Gene Spk362 (Sea Urchin)
Spk362
Sequence
Protein domains of Spk362.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Spk362.AA | urchA | 444-638 | 54 | 2.3e-151 | 491.47 | In-house | 1-208 (208) | Show / Hide |
Range on Protein: 444-638 Range on HMM: 1-208/208 Sequence Identity: 54% (114 aa) LGRGVTGTVYLFRHAVLKIPVAAKLVEYAG---------KYFRNEVRIHQAISGLPWFPTFYGSFDIEGDQAVLAMEFIGSESEDRSYTITDCLEKSMLK |||||.|||.|.||.. ..|||.|..|... ..|.||..|||.....||||||||...|..|....||||.|.|....|||||.||.|.|.. LGRGVYGTVHLYRHRQTDHPVALKVIELPKEYKKMRRKIECFQNEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITWCLDKAMEM TGPDLTRDEWFDVLNDVAEGLKALHTMGFLCNDLKEDNVLVVE-ESGRWRAKIIDLGWASEIATPF---VMPLDEEQIDFYRSGRGCCHIAPECVLEARP ..|.||||.|..|..|.|||||..|..|||||||||||.||.. |.|||||||||.|||.....|| .|..|..|..|||....||||||||.|.|.| RQPALTRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVRKTEFGRWRAKIIDFGWACPCQMPFPACRMHFDQRQKQFYRYCHRCCHIAPECALDAQP CSTSSDVY |||||||| CSTSSDVY |
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| Kinase | Spk362.AA | urch | 444-641 | 42 | 1.9e-113 | 383.19 | In-house | 1-217 (217) | Show / Hide |
Range on Protein: 444-641 Range on HMM: 1-217/217 Sequence Identity: 42% (93 aa) LGRGVTGTVYLFRHAVLKIPVAAKLVEYAG-----------------KYFRNEVRIHQAISGLPWFPTFYGSFDIEGDQAVLAMEFIGSESEDRSYTITD .|||. |.|.|.||. |.||| | .... . |..|...||..|| |.||.||| .||. |. .|.|||||......||.... IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDID-DDLCLVMEFIGDKKTGKSYPLHW CLEKS-MLKTGPDLTRDEWFDVLNDVAEGLKALHTMGFLCNDLKEDNVLVVE-ESGRWRAKIIDLGWASEIATPF-VMPLDEEQIDFYRSGRGCCHIAPE |..|| |....|.|....|.....|...|..|.| .|||.|||||||||... ..|||.|.|||.||......|| .|....|....|..|.|.|||||| CIHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAPE CVLEARPCSTSSDVYSLG |||...|||..|||||.| CVLDGQPCSIASDVYSVG |
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| Kinase | Spk362.AA | urch-unclassified | 479-641 | 32 | 4.2e-42 | 146.18 | In-house | 52-215 (215) | Show / Hide |
Range on Protein: 479-641 Range on HMM: 52-215/215 Sequence Identity: 32% (55 aa) EVRIHQAISGLPWFPTFYGSFDIEGDQAVLAMEFIGSESEDRSYTITDCLEKSMLKTGPDLTRDEWFDVLNDVAEGLKALHTMGFLCNDLKEDNVLVVEE |...|.. .. | || || ..|.. . ..|||.| . . |. . . | | | . .|.... |. .|..|.| |. | |||| .|.|. EAMVHRLFADHPYFPRCYGMVKHEDCPC-IVMEFLGDKQTYTVYPLCQWIHERH-KSNPALSKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWC SG--RWRAKIIDLGWASEIATP---FVMPLDEEQIDFYRSGRGCCHIAPECVLEARPCSTSSDVYSLG . ||.|.|||.| .| .. | . .. |.. |..| |.||| || | | ||.|||| DHDQRWHAYIIDFGMISTMTMPHKQRNFSDHEMRE--YMMGKIYHHMAPEIVLYGQPTSVYSDIYSLG |
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| Kinase | Spk362.AA | urchC | 476-644 | 29 | 2e-24 | 75.82 | In-house | 54-223 (223) | Show / Hide |
Range on Protein: 476-644
Range on HMM: 54-223/223
Sequence Identity: 29% (51 aa)
FRNEVRIHQAISGLPWFPTFYGSFDIEGDQAVLAMEFIGSESEDRSYTITDCLE-KSMLKTGPDLTRDEWFDVLNDVAEGLKALHTMGFLCNDLKEDNVL
.. | |. | .|. |.|| .|| |... . ||||. ..| | .. . |.. .. |. .| ..| | | || | ||||
CEKEARVGQMMSTCPYFPRMYGTVMIDENMCIVT-EFIGDKQQGKVYMLHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVL
VVEESGRWRAKIIDLGWASEIATPFVMPLDEEQIDFYRSGRGCCHIAPECVL-EARPCSTSSDVYSLGRLL
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LEHRKERWHGCIIDMGMVSTMAYPPHQRGFNDVMPDHQKLYGFIHIAPEVLDIDGCQVSVASDIYSVGVIL
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| Kinase | Spk362.AA | urchB | 546-641 | 40 | 1.6e-15 | 52.35 | In-house | 116-212 (212) | Show / Hide |
Range on Protein: 546-641 Range on HMM: 116-212/212 Sequence Identity: 40% (39 aa) DVLNDVAEGLKALHTMGFLCNDLKEDNVLVVEESGRWRAKIIDLGWASEIATPFVM-PLDEEQIDFYRSGRGCCHIAPECVLEARPCSTSSDVYSLG |. |. |. .| | | |||| |||| |. | ||| | .| | | | . .| | | |||| .|. . | ||||.| | DIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEKRGHRYHAVIIDFGMVSTITAPLKMVEVPKELKMAYVHGEEADYIAPEVILHGQSTSISSDVFSVG |
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| S_TKc | Spk362.AA | S_TKc | 438-685 | 18 | 9.5e-12 | -4.65 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 438-685 Range on HMM: 1-231/231 Sequence Identity: 18% (52 aa) SRCSIELGRGVTGTVYLFRHAVLKIPVAAKLVEYAGKYFRNEVRIHQAISGLPWFPTFYGSFDIEGDQAVLAMEFIGS--ESEDRSYTITDCLEKSMLKT . ..|.| |.||. || . || | . . .|.|..|.. . |. ..|..|. | . ||... . | . . | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGD----------LFDYIKKR GPD-----LTRDEWFDVLNDVAEGLKALHTMGFLCNDLKEDNVLVVEESGRWRAKIIDLGWASEIATPFVMPLDEEQIDFYRSGRGCCH----IAPECVL |. .. . .. ....|. .| .|.. ||| .|.|. | . ||.| | | .. . .| .||| . GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------------TTFCGTPWYMAPEVL- EARPCST-SSDVYSLG--------------RLLAIIGRAMRDDDFECFGTQIYLADEEHRPTVQEILDEI-----QPVY . .. ..|..|.| . ... . . .... | .. | |.|||. |.| . | ---GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | Spk362.AA | TKL | 550-641 | 21 | 8.4e-07 | 20.54 | In-house | 140-276 (364) | Show / Hide |
Range on Protein: 550-641 Range on HMM: 140-276/364 Sequence Identity: 21% (30 aa) DVAEGLKALHTMG--------FLCNDLKEDNVLVVEES-----------GRWRAKIIDLGWASEIATPFVMPLDEEQID------FYR--SGRGC---CH |.| |. ||.|. . ||| .|.|| | |..|| |.| . .. . . | . . .| ... | .. DIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRW IAPECVLEA---------------RPCSTSSDVYSLG |||. .. .. |...|||| | MAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG |
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| Kinase | Spk362.AA | Dicty5 | 550-590 | 41 | 7e-06 | 16.27 | In-house | 112-149 (260) | Show / Hide |
Range on Protein: 550-590 Range on HMM: 112-149/260 Sequence Identity: 41% (17 aa) DVAEGLKALHTMGFLCNDLKEDNVLVVEESGRWRAKIIDLG |.| ... || |. ||| |.|. | .| .|||| | DIAQSMRHLHSMNIIHRDLKSMNFLITE---NWKIKIIDFG |
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| Kinase | Spk362.AA | SgK496 | 538-591 | 37 | 1.7e-05 | 14.03 | In-house | 98-148 (265) | Show / Hide |
Range on Protein: 538-591 Range on HMM: 98-148/265 Sequence Identity: 37% (20 aa) DLTRDEWFDVLNDVAEGLKALHTMGFLCNDLKEDNVLVVEESGRWRAKIIDLGW ... .| . ||.||.. || .| |.| |||. . |||| |||. NMELEERLHIALDVVEGIRYLHSQGLVHRDIKLKNVLLDKHN---RAKITDLGF |
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| Kinase | Spk362.AA | urchB | 482-514 | 45 | 3.6e-05 | 14.86 | In-house | 62-93 (212) | Show / Hide |
Range on Protein: 482-514 Range on HMM: 62-93/212 Sequence Identity: 45% (15 aa) IHQAISGLPWFPTFYGSFDIEGDQAVLAMEFIG ||| .|. |.|| |.| || . .| ||.| IHQLMSDSPYFPKFWGTLDI-DNDLCQAQEFVG |
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| Kinase | Spk362.AA | C8 | 553-644 | 20 | 3.7e-05 | 13.97 | In-house | 134-226 (226) | Show / Hide |
Range on Protein: 553-644 Range on HMM: 134-226/226 Sequence Identity: 20% (20 aa) EGLKALHTMGFLCNDLKEDNVLVVEESGRW-RAKIIDLGWASEIATPFVMPLDEEQIDFYRSGRGCCHIAPECVLE----ARPCSTSSDVYSLGRLL .|. .| .. |.| .| || .. |. |.| || . .. . .||| . . . ||..|.| .| DGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNT----CGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | Spk362.AA | Ciliate-C7 | 549-574 | 46 | 6.3e-05 | 12.26 | In-house | 109-134 (164) | Show / Hide |
Range on Protein: 549-574 Range on HMM: 109-134/164 Sequence Identity: 46% (12 aa) NDVAEGLKALHTMGFLCNDLKEDNVL .|.|.|| | ... |||| || | KDIAQGLYYIHSKNCVVNDLKMDNIL |
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| TyrKc | Spk362.AA | TyrKc | 438-681 | 20 | 0.000972 | -162.18 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 438-681 Range on HMM: 1-280/280 Sequence Identity: 20% (62 aa) SRCSIELGRGVTGTVYLFRHAVLKIPVAAKLVE-YAGKYFRNEVRIHQAISGL-PWFP---TFYGSFDIEG------DQAVLAMEFIGSESEDRSYTITD . .||.| |.||. ...||.|| | . .| . |..| || . | . | .|| .| .. . ||. ITLGKKLGEGAFGEVYK---GTWKIQVAVKMLKEDAREDFMREARI---MCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG---------- CLEKSMLKTGPDLTRDEWFDVLNDVAEGLKALHTMGFLCNDLKEDNVLVVEESGRWRAKIIDLGWASEIATP-FVMPLDEEQIDFYRSGRGCCH------ .| . |..|.|. .. . ..|.| || ... || |.|| |. ..|| | | . .| |.. ....... DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQG---ESKDYYRKKEHKGGKTMLPIR -IAPECVLEARPCSTSSDVYS----------------LG---------RLLAIIGRAMRDDDFEC--------FGTQIYL-------ADEEHRPTVQEIL |||| . . ..| |||.| | .... . . .| . . . .| .| | ||| .|| WMAPECINYGK-FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH DEI ... ECF |
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| Kinase | Spk362.AA | TKL | 669-681 | 53 | 0.087482 | 2.22 | In-house | 352-364 (364) | Show / Hide |
Range on Protein: 669-681 Range on HMM: 352-364/364 Sequence Identity: 53% (7 aa) EHRPTVQEILDEI | ||. ||||... EKRPSFQEILKRL |
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| Kinase | Spk362.AA | urchB | 443-467 | 48 | 0.133573 | 1.92 | In-house | 6-30 (212) | Show / Hide |
Range on Protein: 443-467 Range on HMM: 6-30/212 Sequence Identity: 48% (12 aa) ELGRGVTGTVYLFRHAVLKIPVAAK | ||| | | . || |.| | | EIGRGTYGRVVIARHRQTKVPLAIK |
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| Kinase | Spk362.AA | urch-unclassified | 444-465 | 36 | 0.439475 | 0.0 | In-house | 1-22 (215) | Show / Hide |
Range on Protein: 444-465 Range on HMM: 1-22/215 Sequence Identity: 36% (8 aa) LGRGVTGTVYLFRHAVLKIPVA .| | | |.. || .||. IGKGTFGKVFMMRHQREAVPVK |
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