Gene MOK (Sea Urchin)

MOK

Species: Sea Urchin
Alias: MOK, SPU_023957, Spk150
External Links: Sea Urchin Project Link ,
Annotation:

Classification

Group: CMGC
Family: RCK
Subfamily: MOK

Sequence

Name Sequence Type Origin Length Description Download
MOK.AA Protein None 437 None Fasta, JSON
MOK.kin_dom Protein Kinase Domain None 239 None Fasta, JSON

Protein domain

Protein domains of MOK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MOK.AA MOK 1-283 79 1e-242 769.41 In-house 1-283 (283) Show / Hide 
Range on Protein: 1-283
Range on HMM: 1-283/283
Sequence Identity: 79% (226 aa)

YRVLGKKGEGTFSEVLKCQNIQDGTYYACKKMKQNYQSLEQVNNLREIQAMKRLSPHANILELKEVIFDRKTGNLSLVCELMDMNIYELIRGRRHYLPQE
|. .|| ||||||||.| | ..|| |||||.||| ..|.||||||||||||.||.||.|||.|.||.||||||||.|.|||||||||||||||||||||.
YKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQVNNLREIQAMRRLNPHPNILMLHEVVFDRKTGNLALICELMDMNIYELIRGRRHYLPQK

KVKNYIYQLIKALEHMHRNGIFHRDVKPENILIRDDHLKLADFGSCRSVYSKQPFTEYISTRWYRAPECLLTDGYYSYQMDMWSVGCVFYEILSLHPLFP
|...|.|||.|.|.|||||||||||||||||||..|||||||||||||||||||.|||||||||||||||||||||.|||||||||||||||.|||||||
KIMHYMYQLCKSLDHMHRNGIFHRDVKPENILIKQDHLKLADFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGYYTYQMDMWSVGCVFYEIASLHPLFP

GANEVDQIAKIHDVMGTPDATILNKFRNKARGINYNFPSKKGSGIEKLLPNATKQTLEIMNKLCTYDPDERITAKQVIRHAFF
|.||||||.|||||||||...|||||.|..|..||.||.|||||||||.||.|||.||||.|.|||||||||||.|||.|..|
GVNEVDQISKIHDVMGTPCQKILNKFKNQSRAMNYDFPFKKGSGIEKLTPNLTKQCLEIMHKMCTYDPDERITAHQVIQHPYF
Kinase MOK.AA RCK 1-283 46 2.2e-202 648.37 In-house 1-298 (298) Show / Hide 
Range on Protein: 1-283
Range on HMM: 1-298/298
Sequence Identity: 46% (140 aa)

YRVLGKKGEGTFSEVLKCQNIQDGTYYACKKMKQNYQSLEQVNNLREIQAMKRLSPHANILELKEVIFDRKTGNLSLVCELMDMNIYELIRG---RRHYL
| .. ..|.||...|.| ||. .| ..|.||||| . |.|...|||||.....|.||.||..|||||.|..|..|..|.|.||||.|.....   ||.||
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYL

PQEK--VKNYIYQLIKALEHMHRNGIFHRDVKPENILIR----------DDHLKLADFGSCRSVYSKQPFTEYISTRWYRAPECLLTDGYYSYQMDMWSV
|...  .||..||....|.|||..|.||||.|||||...          .||.|.||||.||...||.|.|.|.||||||||||||...||...||.|.|
PENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAV

GCVFYEILSLHPLFPGANEVDQIAKIHDVMGTPDATILNKFRNKARGINYNFPSKKGSGIEKLLPNATKQTLEIMNKLCTYDPDERITAKQVIRHAFF
||..||. .|.|||||..|.||| ||..|||||. .........|...|.|||..||.....|.||......|.|.|....||..||||.|...| .|
GCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase MOK.AA CMGC 1-283 21 1e-116 385.32 In-house 1-513 (513) Show / Hide 
Range on Protein: 1-283
Range on HMM: 1-513/513
Sequence Identity: 21% (113 aa)

YRVLGKKGEGTFSEVLKCQN--------------IQDGTYYACKKMKQNYQSLEQVN-----------NLREIQAMKRLS----------------PHAN
| ...| ||||...| ||..              .... ..| ||.|..    ||              ||||. .|.|.                 | |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

