CLK

Species: Sea Urchin
Alias: SPU_004639, Spk138, CLK
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: CLK

Sequence

Name Sequence Type Origin Length Description Download
CLK.AA Protein None 511 None Fasta, JSON
CLK.kin_dom Protein Kinase Domain None 317 None Fasta, JSON

Protein domain

Protein domains of CLK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CLK.AA CLK 179-495 62 4.8e-256 777.49 In-house 1-350 (350) Show / Hide
Range on Protein: 179-495
Range on HMM: 1-350/350
Sequence Identity: 62% (217 aa)

YAITSTLGEGTFGKVVQCRDNMSGGAKIALKIIKNIEKYREAAKLEIN-VLEKINEK-EGVGKSL--CVKMYDWFDY-HGHVCISFEILGLSIFDFLKDN
| |..|||||||||||.|.|...|....|||||.|.|||||||..||| ...||||| .  .|..  |.||.||||| |||.||.||..||||.||.|.|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

N------YQPYPLDQIKRMSHQLCSAVKFLHDMKITHTDLKPENILFVDS-----RSSIKYDPVKK---------RDVRQVVNCDIRLIDFGSAT---FD
|      |.|||.|.|..|..|||.|||||||||.||||||||||.||||     . ..||...||         .....|.|..|..|||||||   ||
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRFTHFDCTFKYNHKKKINKKSNNCVCHYWHVKNTHICVIDFGSATKIRFD

HEHHSTIVSTRHYRALEVILELGWSQPCDVWSIGCIIFELYTGFTLFQTHDNREHLAMAERILG-NFPSWMIKRTR----KSKYFYHDRVDWNQDNSSGR
||||||||||||||| ||||.|||||||||||||||.||||||||||||||||||||| |||.| ..|.|||.|||    |.|||||.|.||...||.||
HEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNRLDWDWHNSDGR

YVCENCHPFRYYLDSNADEHRLLFDTIEEMLEFDPFKRATLSQVLDHPYF
||.|||.|...|.|....||| |||.|..|||.||.|| |....|.||.|
YVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF

Kinase CLK.AA CMGC 179-495 18 1.6e-102 337.79 In-house 1-513 (513) Show / Hide
Range on Protein: 179-495
Range on HMM: 1-513/513
Sequence Identity: 18% (101 aa)

YAITSTLGEGTFGKVVQCRD-------------NMSGGAKIALKIIKNIEKYREAAK-------------LEINVLEKIN-----------EKEGVGKSL
| | . .||||.|.|..|||             .. .. ..|.|.||| . | | ||              ||  |...|           . ..  .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

CVKMYDWFDYHG-----------------HVCISFEILGLSIFDFLKDNN--YQP------------------------YPLDQIKRMSHQLCSAVK--F
.||.||.| ...                 |... || .. . ....|.|.  ||.                        ... .|. ...|.. ..|  .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

LHDMK--ITHTDLKPENILFVDS----------------RSSIKYDPVKKRDVRQVVNCDIRLIDFGSATFDHEH------------------------H
.| ..  | |.||||||||. .                 .               ..|  ....|||.|.. |.|                        .
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPC---------------QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPY

STIVSTRHYRALEVILELG----------WSQPCDVWSIGCIIFELYTG--------FTLFQTHDN-----------REHLAMAERILGNFPSWMIKRTR
.. |.||.||| |..|  .          ...|.|.||.|||..|.|||         .||..|..            ..|..  ..||... |||....
THYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGK

--------KSKYFYHDRVDWNQDNSSGR----------------------YVCENCHPFRYYLDSNAD--------------------------------
        . .....   .|.. . ...                      .   ...|..     . .                                
RHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKC

EHRLLFDTIEEMLEFDPFKRATLSQVLDHPYF
.. ...| .. ||..|| || | .| |.||||
CDPQAIDLLKKMLQYDPDKRITAEQALQHPYF

Kinase CLK.AA S_TKc 179-495 24 2.7e-71 244.1 SMART 1-231 (231) Show / Hide
Range on Protein: 179-495
Range on HMM: 1-231/231
Sequence Identity: 24% (82 aa)

YAITSTLGEGTFGKVVQCRDNMSGGAKIALKIIKNIEKYREAAKLEINVLEKINEKEGVGKSLCVKMYDWFDYHGHVCISFEILGL---SIFDFLKDNNY
| |  ..|.|.|||| .||..   | . |.||||      | .. ||..|.|       .    ||.||.|.  .|... .| ..    . ||..|....
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

