Gene ERK3 (Sea Urchin)

ERK3

Species: Sea Urchin
Alias: Spk143, SPU_002614, ERK3
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK3

Sequence

Name Sequence Type Origin Length Description Download
ERK3.AA Protein None 774 None Fasta, JSON
ERK3.kin_dom Protein Kinase Domain None 299 None Fasta, JSON

Protein domain

Protein domains of ERK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ERK3.AA ERK3 39-337 70 8.49999999999e-264 858.51 In-house 1-300 (300) Show / Hide 
Range on Protein: 39-337
Range on HMM: 1-300/300
Sequence Identity: 70% (210 aa)

FCDLRPLGYGSSGTVFSAVDSECDKSVAIKRVSLTDKKSCKSALREIRILRKLQHENIVKIYDVIFDGNSDNSEDEDISIPSELRTLCIVQELVDADLRV
||||||||.||.|.|||||||||.|.||||...||||||||.|||||.|.|.|.|.||||.|.|.|...|||..||||.|..||||.|||||....||..
FCDLRPLGCGSNGLVFSAVDSECCKKVAIKKIVLTDKKSCKHALREIKIIRRLDHDNIVKVYEVLFPKGSDNQDDEDIGILFELRTVCIVQEYMETDLAC

VMEQQRISNEHVRLFAYQLLRGLKYLHSANVLHRDLKPENVLINQEDLVLKIGDFGMARIVDPDYSHKGYLTQNVSTQWYRSPELVLQPTDYTKAIDLWS
||||||.|.||.|||.|||||||||.||||||||||||.|..||.||||||||||||||||||.|||||||.....|.|||||.|.|||..||||||.|.
VMEQQRLSEEHARLFMYQLLRGLKYIHSANVLHRDLKPANIFINTEDLVLKIGDFGMARIVDPHYSHKGYLSEGLVTKWYRSPRLLLQPNNYTKAIDMWA

AGCILAEMVTGKPLFPGDHDLELMMLVLDSVQLN-DRDLNEILCTLPSKLLKNYNGYPRHPLKEVLCNLDCHALDLLLAMLTFDPSERITAEEALRSPYF
||||||||.|||.||.|.|.||.|||.|||.... ..|.||.||..|||..|||..||.||||..|||.||||||.|..||||||..|.|||.||..||.
AGCILAEMLTGKMLFAGAHELEQMMLILDSIPVVHEEDKNELLCVMPSKYIKNYMWYPHHPLKQLLCNIDCHALDFLEQMLTFDPMDRLTAEMALQHPYM
Kinase ERK3.AA MAPK 39-337 38 4.6e-148 498.18 In-house 1-328 (328) Show / Hide 
Range on Protein: 39-337
Range on HMM: 1-328/328
Sequence Identity: 38% (129 aa)

FCDLRPLGYGSSGTVFSAVDSE------CDKSVAIKRVS--LTDKKSCKSALREIRILRKL-QHENIVKIYDVIFDGNSDNSEDEDISIPSELRTLCIVQ
...|.|.|.|. |.|.||.| .      |.| ||||..|   ... .|| ..|||..|| . .||||.|..|..   .   . | | . ..|.....||.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEM---Q-D-DQNSLEEFNDIYIVM

ELVDADLRVVMEQQR-ISNEHVRLFAYQLLRG--LKYLHSANVLHRDLKPENVLINQEDLVLKIGDFGMARIVDPDYSHKG-----------YLTQNVST
|| ..||. ....|.  |..|.. | ||.|||  |||.|||||.||||||.|.|.|..... ||.|||.||..||.|.|..           ..|..|.|
ELMETDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDL-KICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVAT

QWYRSPELVLQP--TDYTKAIDLWSAGCILAEMVT-GKPLFPGDHDLELMMLVLDSVQLNDRDLNEILC--TLPSKLLKNY---NGYPRHPLKEVLCN--
.|||.||. | .  ..||||.| ||.|||.|||.| .||||||.. .. . |... .   .... . .|    . ......     ||..|......|  
RWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNAN

--LDCHALDLLLAMLTFDPSERITAEEALRSPYF
   ...|.|||  ||.|||..|||.||||. |||
FNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase ERK3.AA CMGC 39-337 23 1.8e-120 397.83 In-house 1-513 (513) Show / Hide 
Range on Protein: 39-337
Range on HMM: 1-513/513
Sequence Identity: 23% (122 aa)

FCDLRPLGYGSSGTVFSAVDSECDKS--------------VAIKRVSLT-DKKSCK----------SALREIRILRKLQ-----------------HENI
.  ....| |. |.|....| ....               ||||....  ..  .|          .|||||.||..|.                 |.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VKIYDVIFDGNSDNSEDEDISI--PSELRTLCIVQELVDADLRVVMEQQR-----------------------------ISNEHVRLFAYQLLRGLK--Y
||.||.. . |||..|.||..|  . ... |..| |..| ||  ......                             ... |.| ..||.|||||  |
VKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

LHSAN--VLHRDLKPENVLINQEDLV-------------------LKIGDFGMARIVDPDYSHKGY------------------LTQNVSTQWYRSPELV
.||..  ..||||||||.|||..  .                   |||.|||.||...|  .|...                  .|..|.| |||.||. 
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LQP---------TDYTKAIDLWSAGCILAEMVTG--------KPLFP-----------GDHDLELMMLVLDSVQLN----------------DRDLNE--
|           ..||..|| ||.|||.|||.||        |||||           |..... . .  .                     ...  .  
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

-------------------ILCTLPSKLLKN---YNGYPRHPLKEVLCN-----------------------------------LDCHALDLLLAMLTFD
                   ...    . ...   .  .|..|.|..  .                                   .|  |.|||  ||..|
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PSERITAEEALRSPYF
|..|||||.||. |||
PDKRITAEQALQHPYF
Kinase ERK3.AA ERK1 39-337 44 4.4e-91 308.91 In-house 1-289 (289) Show / Hide 
Range on Protein: 39-337
Range on HMM: 1-289/289
Sequence Identity: 44% (134 aa)

FCDLRPLGYGSSGTVFSAVDSECDKSVAIKRVSLTDKKS-CKSALREIRILRKLQHENIVKIYDVIFDGNSDNSEDEDISIPSELRTLCIVQELVDADLR
. .|. .| |  | | ||.|    . ||||..|  . .  |.  ||||.|| . .||||..| |.|          . |    ..| . |||.|.. || 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKISPFEHQTYCQRTLREIKILTRFKHENIINIQDII--------RADTI---EQMRDVYIVQCLMETDLY

VVMEQQRISNEHVRLFAYQLLRGLKYLHSANVLHRDLKPENVLINQEDLVLKIGDFGMARIVDPDYSHKGYLTQNVSTQWYRSPELVLQPTDYTKAIDLW
 ..  |..||.|.  | ||.||||||.|||||||||||| |.|.|.    ||| |||.||| ||.  | |.||  | | ||| ||..|    |||.||.|
KLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTT-CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIW

SAGCILAEMVTGKPLFPGDHDLELMMLVLDSV-QLNDRDLNEILCTLPSKLLKNYNGYPRHPLKEVLCNLDCHALDLLLAMLTFDPSERITAEEALRSPY
| |||||||.  .|.||| | |. . ..|  .      ||| |.       |.     |. |....  . | .|||||  |||| | .||| ||||  ||
SVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPY

F
 
L
Kinase ERK3.AA S_TKc 39-337 28 4.9e-90 306.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 39-337
Range on HMM: 1-231/231
Sequence Identity: 28% (89 aa)

FCDLRPLGYGSSGTVFSAVDSECDKSVAIKRVSLTDKKSCKSALREIRILRKLQHENIVKIYDVIFDGNSDNSEDEDISIPSELRTLCIVQELVDA---D
.  ||..| |. |.|. ... . .. ||||...       ....|||.||.| .|.||||.|||. |                   |..| |..|    |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-----------------DHLYMVMEYCDGDLGD

