Gene ERK5 (Sea Urchin)

ERK5

Species: Sea Urchin
Alias: SPU_025159, ERK5, Spk146
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK5

Sequence

Name Sequence Type Origin Length Description Download
ERK5.AA Protein None 773 None Fasta, JSON
ERK5.kin_dom Protein Kinase Domain None 295 None Fasta, JSON

Protein domain

Protein domains of ERK5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ERK5.AA ERK5 28-322 80 9.3e-244 816.08 In-house 1-295 (295) Show / Hide 
Range on Protein: 28-322
Range on HMM: 1-295/295
Sequence Identity: 80% (238 aa)

YKPLEKIGTGAYGVVCSAINKKNGEKVAIKKIPNSFDELTTAKRTFRELKILRHFRHENVIAIREILMPKEPLSEMKDVYVVFDLMESDLHQIIHSNQPF
||..||||.|||||||||...|||..||||||||.||..|.||||||||||||||||.|.||||.|||||.|.|||||||||||||||||||||||||||
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

SLEHIRFFLYQILRGLKYIHSADVIHRDLKPSNLLVNENCELKVGDFGMARGLSTFSTDKKKMFMTSYVATRWYRAPELLFSSDDYTLAVDVWSVGCILG
.|||||.|||||||||||.|||.||||||||||||||||||||.|||||||||.|||.||..||||.||||||||||||.|||.|||.|.||||||||.|
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

EMIGRKQMFPGKNPIDQLSLIVDVLGMPPTHMLKSTSSDHLYNFFQKNFANKTPKDLSKLYPKADPQGLDLLAKMLIFEPSERITVNKALQHPFL
|||.|.|||||||.|.||.||..||||||.||....|.||.||.|||||.|..|||..|.|||||.|.|||||.||.||||||||||||||||||
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase ERK5.AA MAPK 28-322 50 3.3e-195 654.78 In-house 1-328 (328) Show / Hide 
Range on Protein: 28-322
Range on HMM: 1-328/328
Sequence Identity: 50% (167 aa)

YKPLEKIGTGAYGVVCSAINKK------NGEKVAIKKIPNSFDELTTAKRTFRELKILRHF-RHENVIAIREILMPK-----EPLSEMKDVYVVFDLMES
|..|..|| |||||||||| |.      .|.|||||||.. |. .| .|||.||.|.|||| .|||.| ...|..|.     ..|.|..|.|.|..|||.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHQIIHSNQPFSLEHIRFFLYQILRG--LKYIHSADVIHRDLKPSNLLVNENCELKVGDFGMARGLSTFSTDKKK---------MFMTSYVATRWYRAP
||||||.|.|| | .||..|.||||||  |||||||.||||||||||.||||||.||..|||.||.. ........         |.|| ||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

ELLFS--SDDYTLAVDVWSVGCILGEMIG-RKQMFPGKNPIDQLSLIVDVLGMPPTHMLKSTS-SDHLYNFFQKN--FANKTPKDLSKLYPK----ADPQ
|....  ...|| |||.||||||..||.. ||..||||..|||. ||..|||.|. ....  . |.| .|..| .  . ....|...|..|.    |.||
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

GLDLLAKMLIFEPSERITVNKALQHPFL
 .||| ||| | |..||||  |||||..
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase ERK5.AA ERK 28-322 50 1.4e-164 553.01 In-house 1-307 (307) Show / Hide 
Range on Protein: 28-322
Range on HMM: 1-307/307
Sequence Identity: 50% (157 aa)

YKPLEKIGTGAYGVVCSAINKK-----NGEKVAIKKIPNSFDELTTAKRTFRELKILRHFR-HENVIAIREILMPKEPLSEMKDVYVVFDLMESDLHQII
|. ...|| ||||||||||.|.     .|.|||||||.| || .  .||| ||.|.||||. |||.| .. |.||. |  ...|.|.|..|||.||||||
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPE-QYNDIYCVEELMETDLHQII

HSNQPFSLEHIRFFLYQILRGLKYIHSADVIHRDLKPSNLLVNENCELKVGDFGMAR----GLSTFSTDKKKMFMTSYVATRWYRAPELLFSSDDYTLAV
.| |. | .|. .|.||||.||||||||.||||||||||.|||.|| ||. ||| ||    . .  ..   . ||| |||||||||||.. |  .|| |.
NSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHE-CNQNFMTEYVATRWYRAPEIMLSWQKYTKAM