QP----YPLDQIKRMSHQLCSAVKFLHDMKITHTDLKPENILFVDSRSSIKYDPVKKRDVRQVVNCDIRLIDFGSATFDHEHHSTIVSTRHYRALEVILE
..    .|  ..... .|.|.|....|...| | ||||||||. .                      | ..|||.|..     .|.. |..|.| ||.  
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------------------HIKICDFGLARQL----TTFCGTPWYMAPEVL--

LGWSQ-PCDVWSIGCIIFELYTGFTLFQTHDNREHLAMAERILGNFPSWMIKRTRKSKYFYHDRVDWNQDNSSGRYVCENCHPFRYYLDSNADEHRLLFD
 |..  .||.||.|||..|...| ..|.     .. .| ..|.                                                    . . |
-GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG---------------------------------------------------SPEAKD

TIEEMLEFDPFKRATLSQVLD-------HPYF
 |. .|..|| || |  ..|        ||.|
FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase CLK.AA Pkinase 179-495 24 2.2e-61 215.02 Pfam 1-293 (293) Show / Hide
Range on Protein: 179-495
Range on HMM: 1-293/293
Sequence Identity: 24% (83 aa)

YAITSTLGEGTFGKVVQCRDNMSGGAKIALKIIKNIEKYREAAKL-----EINVLEKINEKEGVGKSLCVKMYDWFDYHGHVCISFEILGL-----SIFD
| | ...|.|.||.| .|..  .|  . |.||||  ..  .  .      || .. ..|      .   |..|||| ...|... .| ..      . ||
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-----HPNI-VRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

FLKDNNYQPY--PLDQIKRMSHQLCSAVKFLHDMKITHTDLKPENILFVDSRSSIKYDPVKKRDVRQVVNCDIRLIDFGSA----TFDHEHHSTIVSTRH
...  .. ..  . ...|..  |........|.|.| | ||||||||.. ..  |.               .....|||.|    .   .  .|.. |..
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDA--------------CVKICDFGLAKQFDY-NNS-MTTFCGTPW

YRALEVIL-ELGWSQPCDVWSIGCIIFELYTGFTLFQTH----DNREHLAMAERILGNFPSWMIKRTRKSKYFYHDRVDWNQDNSSGRYVCENCHPFRYY
|.| |||.   ......|.||.|||..|...| ..|. |    . .....| .||.|  ... .  ..   ||. .|  |                 .  
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---------------F-H

LDSNADEHRLLFDTIEEMLEFDPFKRATLSQVLDHPYF
       .. . | |. .|..|| || |  |.| ||.|
WTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase CLK.AA DYRK 179-322 38 1.1e-49 171.33 In-house 1-147 (320) Show / Hide
Range on Protein: 179-322
Range on HMM: 1-147/320
Sequence Identity: 38% (57 aa)

YAITSTLGEGTFGKVVQCRDNMSGGAKIALKIIKNIEKYREAAKLEINVLEKINEKEGVGKSLCVKMYDWFDYHGHVCISFEILGLSIFDFLKDNNYQPY
| | . .| |.||.||.|.|.  .. ..|.|||.| ...   |. ||. ||..|..    |. ||.||| | ...|.|| || |  . ..||| |. |..
YEILEYIGKGSFGQVVKCWDH-KTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF

-PLDQIKRMSHQLCSAVKFLHDM-KITHTDLKPENILFVD--SRSSIK
 .|  .... .|.. . ||||   .| | |||||||. ..  ..| ||
FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIK

Kinase CLK.AA DYRK1 179-432 30 1.1e-42 147.55 In-house 1-238 (321) Show / Hide
Range on Protein: 179-432
Range on HMM: 1-238/321
Sequence Identity: 30% (77 aa)

YAITSTLGEGTFGKVVQCRDNMSGGAKIALKIIKNIEKYREAAKLEINVLEKINEKEGVGKSLCVKMYDWFDYHGHVCISFEILGLSIFDFLKDNNYQPY
| | | .| | ||.||.  |..     .|.|||||   . . |..|| .|| .|...   |   |..   | .  |.|. ||.|   ..| |.  ...  
YEIDSLIGKGSFGQVVKAYDHQE-QEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGV

PLDQIKRMSHQLCSAVKFLH--DMKITHTDLKPENILFVDSRSSIKYDPVKKRDVRQVVNCDIRLIDFGSATFDHEHHSTIVSTRHYRALEVILELGWSQ
 |  .... .|.| |. |.   ...| | |||||||| . .. |                  |..|||||.    .     .  | ||. ||.|.. .. 
SLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSA-----------------IKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDM

PCDVWSIGCIIFELYTGFTLFQTHDNREHLAMAERILGNFPSWMIKRTRKSKYFYH
  |.||.|||. |. ||  ||   .  . .     .||  |. || .. |.. ...
AIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFE

Kinase CLK.AA Ciliate-E2 179-495 17 8.3e-42 141.29 In-house 1-365 (365) Show / Hide
Range on Protein: 179-495
Range on HMM: 1-365/365
Sequence Identity: 17% (79 aa)

YAITSTLGEGTFGKVVQCRDNMSGG-------------------AKIALKIIKNIEKY-REAAKLEINVLEKINEKEGVGK---------SL----CVKM
| .   .|.|.||.| .|..   .                    .|| .. .|...|.  |. | ||... .||. .   |         .|     .||
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FY--KKINEKNILEQLNHPNIIKM

YDWFD--YHGHVCISFEIL-GLSIFDFLKDN----------NYQPYPLDQIKRMSHQLCS---------------AVKFLHDMK-ITHTDLKPENILFVD
|..|      .. . .| . | . ||..|.|            ... . .||... |...               |...||  . | | |.|||||||  
YECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

SRSSIKYDPVKKRDVRQVVNCDIRLIDFGSATFDH----------------------------------EHHSTIVSTRHYRALEVILELG---------
                      | .|||| ... .                                  . . ||. | .| | |..   .         
----------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKG

WSQPCDVWSIGCIIFELYTGFTLFQTHDNREHLAMAERILGNFPSWMIKRTRKSKYFYHDRVDWNQDNSSGRYVCENCHPFRYYLDSNADEHRLL-----
..  ||.||.|.|..|. .| . |                                                           .      . ..      
YDYKCDIWSLGVILYEMLFGKPPF-----------------------------------------------------------QQQIKQCKIDFPCPEWQ

--------------------FDTIEE----MLEFDPFKRAT-LSQVLDHPYF
                     | |      ||. || || |  .|.|.||.|
KDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase CLK.AA DyrkP 179-431 33 8.7e-42 134.97 In-house 1-239 (323) Show / Hide
Range on Protein: 179-431
Range on HMM: 1-239/323
Sequence Identity: 33% (87 aa)

YAITSTLGEGTFGKVVQCRDNMSGGAKIALKIIKNIEKYREAAKLEINVLEKINEKEGVGKSLCVKMYDWFDYHGHVCISFEILGLSIFDFLK---DNNY
| |   ||   | | .|| | .  .  . .||| |   | . .  || .|  ||    |     ...||.|    |. |  |.|   ...| |   .|  
YQIMEYLGSAAFSKAIQCQDKQT-NQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQ

QPY-PLDQIKRMSHQLCSAVKFLHDMKITHTDLKPENILFVDSRSSIKYDPVKKRDVRQVVNCDIRLIDFGSATFDHEHHSTIVSTRHYRALEVILELGW
|.|  .  ....  |.  |. ..| ... | ||||||||    .|  |              |....|||||. | |.| |  |  | ||| |||.   .
QRYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILM---KSYPK--------------CQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKY

SQPCDVWSIGCIIFELYTGFTLFQTHDNREHLAMAERILGNFPSWMIKRTRKSKYFY
    |.||.|||. ||.||  |||       ||    |.| || ||..  |  . |.
DYRIDMWSLGCILAELWTGNVLFQNDNIQGLLARVIGIIGPFPEWMMQEGRLVQNFF

Kinase CLK.AA HIPK 179-397 33 1.2e-41 128.56 In-house 1-203 (329) Show / Hide
Range on Protein: 179-397
Range on HMM: 1-203/329
Sequence Identity: 33% (74 aa)

YAITSTLGEGTFGKVVQCRDNMSGGAKIALKIIKNIEKYREAAKLEINVLEKINEKEGVGKSLCVKMYDWFDYHGHVCISFEILGLSIFDFLKDNNYQPY
| .   || ||||.|| |    . .  .|.||.||   |    . |. .|...  .|       |..|. |. . |.|. ||.|   ..||.|.|.. | 
YEVLEFLGRGTFGQVVKCW-KRGTNEMVAIKILKNHPYYARQGQIEVSILHCL-SQENADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPL

PLDQIKRMSHQLCSAVKFLHDMKITHTDLKPENILFVDSRSSIKYDPVKKRDVRQVVNCDIRLIDFGSATFDHEH-HSTIVSTRHYRALEVILELGWSQP
||  |. .  |   | . | .. . | |||||||. ||              .|.     .. ||||||    .   .| .  |.||| |.|| |   . 
PLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVD-------------PTRCPYR--VKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCEN

CDVWSIGCIIFELYTGFTLF
 |.|| ||.| ||. |  |.
HDMWSLGCVIAELFLGWPLY

Kinase CLK.AA DYRK2 179-313 36 2.3e-39 125.44 In-house 1-134 (318) Show / Hide
Range on Protein: 179-313
Range on HMM: 1-134/318
Sequence Identity: 36% (49 aa)

YAITSTLGEGTFGKVVQCRDNMSGGAKIALKIIKNIEKYREAAKLEINVLEKINEKEGVGKSLCVKMYDWFDYHGHVCISFEILGLSIFDFLKDNNYQPY
| | . .| | || || | |    . ..|.|.| |  .. . |  ||..|..| ..   . . ||.| | | . .|.|| || |.... ...| |..| .
YEILEVIGKGSFGQVVKCYDHKT-KQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGF

PLDQIKRMSHQLCSAVKFLHDMKITHTDLKPENIL
 |  . |. |..  . .|||  .| | ||||||||
SLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENIL

Kinase CLK.AA CAMK 184-394 19 2e-37 117.67 In-house 1-331 (425) Show / Hide
Range on Protein: 184-394
Range on HMM: 1-331/425
Sequence Identity: 19% (66 aa)

TLGEGTFGKVVQCRDNMSGG-----------AKIALKIIKN-----------------------------IEKYREAAKLEINVLEKINEKEG-VGKSLC
|||.|.||||  |..  ..|            | | |||.                               .| |.  . ||... |...... .     
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKMYDWFDYHGH-------------------VCISF---EIL---GL--SIFDFLKDNNY-------------QPYPLDQIKRMSHQLCSAVKFLHDMKI
.|.|.... . .                   ... .   |      |   .||..... .               .. .. .|. .|.||||...|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

THTDLKPENILFVDSRSSIK-------YDPVKKRDVRQVVNCDIRLIDFGSAT-FDHEH-------------------------HSTIVSTRHYRA-LEV
 | ||||||||..|. ..         . .          |..| .|||| |. ||. .                          .| . | .| |  ||
VHRDLKPENILLDDNNDDSDPVEHDEIF-D--------WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEV

IL--------------ELGWSQPCDVWSIGCIIFELYTGF
..              . . ...||.||.|.| . . .|.
LNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGY

Kinase CLK.AA DYRK 336-495 29 3.7e-29 103.2 In-house 143-320 (320) Show / Hide
Range on Protein: 336-495
Range on HMM: 143-320/320
Sequence Identity: 29% (56 aa)

NCDIRLIDFGSATFDHEHHSTIVSTRHYRALEVILELGWSQPCDVWSIGCIIFELYTGFTLFQTHDNREHLAMAERILGNFPSWMIKRT--RKSKYFYHD
...| .|||||..| |.. .| .  |.||| |||| .  . . |.|| |||. ||.||  ||.  .. . ||.   .|| .|.|||.    |. ..|. .
KSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC

RVDWNQDNSSGRYVCENCHPFRYY-------------------------LDSNADEHRLLF-DTIEEMLEFDPFKRATLSQVLDHPYF
           .| .    . . .                         .|.  . ....| | |. .|..|| || | || |.|| |
----------FMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQCDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF

Kinase CLK.AA DYRK2 338-495 29 4.2e-23 71.67 In-house 142-318 (318) Show / Hide
Range on Protein: 338-495
Range on HMM: 142-318/318
Sequence Identity: 29% (53 aa)

DIRLIDFGSATFDHE-HHSTIVSTRHYRALEVILELGWSQPCDVWSIGCIIFELYTGFTLFQTHDNREHLAMAERILGNFPSWMIKR------TRKSKYF
.| .||||| .|.|. .  | . .| ||| |||| .  . . | || |||. |||||. ||   .  . .|.   .||  |. ...       .|.  .|
GIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFF

Y--------------HDRVDWNQDNSSGRYVCENCHPFRYYLDSNADEHRLLFDTIEEMLEFDPFKRATLSQVLDHPYF
                . .  .  |. |.    .  .. ..|    ||  .. | |   .| || .| | || |.||..
NSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDE--NFIDFIKRCFEWDPSERMTPSQALKHPWI

Kinase CLK.AA PRP4 179-322 31 1.8e-21 75.42 In-house 1-147 (320) Show / Hide
Range on Protein: 179-322
Range on HMM: 1-147/320
Sequence Identity: 31% (46 aa)

