Gene Ccrk (Sea Urchin)

Ccrk

Species: Sea Urchin
Alias: Spk136, Ccrk, SPU_004789
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CCRK

Sequence

Name Sequence Type Origin Length Description Download
Ccrk.AA Protein None 338 None Fasta, JSON
Ccrk.kin_dom Protein Kinase Domain None 285 None Fasta, JSON

Protein domain

Protein domains of Ccrk.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Ccrk.AA CCRK 4-288 86 3.5e-246 824.13 In-house 1-285 (285) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-285/285
Sequence Identity: 86% (247 aa)

YSILDRIGEGAHGIVFKAKHIETGEIVALKKVPLRKLDDGIPNTALREIKALQEIEENQYVVKLKDVFPHGTGFVLVFEFMLSDLSEVIRNSDQPLTEAQ
|.||||||||||||||||||.|||||||||||.||.|||||||.||||||||||||.|||||.||||||||||||||||||||||.||.|....||.|||
YCILDRIGEGAHGIVFKAKHVETGEIVALKKVALRRLDDGIPNQALREIKALQEIEDNQYVVQLKDVFPHGTGFVLVFEFMLSDLAEVVRHAQRPLAEAQ

VKSYMLMLLKGITHCHENSIMHRDLKPANLLISETGHLKIADFGLARVFSNDEGRQYSHQVATRWYRAPELLYGARKYDEGADLWAVGCIFGELLNNSPI
|||||.|||||..|||||.|||||||||||||||.||||||||||||||||||||||.||||||||||||||||||.||.|.||||||||.|||||||||
VKSYMQMLLKGVAHCHENNIMHRDLKPANLLISESGHLKIADFGLARVFSNDEGRQYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNNSPI

FPGENDIEQLCCVLRILGTPTEKTWPGMKDLPDYNKITFPENPPIPLEQIVPDASPEALDLLKKFLVYPSRQRISASEALLHPYF
|||||||||||||||||||||.|.||.||||||||||.|.|.||.||||.||||||.||||||.|||||.||||.||.||||.||
FPGENDIEQLCCVLRILGTPTPKVWPEMKDLPDYNKISFKEQPPMPLEQVVPDASPQALDLLKQFLVYPPRQRIAASQALLHQYF
Kinase Ccrk.AA CDK 4-288 40 1.6e-158 510.95 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-284/284
Sequence Identity: 40% (130 aa)

YSILDRIGEGAHGIVFKAKHIETG-----EIVALKKVPLRK-----LDDGIPNTALREIKALQEIEENQYVVKLKDVFPHG-----------TGFVLVFE
| .|..||||..|.|.||.. .||     .||||||. . .      ..|.| ||.|||. |.|.  ....|||.||...            . ...|||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

FMLSDLSEVIRNSDQPLTEAQVKSYMLMLLKGITHCHENSIMHRDLKPANLLISETGH-----LKIADFGLARVFSN--D---EGRQYSHQVATRWYRAP
.|  ||.....          .|.||..||.|. .||.| ||||||||.|.||...|.     |||||||||| |..  .   . | |.|.| |.|||||
YMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAP

ELLYGARKYD--EGADLWAVGCIFGELLN---NSPIFPGENDIEQLCCVLRILGTPTEKTWPGMKDLPDYNKITFPENPPIPLEQIVPDASPEALDLLKK
||| |...|.   . |.|.|||||.|...   . |.|||...|.||... ||.|||||..|||...||||                         ||| |
ELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNK

FLVYPSRQRISASEALLHPYF
.|.|   .||||..|| ||||
MLCYDPKKRISAEQALQHPYF
Kinase Ccrk.AA CDK7 4-288 47 1.1e-152 410.18 In-house 1-288 (288) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-288/288
Sequence Identity: 47% (139 aa)

YSILDRIGEGAHGIVFKAKHIETGEIVALKKVP----LRKLDDGIPNTALREIKALQEIE-ENQYVVKLKDVFPHGTGFVLVFEFMLSDLSEVIRNSDQP
| ... ||||  . |.||   .||.||| ||.         .|||  ||.|||| |||.. .|  |. | |.| | .   |||.||  || .||. .   
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDN--VIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSII

LTEAQVKSYMLMLLKGITHCHENSIMHRDLKPANLLISETGHLKIADFGLARVFSNDEGRQYSHQVATRWYRAPELLYGARKYDEGADLWAVGCIFGELL
|| | .|.||.|.|.|. .|| | | |||||| |||..| | |||||||||| .     | |.||| ||||||||||.||| |  | |.|.||||| ||.
LTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPN-RIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELM

NNSPIFPGENDIEQLCCVLRILGTPTEKTWPGMKDLPDYNKIT-FPENPPIPLEQIVPDASPEALDLLKKFLVYPSRQRISASEALLHPYF
   |..||..|| ||  . ..||||||..||.|  ..||.|.. ||.   .||..|   || ..|||... .     .|......| .|||
LRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase Ccrk.AA CMGC 4-288 27 2.2e-139 461.15 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-513/513
Sequence Identity: 27% (139 aa)

YSILDRIGEGAHGIVFKAKH--------------IETGEIVALKKVPLRK---------LDDGIPNTALREIKALQEIE---------------ENQY-V
| |...||||. |.|.|...              .||.||||.||. ...         . ||.| .|||||| |...                ..   .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VKLKDVFPHGT-----------------GFVLVFEFMLSDLSEVIRNSD--------QPLTEAQ------------VKSYM------LMLLKGIT--HCH
|||.|.| |                    . ||||.|  || ..|.|          .||.| .            .|..|       ..|.|.   .||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

ENS--IMHRDLKPANLLISET--------------------GHLKIADFGLARVFSND--------------------EGRQYSHQVATRWYRAPELLYG
 .   |.||||||.|.||...                    |.|||.|||||| ...                     ..|.|.|.|.||||||||.| |
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

A---------RKYDEGADLWAVGCIFGELLNN--------SPIFPGEND-----------IEQLCCVLRILGTPT---------------EKTWPGMKDL
.         ..|... | |.|||||.|....         |.|||...           |.|| .  ..|||||               |..||.|..|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PDYNK-------------IT------------FPENPPIPLEQIVPD-----------------------------------ASPEALDLLKKFLVYPSR
|.|||             ..            ||. ||.|.....|.                                   ..|.|.||||| |.|   
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

QRISASEALLHPYF
.||.|..|| ||||
KRITAEQALQHPYF
Kinase Ccrk.AA CDC2 4-288 44 7.6e-132 407.7 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-301/301
Sequence Identity: 44% (136 aa)

YSILDRIGEGAHGIVFKAKHIETGEIVALKKVPLRKLDDG--IPNTALREIKALQEIEENQYVVKLKDVFPHGTGFVLVFEFMLSDLSEVIR---NSDQP
|  . .||||  |.|.|.|. .|..||||||. |   |.|  .| ||.|||  |.|. . . .|||.||.       .|||..  || .  .    ....
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LTEAQVKSYMLMLLKGITHCHENSIMHRDLKPANLLISETGHLKIADFGLARVFSNDEGRQYS--HQVATRWYRAPELLYGARKYDEGADLWAVGCIFGE
.... |||||  .|.|. .|| . |||||||| |.||...| .||||||||| |.    |.|   | | |.||||||.| |...|. . |.|..|||| |
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPI-RTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAE

L---LNNSPIFPGENDIEQLCCVLRILGTPTEKTWPGMKDLPDYNKITFPENPPIPLEQIVPD---------ASPEALDLLKKFLVYPSRQRISASEALL
.    .. |.|.|.  |.||. . ||||||.|.||||...|||| | |||. .|. |..|.|.         . ||..|||.. |.|   .|||| ||| 
MFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDY-KNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQ

HPYF
||||
HPYF
Kinase Ccrk.AA CDK5 4-288 44 2.4e-116 369.24 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-287/287
Sequence Identity: 44% (131 aa)

YSILDRIGEGAHGIVFKAKHIETGEIVALKKVPLRKLDDGIPNTALREIKALQEIEENQYVVKLKDVFPHGTGFVLVFEFMLSDLSEVIRNSDQPLTEAQ
|. ...||||  |.|.||.  ||.||||||.| |   | |.| ||.|||  |.|.   . .| | ||       .|||||.  ||   . .    .  . 
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKH-KNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHI

VKSYMLMLLKGITHCHENSIMHRDLKPANLLISETGHLKIADFGLARVFSNDEG---RQYSHQVATRWYRAPELLYGARKYDEGADLWAVGCIFGELL-N
.||.|. ||||.  |||. ..|||||| ||||.  |.|| ||||||| |    |   | ||| | | |||.|  | |...|    |.| .|||| |.  .
IKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAF----GIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANA

NSPIFPGENDIEQLCCVLRILGTPTEKTWPGMKDLPDYN--KITFPENPPIP-LEQIVPDASPEALDLLKKFLVYPSRQRISASEALLHPYF
  | ||| .. .||  . .|.|||.| .||.. .||||.     .|  |. . ..||||  . . .|||.| |..   ||||| .|| ||||
GRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase Ccrk.AA PITSLRE 4-288 41 7e-100 338.14 In-house 1-295 (295) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-295/295
Sequence Identity: 41% (123 aa)

YSILDRIGEGAHGIVFKAKHIETGEIVALKKVPLR--KLDDGIPNTALREIK-ALQEIE-ENQYVVKLKDVF--PHGTGFVLVFEFMLSDLSEVIRNSD-
. .|.||.||. |.|..||  .|.||||||.. .   |  .|.| |.||||.  | ..  .|  .|..| .     ..   .|.|..  ||  .. |   
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPN--IVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKR

--QPLTEAQVKSYMLMLLKGITHCHENSIMHRDLKPANLLISETGHLKIADFGLARVFSNDEGRQYSHQVATRWYRAPELLYGARKYDEGADLWAVGCIF
  || .. ..|. |. ||.|. | | | ||||||| .|||.|  | |||.|||||| .     . |.  | | |||||||| |..||    |.| |||||
RNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSP-IKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIF

GELLNNSPIFPGENDIEQLCCVLRILGTPTEKTWPGMKDLPDYNKIT-FPENPPIPLEQIVP---DASPEALDLLKKFLVYPSRQRISASEALLHPYF
.|..   |.|.|...|.|. |.   .|||||| ||| ..||  .... ||. |.  | ...|     |  ..||| ..| |   .||.||.|| ||.|
AEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase Ccrk.AA RCK 4-288 36 2.6e-98 312.57 In-house 1-298 (298) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-298/298
Sequence Identity: 36% (111 aa)

YSILDRIGEGAHGIVFKAKHIETGEIVALKKVPLRKLDDGIPNTALREIKALQEIEENQYVVKLKDVFPHGT--GFVLVFEFMLSDLSEVIRN---SDQP
| |....|.|. | |.||. .||||||| ||   .|. .    . |||||.|  .  .  ..|||.|. . .     .|||.|  .|.. ...   ....
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK-QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKY

LTEAQ--VKSYMLMLLKGITHCHENSIMHRDLKPANLLISE---------TGHLKIADFGLARVFSNDEGRQ-YSHQVATRWYRAPELLYGARKYDEGAD
|.| |  .|..|  .|.|. |.|.. ..|||||| |.....         ..|.|||||||.| . .   .. |   | ||||||||.|  . .|..  |
LPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRS---KPPYTDYVSTRWYRAPECLLRCTYYNSPMD

LWAVGCIFGELLNNSPIFPGENDIEQLCCVLRILGTPTEKTWPGMKDLPDYNKITFPENPPIPLEQIVPDASPEALDLLKKFLVYPSRQRISASEALLHP
.||||||. ||    | ||| . | |.   . ..|||. |.||  . |     ..||  ...||.|..|..|.....|..| | .    ||.|..|| ||
IWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHP

YF
||
YF
Kinase Ccrk.AA S_TKc 4-288 29 1e-94 321.89 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-231/231
Sequence Identity: 29% (89 aa)

YSILDRIGEGAHGIVFKAKHIETGEIVALKKVPLRKLDDGIPNTALREIKALQEIEENQYVVKLKDVFPHGTGFVLVFEFMLS---DLSEVIRNSDQP--
| ||. ||.|| | |.|..|..||.|||.|...         ....|||. |..     ..|||.||| . . . .|.|..     || ..|..   .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LTEAQVKSYMLMLLKGITHCHENSIMHRDLKPANLLISETGHLKIADFGLARVFSNDEGRQYSHQVATRWYRAPELLYGARKYDE-GADLWAVGCIF
   ..| ....||  ..... .||.. |.||||||.|.|..|  |.||.||||||..        .... |.||.|||.|    .|.   .| |..|||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL

GELLNNSPIFPGENDIEQLCCVLRILGTPTEKTWPGMKDLPDYNKITFPENPPIPLEQIVPDASPEALDLLKKFLVYPSRQRISASEALL-------HPY
 |.|   | ||   .....  ...                                       ||||.|...| |..  ..|..| |||        ||.
YEMLCGYPPFP---QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

F
|
F
Kinase Ccrk.AA CDK-Unclassified 4-288 32 8.6e-94 308.93 In-house 1-324 (324) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-324/324
Sequence Identity: 32% (104 aa)

YSILDRIGEGAHGIVFKAKHIETGEIVALKKVPLRKLDD----------GIPNTALREIKALQEIEENQYVVKLKDVFPHGTGFV-------------LV
| ..  .|||..|.|.|| . .|  .|| ||. .    .           .. |..|||. ||  ..  .. |. |...  ..               .|
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNH-MNIIKFMDMHYDHDRCSKNPYYDNLHPSFYMV

FEFMLSDLSEVIRNSDQPLTEAQVKSYMLMLLKGITHCHENSIMHRDLKPANLLISETG-----HLKIADFGLARVFSN-----------DEGRQYSHQV
 | |  ... .  |   .|   |.. .|. .|.||   |.| |||||.||.|..|. ..      |||||||.|.   |           |...||| ||
MEYMPYTWYNQLHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYSTQV

ATRWYRAPELLYGARKYDEGADLWAVGCIFGELLNNSPIFPGENDIEQLCCVLRILGTPTEKTWPGMKDLPDYNKITFPENPPIP-LEQIVPDASPEALD
.|||||||||| | ..|| | | |..|||. |..   |||.| ..|||.  . ..||||.|  || . ..|||.||.|.  ...   . .    .   ..
STRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDMWPDWRYMPDYCKIFFKYKQKFHWWNRFPKCKHASENN

LLKKFLVYPSRQRISASEALLHPYF
..   ..|    | ...|.| ||.|
CEFQMVMYQPYNRWKCMEILQHPWF
Kinase Ccrk.AA Pkinase 4-288 31 2.3e-91 314.66 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-293/293
Sequence Identity: 31% (95 aa)

YSILDRIGEGAHGIVFKAKHIETGEIVALKKVPLRKLDDGIPNTALR--EIKALQEIEENQYVVKLKDVFPHGTGFVLVFEFMLS-----DLSEVIR-NS
| |. .||.|. | |.|..|. ||.|||.|....|. ... . |..|  ||. ....    ..|.|.|.|  ..   .|.|..       ||...|.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

DQPL--TEAQVKSYMLMLLKGITHCHENSIMHRDLKPANLLISETGHL----KIADFGLARVFSNDEGRQYSHQVATRWYRAPELLYGARKYDEGADLWA
. ..  .| ..|.||. .|.|. .||...|.||||||.|.||...||.    ||.|||||..|..  .. ... . |.||.|||.. |...|.  .| |.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

VGCIFGELLNNSPIFPGE----NDIEQLCCVLRILGTPTEKTWPGMKDLPDYNKITFPENPPIPLEQIVPDASPEALDLLKKFLVYPSRQRISASEALLH
.|||. |.|.  |.|||.    | ..|. .. ||.|.|..  ||   . .... ... . . . ..   . .|.|..|..|. | .   .|..| ..| |
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQH

PYF
|.|
PWF
Kinase Ccrk.AA MAPK 4-288 33 6.9e-88 298.28 In-house 1-328 (328) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-328/328
Sequence Identity: 33% (111 aa)

YSILDRIGEGAHGIVFKAKHIE------TGEIVALKKVP--LRKLDDGIPNTALREIKALQEI--EENQYVVKLKDVFPH------GT-----GFVLVFE
| || .||.|| |.|..|.. .      .|..||.||..   ... .     ..|||| |...   ||  ..||.|.|        ..      . .|.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCK--RTYREIKLLRHFHHHEN--IIKLLDIFTPEMQDDQNSLEEFNDIYIVME

FMLSDLSEVIRNSDQPLTEAQVKSYMLMLLKG--ITHCHENSIMHRDLKPANLLISETGHLKIADFGLARVFSNDEGRQY-------------SHQVATR
.| .||  .|.  . ||..  ... |  .|.|  . . |   . ||||||.|.|. | . |||.||||||.. ...   .             .  ||||
LMETDLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATR

WYRAPELLYG--ARKYDEGADLWAVGCIFGELLN-NSPIFPGENDIEQLCCVLRILGTPTEKTWPGMK--DLP-DYNKIT--FPENPPIPLEQIVPD---
||||||.. .  ...|... | |.|||||.|.|. . |.|||.. |.|. ... .||||.|  .  ..  . . .| .    .|  |..|.|.. |.   
WYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANF

-ASPEALDLLKKFLVYPSRQRISASEALLHPYF
 |.|.|.|||.| ||    .||.. ||| ||||
NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase Ccrk.AA TyrKc 4-288 19 1e-12 -17.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-280/280
Sequence Identity: 19% (62 aa)

YSILDRIGEGAHGIVFKAKHIETGEIVALKKVPLRKLDDGIPNTALREIKALQEI-EENQYVVKLKDVFPHG-------TGFVLVFEFMLS-DLSEVIRN
 . .. .|||| |.|.|.. .   . || |..   .         .||.. . ..  ... .|.|  |  ..           .|.|.|   || . .|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

SDQPLTEAQVKSYMLMLLKGITHCHENSIMHRDLKPANLLISETGHLKIADFGLARVFSND-----EGRQYS------HQ--VATRWYRAPELLYGARKY
.   |. ..  |...   .|  . |.. . ||||   | |..| .. ||.||||.|   .|     ..  |.          .  ||. ||| .   .|.
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKF

DEGADLWAVGCI------FGELLNNSPIF--PGENDIEQLCCVLRILGTPTEKTWPGMKDLPDYNKITFPENPPIPLEQIVPDASPEALDLLKKFLVYPS
 .  | |. |        .|.     .|.      .. ..    . .  | .   | |                       . ...|  .. |.   .  
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS--------------------F-VCCPDEMYQIMKQCWHEDP

RQRISASEALLHPYF
 .| . ||   | .|
EDRPTFSEI--HECF
Kinase Ccrk.AA Pkinase_Tyr 4-175 25 1.7e-10 36.15 Pfam 1-186 (270) Show / Hide 
Range on Protein: 4-175
Range on HMM: 1-186/270
Sequence Identity: 25% (50 aa)

YSILDRIGEGAHGIVFKAKHI----ETGEIVALKKVPLRKLDDGIPNTA------LREIKALQEIEENQYVVKLKDVFP-HGTG--FVLVFEFMLS-DLS
 ...  .|||| | |.|..      .|.  || |...     .|    .      .||.| . ..  .. .|.|  |   .|      .|.|.|   || 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

EVIRNS---DQPLTEAQVKSYMLMLLKGITHCHENSIMHRDLKPANLLISETGHLKIADFGLARVFSNDEGRQ-YSHQ---VATRWYRAPELL
.  |.    .||||  .  .. .   ||  . ... . ||||   | |..|... ||.||||||    ...   ....   .  .|. ||| .
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWM-APECI