DVWSVGCILGEMIGRKQMFPGKNPIDQLSLIVDVLGMP-PTHMLKSTSSDHLYNFFQKNFAN--KTPKDLSKLYPKAD--PQGLDLLAKMLIFEPSERIT
|.||.|||. ||.||| .||||. ..|...| ...| | .   |.   |. ....  ||. |  ..||......|.|.  ||..||| ||| | |..|||
DIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYI-KNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRIT

VNKALQHPFL
|  .|.||..
VEECLEHPYF
Kinase ERK5.AA CMGC 28-322 26 2.2e-148 491.25 In-house 1-513 (513) Show / Hide 
Range on Protein: 28-322
Range on HMM: 1-513/513
Sequence Identity: 26% (139 aa)

YKPLEKIGTGAYGVVCSAIN--------------KKNGEKVAIKKIPNSFDELTTAK----------RTFRELKILRHFR-----------------HEN
|. ..||| |.||||.....              ....|.|||||| | | . ..||          |..||.|||.|..                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VIAIREILMPKEP------------LSEMKDVYVVFDLMESDLHQIIHSNQ---------PFSLEH------------IRFFL------YQILRGLK--Y
.. ...|...|..            . .....| ||..|. ||.|.|..||         |.|  |            |..|.      ||||||||  |
IVKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

IHSAD--VIHRDLKPSNLLVNENCEL--------------------KVGDFGMARGLSTFSTDKK----------------KMFMTSYVATRWYRAPELL
.||..  .|||||||.|.|.|.||||                    |..|||.|| ... | ...                 ...|.||.||||||||.|
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

FSS---------DDYTLAVDVWSVGCILGEMIGR--------KQMFPGKNP-----------IDQLSLIVDVLGMPPTHMLKSTS--------SDHLYNF
...         ..|| ..|.||||||..||. .        | .|||..            |||| .|..|||.|. .|....         ..  .|.
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNM

FQ-------------------KN------------FANKTPKDLSKLYPK-----------------------------------ADPQGLDLLAKMLIF
 .                   ..            | .. ||....|.|.                                   .|||..||| |||..
IKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQY

EPSERITVNKALQHPFL
.|..|||.  |||||..
DPDKRITAEQALQHPYF
Kinase ERK5.AA p38 28-322 45 9.1e-134 450.7 In-house 1-289 (289) Show / Hide 
Range on Protein: 28-322
Range on HMM: 1-289/289
Sequence Identity: 45% (136 aa)

YKPLEKIGTGAYGVVCSAINKKNGEK---VAIKKIPNSFDELTTAKRTFRELKILRHFRHENVIAIREILMP-KEPLSEMKDVYVVFDLMESDLHQIIHS
|. |. .|.|||| ||.|. .. |.|   |||||.   | .   ||||.|||. |.| |||||| . ..  |  . .....|||.|  .|..||..|. .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

NQPFSLEHIRFFLYQILRGLKYIHSADVIHRDLKPSNLLVNENCELKVGDFGMARGLSTFSTDKKKMFMTSYVATRWYRAPELLFSSDDYTLAVDVWSVG
 . .| .||.| .|||||||||||||..|||||||||. |||.|||.. ||| ||        ..   || ||||||||||| ...  .|| .||.||||
QR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR--------HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVG

CILGEMIGRKQMFPGKNPIDQLSLIVDVLGMPPTHMLKSTSSDHLYNFFQKNFANKTPKDLSKLYPKADPQGLDLLAKMLIFEPSERITVNKALQHPFL
||. |.| ..  |||...||||  |. |.| |.. ...  .|..  |. | . .  . .|.......|.|| .||| |||.  |  |||.  |.|||..
CIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQ-SYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase ERK5.AA ERK1 28-322 50 1.6e-118 400.09 In-house 1-289 (289) Show / Hide 
Range on Protein: 28-322
Range on HMM: 1-289/289
Sequence Identity: 50% (149 aa)

YKPLEKIGTGAYGVVCSAINKKNGEKVAIKKIPNSFDELTTAKRTFRELKILRHFRHENVIAIREILMPKEPLSEMKDVYVVFDLMESDLHQIIHSNQPF
|  |. || ||||.||||. . ....||||||   |.  |  .|| ||.|||  |.|||.| |..|.   . . .|.|||.| .||| || ... . |. 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKI-SPFEHQTYCQRTLREIKILTRFKHENIINIQDIIR-ADTIEQMRDVYIVQCLMETDLYKLLKT-QHL