YAITSTLGEGTFGKVVQCRDNMSGGAKIALKIIKNIEKYREAAKLEINVLEKINEK--EGVGKSLCVKMYDWFDYHGHVCISFEILGLSIFDFLKDN-NY
|.. .  |.| |. |..|||.  | ...| ||| | |  .     |. .| |.|..      |. ||.|.. | .. | |. || .  .  . ||     
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

QPYPLDQIKRMSHQLCSAVKFLHDMKITHTDLKPENILFVDSRSSIK
    |. .   . ||  | | |   .| | |.|| |||   |.. .|
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNESKNTLK

Kinase CLK.AA PRP4 339-430 37 3e-10 33.82 In-house 146-239 (320) Show / Hide
Range on Protein: 339-430
Range on HMM: 146-239/320
Sequence Identity: 37% (36 aa)

IRLIDFGSATFDHEHHST--IVSTRHYRALEVILELGWSQPCDVWSIGCIIFELYTGFTLFQTHDNREHLAMAERILGNFPSWMI-KRTRKSKYF
. ..|||||   ||   |   || | ||| |.|.        |.||.|| ..|||||  .|    | . | ..  . | .|  || |   |...|
LKMCDFGSASHIHENEITPYLVS-RFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMFPGKTNNHMLKLFMDYKGKMPNKMIRKGQFKDNHF

Kinase CLK.AA TyrKc 179-476 16 5.8e-08 -93.93 SMART 1-280 (280) Show / Hide
Range on Protein: 179-476
Range on HMM: 1-280/280
Sequence Identity: 16% (55 aa)

YAITSTLGEGTFGKVVQCRDNMSGGAKIALKIIKNIEKYREAAKLEINVLEKI-NEKEGVGKSL--CVKMYDWFDYHGHVCISFEILGL-SIFDFLKDNN
     .|||| ||.|.... .     . | | .|.    ||.   |.... |.  . . . . .  |..    | | . ..| .|   . .  |.|... 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

YQPYPLDQIKRMSHQLCSAVKFLHDMKITHTDLKPENILFVDSRSSIKYDPVKKRDVRQVVNCDIRLIDFGSATFDHEH------HSTIVSTR--HYR--
 .  ....   ...| ..   .||.... | ||   |.|  . .                    ..  ||| . . ...      .......   . .  
PK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTM

------ALEVILELGWSQPCDVWSIGCIIFELYT-GFTLFQT-----HDNRE---HLAMAERILGNFP----SWMIKRTRKSKYFYHDRVDWNQDNSSGR
      |.|.| .   .   |||| |  ..|..| | .          .|.|   ..   .|          |                        .  
LPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------F--

YVCENCHPFRYYL-----DSNADEHRLLFDTIEEML
 ||  |..  | .     . .... |  | .| | .
-VC--CPDEMYQIMKQCWHEDPED-RPTFSEIHECF

Kinase CLK.AA CAMK 470-495 50 9.6e-08 20.27 In-house 400-425 (425) Show / Hide
Range on Protein: 470-495
Range on HMM: 400-425/425
Sequence Identity: 50% (13 aa)

DTIEEMLEFDPFKRATLSQVLDHPYF
| |  ||. || ||.|..|.|.|| .
DLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase CLK.AA PRP4 470-495 38 1e-06 20.32 In-house 295-320 (320) Show / Hide
Range on Protein: 470-495
Range on HMM: 295-320/320
Sequence Identity: 38% (10 aa)

DTIEEMLEFDPFKRATLSQVLDHPYF
| ....|  || || |. ..| ||..
DLLDKCLMLDPKKRITCNEALKHPFI

Kinase CLK.AA DYRK1 470-495 42 1.3e-05 15.18 In-house 296-321 (321) Show / Hide
Range on Protein: 470-495
Range on HMM: 296-321/321
Sequence Identity: 42% (11 aa)

DTIEEMLEFDPFKRATLSQVLDHPYF
| |. ||..|| .| |  ..| |..|
DLIKRMLQYDPKQRITPYYALQHSFF

Kinase CLK.AA DyrkP 464-495 28 0.019547 3.06 In-house 292-323 (323) Show / Hide
Range on Protein: 464-495
Range on HMM: 292-323/323
Sequence Identity: 28% (9 aa)

EHRLLFDTIEEMLEFDPFKRATLSQVLDHPYF
.  .  | . ..|  |  .| |    |.||.|
DDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF