |.. .|  |. ..|.|.|.|..   .    |... ..|. ... | |  ||.||..||..
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLWG
Kinase 18670.AA WEE 630-718 20 1.2e-17 55.8 In-house 80-188 (297) Show / Hide 
Range on Protein: 630-718
Range on HMM: 80-188/297
Sequence Identity: 20% (23 aa)

LHIQMEFCGGS-TLREMIDNHFFCAEKEKRISSKQKKSLLAQILEALKYLHEK-ELIHRDLKPQNILLDQSG--------------------QIKLVDFG
..||||.| |.  |.  .  .  |. . .... .. . .| .|...|...|..  ..| |.|| ||..   .                     .|. |||
MYIQMEYCNGGSNLLQFWIQQ--CHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFG

LATTLKKERQI
..|...... .
HVTDMNSNNNN
Kinase 18670.AA NEK 630-717 29 1.8e-17 58.45 In-house 81-178 (286) Show / Hide 
Range on Protein: 630-717
Range on HMM: 81-178/286
Sequence Identity: 29% (31 aa)

LHIQMEFCG-GSTLREM---IDNH-----FFCAEKEKRISSKQKKSLLAQILEALKYLHEK-----ELIHRDLKPQNILLDQSGQ----IKLVDFGLATT
|.| ||.|  | .| ..   | ..     .|  |        |    ..|.. ||||.|..       .|||.||||| |. ..     .|. |||..  
LCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEE--------QIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKV

LKKERQ
|.....
LNHTTD
Kinase 18670.AA Pkinase 428-499 28 1.4e-16 59.7 Pfam 1-74 (293) Show / Hide 
Range on Protein: 428-499
Range on HMM: 1-74/293
Sequence Identity: 28% (21 aa)

FEEVEQIGKGGFGQVYKVKNRLDSLNYAVKKIKLDINQKELTKKTLK--EVKLLSILQHNHIVRYYQAWLEKPD
.. ...||.|.||.||| ... ..  .|||.||.. . ..  .  ..  |....  |.| .|||.| .. .|..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDH
Kinase 18670.AA PEK-Unclassified 662-714 40 4.3e-15 48.37 In-house 613-667 (835) Show / Hide 
Range on Protein: 662-714
Range on HMM: 613-667/835
Sequence Identity: 40% (22 aa)

KQKKSLLAQILEALKYLHEKE-LIHRDLKPQNILLDQS-GQIKLVDFGLATTLKK
.|    . ||. ||.. |    ..|||.|| || . |.  |||  ||||.... |
QQCREITRQIIKALYHIHHQCKMVHRDIKPHNIFVCQNPMQIKIGDFGLVKKIEK
Kinase 18670.AA PEK 630-710 28 5.5e-14 41.91 In-house 414-514 (758) Show / Hide 
Range on Protein: 630-710
Range on HMM: 414-514/758
Sequence Identity: 28% (30 aa)

LHIQMEFCGGSTLREMIDNH-FFCAEKEKRISSKQKKSLLAQILEALKYLHEKELIHRDLKPQNILLDQSGQ------------------------IKLV
. |||. | . ||.  . |   .    .  .     ...  ||.|.. |.| | .||||||| || . . .|                        ||. 
MYIQMQLCRKETLKDWMRNRCTMESRPWMHM-----LHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDGGHQIIKIG

DFGLAT
||||.|
DFGLVT
Kinase 18670.AA Ciliate-E2 428-491 21 4e-13 41.38 In-house 1-98 (365) Show / Hide 
Range on Protein: 428-491
Range on HMM: 1-98/365
Sequence Identity: 21% (21 aa)

FEEVEQIGKGGFGQVYKVKNRLD-----------------------SLNYAVKKI-KLDINQKELTKKTLKEVK----------LLSILQHNHIVRYY
.. ...||.|.||.|||.|....                       .  ||.| . | .|.|..  .. ..|..          .|..|.|..|...|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY
Kinase 18670.AA TyrKc 428-883 11 3.6e-11 -42.13 SMART 1-280 (280) Show / Hide 
Range on Protein: 428-883
Range on HMM: 1-280/280
Sequence Identity: 11% (56 aa)

FEEVEQIGKGGFGQVYKVKNRLDSLNYAVKKIKLDINQKELTKKTLKEVKLLSIL--QHNHIVRYYQAWLEK-------PDEKTLQEFENSEEEDELRED
 .  ...| | ||.||| . .   .. |||..| |       .  ..| .... |  .| .||| | . ...       .    . |.      ..   .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

SKEEECSSENDSAPSKASKESSMCFEFIESSEESSLPFEFENYSDNGIVFEDSDGDEEQKQKNQNSSTANNKQETHKRKESQIQDIDETDFFTKEDKKKH
....                                                                                                
HRPK------------------------------------------------------------------------------------------------

HKKKKSKDFRLLHIQMEFCGGSTLREMIDNHFFCAEKEKRISSKQKKSLLAQILEALKYLHEKELIHRDLKPQNILLDQSGQIKLVDFGLATTLKKE---
                                        .. |.. |   || .   |||.| .|||||   |.|..  ...|  ||||.  .. .   
----------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQ

----RQI------ERKAVLNLKRAS--SVQSN-FYNAS-------------SLPGEIDYKD-----KKSENSNNYFPSEITRGVGTGVYRAPEQE----N
      .       .|..| ..  .  . . . |  .|             .. |.  | .     ..        ..|. . | .| .. . ..     
GESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTY-GQQPYPGMIQQMMS--------NQEVIEYVKQGYRMPQPPNDYPMS

TSSYCTKADMFSLGILNQAKQYFNNLIFKINKIGVIIFEMWYPLPTFMEKYQTLKEIREKNQLPQDFNLKVGNDAKEIRDILTKLLDPDPSKRYSAEELL
                                                                  |        .|. .| ..  . ||..| . .|. 
------------------------------------------------------------------F----VCCPDEMYQIMKQCWHEDPEDRPTFSEIH

KTL
. .
ECF
Kinase 18670.AA Pkinase_Tyr 634-709 31 3.7e-08 28.24 Pfam 86-158 (270) Show / Hide 
Range on Protein: 634-709
Range on HMM: 86-158/270
Sequence Identity: 31% (24 aa)

MEFCGGSTLREMIDNHFFCAEKEKRISSKQKKSLLAQILEALKYLHEKELIHRDLKPQNILLDQSGQIKLVDFGLA
||.. .  |..   .|    | ..... |.. .  .|| ... ||..| .|||||   |.|.. ....|  |||||
MEYMPHGDLLDYLRKHR---EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase 18670.AA PEK 814-885 23 9.2e-08 20.7 In-house 691-758 (758) Show / Hide 
Range on Protein: 814-885
Range on HMM: 691-758/758
Sequence Identity: 23% (17 aa)

GVIIFEMWYP-LPTFMEKYQTLKEIREKNQLPQDFNLKVGNDAKEIRDILTKLLDPDPSKRYSAEELLKTLED
| | ||. .|   | ||.  |.. .| . |.| .|  |.     . .. .  .....|. | .| .... . .
GLIFFELIHPGFSTQMERIRTMCDLR-NGQWPKWFTQKYP----QEYEFIQQMMSMNPDERPTADQISMHDFF
Kinase 18670.AA PEK-Unclassified 813-883 32 8e-07 18.64 In-house 770-835 (835) Show / Hide 
Range on Protein: 813-883
Range on HMM: 770-835/835
Sequence Identity: 32% (23 aa)

IGVIIFEMWYPLPTFMEKYQTLKEIREKNQLPQDFNLKVGNDAKEIRDILTKLLDPDPSKRYSAEELLKTL
.|.|.|.|  .. | ||. .|.  .. |  ||. |  |    |  |.| |      || ||     . .||
VGIIFFQMFHQMNTTMERVKTIQNCK-KGELPKHFCAKFPRLAEIIKDSLSN----DPQKRPLLSKIEQTL
Kinase 18670.AA STE-Unique 813-885 19 2e-06 17.97 In-house 539-616 (616) Show / Hide 
Range on Protein: 813-885
Range on HMM: 539-616/616
Sequence Identity: 19% (15 aa)

IGVIIFEMWYPLPTFMEKYQTLK--EIREKNQLPQD---FNLKVGNDAKEIRDILTKLLDPDPSKRYSAEELLKTLED
.| ..|.|   .|.... |  .   |.. ..  ..      .     ..| .... |.|...|..| ||..||. .  
LGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase 18670.AA Pkinase 821-883 20 5e-06 22.47 Pfam 242-293 (293) Show / Hide 
Range on Protein: 821-883
Range on HMM: 242-293/293
Sequence Identity: 20% (13 aa)

WYPLPTFMEKYQTLKEIREKNQLPQDFNLKVGNDAKEIRDILTKLLDPDPSKRYSAEELLKT--L
|.. ..|.  ..   .        . . ..  |  .| .|.....|..||.||..||..|.   .
WCSISYFF-FRH-W-H--------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 18670.AA Ciliate-E2 813-881 19 8e-06 15.88 In-house 282-361 (365) Show / Hide 
Range on Protein: 813-881
Range on HMM: 282-361/365
Sequence Identity: 19% (17 aa)

IGVIIFEMWYPLPTFMEKYQTLKEIREKNQLPQDFNL-------------KVGNDAKEIRDILTK----LLDPDPSKRYS-AEELLK
.|||..|| .  | |        .. .....  ...              .  .  .|  |.. |    .|. ||.||.. .|..|.
LGVILYEMLFGKPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 18670.AA NEK 856-882 22 4e-05 14.43 In-house 257-283 (286) Show / Hide 
Range on Protein: 856-882
Range on HMM: 257-283/286
Sequence Identity: 22% (6 aa)

KEIRDILTKLLDPDPSKRYSAEELLKT
.. .......| .||..|.|....|..
QDLQNLISQMLQKDPEQRPSCNQILEM
Kinase 18670.AA CMGC 830-881 20 0.000216 9.32 In-house 436-509 (513) Show / Hide 
Range on Protein: 830-881
Range on HMM: 436-509/513
Sequence Identity: 20% (15 aa)

KYQTLKEIREKNQLPQDFN------------LKVGN-----------DAKEIRDILTKLLDPDPSKRYSAEELLK
.....|..  ... ..| |             |...           . .. .| | |.|  ||.|| .||. |.
PPKPWKNLFPWHPNWDD-NNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQ
Kinase 18670.AA Pkinase_Tyr 428-491 26 0.000544 14.14 Pfam 1-70 (270) Show / Hide 
Range on Protein: 428-491
Range on HMM: 1-70/270
Sequence Identity: 26% (19 aa)

FEEVEQIGKGGFGQVYKVKNR----LDSLNYAVKKIKLDINQKEL--TKKTLKEVKLLSIL-QHNHIVRYY
 .  ...|.| ||.||| . .     . .  |||..  .   .|    .. ..|.|... | .| .|||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase 18670.AA PEK 765-795 29 0.000615 7.68 In-house 646-692 (758) Show / Hide 
Range on Protein: 765-795
Range on HMM: 646-692/758
Sequence Identity: 29% (14 aa)

TRGVGTGVYRAPEQ-ENT---------S------SYCTKADMFSLGI
| .|||  |..|||  ..         .      .|  | | .|||.
TVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGL
Kinase 18670.AA PEK-Unclassified 763-795 31 0.003287 5.66 In-house 729-772 (835) Show / Hide 
Range on Protein: 763-795
Range on HMM: 729-772/835
Sequence Identity: 31% (14 aa)

EITRGVGTGVYRAPEQE-----------NTSSYCTKADMFSLGI
|||  .|| .|  .|||               |  ..|..|.||
EITSTCGTYTYSSNEQESQKKVRIKAHFQADFYNHRTDIYSVGI
Kinase 18670.AA WEE 856-885 23 0.006007 5.81 In-house 268-297 (297) Show / Hide 
Range on Protein: 856-885
Range on HMM: 268-297/297
Sequence Identity: 23% (7 aa)

KEIRDILTKLLDPDPSKRYSAEELLKTLED
.| ....   ..|||..| ....||.. . 
QELKQLIKWMMHPDPEQRPTCQQLLQHPVL
Kinase 18670.AA Pkinase 768-796 40 0.031913 8.94 Pfam 172-201 (293) Show / Hide 
Range on Protein: 768-796
Range on HMM: 172-201/293
Sequence Identity: 40% (12 aa)

VGTGVYRAPEQEN-TSSYCTKADMFSLGIL
.||  |.|||  .  . | .|.||.|.|..
CGTPWYMAPEVIRGGQYYGPKVDMWSCGCI