Gene Sgk071b (Sea Urchin)
Sgk071b
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| Sgk071b.AA | Protein | None | 285 | None | Fasta, JSON |
| Sgk071b.kin_dom | Protein Kinase Domain | None | 191 | None | Fasta, JSON |
Protein domains of Sgk071b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Sgk071b.AA | SgK071 | 1-201 | 52 | 2.6e-143 | 482.39 | In-house | 1-216 (283) | Show / Hide |
Range on Protein: 1-201 Range on HMM: 1-216/283 Sequence Identity: 52% (113 aa) MISTFAEGPQGVTFLVKHRTNGKTYILKKIECNDDPEANRALREVMRLTKLSHRHLAVPRDAFVHWDSAEAAMYLCIVSDYFVTGDLDSFLKEKSRKGKS . | |||.|.|.|...||....|..||.||..||.||.|||.|.||.|.|..|..|.|||||..|||||||||.||...||.|.|.|||..|.|. LLYMLNPGAQGVNFVVEHMETGKKFVIKQVECMDDHHANKALEEVMPLQKLQHPHICVYHDMFVHWDKEEAAMYLCIVMDYYKMGDFDRFMKEKRKKKKI MCESDMQRWMGQLLHAITYLHDSGIAHTDLKPSNVYLTPQMDLRIGDFGIRTVIEDLHRFRCRTRT---------------AVWSLYWSPPEVFEGPHGS |||..||||.||.||||.|||...|.|.||||||.|||.||.....||||.|...|.|...||.|| .|||.||..|||.|.|... MCEEWMQRWCGQMLHAIEYLHHRNIIHRDLKPSNIYLTDQMHCKLQDFGIQTIMTDKHKWNCRARTENTALSGPSTLILSADVWSMYWMAPEVLEFPFSQ KTDIWSLGCMLFEMTA |.|||||||....||. KSDIWSLGCIILDMTT |
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| Kinase | Sgk071b.AA | S_TKc | 1-269 | 23 | 1.2e-35 | 125.66 | SMART | 3-231 (231) | Show / Hide |
Range on Protein: 1-269 Range on HMM: 3-231/231 Sequence Identity: 23% (66 aa) MISTFAEGPQGVTFLVKHRTNGKTYILKKIECNDDPEANRALREVMRLTKLSHRHLAVPRDAFVHWDSAEAAMYLCIVSDYFVT--GDLDSFLKEKSRKG .. . .| |. ....|. |. . .|.| ....||. | | | .. |.|.. .|..| .| . ||| ...|.. |.| ILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHG --KSMCESDMQRWMGQLLHAITYLHDSGIAHTDLKPSNVYLTPQMDLRIGDFGIRTVIEDLHRFRCRTRTAVWSLYWSPPEVFEGPHGS-KTDIWSLGCM . . | . ...| |.. |. |.|. || | ||||.|. |. . |.|||. ... .| . .... .|||. ..| | |.||.||. LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCI LFEMTA---MVHQSVLKSRAVLLQLRVGDRVEFLETLKQIGLGYEKSCHICDCVMQMLLADHDVRPSARDVLK-------MHYP |.|| . . . ...|.|| | .| ....| | . ||.| ..|. . . LYEMLCGYPPFP-------------------QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | Sgk071b.AA | NEK-Unclassified | 80-269 | 29 | 3.5e-35 | 113.72 | In-house | 73-258 (258) | Show / Hide |
Range on Protein: 80-269 Range on HMM: 73-258/258 Sequence Identity: 29% (57 aa) DYFVTGDLDSFLKEKSRKGKSMCESDMQRWMGQLLHAITYLHDSGIAHTDLKPSNVYLTPQMDLRIGDFGIRTVIEDLHRFRCRTRTAVWSLYWSPPEVF || |.|| .. . | . | . .| .|. |. | | | | ||||.|..|| . .||||| ..... | . || | . | ||| DYCDGGNLDRRIQKHRKKNEPFDEGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHT---RDKARTCVGTMCWMSPEVC EG-PHGSKTDIWSLGCMLFEMTAMV----HQSVLKSRAVLLQLRVGDR-VEFLETLKQIGLGYEKSCHICDCVMQMLLADHDVRPSARDVLKMHYP . | . |.|||||...|| . .. . |. .| .| | | .. | | . . || . . |||| ... . | QDQPYNNRSDVWSLGCIIYEMCTCEPFFDTHNMGE---VYMKIKQDDNRLE--EALEPVSKTY--STDLQQVIRFMLRRNFQQRPSATEIVEQDYI |
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| Kinase | Sgk071b.AA | Pkinase | 11-199 | 23 | 9.4e-28 | 99.21 | Pfam | 13-205 (293) | Show / Hide |
Range on Protein: 11-199 Range on HMM: 13-205/293 Sequence Identity: 23% (49 aa) GVTFLVKHRTNGKTYILKKIECNDDPEANR--ALR--EVMRLTKLSHRHLAVPRDAFVHWDSAEAAMYLCIVSDYFVTG----DLDSFLKEKSRKGKSM- |. .. .|. .||.. .|.|. .. . . ..| |. . .|.| . .|.| ....| .| | || .... ...... GCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFY -CESDMQRWMGQLLHAITYLHDSGIAHTDLKPSNVYLTPQMDL----RIGDFGIRTVIEDLHRFRCRTRTAVWSLYWSPPEV--FEGPHGSKTDIWSLGC | . ...| |.| .. |.|. || | ||||.|. . .... .|.|||. ... . . | . .... .||| . ..|.| |.||.|| FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGC MLFEM .|.|| ILYEM |
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| Kinase | Sgk071b.AA | CAMK | 4-199 | 16 | 1.6e-25 | 78.57 | In-house | 1-327 (425) | Show / Hide |
Range on Protein: 4-199
Range on HMM: 1-327/425
Sequence Identity: 16% (54 aa)
TFAEGPQGVTFLVKHR-TNGKT-----------YILKKIECN----------------------------DDPEANRALREVMRLTKLS-------HRHL
| .| |. .|..|. |.||. . | |. . .. . .||. . ||. |...
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
AVPRDAFV----------------HWDSAEAAMYLCI-VSDYFVTG----DLDSFLKEKSRKG-----------KSMCESDMQRWMGQLLHAITYLHDSG
... .. . . ||. ...| | || ....|....| . ..|.. .|.. |.. |. |.|. .
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN
IAHTDLKPSNVYLTPQM-----------------DLRIGDFGIRTVIEDLHRFRCR--------------------TRTAVWSLYWSP-PEVFEG-----
|.| |||| |. |. . .. | ||| ..... . .. .| . ... . |||..|
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN
----------PHGSKTDIWSLGCMLFEM
..| |.|.||.|..|. |
MQNATDEEKPYYGPKCDMWSCGVILYIM
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| Kinase | Sgk071b.AA | NEK4 | 1-204 | 30 | 2.8e-24 | 84.2 | In-house | 3-200 (257) | Show / Hide |
Range on Protein: 1-204 Range on HMM: 3-200/257 Sequence Identity: 30% (64 aa) MISTFAEGPQGVTFLVKHRTNGKTYILKKIECN--DDPEANRALREVMRLTKLSHRHLAVPRDAFVHWDSAEAAMYLCIVSDYFVTGDLDSFLKEKSRKG . | | .||.|| .| |..||.. . | |..|. | .| | . . | .|.|| . ||| ||.. |. HMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESW----EIENGQFLYIVMGFCEGGDLYRKLKQQ--KN KSMCESDMQRWMGQLLHAITYLHDSGIAHTDLKPSNVYLTPQMDLRIGDFGIRTVIEDLHRFRCRTRTAVWSLYWSPPEVFEG-PHGSKTDIWSLGCMLF . . |. | | | |.|. | | ||| |..|| . ..|||||| |... . .| . |. ||.| | | ||||||| .. QFLEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDM---AKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVY EMTAMVH || . | EMITLKH |
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| Kinase | Sgk071b.AA | Ciliate-E2-Unclassified | 74-199 | 24 | 5.7e-21 | 69.48 | In-house | 95-263 (352) | Show / Hide |
Range on Protein: 74-199
Range on HMM: 95-263/352
Sequence Identity: 24% (41 aa)
YLCIVSDYFVTGDLDSFLKEKS-------------RKGKSMCESDMQ-----RWMGQLLHAITYLHDSG-IAHTDLKPSNVYLTPQM---DLRIGDFGIR
...|| .|. ||| ..|... ...| | .. ... |.| .. ||| .. | | |.||.|. .. .. ..| ||||
NIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGIS
T-----VIEDLHRF--------RCRTRTAVWSLYWS----PPEVFEG-PHG----SKTDIWSLGCMLFEM
. .| .. .... | ..... .|||..| .. | ||||||. |.||
KKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM
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| Kinase | Sgk071b.AA | TKL | 5-199 | 16 | 6.6e-21 | 72.01 | In-house | 1-282 (364) | Show / Hide |
Range on Protein: 5-199
Range on HMM: 1-282/364
Sequence Identity: 16% (49 aa)
FAEGPQGVTFLVKHRTNG--------KTYILKKIECNDDP---------------------------EANRALREVMRLTKLSHRHLAVPRDAFVHWDSA
.| |. . |.| .| |. ||. ..| . . .|.| . .|.| .. |. . .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIV----QFMGYCCC
EA---AMY--------LCIVSDYFVTGD-LDSFLKEKSRKGKSMCESDMQRWMGQLLHAITYLHDSG--------IAHTDLKPSNVYLTPQMD-------
. ... |||| .| |. |. .. . . ||. . .. ||| .. |.| |||..|. . .
PPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMY
-------LRIGDFGIRTVIEDLH----------------RFRCRTRTAVWSLYWSPPEVFE-----------------GPHGSKTDIWSLGCMLFEM
. |.|||. .... . |..| | . ...| .|||.. .. |.|..| | .|.|.
NPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
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| Kinase | Sgk071b.AA | Ciliate-E2 | 74-199 | 21 | 7.8e-19 | 61.26 | In-house | 108-289 (365) | Show / Hide |
Range on Protein: 74-199 Range on HMM: 108-289/365 Sequence Identity: 21% (40 aa) YLCIVSDYFVTGDLDSFLKEK---------SRKGKSMCESDMQRWMGQLLH---------------AITYLHDSG-IAHTDLKPSNVYLTPQMDLRIGDF .. .| .|. ||| ...|.. . . |.. | ... | |.| |. ||| . | | |.||.|. . . | || NIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDF GI-RTVIEDLHRFR---------------------------CRTRTAVWSLYWSPPEVFEGP----------HGSKTDIWSLGCMLFEM |. . . .| . . ..| ..... .||...| .. | ||||||..|.|| GLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM |
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| Kinase | Sgk071b.AA | CMGC | 11-149 | 17 | 7.9e-19 | 57.65 | In-house | 13-249 (513) | Show / Hide |
Range on Protein: 11-149 Range on HMM: 13-249/513 Sequence Identity: 17% (42 aa) GVTFLVKH--------------RTNGKTYILKKIECN-DDPEAN----------RALREVMRLTKLS-----------------HRHLAVPRDAFVHWDS || . .. . ... . .||| . .. .| |||||.. | .|. | .. .| |.| .| GVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNS AEAAM-----------YLCIVSDYFVTGDLDSFLKEKSR-----KGKSMCESD------------MQRWM------GQLLHAIT--YLHDSG--IAHTDL . .|..| .| . || ..|.... ... . | . | |.| .. |.| . | |.|| DGNEYEDKHIISQHFNHLYLVFEYMDH-DLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDL KPSNVYLTPQ--------------------MDLRIGDFG ||.|. .... . |.|.||| KPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFG |
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| Kinase | Sgk071b.AA | NEK1 | 1-150 | 28 | 7.3e-14 | 44.62 | In-house | 3-167 (276) | Show / Hide |
Range on Protein: 1-150 Range on HMM: 3-167/276 Sequence Identity: 28% (48 aa) MISTFAEGPQGVTFLVKHRTNGKTYILKKIECND--DPEANRALREVMRLTKLSHRHLAVPRDAFVHWDSAEAAMYLCIVSDYFVTGDLDSFLKEKSRKG |.. || | ..||||. |..| .| | . . | ....|| |.|. | ...|. .. | || .| ||| ... ||| YIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFE----ENGCGILYIVMEYCDGGDLMQKINRQKRKG KSMCESDMQRWMGQLLHAITYLHDSGIAHTDLKPSNVYLT-PQMD----------------LRIGDFGI |. | | |. | . || | | |.|..|. || . . ...||||| KLFSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGI |
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| Kinase | Sgk071b.AA | NEK | 74-150 | 36 | 4.5e-13 | 42.74 | In-house | 80-169 (286) | Show / Hide |
Range on Protein: 74-150 Range on HMM: 80-169/286 Sequence Identity: 36% (33 aa) YLCIVSDYFV-TGDLDSF---LKEKSRKGKSMCESDMQRWMGQLLHAITYLHDS-----GIAHTDLKPSNVYLTPQMD----LRIGDFGI .|||| .| |||. . .|.. ||| . |. .|. |.. |. |.|| | | |.||.|. || . ..|||||| CLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGI |
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| Kinase | Sgk071b.AA | TyrKc | 25-267 | 17 | 1e-08 | -81.61 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 25-267 Range on HMM: 1-280/280 Sequence Identity: 17% (51 aa) YILKKI---------------------ECNDDPEANRALREVMRLTKL--SHRHLAVPRDAFVHWDSAE-----AAMYLCIVSDYFVTGDLDSFLKEKSR |.|. ...| .|| ..|| .| .. ... . . . |.|| | |||...|... . ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIV----RLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP KGKSMCESDMQRWMGQLLHAITYLHDSGIAHTDLKPSNVYLTPQMDLRIGDFGIRTVIEDL-------HRFRCRT---RTAVWSLYWSPPEVF-EGPHGS | | .|. .. | |||. .. | || |. .. . .|.||| |.| | .. . ... . | .||.. .| . K---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT KTDIWSLGCMLFEMTAMVHQSV-------LKSRAVLLQLRVGDRVEFLETLKQIGLGYE-----KSCHICDCVMQMLLAD-HDVRPSARDVLKMH |.|.|| | ...|. | .. . |. ... |.| . . . . . . .|.. . . ||. ... . KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY------PMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | Sgk071b.AA | NEK | 172-201 | 51 | 2e-06 | 19.31 | In-house | 189-219 (286) | Show / Hide |
Range on Protein: 172-201 Range on HMM: 189-219/286 Sequence Identity: 51% (16 aa) YWSPPEVF-EGPHGSKTDIWSLGCMLFEMTA |. |||. . | ..| ||||||| |.|| . YYMSPEVCQNKPYNNKSDIWSLGCVLYEMCT |
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| Kinase | Sgk071b.AA | NEK1 | 186-204 | 57 | 1.1e-05 | 15.84 | In-house | 201-219 (276) | Show / Hide |
Range on Protein: 186-204 Range on HMM: 201-219/276 Sequence Identity: 57% (11 aa) KTDIWSLGCMLFEMTAMVH |.||||||| | | .. | KSDIWSLGCVLYELCTLKH |
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| Kinase | Sgk071b.AA | CMGC | 175-199 | 27 | 1.9e-05 | 12.88 | In-house | 293-328 (513) | Show / Hide |
Range on Protein: 175-199 Range on HMM: 293-328/513 Sequence Identity: 27% (10 aa) PPEVFEGP-----------HGSKTDIWSLGCMLFEM .||. | ... |.||.||...|| APEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEM |
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| Kinase | Sgk071b.AA | NEK | 7-55 | 28 | 0.000579 | 10.3 | In-house | 9-65 (286) | Show / Hide |
Range on Protein: 7-55 Range on HMM: 9-65/286 Sequence Identity: 28% (16 aa) EGPQGVTFLVKHRTNGKT-----YILKKIECNDD--PEANRAL-REVMRLTKLSHRH .| .|. ..|... .|| |..||| . | |. || | .| | . QGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPN |
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| Kinase | Sgk071b.AA | NEK | 248-269 | 40 | 0.017811 | 5.0 | In-house | 265-286 (286) | Show / Hide |
Range on Protein: 248-269 Range on HMM: 265-286/286 Sequence Identity: 40% (9 aa) QMLLADHDVRPSARDVLKMHYP ||| |.. |||....|.| . QMLQKDPEQRPSCNQILEMPFI |
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| Kinase | Sgk071b.AA | NEK4 | 246-269 | 41 | 0.03562 | 3.83 | In-house | 234-257 (257) | Show / Hide |
Range on Protein: 246-269 Range on HMM: 234-257/257 Sequence Identity: 41% (10 aa) VMQMLLADHDVRPSARDVLKMHYP | ||| . ||| .|...| | VYQMLEKQPTKRPSIFDIFQMPYI |
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| Kinase | Sgk071b.AA | SgK071 | 249-268 | 30 | 0.12794 | 1.42 | In-house | 264-283 (283) | Show / Hide |
Range on Protein: 249-268 Range on HMM: 264-283/283 Sequence Identity: 30% (6 aa) MLLADHDVRPSARDVLKMHY || . |.|..||... . MLHINPQDRISIKDVMHITF |
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