ILELKEVIFDRKTG---------------NLSLVCELMDMNIYELIRG--------RRHYLPQEK------------VKNYI------YQLIKALE--HM
|. |.... ....                .| || |.||.. |..|.         |...|.. .            .|...      ||....|.  ..
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HRNG--IFHRDVKPENILIRDD---------------------HLKLADFGSCRSVYSK----------------------QPFTEYISTRWYRAPECLL
|...  |.||| ||||||| ..                     .||..|||..|.. .                       .|.|.|..|||||||| ||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

TDGYYS---------YQMDMWSVGCVFYEILS--------LHPLFPGANE-----------VDQIAKIHDVMGTPD---------------AT-------
 ...|.         ...|||||||.|.|..         ..||||| .|           .||..|| .|.|||.                        
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

------------------ILNKFRNKARGINYNFPSKKGSGIEKLLPN-----------------------------------ATKQTLEIMNKLCTYDP
                  ....|  ... .| .|| ...  ...| |.                                   ...| .. ..|. .|||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

DERITAKQVIRHAFF
|.||||.|  .| .|
DKRITAEQALQHPYF
Kinase MOK.AA MAK 1-283 32 3.7e-106 339.0 In-house 1-352 (352) Show / Hide 
Range on Protein: 1-283
Range on HMM: 1-352/352
Sequence Identity: 32% (115 aa)

YRVLGKKGEGTFSEVLKCQN------------------------------IQDGTYYACKKMKQNYQSLEQVNNLREIQAMKRLSPHANILELKEVIFDR
| .. . | ||. .|.. .                               |  |   | |.||. . |.|   ||||. ..| |. |.||  ||||| | 
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDS

KTGNLSLVCELMDMNIYELIRGRRH-YLPQEKVKNYIYQLIKALEHMHRNGIFHRDVKPENILIRD------------------DHLKLADFGSCRSVYS
    | .| | |  | |... .|.  ..|   ..| .||   .| .||..| |||| |||||..                    . .|.||||  | . |
ENDHLYFVFEYMKENLYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIRS

KQPFTEYISTRWYRAPECLLTDGYYSYQMDMWSVGCVFYEILSLHPLFPGANEVDQIAKIHDVMGTPDATI----------------LNKFRNKARGINY
| |.| |.||||||||| ||  .|||  .||| |||.  |. .. |||||..|.||| ||  |.|||. .                      . |  .|.
KPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQLAHMMNF

NFPSKKG---SGIEKLLPNATK-QTLEIMNKLCTYDPDERITAKQVIRHAFF
 ||   .   . ...|.||. .   .|.| ..  .||..| ||.|  .. .|
RFPQCVPPSIMPLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase MOK.AA S_TKc 1-283 28 3.5e-86 293.54 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-283
Range on HMM: 1-231/231
Sequence Identity: 28% (85 aa)

YRVLGKKGEGTFSEVLKCQNIQDGTYYACKKMKQNYQSLEQVNNLREIQAMKRLSPHANILELKEVIFDRKTGNLSLVCELMDM---NIYELIRGRRH--
|..| | |.|.|..| ||... .| ..|.|..|         . .|||| .|.   | ||  |..|. |   ..| .| |..|    . ...|. |..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

---YLPQEKVKNYIYQLIKALEHMHRNGIFHRDVKPENILIRDDHLKLADFGSCRSVYSKQPFTEYISTRWYRAPECLLTDGYYSY-QMDMWSVGCVFYE
   ..|   .. |.||...|||..|..|| |||.||||||. . |.|..|||..| .      | .. |.||.||| |     |..   |.||.||..||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

ILSLHPLFPGANEVDQIAKIHDVMGTPDATILNKFRNKARGINYNFPSKKGSGIEKLLPNATKQTLEIMNKLCTYDPDERITAKQVIR-------HAFF
 |.  |.||      |.... ...|                                    ... .....|....||..|.|| .. .       | .|
MLCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MOK.AA CDK 1-283 30 4.6e-85 272.09 In-house 1-284 (284) Show / Hide 
Range on Protein: 1-283
Range on HMM: 1-284/284
Sequence Identity: 30% (99 aa)

YRVLGKKGEGTFSEVLKCQNIQDG-----TYYACKKMK---QNYQSLE----QVNNLREIQAMKRLSPHANILELKEVIFDRKTG---------NLSLVC
|  | | ||||. .| |... |.|      ..| || .   .  .. |        .|||  .| |  |.||  |..|. . ..          .|..| 
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEG-REEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVF

ELMDMNIYELIRGRRHYLPQEKVKNYIYQLIKALEHMHRNGIFHRDVKPENILIRDDH------LKLADFGSCRSVYS-------KQPFTEYISTRWYRA
| ||.  .....          .|.|..||...|...|.|.| ||| || |||| ..       ||.||||  |   .        ...|  . |.||||
EYMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRA

PECLLTDGYYS--YQMDMWSVGCVFYEILS---LHPLFPGANEVDQIAKIHDVMGTPDATILNKFRNKARGINYNFPSKKGSGIEKLLPNATKQTLEIMN
|| || .  ||   . |||||||.|.|..      ||||| .| ||. || ...|||.  .   .                               . .|
PELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLN

KLCTYDPDERITAKQVIRHAFF
|. .|||. ||.|.|   | .|
KMLCYDPKKRISAEQALQHPYF
Kinase MOK.AA CDC2 1-283 32 6.6e-83 254.55 In-house 1-301 (301) Show / Hide 
Range on Protein: 1-283
Range on HMM: 1-301/301
Sequence Identity: 32% (99 aa)

YRVLGKKGEGTFSEVLKCQNIQDGTYYACKKMKQNYQSLEQ---VNNLREIQAMKRLSPHANILELKEVIFDRKTGNLSLVCELMDMNIYELIR---GRR
|  . | ||||. .| ||.. |.... | || .  ... .       .|||  .| | .| ||  |..||.     .| .| | .||.  .. .   . .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

HYLPQEKVKNYIYQLIKALEHMHRNGIFHRDVKPENILIRDD-HLKLADFGSCRSV-YSKQPFT--EYISTRWYRAPECLLTDGYYSYQMDMWSVGCVFY
 ..|...||.|.||....... |...|.||| || |||| ..  .|.||||  | . . . . |    . |.|||||| || . .||   ||||.||.|.
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFA

EI---LSLHPLFPGANEVDQIAKIHDVMGTPDATILNKFRNKARGINYNFPSKKGSGIEKLLPN---------ATKQTLEIMNKLCTYDPDERITAKQVI
|.    . .|||.|  | ||. ||  ..|||.  ...    .    .  ||  | ....|..||         .... ... ...  |||  ||.||. .
EMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVT-QLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEAL

RHAFF
.| .|
QHPYF
Kinase MOK.AA Pkinase 1-283 29 1.8e-77 268.47 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1-283
Range on HMM: 1-293/293
Sequence Identity: 29% (91 aa)

YRVLGKKGEGTFSEVLKCQNIQDGTYYACKKMKQNYQSLEQ-VNNLR--EIQAMKRLSPHANILELKEVIFDRKTGNLSLVCELMDM-----NIYELIR-
|....| |.|.|..| ||... .|  .|.|..|   .. .. ....|  ||| ||||  | ||..|...  |   ... .| |....       ...|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

GRRHYL--PQEKVKNYIYQLIKALEHMHRNGIFHRDVKPENILIR-DDHL----KLADFGSCRS--VYSKQPFTEYISTRWYRAPECLLTDGYYSYQMDM
 |.  .  . . .|.|.||....||..|..|| |||.|||||||  ..|.    |..|||...     ... .| .  |.||.||| .... ||..  ||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSVGCVFYEILSLHPLFPGA----NEVDQIAKIHDVMGTPDATILNKFRNKARGINYNFPSKKGSGIEKLLPNATKQTLEIMNKLCTYDPDERITAKQVI
||.||..|| |. .|.|||.    | .||...|  .||.|      . ... .    ..   .    ... .|...  ..........|| .|.||.|. 
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQIL

RHAFF
 | .|
QHPWF
Kinase MOK.AA CDKL 1-283 35 2.9e-72 246.34 In-house 1-286 (286) Show / Hide 
Range on Protein: 1-283
Range on HMM: 1-286/286
Sequence Identity: 35% (103 aa)

YRVLGKKGEGTFSEVLKCQNIQDGTYYACKKMKQ-NYQSLEQVNNLREIQAMKRLSPHANILELKEVIFDRKTGNLSLVCELMDMNIYELIRGRRHYLPQ
|  ||| |||    |.|| |   |.. | || |   .. ..  . .|||   | |  | || .|.||   |. . | || | .| .. ..   . . ...
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLK-HENIVNLIEVF--RRKRKLHLVFEYCDHTVLHELEEYPNGVDE

EKVKNYIYQLIKALEHMHRNGIFHRDVKPENILIR--DDHLKLADFGSCRSVYSKQP--FTEYISTRWYRAPECLLTDGYYSYQMDMWSVGCVFYEILSL
..|..|..|..||... | . . |||.|||||||   .. .|| |||  |   .|.    |.|  |||||||| |. |  |.   |.|..|||. | .. 
HVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDG

HPLFPGANEVDQIAKIHDVMGTPDATILNKFRNKARGINYNFPS-KKGSGIEKLLPNAT-KQTLEIMNKLCTYDPDERITAKQVIRHAFF
.||.|| ...||  .|  ..|.  .   . |. . . .   ||  ..   .|| .||.  | .| .| |.   |||||.|..|  .| .|
QPLWPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase MOK.AA MAPK 1-283 28 2.1e-57 197.03 In-house 1-328 (328) Show / Hide 
Range on Protein: 1-283
Range on HMM: 1-328/328
Sequence Identity: 28% (94 aa)

YRVLGKKGEGTFSEVLKCQNIQ------DGTYYACKKMK---QNYQSLEQVNNLREIQAMKRLSPHANILELKEVIFDR-----KT----GNLSLVCELM
|. | . |.| .  | ..          .|.. | ||.    || ..   .  .|||  ....  | ||  |....        ..      . .| |||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRT--YREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELM

DMNIYELIRGRRHYLPQEKVKNYIYQLIKA--LEHMHRNGIFHRDVKPENILIR-DDHLKLADFGSCRSVYSK-------QPF--------TEYISTRWY
. . . .|. ..  |  . ..  .||....  | ..|  .. ||| ||.|||.  .. ||..|||  ||. ..       . .        |||..||||
ETDLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWY

RAPECLLTD--GYYSYQMDMWSVGCVFYEILS-LHPLFPGANEVDQIAKIHDVMGTPDATILNKFR-NKAR---GINYN-FPSKKGSGIEKLLPN----A
|||| .|      |. ..||||||| | | |.  .||||| . .||. .| .|.|||.   ...   ...      ... .| ...   ||..||    |
RAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNA

TKQTLEIMNKLCTYDPDERITAKQVIRHAFF
. | .  . |. . |||.|||... ..| .|
NPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase MOK.AA p38 1-283 30 6.1e-56 189.59 In-house 1-289 (289) Show / Hide 
Range on Protein: 1-283
Range on HMM: 1-289/289
Sequence Identity: 30% (89 aa)

YRVLGKKGEGTFSEVLKCQNIQDGTY---YACKKMKQNYQSLEQVNNL-REIQAMKRLSPHANILELKEVIFD--RKTGNLS---LVCELMDMNIYELIR
|. |   |.| . .| |    . |..    | ||.   .|| .      ||.   | .  | |...| .|     .   ...   .| ..|.   . ...
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMR-HENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMK

GRRHYLPQEKVKNYIYQLIKALEHMHRNGIFHRDVKPENILIRDD-HLKLADFGSCRSVYSKQPFTEYISTRWYRAPECLLTDGYYSYQMDMWSVGCVFY
  |  |  ....  .||....|   |  || ||| || || . .|  |.  |||  |     .  |.|. |||||||| .|  . |    |.|||||.  
CQR--LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR--HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMA

EILSLHPLFPGANEVDQIAKIHDVMGTPDATILNKFRNK-ARGINYNFPSKKGSGIEKLLPNATKQTLEIMNKLCTYDPDERITAKQVIRHAFF
|...  .|||| . .||. .|  |.||||.....|  .. ||    . |  .    ......|. | .. . |.   ||| ||||.. ..|..|
ELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase MOK.AA CDK4 1-218 36 4.6e-46 155.92 In-house 1-228 (290) Show / Hide 
Range on Protein: 1-218
Range on HMM: 1-228/290
Sequence Identity: 36% (84 aa)

YRVLGKKGEGTFSEVLKCQNIQDGTYYACKKMKQNYQSLEQ-----VNNLREIQAMKRL--SPHANILELKEVIFDRKTGN----LSLVCELMDMNIYEL
|  .   ||| .  | .   ...|  .| |. .   .. |      .  .|||  |..|  . |.||  |..|     |.     . .| |. |    ..
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVR--IPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTY

IRGRRH-YLPQEKVKNYIYQLIKALEHMHRNGIFHRDVKPENILI-RDDHLKLADFGSCRSVYSKQ-PFTEYISTRWYRAPECLLTDGYYSYQMDMWSVG
..      .|.. .|    ||. ...  | . | ||| ||.|||. .| |.||||||  | .|| |  .|  . | |||||| ||   ||    ||||||
LDKCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLAR-IYSFQMALTPVVVTLWYRAPEVLLQS-YYNTPVDMWSVG

CVFYEILSLHPLFPGANEVDQIAKIHDVMGTP
|.| |.    |||.| .|.||  || ||||.|
CIFAEMYCRRPLFCGQSEKDQLHKIFDVMGLP
Kinase MOK.AA TyrKc 1-282 21 3.5e-13 -9.49 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-282
Range on HMM: 1-280/280
Sequence Identity: 21% (69 aa)

YRVLGKKGEGTFSEVLKCQNIQDGTYYACKKMKQNYQSLEQVNNLREIQAMKRL-SPHANILELKEVIFDRKT-----GNLSLVCELMDM-NIYELIRGR
 . . | ||| | || |.. .   .  | |..| .     .   .||.. |..|   | ||. |  |. . .      . | .| |.|.  .  . .| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

RHYLPQEKVKNYIYQLIKALEHMHRNGIFHRDVKPENILIRDDH-LKLADFGSCRSVYSK-------QPFT------EY--ISTRWYRAPECLLTDGYYS
|. |. ..  .. .|  .  |. |.... |||    |.|. ..|  | .||| .| .|..       .  .      .   .  ||. ||||.  .| ..
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKFT

YQMDMWSVGCVFYEILSL-HPLFPG-------ANEVDQIAKIHDVMGTPDA----TILNKFRNKARGINYNFPSKKGSGIEKLLPNATKQTLEIMNKLCT
 . | || | . .||...  .  ||       . || .  |  . |  |.                                  . ...   .|| . . 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------F-VCCPDEMYQIMKQCWH

YDPDERITAKQVIRHAF
.||..| | ... .. |
EDPEDRPTFSEI-HECF
Kinase MOK.AA CDK4 237-283 25 1.6e-09 28.66 In-house 244-290 (290) Show / Hide 
Range on Protein: 237-283
Range on HMM: 244-290/290
Sequence Identity: 25% (12 aa)

FPSKKGSGIEKLLPNATKQTLEIMNKLCTYDPDERITAKQVIRHAFF
||...   .... |   || .. ..|  .|... |..| |   | .|
FPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase MOK.AA Pkinase_Tyr 8-195 24 1.3e-07 26.46 Pfam 8-210 (270) Show / Hide 
Range on Protein: 8-195
Range on HMM: 8-210/270
Sequence Identity: 24% (51 aa)

GEGTFSEVLKCQNI----QDGTYYACKKMKQNYQSLE--QVNNLREIQAMKRLSPHANILELKEVIF-DRKTGNLSLVCELMDM-NIYELIRGR---RHY
||| | || |.       ....  | |..|... . .  .   .||.. || |  | ||. |  |.  ... ... .| |.|   . ..  | .   .. 
GEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQP

LPQEKVKNYIYQLIKALEHMHRNGIFHRDVKPENILIR-DDHLKLADFGSCRSV-----Y-SKQPFTEYISTRWYRAPECLLTDGYYSYQMDMWSVGCVF
|. .   .. .|  |..|. ..... |||.   |.|.  . . | .||| .| .     |  |.  .  .  .|. ||||. .   .. . | || | . 
LTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWM-APECINYGK-FTTKSDVWSFGVLM

YEILSL
.||...
WEIFTY