SLEHIRFFLYQILRGLKYIHSADVIHRDLKPSNLLVNENCELKVGDFGMARGLSTFSTDKKKMFMTSYVATRWYRAPELLFSSDDYTLAVDVWSVGCILG
| .|| .||||||||||||||| |.||||||||||.|  |.||. |||.|| ..   .|    |.| |||||||||||..  |  || ..|.||||||| 
SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-IADPEHD-HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILA

EMIGRKQMFPGKNPIDQLSLIVDVLGMPPTHMLKSTSSDHLYNFFQKNFANKTPKDLSKLYPKADPQGLDLLAKMLIFEPSERITVNKALQHPFL
||.  . .||||  .||| .|. ||| |  . |.    .   |. |     |.   . .|.||||.. |||| ||| | | .|||| .|| ||.|
EMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQ-SLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase ERK5.AA nmo 29-322 45 4.6e-115 355.43 In-house 2-292 (292) Show / Hide 
Range on Protein: 29-322
Range on HMM: 2-292/292
Sequence Identity: 45% (134 aa)

KPLEKIGTGAYGVVCSAINKKNGEKVAIKKIPNSFDELTTAKRTFRELKILRHFRHENVIAIREILMPKEPLSEMKDVYVVFDLMESDLHQIIHSNQPFS
.|   || ||.||| |    ..| .||.||.|| | .|  .|| |||||.|  |.|.||.. ..|| | . .. ....||| .|| ||||.|| | |. |
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPH-KDFFQEIYVVTELMQSDLHKIIVSPQHLS

LEHIRFFLYQILRGLKYIHSADVIHRDLKPSNLLVNENCELKVGDFGMARGLSTFSTDKKKMFMTSYVATRWYRAPELLFSSDDYTLAVDVWSVGCILGE
 .|.. |||||||||||.|||...|||.|| ||||| || ||. |||.||   .   |..|  ||  | | .|||||.|  .  || |||.|||||| .|
SDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLAR---VWEQDQSKH-MTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAE

MIGRKQMFPGKNPIDQLSLIVDVLGMPPTHMLKSTSSDHLYNFFQKNFANKTPKDLSKLYP--KADPQGLDLLAKMLIFEPSERITVNKALQHPFL
..||. .|  ..||.|| .|.|.|| |    .|            .   .   . | .|    .|     .||..||.|.|. || .. ||.||.|
LLGRRILFQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase ERK5.AA ERK7 28-322 40 8.3e-115 387.71 In-house 1-292 (292) Show / Hide 
Range on Protein: 28-322
Range on HMM: 1-292/292
Sequence Identity: 40% (119 aa)

YKPLEKIGTGAYGVVCSAINKKNGEKVAIKKIPNSFDELTTAKRTFRELKILRHFR-HENVIAIREILMPKEPLSEMKDVYVVFDLMESDLHQIIHSNQP
|. ....| ||||.|  |. |. .. ||.|||   | . | | |||||  .|. |. |.|.| . ...  .      .|.|.||. ||.||| .|   . 
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRAD----NDRDIYLVFEFMETDLHAVIRKGNI

FSLEHIRFFLYQILRGLKYIHSADVIHRDLKPSNLLVNENCELKVGDFGMARGLSTFST-DKKKMFMTSYVATRWYRAPELLFSSDDYTLAVDVWSVGCI
    | .. .||.|| .||.||..||||||||||.|.. .| .|| |||.|| ..     |...  .| ||||||||||| | .|  || .|| ||.|||
LKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCI

LGEMIGRKQMFPGKNPIDQLSLIVDVLGMPPTHMLKSTSSDHLYNFFQKNFANKTPKDLSKLYPKADPQGLDLLAKMLIFEPSERITVNKALQHPFL
||||.  | ||||   ..|. .|..... |    ...  |.   |  ...   . .| |....|.. ....||| ..|.| | .|.|...|||||. 
LGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMN-QQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase ERK5.AA CDK 28-322 33 2e-104 335.04 In-house 1-284 (284) Show / Hide 
Range on Protein: 28-322
Range on HMM: 1-284/284
Sequence Identity: 33% (108 aa)