LRVVMEQQR-------ISNEHVRLFAYQLLRGLKYLHSANVLHRDLKPENVLINQEDLVLKIGDFGMARIVDPDYSHKGYLTQNVSTQWYRSPELVLQPT
|. ......       ..  |.| ..||....|.|.|| ...||||||||.|...   ..||.|||.||..          |  . | ||..||..    
LFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL----------TTFCGTPWYMAPEVL----

DYTK-AIDLWSAGCILAEMVTGKPLFPGDHDLELMMLVLDSVQLNDRDLNEILCTLPSKLLKNYNGYPRHPLKEVLCNLDCHALDLLLAMLTFDPSERIT
 |.| ..| || ||||.||..|.|.||  .. ... ...                                        .  |.|..  .|..||..|.|
GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------------------------------------SPEAKDFIRKCLQKDPEKRPT

AEEALR-------SPYF
| |||.        |.|
A-EALQDEWDIKCHPWF
Kinase ERK3.AA Pkinase 39-337 27 4.1e-86 297.19 Pfam 1-293 (293) Show / Hide 
Range on Protein: 39-337
Range on HMM: 1-293/293
Sequence Identity: 27% (90 aa)

FCDLRPLGYGSSGTVFSAVDSECDKSVAIKRVSLTDKKSCK--SALR--EIRILRKLQHENIVKIYDVIFDGNSDNSEDEDISIPSELRTLCIVQELVDA
.. .|..| ||.|.|. ...    | ||.|.... ..||.|  ...|  ||.|...|.|.|||..||.  |                 . ...|.|... 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----------------KDHIYMVMEYCEG

-----DLR-VVM--EQQRI--SNEHVRLFAYQLLRGLKYLHSANVLHRDLKPENVLINQEDLVL----KIGDFGMARIVDPDYSHKGYLTQNVSTQWYRS
     ||  ...  .. ..  | .... ..||.||||.|.|| ...||||||||.||. .. ..    ||.||| |. .|  | ... .|  . | ||..
GLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMA

PELVLQPTDYTKAIDLWSAGCILAEMVTGKPLFPGD------HDLELMMLVLD------SVQLNDRDLNEILCTLPSKLLKNYNGYPRHPLKEVLCNLDC
||...  ..|....| ||.||||.||..|.|.|||.       ..... ....      . ..... . . . . . .            ....  |.. 
PEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----------F-HWTF-HNWSE

HALDLLLAMLTFDPSERITAEEALRSPYF
 ..|..  .|..||..|.|||..| .|.|
ECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase ERK3.AA p38 39-337 35 2e-79 270.15 In-house 1-289 (289) Show / Hide 
Range on Protein: 39-337
Range on HMM: 1-289/289
Sequence Identity: 35% (108 aa)

FCDLRPLGYGSSGTVFSAVDSECDKS---VAIKRVS--LTDKKSCKSALREIRILRKLQHENIVKIYDVIFDGNSDNSEDEDISIPSELRTLCIVQELVD
. .|.|.| |. |.| .|.|.. ..    ||||. .    .    | . ||.| |. ..|||.... ||          ....   ....   .| .. .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTP------PAHSM---NDFQDVYMVTHFMG

ADLRVVMEQQRISNEHVRLFAYQLLRGLKYLHSANVLHRDLKPENVLINQEDLVLKIGDFGMARIVDPDYSHKGYLTQNVSTQWYRSPELVLQPTDYTKA
|||  .| .||.| .|...  ||.|||||| |||.. |||||| |. .| ||  |.| ||| ||      .    .|. | | |||.|| .|   .||..
ADLNNIMKCQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVN-EDCELRILDFGLAR------HCDDEMTGYVATRWYRAPEIMLNWMHYTQT

IDLWSAGCILAEMVTGKPLFPGDHDLELMMLVLDSVQLNDRDLNEILCTLPSK-LLKNYNGYPRHPLKEVLCNLDCHALDLLLAMLTFDPSERITAEEAL
.| || |||.||..||..|||||  .. .  ..  .   |. . . .    ..  ...|  .||  ...|. . .  |.|||  ||  ||  |||||||.
VDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAM

RSPYF
. |||
QHPYF
Kinase ERK3.AA ERK 39-255 41 3.7e-76 259.33 In-house 1-219 (307) Show / Hide 
Range on Protein: 39-255
Range on HMM: 1-219/307
Sequence Identity: 41% (96 aa)

FCDLRPLGYGSSGTVFSAVDSE-----CDKSVAIKRV--SLTDKKSCKSALREIRILRKLQ-HENIVKIYDVIFDGNSDNSEDEDISIPSELRTLCIVQE
. .. ..|.|. |.|.||.| |     ... |||| .     ... || .||||..|| .  ||||....|..    ..  . .||          .|.|
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPE--QYNDI---------YCVEE

LVDADL-RVVMEQQRISNEHVRLFAYQLLRGLKYLHSANVLHRDLKPENVLINQEDLVLKIGDFGMARIVDPDYSH-----KGYLTQNVSTQWYRSPELV
| . || ..   ||..| .|.  | ||.|.||||.|||||.|||||| |.|.| .. .||| ||| ||..|..|.      ....|. |.| |||.||. 
LMETDLHQIINSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVN-SNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIM

LQPTDYTKAIDLWSAGCILAEMVTGKPLFPG
|  ..||||.| ||.|||.|||. .||||||
LSWQKYTKAMDIWSCGCIFAEMLGRKPLFPG
Kinase ERK3.AA CDK 39-260 35 7.1e-76 242.2 In-house 1-232 (284) Show / Hide 
Range on Protein: 39-260
Range on HMM: 1-232/284
Sequence Identity: 35% (89 aa)

FCDLRPLGYGSSGTVFSAVDSECD-----KSVAIKRVSLTDK-------KSCKSALREIRILRKLQHENIVKIYDVIFDGNSDNSEDEDISIPSEL-RTL
.. |  .| |. |.|. | | . .     . ||.|.. .  .           .|.||| .|..| |.||||..||. . |.|..   |        ..|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDK-----HENKL

CIVQELVDADLRVVMEQQRISNEHVRLFAYQLLRGLKYLHSANVLHRDLKPENVLINQEDL----VLKIGDFGMARIVDP----DYSHKGYLTQNVSTQW
 .| | .| ||  .|.        .. . .|||||| |.|| ...|||||| | |||        .|||.||| ||.       .      .| .| | |
YMVFEYMDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMS-EPNRTYTHEVVTLW

YRSPELVLQPTDYT--KAIDLWSAGCILAEMVT---GKPLFPGDHDLE
||.||| |  ..|.   .||.||.|||.|||.|   .||||||| ...
YRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEID
Kinase ERK3.AA ERK5 39-337 36 4e-73 249.25 In-house 1-295 (295) Show / Hide 
Range on Protein: 39-337
Range on HMM: 1-295/295
Sequence Identity: 36% (114 aa)

FCDLRPLGYGSSGTVFSAVDSECDKSVAIKRV--SLTDKKSCKSALREIRILRKLQHENIVKIYDVIFDGNSDNSEDEDISIPSELRTLCIVQELVDADL
.  .  .| |  | | ||.     . ||||..  .       |  .||..|||  .|.||. | |..                ||..   .| .|...||
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDIL----------MPKVPYSEMKDVYVVFDLMESDL

-RVVMEQQRISNEHVRLFAYQLLRGLKYLHSANVLHRDLKPENVLINQEDLVLKIGDFGMARIVDP--DYSHKGYLTQNVSTQWYRSPELVLQPTDYTKA
  ..  .| .. ||.| | ||.||||||.|||.|.|||||| |.|.| |   |||||||||| .       |. ..|. | | ||| |||..   |||.|
HQIIHSNQPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQA

IDLWSAGCILAEMVTGKPLFPGDHDLELMMLVLDSVQLNDRDLNEILCTLPSKLLKNYNGY---PRHP--LKEVLCNLDCHALDLLLAMLTFDPSERITA
||.|| |||. ||.. . .|||   .. . |... . .       .. .  .  ..||      .| |  ...|    |  |||||  || |.||||||.
IDVWSVGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPP---PHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITV

EEALRSPYF
 .||. |. 
NKALQHPFL
Kinase ERK3.AA CDC2 39-256 34 1.6e-68 209.52 In-house 1-212 (301) Show / Hide 
Range on Protein: 39-256
Range on HMM: 1-212/301
Sequence Identity: 34% (80 aa)

FCDLRPLGYGSSGTVFSAVDSECDKSVAIKRVSLTDKKSC----KSALREIRILRKLQ-HENIVKIYDVIFDGNSDNSEDEDISIPSELRTLCIVQELVD
.. .. .| |. | |. . | . .. ||.|.. |.          .|.||| .| .|. |.||||. |||.                  . | .| | .|
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-----------------NKLYMVFEYLD

ADLRVVME-----QQRISNEHVRLFAYQLLRGLKYLHSANVLHRDLKPENVLINQEDLVLKIGDFGMARIVDPDYSHKGYLTQ-NVSTQWYRSPELVLQP
 ||.  |.     .. .. . |. ..||.|.|. ..|.  ..|||||| | ||. .   .||.||| || .   . .. |.|. .| | |||.||. |  
MDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN-IKIADFGLARAF--GIPIRTYTTEHEVVTLWYRAPEILLGC

TDYTKAIDLWSAGCILAEM---VTGKPLFPGD
 .|. ..|.|| |||.|||   || ||||.||
KRYSTPVDMWSIGCIFAEMFMDVTKKPLFHGD
Kinase ERK3.AA MAPK-Unclassified 45-197 40 3.8e-47 162.95 In-house 7-157 (575) Show / Hide 
Range on Protein: 45-197
Range on HMM: 7-157/575
Sequence Identity: 40% (65 aa)

LGYGSSGTVFSAVDSEC-DKSVAIKRVS--LTDKKSCKSALREIRILRKLQHENIVKIYDVIFDGNSDNSEDEDISIPSELRTLCIVQELVDA---DLRV
.| |. | |  |.|.    . ||||.|    ...  || .|||||||| | |.||..| |.. .    |          |  .. || ..      ||  
IGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHN---------QEFDDIYIVMDYMQTSLFDLHQ

VMEQQR--ISNEHVRLFAYQLLRGLKYLHSANVLHRDLKPENVLINQEDLVLKIGDFGMAR
.  .     . .|.. | ||.||||||||||...|||||| |.|||| |. ..| ||||.|
IIKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQ-DCSVRICDFGMSR
Kinase ERK3.AA MAPK-Unclassified 201-256 40 3.8e-22 76.5 In-house 397-463 (575) Show / Hide 
Range on Protein: 201-256
Range on HMM: 397-463/575
Sequence Identity: 40% (27 aa)

PDYSHKGYLTQNVSTQWYRSPELVLQPTDYTKAIDLWSAGCILAEMVTG-----------KPLFPGD
.| .|....|| |.| ||| ||. |   .|....|.||.|||.|||.             .|||||.
NDCHHCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQ
Kinase ERK3.AA Pkinase_Tyr 39-207 24 7.6e-18 61.07 Pfam 1-172 (270) Show / Hide 
Range on Protein: 39-207
Range on HMM: 1-172/270
Sequence Identity: 24% (46 aa)

FCDLRPLGYGSSGTVFSAVDS----ECDKSVAIKRV-SLTDKKS--CKSALREIRILRKL-QHENIVKIYDVIFDGNSDNSEDEDISIPSELRT--LCIV
   .. || |. |.|. ..      . .  ||.| .   ....    .. .||..|...| .|.|||. | |.                .. .   ..||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT---------------DQGEPNQIYIV

QELVDA-DLRVVMEQQ-----RISNEHVRLFAYQLLRGLKYLHSANVLHRDLKPENVLINQEDLVLKIGDFGMARIV--DPDY-SHKG
 |..   ||.    ..     ... ..   ...|  .|. ||.| |  ||||   |.|..  ..| ||.|||.|| .  |  |   .|
MEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-NNVVKICDFGLARDIYNDDYYYRKRG
Kinase ERK3.AA TyrKc 39-337 22 2.3e-14 9.57 SMART 1-280 (280) Show / Hide 
Range on Protein: 39-337
Range on HMM: 1-280/280
Sequence Identity: 22% (73 aa)

FCDLRPLGYGSSGTVFSAVDSECDKSVAIKRVSLTDKKSCKSALREIRILRKL--QHENIVKIYDVIFDG--NSDNSEDEDISIPSEL---RTLCIVQEL
   .. || |  |.|. .. .     ||.| .        .  .||.||..||  .|.|||..| |. ..  |                    |.|| |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--------------FMYIEPLMIVMEY

VDA-DLRVVMEQQR--ISNEHVRLFAYQLLRGLKYLHSANVLHRDLKPENVLINQEDLVLKIGDFGMARIVDPD--------YSHKGY--LTQN-VSTQW
..  ||.      |  .....   |..|  .|  |||| |. ||||   |.|.. .  . ||.|||..| .. |        | .|     .   .   |
MPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

YRSPELVLQPTDYTKAIDLWSAGCILAEMVT-GKPLFPGD----HDLELMMLVLDSVQLNDRDLN--EILCTLPSKLLKNYNGYPRHPLKEVLCNLDCHA
. .|| ...   .| . | || |  . |. | |..  ||.     . . ..  ...    ..  |  . .                     | |  . . 
M-APE-CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS-----------------F--VCCPDEMYQ

LDLLLAMLTFDPSERITAEEALRSPYF
  . .    .||..| | .|     .|
--IMKQCWHEDPEDRPTFSEI--HECF
Kinase ERK3.AA ERK 286-337 42 4.7e-14 48.9 In-house 252-307 (307) Show / Hide 
Range on Protein: 286-337
Range on HMM: 252-307/307
Sequence Identity: 42% (24 aa)

KLLKNYNG--YPRHPLKEVLCN--LDCHALDLLLAMLTFDPSERITAEEALRSPYF
|..||..   .|  |....  |  .   |.|||  ||.|||..|||.||.|. |||
KYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase ERK3.AA CDK 288-337 36 1.4e-13 39.7 In-house 255-284 (284) Show / Hide 
Range on Protein: 288-337
Range on HMM: 255-284/284
Sequence Identity: 36% (18 aa)

LKNYNGYPRHPLKEVLCNLDCHALDLLLAMLTFDPSERITAEEALRSPYF
| .|                    |||  ||..||. ||.||.|| .|||
LPDY--------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase ERK3.AA CDC2 294-337 37 2e-13 37.1 In-house 249-301 (301) Show / Hide 
Range on Protein: 294-337
Range on HMM: 249-301/301
Sequence Identity: 37% (20 aa)

YPRHPLKEVLCN---------LDCHALDLLLAMLTFDPSERITAEEALRSPYF
...  |.... |         ||  ..|||  ||  ||. ||.|.|||. |||
WKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase ERK3.AA MAPK-Unclassified 307-337 48 7.2e-10 31.34 In-house 545-575 (575) Show / Hide 
Range on Protein: 307-337
Range on HMM: 545-575/575
Sequence Identity: 48% (15 aa)

DCHALDLLLAMLTFDPSERITAEEALRSPYF
.| ..|..  || |.|. ||||..||  |||
NCECIDFVQKMLQFNPWKRITADQALEHPYF