Gene PRP4 (Sea Urchin)

PRP4

Species: Sea Urchin
Alias: Spk155, PRP4, SPU_000244
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: PRP4

Sequence

Name Sequence Type Origin Length Description Download
PRP4.AA Protein None 1044 None Fasta, JSON
PRP4.kin_dom Protein Kinase Domain None 1005 None Fasta, JSON

Protein domain

Protein domains of PRP4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PRP4.AA PRP4 724-1040 74 1.1e-258 865.64 In-house 1-320 (320) Show / Hide 
Range on Protein: 724-1040
Range on HMM: 1-320/320
Sequence Identity: 74% (238 aa)

YAVYGYTGQGVFSNVVRARDTARGKLDVAIKIIRNNDLMQKTGMKELEYLKRLNDQ--DREDKFHCVRLFRSFSYRQHLCLVFEPLSMNLREVLKRYGKD
|.||||.||||||||.|.||..||. .|||||||||..|.|||..|||.|..|||.  |..|||||||.||.|..|||.|||||..|||||||||.||||
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

VGLHIKAVRSYTQQLFLALKLLKRCNILHADIKPDNILVNESKSVLKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGMNYDAAIDMWSTGCTIFELAA
||||.||||||.||||||||.||.|||||||||||||||||||..||.||||||||...|.||||||||||||||||||..||..|||||.|||..||..
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYT

GKIMFPGKTNNHMLKLFMDLKGKMPHKIIRKGILRDKHFDPNCNFKYVEVDKVTEREKVTVMTVINPTKDLTTELLGY-QRLPEDQQRKVLQLKDVLDRC
|||||||||||||||||||.|||||.|.||||...|.|||.||||.|.|||||||||||||||.|.||||...||... ||.||||..||.|.||.||.|
GKIMFPGKTNNHMLKLFMDYKGKMPNKMIRKGQFKDNHFDQNCNFMYQEVDKVTEREKVTVMTYIKPTKDIYQELIECNQRIPEDQMKKVHQFKDLLDKC

LMLDPSKRISINEVLRHSFI
|||||.|||..||.|.|.||
LMLDPKKRITCNEALKHPFI
Kinase PRP4.AA DYRK 724-1040 39 9.90000000001e-170 570.17 In-house 1-320 (320) Show / Hide 
Range on Protein: 724-1040
Range on HMM: 1-320/320
Sequence Identity: 39% (128 aa)

YAVYGYTGQGVFSNVVRARDTARGKLDVAIKIIRNNDLMQKTGMKELEYLKRLNDQDREDKFHCVRLFRSFSYRQHLCLVFEPLSMNLREVLKRYGKDVG
| ...|.|.|.|..||...|. ... .|||||||||  .......|.. |..||.||..||.|||.....| .|.|||.|||.|||||.|.||.......
YEILEYIGKGSFGQVVKCWDH-KTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF

LHIKAVRSYTQQLFLALKLLKRC-NILHADIKPDNILVNE--SKSVLKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGMNYDAAIDMWSTGCTIFELA
.....||...||....||.|... ||.|.|.||.||....  .|| .|..||||...... .|..|..||||||||.|.|. |. |||||| ||.. || 
FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQ-RIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELF

AGKIMFPGKTNNHMLKLFMDLKGKMPHKIIRKG--ILRDKHFDPNCNFKYVEVDKVTEREKVTVMTVI---NPTKDLTTELLGYQR--LPEDQQRKVLQL
 |...|||......|...|...|..|...|.||    ..|.||    |.| |.|..|...|.|... .   .|||. ...... .|   |..| ....|.
TGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC---FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQF

KDVLDRCLMLDPSKRISINEVLRHSFI
|| ...||..||.|||. .. |.|...
KDFIKKCLQWDPHKRITPSQALQHPWF
Kinase PRP4.AA CMGC 724-1040 19 7.4e-98 322.16 In-house 1-513 (513) Show / Hide 
Range on Protein: 724-1040
Range on HMM: 1-513/513
Sequence Identity: 19% (100 aa)

YAVYGYTGQGVFSNVVRARDT-------------ARGKLDVAIKIIRNNDLMQKTGM-------------KELEYLKRLN-----------DQDREDKFH
| . .. |.| ...|...||.              ...  ||||.|.|.  .. ..               |...||.||           | | ... .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

CVRLFRSFSYRQ-----------------HLCLVFEPLSMNLREVLKRYGK-DVG------------------------LHIKAVRSYTQQLFLALK--L
.|.|. .| ...                 ||.|||| . ..| ...|.. . . |                        . | ..| |..|.. .||   
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

LKRCN--ILHADIKPDNILVNESKSV-------------------LKLCDFGSASHVADN-----------------------DITPYLVSRFYRAPEII
. . .  |.| |.|| |||.|. . .                   ||.||||.| .. ..                        .|.| |.|.||||||.
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

IG----------MNYDAAIDMWSTGCTIFELAAG--------KIMFPGKTN-----------NHMLKLFMDLKGKMPHKIIRKGILRD------KHFDPN
.|          |.|. .||||| || ..|.  |        |..|||...            ..|.. ... |. . ..|.||  |.      .  .||
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGK-RHFNFCKHEEEWPN

CNFKYVEVDKVTERE--------KVTVMTVINPTKDLTTELL-GYQRLPEDQQR--------------------------------KVLQLKDVLDRCLM
.. ..    . . ..        .  . . |...... .      ..|  ....                                   |. | |...| 
MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQ

LDPSKRISINEVLRHSFI
.||.|||.. . |.| ..
YDPDKRITAEQALQHPYF
Kinase PRP4.AA S_TKc 724-1040 22 7e-73 249.36 SMART 1-231 (231) Show / Hide 
Range on Protein: 724-1040
Range on HMM: 1-231/231
Sequence Identity: 22% (73 aa)

YAVYGYTGQGVFSNVVRARDTARGKLDVAIKIIRNNDLMQKTGMKELEYLKRLNDQDREDKFHCVRLFRSFSYRQHLCLVFEPLSM---NLREVLKRYGK
| .    |.| |. | ..|..   .  ||||||.      .. ..|.. ||.       .  . |.|. .|   .||..|.| ..    .|....|..|.
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

---DVGLHIKAVRSYTQQLFLALKLLKRCNILHADIKPDNILVNESKSVLKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGMNYDA-AIDMWSTGCTI
   .....   .|.|..|...||. . . .|.| |.||.|||..|   ..|.||||.| ..     | . ....|.|||..    |.  ..|.|| ||..
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

FELAAGKIMFPGKTNNHMLKLFMDLKGKMPHKIIRKGILRDKHFDPNCNFKYVEVDKVTEREKVTVMTVINPTKDLTTELLGYQRLPEDQQRKVLQLKDV
.|...|.  ||  . . |.|. .                                                                        ..|| 
YEMLCGYPPFP--QMQMMFKKIG----------------------------------------------------------------------SPEAKDF

LDRCLMLDPSKRISINEVLR-------HSFI
...||  ||.||... |.|.       | ..
IRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PRP4.AA DYRK2 724-928 38 5.9e-63 203.44 In-house 1-204 (318) Show / Hide 
Range on Protein: 724-928
Range on HMM: 1-204/318
Sequence Identity: 38% (80 aa)

YAVYGYTGQGVFSNVVRARDTARGKLDVAIKIIRNNDLMQKTGMKELEYLKRLNDQDREDKFHCVRLFRSFSYRQHLCLVFEPLSMNLREVLKRYGKDVG
| .    |.| |  ||.. |  .... ||||.|||     ..   |.. |...  ||.   . ||... .| .| |.|..|| ||||| | .|.  .  |
YEILEVIGKGSFGQVVKCYDHKTKQH-VAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQ-G

LHIKAVRSYTQQLFLALKLLKRCNILHADIKPDNILVNES-KSVLKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGMNYDAAIDMWSTGCTIFELAAG
.  . ||  ....  .|..|.. || |.| || ||| ..  .| .|. ||||   .    |  |  ||||||||.|.|. |. |||||| ||.. ||  |
FSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTG

KIMFPG
...|||
YPLFPG
Kinase PRP4.AA HIPK 724-1040 30 2.4e-57 178.96 In-house 1-329 (329) Show / Hide 
Range on Protein: 724-1040
Range on HMM: 1-329/329
Sequence Identity: 30% (102 aa)

YAVYGYTGQGVFSNVVRARDTARGKLDVAIKIIRNNDLMQKTGMKELEYLKRLNDQDREDKFHCVRLFRSFSYRQHLCLVFEPLSMNLREVLKRYGKDVG
| |  . |.| |  ||..   . . . |||||..|.    . |  |.. |..| ... .. .| || .  |  ..| ||||| |  || . .|   |   
YEVLEFLGRGTFGQVVKCWKRGTNEM-VAIKILKNHPYYARQGQIEVSILHCLSQENADE-YHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQN-KFMP

LHIKAVRSYTQQLFLALKLLKRCNILHADIKPDNI-LVNESKS--VLKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGMNYDAAIDMWSTGCTIFELA
| .|..|  .||   ||. ||   ..|||.||.|| || ...     |  |||||||| .    .|| ||.|||||||.|. .  ..|||| || | || 
LPLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELF

AGKIMFPGKTNNHMLKLFMDLKGKMPHKIIRKGILRDKHF--DPNCNFKYVEVDKVTEREKVTVMT-------VINPTKDLTTELLGYQRLPEDQQRKVL
 |   .||  .      .    ..    .. ..    . |  | . .|..    .. | |. | .        ..|   |     .     ..|   .. 
LGWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQSKFRPWRLKHIEEHEQQTSVKSKEARKYIFNCLDDMPEVNMLVDPERQDYRVEKI

QLK---DVLDRCLMLDPSKRISINEVLRHSFI
  .   .|| . . .|. |||.  | |.|.|.
DRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase PRP4.AA DYRK1 724-1040 33 2.5e-54 186.81 In-house 1-321 (321) Show / Hide 
Range on Protein: 724-1040
Range on HMM: 1-321/321
Sequence Identity: 33% (109 aa)

YAVYGYTGQGVFSNVVRARDTARGKLDVAIKIIRNNDLMQKTGMKELEYLKRLNDQDREDKFHCVRLFRSFSYRQHLCLVFEPLSMNLREVLKRYGKDVG
| .    |.| |  ||.| |. . .  ||||||.|          |.  |  .| .|.|.|.. |.| | | .| ||||||| || || ..| |  .  |
YEIDSLIGKGSFGQVVKAYDHQE-QEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLL-RNTHFRG

LHIKAVRSYTQQLFLALKLLK--RCNILHADIKPDNI-LVNESKSVLKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGMNYDAAIDMWSTGCTIFELA
  .  .| . ||.  ||  .     .|.| |.||.|| |.|  .| .|. ||||. .. .  |  |. |||||.||...|..|| |||||| || . |. 
VSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMH

AGKIMFPGKTNNHMLKLFMDLKGKMPHKIIRKGILRDKHFDPNCNFKYVEVDKVTEREKVTVMTVINPTKDLTTELLGYQRLPEDQQRK---------VL
 |  .| |.     ..  ..  |  |...| ..    |.|.     |  .   .  ...    .  .|..    |.|| .    .  ||          |
TGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFE-----KDPDNTWYCKKTRDKKKHYKEPCTRKLHEILGVETGGPGGRRKGEPGHSVEDYL

QLKDVLDRCLMLDPSKRISINEVLRHSFI
. ||.. | |  || .||.  ..|.|||.
KFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase PRP4.AA GSK 801-937 40 3.7e-47 141.73 In-house 89-230 (328) Show / Hide 
Range on Protein: 801-937
Range on HMM: 89-230/328
Sequence Identity: 40% (57 aa)

CLVFEPLSMNLREVLKRY-GKDVGLHIKAVRSYTQQLFLALKLLKRCNILHADIKPDNILVNESKSVLKLCDFGSASHVADND---ITPYLVSRFYRAPE
|||.| . ..| .|...|   .  . |. .. |. |.| .|. |   .| | ||||.||||.... |||.||||||  . .|     ..| .||.|||||
CLVMEYMPQTLYQVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPE

IIIG-MNYDAAIDMWSTGCTIFELAAGKIMFPGKTNNHMLKL
 |.| .||. .||.|| || ..|.  |...|||.. ...|..
LIFGCTNYTCQIDVWSCGCVMAEMLKGQPLFPGDSSVDQLVE
Kinase PRP4.AA YAK 724-960 35 1.9e-45 152.14 In-house 1-239 (347) Show / Hide 
Range on Protein: 724-960
Range on HMM: 1-239/347
Sequence Identity: 35% (86 aa)

YAVYGYTGQGVFSNVVRARDTARGKLDVAIKIIRNNDLMQKTGMKELEYLKRLNDQ-DREDKF---HCVRLFRSFSYRQHLCLVFEPLSMNLREVLKRYG
| |    ||| |  ||  .      | .|.|.| |       .  |   |. ||.| | ..|    | .|.  .| .. |.||||| ||.|| | ||   
YIVLDMLGQGTFGQVVKCQNCDTNEL-FAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQ-N

KDVGLHIKAVRSYTQQLFLALKLLKRCNILHADIKPDNILVNE-SKSVLKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGMNYDAAIDMWSTGCTIFE
|  |. .  .| .| |   ..  |.  .| | | || ||.     |  .|. ||||.   .   .. |  .|.||.||||..| | ..||||| || . |
KFCGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKM-VYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAE

LAAGKIMFPGKTNNHMLKLFMDLKGKMPHKIIRKGILRDKHF
|  |  .|||      .|   |  |. |  .| .|  . | |
LFLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF
Kinase PRP4.AA Pkinase 724-938 26 1.1e-36 130.83 Pfam 1-227 (293) Show / Hide 
Range on Protein: 724-938
Range on HMM: 1-227/293
Sequence Identity: 26% (64 aa)

YAVYGYTGQGVFSNVVRARDTARGKLDVAIKIIRNNDLMQKTGMK-----ELEYLKRLNDQDREDKFHC--VRLFRSFSYRQHLCLVFEPLSM-----NL
| . .  |.| |. | ....   ||  ||.|||.  .   .  .      |....||||        |.  |||...| ...|...|.| . .      |
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDL

REVLK--RYGKDVGLHIKAVRSYTQQLFLALKLLKRCNILHADIKPDNILVNESKSVL----KLCDFGSAS---HVADNDITPYLVSRFYRAPEIII-GM
 ....  |.|.   .  . ...|  |.. .|. . ...|.| |.||.|||.. .. ..    |.||||.|    .  .   | . ....|.|||.|  | 
FDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQ

NYDAAIDMWSTGCTIFELAAGKIMFPGK----TNNHMLKLF
 |. ..|||| ||...|.. |.  |||.    . . .....
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMI
Kinase PRP4.AA MAPK 847-929 40 2.1e-30 102.18 In-house 137-238 (328) Show / Hide 
Range on Protein: 847-929
Range on HMM: 137-238/328
Sequence Identity: 40% (42 aa)

NILHADIKPDNILVNESKSVLKLCDFGSASHVADN----------------DITPYLVSRFYRAPEIIIG---MNYDAAIDMWSTGCTIFELAA-GKIMF
|..| |.|| ||||||    ||.|||| | .....                . |.| . |.||||||. .   |.|. |.|||| ||   |.   .|..|
NVIHRDLKPSNILVNE-NCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLF

PGK
|||
PGK
Kinase PRP4.AA CLK 724-859 30 8.3e-29 82.92 In-house 163-308 (350) Show / Hide 
Range on Protein: 724-859
Range on HMM: 163-308/350
Sequence Identity: 30% (44 aa)

YAVYGYTGQGVFSNVVRARDTARGKLDVAIKIIRNNDLMQKTGMKELE-YLKRLNDQ-DREDKFH--CVRLFRSFSY-RQHLCLVFEPLSMNLREVLKRY
| ..   |.|.|. ||. .|. .||  ||.||||| .        |..  .| .|   | . |.   |.... .| |   | |.||| .  .. ...|  
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

G-----KDVGLHIKAVRSYTQQLFLALKLLKRCNILHADIKPDNIL
.     |  .. | ..|. . ||  |.| |    . | | || ||.
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENIC
Kinase PRP4.AA CLK 868-960 33 3.7e-11 28.97 In-house 187-285 (350) Show / Hide 
Range on Protein: 868-960
Range on HMM: 187-285/350
Sequence Identity: 33% (33 aa)

KLCDFGSAS-HVADNDITPYLVS-RFYRAPEIIIGMNYDAAIDMWSTGCTIFELAAGKIMFPGKTNNHMLKLFMDLKG-KMPHKIIRKGI---LRDKHF
.. |||||     |.   . .|| | |||||.| |. .    | || || .|||  |  .|..  |   | .   . |   |   |.. .     .|.|
CVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYF
Kinase PRP4.AA TyrKc 724-1039 16 1.8e-09 -69.69 SMART 1-280 (280) Show / Hide 
Range on Protein: 724-1039
Range on HMM: 1-280/280
Sequence Identity: 16% (56 aa)

YAVYGYTGQGVFSNVVRARDTARGKLDVAIKIIRNNDLMQKTGMKELEYLKRL--NDQDREDKFHCVRLFRSFSYR-------QHLCLVFEPLSM-NLRE
       | | |  |.... .    ..||.| ....   ..  |.|.. ...|  . .      . |||.   .         . |..|.|  .  .|..
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGHHP------NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

VLKRYGKDVGLHIKAVRSYTQQLFLALKLLKRCNILHADIKPDNILVNESKSVLKLCDFGSASHVADNDIT----PYLV------SR-----FYRAPEII
 |......  |  |   |.  |       | . |. | |.   |.||.| . . | .||| .  . | | .     | .      ..        ||| |
YLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

IGMNYDAAIDMWSTGCTIFELAA-GKIMFPG-----KTNNHMLKLFMDLKGKMPHKI---IRKGILRDKHFDPNCNFKYVEVDKVTEREKVTVMTVINPT
    .  . | || | ...|.   |.   ||     ..| ..... .. .  .. .    .                                       
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------------------

KDLTTELLGYQRLPEDQQRKVLQLKDVLDRCLMLDPSKRISINEVLRHSF
                  .    . ..  .| . ||..| . .|. .. |
----------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase PRP4.AA CLK 1012-1040 44 5.6e-09 22.3 In-house 322-350 (350) Show / Hide 
Range on Protein: 1012-1040
Range on HMM: 322-350/350
Sequence Identity: 44% (13 aa)

QLKDVLDRCLMLDPSKRISINEVLRHSFI
|| | . ..|. ||||||.  ..| | | 
QLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase PRP4.AA Pkinase 1013-1040 35 2.6e-07 26.92 Pfam 266-293 (293) Show / Hide 
Range on Protein: 1013-1040
Range on HMM: 266-293/293
Sequence Identity: 35% (10 aa)

LKDVLDRCLMLDPSKRISINEVLRHSFI
.||....|| .||.||... ..| | ..
CKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PRP4.AA DYRK2 1017-1040 37 1.8e-05 13.39 In-house 295-318 (318) Show / Hide 
Range on Protein: 1017-1040
Range on HMM: 295-318/318
Sequence Identity: 37% (9 aa)

LDRCLMLDPSKRISINEVLRHSFI
. ||.  |||.|..  . |.| .|
IKRCFEWDPSERMTPSQALKHPWI
Kinase PRP4.AA MAPK 1015-1040 42 2.4e-05 14.22 In-house 303-328 (328) Show / Hide 
Range on Protein: 1015-1040
Range on HMM: 303-328/328
Sequence Identity: 42% (11 aa)

DVLDRCLMLDPSKRISINEVLRHSFI
| |.. | .||.|||.. | |.| ..
DLLEKMLVFDPDKRITVEEALQHPYF
Kinase PRP4.AA GSK 1015-1040 42 8e-05 10.02 In-house 303-328 (328) Show / Hide 
Range on Protein: 1015-1040
Range on HMM: 303-328/328
Sequence Identity: 42% (11 aa)

DVLDRCLMLDPSKRISINEVLRHSFI
| . .||  ||.||.|  |.. | | 
DLISKCLVYDPKKRLSPLEACAHPFF
Kinase PRP4.AA GSK 724-754 26 0.00028 8.32 In-house 170-207 (328) Show / Hide 
Range on Protein: 724-754
Range on HMM: 170-207/328
Sequence Identity: 26% (10 aa)

YAVYGYTGQGVFSNVVRARDT----ARGKL---DVAIK
|  .   |.|.|..|..| ..      ..     ||||
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIK
Kinase PRP4.AA MAPK 724-754 30 0.056865 2.34 In-house 184-219 (328) Show / Hide 
Range on Protein: 724-754
Range on HMM: 184-219/328
Sequence Identity: 30% (11 aa)

YAVYGYTGQGVFSNVVRARDTARGKLD-----VAIK
|    . ||| .  |. |.|. ..  .     ||||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIK
Kinase PRP4.AA YAK 1004-1040 24 0.107072 1.09 In-house 313-347 (347) Show / Hide 
Range on Protein: 1004-1040
Range on HMM: 313-347/347
Sequence Identity: 24% (9 aa)

EDQQRKVLQLKDVLDRCLMLDPSKRISINEVLRHSFI
. ..| ..   | .   | |.| .| .      | ||
NNRHRDCFI--DFINQLLQLNPRERWKPMQAMQHPFI