YKPLEKIGTGAYGVVCSAINKKNG-----EKVAIKKIPNSFD----ELTTAKR-TFRELKILRHFRHENVIAIREILMPKEPLSEM-----KDVYVVFDL
|. ||||| |.||||  |..|..|     . ||.|||    .    | .     . || ..|..  |.|.. .... . |.. ..      . .| ||. 
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MESDLHQIIHSNQPFSLEHIRFFLYQILRGLKYIHSADVIHRDLKPSNLLVNENCE-----LKVGDFGMARGLSTFST-DKK-KMFMTSYVATRWYRAPE
|. || ....         |. ...|.|||| |.||  ..||||||.|.|.|.| |     ||..||| ||  .  .  . .  . .|. | |.||||||
MDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMS-EPNRTYTHEVVTLWYRAPE

LLFSSDDYT--LAVDVWSVGCILGEMIG---RKQMFPGKNPIDQLSLIVDVLGMPPTHMLKSTSSDHLYNFFQKNFANKTPKDLSKLYPKADPQGLDLLA
||. | .|.   ..|.||||||..||.    || .|||.. |||| .| ...| |   .  . ..  .|                           ||| 
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DLLN

KMLIFEPSERITVNKALQHPFL
||| ..|. ||.   |||||..
KMLCYDPKKRISAEQALQHPYF
Kinase ERK5.AA S_TKc 28-322 28 1.6e-100 341.19 SMART 1-231 (231) Show / Hide 
Range on Protein: 28-322
Range on HMM: 1-231/231
Sequence Identity: 28% (90 aa)

YKPLEKIGTGAYGVVCSAINKKNGEKVAIKKIPNSFDELTTAKRTFRELKILRHFRHENVIAIREILMPKEPLSEMKDVYVVFDLMES---DLHQIIHSN
|. |.||| ||.|.|. ...|| |..||||.|.         ... ||..||.. .|.|.. . ..          ...|.|.....    ||...|...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKR

QP------FSLEHIRFFLYQILRGLKYIHSADVIHRDLKPSNLLVNENCELKVGDFGMARGLSTFSTDKKKMFMTSYVATRWYRAPELLFSSDDYTL-AV
..      |.  |.||..|||...|.|.||  .|||||||.|.|..|  ..|..|||.|| |            |... |.||.|||.|     |.  ..
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL----GYGKCKC

DVWSVGCILGEMIGRKQMFPGKNPIDQLSLIVDVLGMPPTHMLKSTSSDHLYNFFQKNFANKTPKDLSKLYPKADPQGLDLLAKMLIFEPSERITVNKAL
|.||.|||| ||. ..  ||      |. .. ...|                                      .|...|.. |.| ..|..|.|. .||
DWWSCGCILYEMLCGYPPFP------QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EAL

Q-------HPFL
|       ||..
QDEWDIKCHPWF
Kinase ERK5.AA Pkinase 28-322 28 9.1e-95 325.94 Pfam 1-293 (293) Show / Hide 
Range on Protein: 28-322
Range on HMM: 1-293/293
Sequence Identity: 28% (91 aa)

YKPLEKIGTGAYGVVCSAINKKNGEKVAIKKIPNSFDELTTAKRTFR--ELKILRHFRHENVIAIREILMPKEPLSEMKDVYVVFDLMES-----DLHQI
|. ..||| |..|.|. ...|..|..||.|.|. . ..    .. .|  |..|.....|.|.. .... .        ...|.|....|      ||. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDY

IH--SNQPF--SLEHIRFFLYQILRGLKYIHSADVIHRDLKPSNLLVNENCEL----KVGDFGMARGLSTFSTDKKKMFMTSYVATRWYRAPELLFSSDD
|.  .. .|  | ....|..|||||||.|.||  .|||||||.|.|...|...    |..||| |. ..      ..  ||... |.||.|||.. .. .
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQY

YTLAVDVWSVGCILGEMIGRKQMFPGK----NPIDQLSLIVDVLGMPPTHMLKSTSSDHLYNFFQKNFANKTPKDLSKLYPKADPQGLDLLAKMLIFEPS
|. .||.||.|||| ||. ..  |||.    | .||. .|. ..| |.      ..|  ...|..   .    . .... ..... ..|.. ..| . |.
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-H----F-HWTF-HNWSEECKDFIKWCLCKDPK

ERITVNKALQHPFL
.|.|   .||||..
KRPTAEQILQHPWF
Kinase ERK5.AA MAPK-Unclassified 28-184 49 2e-85 290.09 In-house 1-173 (575) Show / Hide 
Range on Protein: 28-184
Range on HMM: 1-173/575
Sequence Identity: 49% (85 aa)

YKPLEKIGTGAYGVVCSAINKKN-GEKVAIKKIPNSFDELTTAKRTFRELKILRHFRHENVIAIREILMPKEPLS-EMKDVYVVFDLMES---DLHQIIH
| . . || ||||.|| |. ||| . .|||||..  |   |..||. ||. |||.  |.|.|.|..|...||..  | .|.|.| |.|..   ||||||.
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

SNQ-PFSLEHIRFFLYQILRGLKYIHSADVIHRDLKPSNLLVNENCELKVGDFGMAR----------GLSTFS
||| . . .||. |.|||||||||.||| .|||||||||||.|..| ... ||||.|             |||
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSIEDNQNLRFSFFTFS
Kinase ERK5.AA MAPK-Unclassified 192-322 32 1.5e-46 160.96 In-house 405-575 (575) Show / Hide 
Range on Protein: 192-322
Range on HMM: 405-575/575
Sequence Identity: 32% (56 aa)

MTSYVATRWYRAPELLFSSDDYTLAVDVWSVGCILGEMIGR-----------KQMFPGKN--------------------PIDQLSLIVDVLGMPPTHML
|| ||.||||||||...|. .|. .|| ||.|||..||. .           ...|||..                     .||. .|.|.|||||   .
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

KSTSSDHLYNFFQKNFANKTPKDLSKLYPKADP----------QGLDLLAKMLIFEPSERITVNKALQHPFL
    .|    . |  |. ||| . . |.. . |          . .|.. ||| | |. |||   ||.||. 
NFITCDSARKYIQS-FKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase ERK5.AA Pkinase_Tyr 28-221 27 8e-22 74.53 Pfam 1-199 (270) Show / Hide 
Range on Protein: 28-221
Range on HMM: 1-199/270
Sequence Identity: 27% (56 aa)

YKPLEKIGTGAYGVVCSAINK----KNGEKVAIKKIPNSFDELT-TAKRTFRELKILRHF-RHENVIAIREILM-PKEPLSEMKDVYVVFDLMES-DLHQ
 . ..|.| ||.|.|. .. |    ... .||.|..... ..     .  .||.||.... .|.|..    . .  .||      .|.|. .|.  ||. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN----QIYIVMEYMPHGDLLD

IIHS----NQPFSLEHIRFFLYQILRGLKYIHSADVIHRDLKPSNLLVNENCELKVGDFGMARGLSTFSTDKK-KMFMTSYVATRWYRAPELLFSSDDYT
  ..    .||......  . .|| .|. | .|   |||||   | ||.||   |..|||.|| .  ...|   ..   . .  .|. ||| .. .  .|
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYYYRKRGGGKLPIKWM-APECINYGK-FT

LAVDVWS
 . ||||
TKSDVWS
Kinase ERK5.AA TyrKc 28-288 21 4.5e-16 37.16 SMART 1-280 (280) Show / Hide 
Range on Protein: 28-288
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

YKPLEKIGTGAYGVVCSAINKKNGEKVAIKKIPNSFDELTTAKRTFRELKILRHF--RHENVIAIREILMPK-------EPLSEMKDVYVVFDLMES-DL
 . ..|.| ||.|.|. .. |   ..||.|.. ..       .   ||..|....  .|.|....  . . .       |||      ..|. .|.  ||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPL------MIVMEYMPHGDL

HQIIHSNQP-FSLEHIRFFLYQILRGLKYIHSADVIHRDLKPSNLLVNENCELKVGDFGMARGLSTF------STDKKKMF--MTSY-VATRWYRAPELL
.. .....| .....   | .|| .|  |.||  .|||||   | ||.||   |..|||..| .         .  ..|.    . . .  ||. ||| .
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI

FSSDDYTLAVDVWSVGCILGEMIGRKQMFPG------KNPIDQLSLIVDVLGMPPTHM-----LKSTSSDHLYNFFQKNFANKTPK-----DLSKLY
     .| . |||| |  . |.  . |. .       ..... . .. .   ||. .         . .| .|.  ..  . .  .     .. .. 
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF