Gene IRE1 (Sea Urchin)

IRE1

Species: Sea Urchin
Alias: SPU_009434, Spk164, IRE1
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: IRE

Sequence

Name Sequence Type Origin Length Description Download
IRE1.AA Protein None 304 None Fasta, JSON
IRE1.kin_dom Protein Kinase Domain None 143 None Fasta, JSON

Protein domain

Protein domains of IRE1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRE1.AA IRE 4-146 54 2.3e-95 323.13 In-house 138-292 (292) Show / Hide 
Range on Protein: 4-146
Range on HMM: 138-292/292
Sequence Identity: 54% (85 aa)

VHRDIKPHNVLISQ--PNQHG-KVKAMISDFGLCKKLSAGRMSFSR--RSGVAGTDGWIAPEMLTG--QDRTTTAIDIFSLGCVFYYVLSNGKHPFG-DS
||||.||||.||..  ||||| ....|||||||||.|..||.||.|  |||..||.||..||||..  |.|.|...||||.|||||||..||.|||| |.
VHRDLKPHNILIHMNRPNQHGENNRFMISDFGLCKMLVEGRYSFTRNIRSGPTGTWGWHPPEMLQEFCQKRKTKSVDIFSMGCVFYYVMTNGQHPFGNDK

LHRQANIISGEYSLDLLPPDDEIA----HQLITQMVDPYFDTRPEANAILRHPFF
|||||||..|.|.|| | ......    ..||.||.......||.....|.||||
LHRQANILKGKYNLDQLKHHNHWHIVIACDLIHQMIHHDPQKRPTIKECLNHPFF
Kinase IRE1.AA Ciliate-E2 4-146 23 6.8e-27 89.34 In-house 183-365 (365) Show / Hide 
Range on Protein: 4-146
Range on HMM: 183-365/365
Sequence Identity: 23% (47 aa)

VHRDIKPHNVLISQPNQHGKVKAMISDFGLCK----------------KLSAGRMSFSRRSG-------------VAGTDGWIAPEMLTGQDRTT-----
.|||||| |.|.            |.||||.|                ..   .   || .|             ..|| |  |||.| |.. ..     
IHRDIKPENILF----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQK

---TAIDIFSLGCVFYYVLSNGKHPFGDSLHRQANIISGEYSLD----------------LLPPDDEIAHQLITQ----MVDPYFDTRPE-ANAILRHPF
   ...||.|||...|. |. ||.||      | .|. ......                     .. . .|| .    | .   . |.  .. || ||.
GYDYKCDIWSLGVILYEMLF-GKPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPW

F
|
F
Kinase IRE1.AA Pkinase 4-146 25 2.3e-26 94.33 Pfam 130-293 (293) Show / Hide 
Range on Protein: 4-146
Range on HMM: 130-293/293
Sequence Identity: 25% (43 aa)

VHRDIKPHNVLISQPNQHGKVKAMISDFGLCKKLSAGRMSFSRRSGVAGTDGWIAPEMLTGQDRTTTAIDIFSLGCVFYYVLSNGKHPFG--------DS
.|||.|| |.||.. .. .  .  |.||||.|...    . |  ....|| ...||| . |.   ....|..|.||..|..|. |. ||         | 
IHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQ

LHRQANIISGEYSLDLLPPDD-------------------EIAHQLITQMVDPYFDTRPEANAILRHPFF
... ..| ..... |   ...                   | . ..|. . ..    || |  || ||.|
MQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase IRE1.AA CAMK 4-146 18 1.1e-22 69.34 In-house 201-425 (425) Show / Hide 
Range on Protein: 4-146
Range on HMM: 201-425/425
Sequence Identity: 18% (41 aa)

VHRDIKPHNVLISQPNQHGK------------VKAMISDFGLCKKLSAGRMSF--------------------SRRSGVAGTDGWIA-PEMLTG------
||||.|| |.|... | .               .  |.|||. .|.  |  .|                       . . || . .| ||.| |      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------QDRTTTAIDIFSLGCVFYYVLSNGKHPFGDSLHRQA---------------NIISGEYSLDLLPPDD----------------------EIAH
       ..  . ..|. |.|.. |  |. |. || .. . .                .|..|.|. .  . ..                      . . 
QNATDEEKPYYGPKCDMWSCGVILYIMLC-GYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

QLITQMVDPYFDTRPEANAILRHPFF
.|| .|  .  . |. .  .|.||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase IRE1.AA Ciliate-E2-Unclassified 4-146 23 1e-20 68.64 In-house 166-352 (352) Show / Hide 
Range on Protein: 4-146
Range on HMM: 166-352/352
Sequence Identity: 23% (44 aa)

VHRDIKPHNVLISQPNQHGKVKAMISDFGLCKKLS------------AGRMSFSRRSGVAGTDGWI----APEMLTGQDRTT---TAIDIFSLGCVFYYV
.|||||| |.|... ..  . .  |.|||..||.              .. .. . . ..|| . .    |||.| ||   .    ..||.|||...|. 
IHRDIKPENILFDNNGK--NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM

LSNGKHPFGDSL------------------HRQANIISGEYSLDLLPP--DDEIAH--------QLITQMVDPYFDTRPEANAILRHPFF
|  |..||.|                      . ||. .... .  |.  .. . .        .|. .| .   . |. .. || ||.|
L-FGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase IRE1.AA TKL 4-144 18 6e-19 64.88 In-house 162-364 (364) Show / Hide 
Range on Protein: 4-144
Range on HMM: 162-364/364
Sequence Identity: 18% (38 aa)

VHRDIKPHNVLISQPNQH---------GKVKAMISDFGLCKKLSAGR-MSFS---------------RRSGVAGTDGWIAPEMLTGQDRTTTAI------
.|||.|..|.|. . ...           ... |.||||.. .|    |. .               ... . || .| |||.| ||. .| .       
IHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFC

---------DIFSLGCVFYYVLSNGKHPFGDSLHRQAN---------IISGEYSLDLLPP--------------DDEIAHQLITQMVDPYFDTRPEANAI
         |..| | |.. .|.  . |. |  ...           .. .. .| ...|               ..   .|...  |.  . || .. |
KGFEYSEKCDVYSFGIVLWEILTRCR-PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEI

LRHP
| . 
LKRL
Kinase IRE1.AA STE 4-80 28 1.7e-16 54.86 In-house 174-257 (359) Show / Hide 
Range on Protein: 4-80
Range on HMM: 174-257/359
Sequence Identity: 28% (27 aa)

VHRDIKPHNVLISQPNQHGKVKAMISDFGLCKKLSAGRM------------SFS-RRSGVAGTDGWIAPEMLTGQDRT-----TTAIDIFSLGCV
.|||||| |.|.          . ..|||.|..|.                . . .|  ..||  | |||........     .|  || ||||.
IHRDIKPANILL----------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCT
Kinase IRE1.AA Ciliate-E2a 4-92 32 2.1e-14 38.86 In-house 124-216 (275) Show / Hide 
Range on Protein: 4-92
Range on HMM: 124-216/275
Sequence Identity: 32% (32 aa)

VHRDIKPHNVLIS--QPNQHGKVKAMISDFGLCKKL--SAGRMSFSRRSGVAGTDGWIAPEMLTGQD---RT--TTAIDIFSLGCVFYYVLSNGKHPF
.|||.|| |.|.    .|   . . .|.|||| ..     ..  |..     || | .||| |   .   ..  .|  |..|.|..||  |. || ||
MHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQK----CGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLC-GKPPF
Kinase IRE1.AA STE-Unique 4-128 19 2.6e-14 46.69 In-house 427-591 (616) Show / Hide 
Range on Protein: 4-128
Range on HMM: 427-591/616
Sequence Identity: 19% (33 aa)

VHRDIKPHNVLISQPNQHGKV-KAMISDFGLCKKLSAG-----------------------------------RMSFSRRSGVAGTDGWIAPEMLTGQ--
.|||.||||....|  . |.| |. |.|||. ......                                     . . . .  || ....|| ....  
IHRDLKPHNIFCMQ-DGKGRVCKVKICDFGHATCCQPDHFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQ

--DRTTTAIDIFSLGCVFYYVLSNGKHPFGDSLHRQA--NIISGEYSLDLLPPDDEIAHQLITQMVD
      |  ||.||||..   . .| .|..   |.||   ..   ... .  |...|. ..  ....
INNPYDTKVDIWSLGCMCFHMC-CGCPPWHQRYHMQAYIEMCIHIHCQPPQCPIENIPPKCQPEQQQ
Kinase IRE1.AA PLK1 4-146 33 2.7e-14 43.15 In-house 121-253 (253) Show / Hide 
Range on Protein: 4-146
Range on HMM: 121-253/253
Sequence Identity: 33% (48 aa)

VHRDIKPHNVLISQPNQHGKVKAMISDFGLCKKLSAGRMSFSRRSGVAGTDGWIAPEMLTGQDRTTTAIDIFSLGCVFYYVLSNGKHPFGDSLHRQA--N
.|||.|  |. .   |.| .||  | ||||  |.    ..  |.   .||  .||||.|. .   .  .||.|.||..| .|  |. ||  .  ..    
IHRDLKLGNLFL---NDHLQVK--IGDFGLATKCE---YDGERKKTLCGTPNYIAPEVLN-KKGHSFEVDIWSIGCIMYILLF-GQPPFETKCLKETYSR

IISGEYSLDLLPPDDEIAHQLITQMVDPYFDTRPEANAILRHPFF
|   ||..       . |.||| .|.||  . ||.....|.  ||
IKKNEYRIPSH--ISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase IRE1.AA AGC 4-82 21 3.8e-14 31.48 In-house 176-296 (395) Show / Hide 
Range on Protein: 4-82
Range on HMM: 176-296/395
Sequence Identity: 21% (28 aa)

VHRD-IKPHNVLISQPNQHGKVKAMISDFGLCKKLSAGR---------MSFSRRS---------------------------------------GVAG--
.||| .|| |.|. .         ...||||||..  ..         |.|.. .                                          |  
IHRDYLKPENILLDED-----GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHW-HNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPC

TDGWIAPEMLTGQDRTTTAIDIFS--LGCVFY
|   .|||.|      . | |. |  |||..|
TPEYMAPEIL-----YGKACDWWSFGLGCLMY
S_TKc IRE1.AA S_TKc 2-146 14 5.3e-08 -59.6 SMART 1-231 (231) Show / Hide 
Range on Protein: 2-146
Range on HMM: 1-231/231
Sequence Identity: 14% (38 aa)

FS--------------------------------------------------------------------------------------------------
.                                                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYM

---------------VHRDIKPHNVLISQPNQHGKVKAMISDFGLCKKLSAGRMSFSRRSGVAGTDGWIAPEMLTGQDRTTT-AIDIFSLGCVFYYVLSN
               .|||.|| |.|...         .|.||||...|          . . ||  ..|||.|      .. ..|. |.||..|  |. 
YQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLC-

GKHPFGDSLHRQANIISGEYSLDLLPPDDEIAHQLITQMVDPYFDTRPEANAILR-------HPFF
|. ||   ...  ..|            .. | ..| .. .   . || |  .|.       ||.|
GYPPFP-QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRE1.AA Ciliate-E2a 119-146 28 0.005484 4.66 In-house 248-275 (275) Show / Hide 
Range on Protein: 119-146
Range on HMM: 248-275/275
Sequence Identity: 28% (8 aa)

AHQLITQMVDPYFDTRPEANAILRHPFF
. .|. .|....   |. |. .| ||.|
CKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase IRE1.AA AGC 137-146 50 0.005672 1.93 In-house 386-395 (395) Show / Hide 
Range on Protein: 137-146
Range on HMM: 386-395/395
Sequence Identity: 50% (5 aa)

ANAILRHPFF
|. | .||.|
AEEIKNHPWF
Kinase IRE1.AA STE 134-146 46 0.068168 2.62 In-house 345-359 (359) Show / Hide 
Range on Protein: 134-146
Range on HMM: 345-359/359
Sequence Identity: 46% (7 aa)

RPEANAILR--HPFF
|| |.  |.  |||.
RPTASQLLKSEHPFI
Ribonuc_2-5A IRE1.AA Ribonuc_2-5A 151-277 48 3.8e-69 240.83 Pfam 1-137 (137) Show / Hide 
Range on Protein: 151-277
Range on HMM: 1-137/137
Sequence Identity: 48% (67 aa)

KQLAFFQDVSDRIEKEPLD--CPLLVALETGAQNVVR-GDWRNNITEELQTDLRKF-RA---YRGHSVRDLLRAMRNKKHHFREL-PEEVKASLGKVPDQ
|.|.|..|||||.|.|. |   |.|.|||.....||. |||. .|  ....|..|. |    | | |||||||||||||||..|. |||.|..|| .||.
KRLRFLCDVSDRFEIEDRDPPSPILQALERTSRCVVGFGDWHKKIDKAFMDDMGKYYRKRKNYYGDSVRDLLRAMRNKKHHYHEMKPEEMKEILGDLPDG

FVKYFTSRFPLLLLHVYDALS--LCREEPVLSKYYYN
|..|||.||| ||.|.| ...   |..|....|||..
FLQYFTERFPHLLMHCYHVMQECHCEHEEHFHKYYKP
PUG IRE1.AA PUG 209-266 40 1.6e-22 82.08 SMART 1-66 (66) Show / Hide 
Range on Protein: 209-266
Range on HMM: 1-66/66
Sequence Identity: 40% (27 aa)

HSVRDLLRAMRNKKHHFREL--------PEEVKASLGKVPDQFVKYFTSRFPLLLLHVYDALSLCR
 |||||||.|||..||.||.        ....|  .|.||..|  |||..|| |..|.......|.
ESVRDLLRYMRNIYHHPREEKFRKIRMENKAFKEKMGQVPGGFECYFTCGFPDLMIHAWEHYFFCK