Gene Spk385 (Sea Urchin)
Spk385
Sequence
Protein domains of Spk385.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Spk385.AA | urchB | 130-321 | 82 | 2.4e-177 | 595.45 | In-house | 1-193 (212) | Show / Hide |
Range on Protein: 130-321 Range on HMM: 1-193/212 Sequence Identity: 82% (160 aa) IIALKEIGRGSYGRVVIARHRSTGVPLAIKEPSWSDNFASPGEMVEELK-ATRTRATKEAMIQQLMSGSPYFPKFWGTLDLGNELCQAVEFVGCKKTGTG |..|.|||||.||||||||||.|.||||||.|.||||..||.|||.||. |||||.||||||.||||.||||||||||||..|.||||.|||||||||.| INDLQEIGRGTYGRVVIARHRQTKVPLAIKQPCWSDNYQSPNEMVDELHDATRTRVTKEAMIHQLMSDSPYFPKFWGTLDIDNDLCQAQEFVGCKKTGIG YPLHEPPSLSMGNVVKIAGDIVKGVMEFHDHGLLHNDLKNDNVLLEKRGKRYNAVIIDFGMASTITAPAKMVGVPKELKMAYVHGGEADYIAP |||||||.|||.|||.||.|||||.||||||||||||||||||||||||.||.||||||||.||||||.|||.||||||||||||.||||||| YPLHEPPPLSMCNVVDIAEDIVKGMMEFHDHGLLHNDLKNDNVLLEKRGHRYHAVIIDFGMVSTITAPLKMVEVPKELKMAYVHGEEADYIAP |
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| Kinase | Spk385.AA | urch | 136-321 | 53 | 7e-113 | 381.31 | In-house | 1-198 (217) | Show / Hide |
Range on Protein: 136-321 Range on HMM: 1-198/217 Sequence Identity: 53% (105 aa) IGRGSYGRVVIARHRSTGVPLAIKEPSWSDNFASPGEMVEELK-ATRTRATKEAMIQQLMSGSPYFPKFWGTLDLGNELCQAVEFVGCKKTGTGYPLHEP ||||.||||...|||.|..|.|||.|.|..|.....||..| . |...|.|||||..|||||.||||||.|..|....||...||.|.||||. ||||.. IGRGTYGRVHLYRHRQTKQPVAIKMPCWPQNYTDMNEMEMEEWKANHERFTKEAMVHQLMSGHPYFPKFYGCVDIDDDLCLVMEFIGDKKTGKSYPLHWC PS----------LSMGNVVKIAGDIVKGVMEFHDHGLLHNDLKNDNVLLEKRGK-RYNAVIIDFGMASTITAPAKMVGVPKELKMAYVHGGEADYIAP .. ||. |...|| |||.|.|..||||.||||||.|||||||||. |..|||||||...|.|.|.||...|.|....|.||.....||| IHKSRMCMPNPHLSKWNWLNIAEDIVHGMMAMHDHGFLHNDLKEDNVLLEKRGHGRWHAVIIDFGWVCTMTMPFKMMHFPDEEMREYMHGHGYCHIAP |
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| Kinase | Spk385.AA | urchC | 131-294 | 41 | 1.3e-60 | 194.88 | In-house | 2-174 (223) | Show / Hide |
Range on Protein: 131-294 Range on HMM: 2-174/223 Sequence Identity: 41% (73 aa) IALKEIGRGSYGRVVIARHRSTGVPLAIKEPSWSDNFASPGEMVE-ELKATRTRATKEAMIQQLMSGSPYFPKFWGTLDLGNELCQAVEFVGCKKTGTGY |..||.||||.| .| | |||.| .| .| | | |. | .|||.. |.||..||||.. ||. .. ..| ||.| |..| | TILEMIGKGSYGEVMLGRLNGEKDPVAIKRPYVPQHFT--PEKEESEWKQNNGRCEKEARVGQMMSTCPYFPRMYGTVMIDENMCIVTEFIGDKQQGKVY PLHEPPS----------LSMGNVVKIAGDIVKGVMEFHDHGLLHNDLKNDNVLLEKRGKRYNAVIIDFGMASTIT .||. .. | | || ||..||. || |||||| | |||||| |. | ..||| || ||.. MLHDAMCPRKGCDPIPYVQKWNMVAIAEDIIRGVHFMHDFGLLHNDIKDDNVLLEHRKERWHGCIIDMGMVSTMA |
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| Kinase | Spk385.AA | urch-unclassified | 136-321 | 34 | 1.3e-53 | 184.45 | In-house | 1-196 (215) | Show / Hide |
Range on Protein: 136-321 Range on HMM: 1-196/215 Sequence Identity: 34% (67 aa) IGRGSYGRVVIARHRSTGVPLAIK-EPSWSDNFASPGEMVEELKATRTRATKEAMIQQLMSGSPYFPKFWGTLDLGNELCQAVEFVGCKKTGTGYPL--- || |..|.| || . || ..| . . . .|. . .. |..||||...|....||||. | .... .| ..|| | |.|.| ||| IGKGTFGKVFMMRHQREAVPVKVKMIHEHHNDYDYEMRMQ-NKLLMHERIMKEAMVHRLFADHPYFPRCYGMVKHEDCPCIVMEFLGDKQTYTVYPLCQW --HEP---PSLSMGNVVKIAGDIVKGVMEFHDHGLLHNDLKNDNVLLEKRGK--RYNAVIIDFGMASTITAPAKMVGVPKELKMAYVHGGEADYIAP . | || . |. ||..| .. |. .||||||| .|.||..... | | ||||||.||.| |.| . . . | | ..|| IHERHKSNPALSKHHWINICMDICHGMHAMHEMDLLHNDLKSNNILLQWCDHDQRWHAYIIDFGMISTMTMPHKQRNFSDHEMREYMMGKIYHHMAP |
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| Kinase | Spk385.AA | urchA | 136-296 | 31 | 4.8e-33 | 103.98 | In-house | 1-165 (208) | Show / Hide |
Range on Protein: 136-296 Range on HMM: 1-165/208 Sequence Identity: 31% (55 aa) IGRGSYGRVVIARHRSTGVPLAIKEPSWSDNFASPGEMVEELKATRTRATKEAMIQQLMSGSPYFPKFWGTLDL-GNELCQAVEFVGCKKTGTG----YP ||| || | ||| |. | |.| .. |.|... . . . .|. |.|. ...|.||.| | ... . | ||.| || LGRGVYGTVHLYRHRQTDHPVALK------VIELPKEYKKMRR-KIECFQNEMQIHQVLGCEPWFPTFYGCCEICEDKVGMAMEFCGDEMTGESYTITWC LHE-----PPSLSMGNVVKIAGDIVKGVMEFHDHGLLHNDLKNDNVLLEK-RGKRYNAVIIDFGMASTITAP | | |. ... || .| |. | | ||||.||.|. | . | |.||||| |. . .| LDKAMEMRQPALTRDQWMNVMLDIAEGLKVMHEKGFLCNDLKEDNCLVRKTEFGRWRAKIIDFGWACPCQMP |
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| Kinase | Spk385.AA | S_TKc | 130-402 | 17 | 1.5e-12 | 6.97 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 130-402
Range on HMM: 1-231/231
Sequence Identity: 17% (52 aa)
IIALKEIGRGSYGRVVIARHRSTGVPLAIKEPSWSDNFASPGEMVEELKATRTRATKEAMIQQLMSGSPYFPKFWGTLDLGNELCQAVEFVGC--KKTGT
|..||.|..|.| .||..|| |||. . .. .| | . . |. |. .. . ..|. |... .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFD
GYPLHEPPS----LSMGNVVKIAGDIVKGVMEFHDHGLLHNDLKNDNVLLEKRGKRYNAVIIDFGMASTITAPAKMVGVPK-----ELKMAYVHGG-EAD
. .. .. . ... |.... |.|| .| ||| .|.|| . . |.|||.| . ..| | | .|. ..|
YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---TTFCGTPWYMAPEVL----GYGKCKCD
Y-------------IAPFGIWMSSQHPSLQMCFQSAVSSPIGERYLEVKTNFILTVSHRSPAVRELSKLGAQCMADNPDHRPSLDTIQS--QITKLHRPS
|| .|| |. . .|. . .|. .|..||. . . |.|
WWSCGCILYEMLCGYPPFP--------QMQMMFKKIG-------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | Spk385.AA | Ciliate-C7 | 237-294 | 39 | 2.1e-11 | 33.31 | In-house | 99-153 (164) | Show / Hide |
Range on Protein: 237-294 Range on HMM: 99-153/164 Sequence Identity: 39% (23 aa) LSMGNVVKIAGDIVKGVMEFHDHGLLHNDLKNDNVLLEKRGKRYNAVIIDFGMASTIT |. . .|.| || | . |. ... |||| || | | |||..|||.| .| LNEISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNG---NAVVCDFGLADNLT |
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| Kinase | Spk385.AA | Pkinase | 130-290 | 20 | 1.5e-09 | 34.81 | Pfam | 1-159 (293) | Show / Hide |
Range on Protein: 130-290
Range on HMM: 1-159/293
Sequence Identity: 20% (35 aa)
IIALKEIGRGSYGRVVIARHRSTGVPLAIKEPSWSDNFASPGEMVEELKATRTRATKEAMIQQLMSGSPYFPKFWGTLDLGNELCQAVEFVGCK----KT
. .. ||.||.|.| ...|..|| |.|. . ..| ..... | . |. | . . ..|. ..... ..... |....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKI------IKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDL
G----TGYPLHEPPSL--SMGNVVKIAGDIVKGVMEFHDHGLLHNDLKNDNVLLEKRGKRYNA----VIIDFGMA
| .. .. |. . ... |..|. |..| .| ||| .|.|. ..| . |.||| |
FDYIST----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNG---HIDACVKICDFGLA
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| Kinase | Spk385.AA | LISK | 135-160 | 50 | 2.9e-08 | 22.73 | In-house | 1-26 (296) | Show / Hide |
Range on Protein: 135-160 Range on HMM: 1-26/296 Sequence Identity: 50% (13 aa) EIGRGSYGRVVIARHRSTGVPLAIKE |||.|..| |. .|| || . |||. EIGKGFFGKVYKGTHRQTGQVMAIKM |
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| Kinase | Spk385.AA | CAMK | 135-159 | 29 | 8.4e-08 | 20.46 | In-house | 1-37 (425) | Show / Hide |
Range on Protein: 135-159 Range on HMM: 1-37/425 Sequence Identity: 29% (11 aa) EIGRGSYGRVVIARHRSTG------------VPLAIK ..||||.| | ..|..|. . ||| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIK |
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| Kinase | Spk385.AA | CAMKL | 257-294 | 42 | 1.4e-07 | 20.08 | In-house | 144-180 (297) | Show / Hide |
Range on Protein: 257-294 Range on HMM: 144-180/297 Sequence Identity: 42% (16 aa) HDHGLLHNDLKNDNVLLEKRGKRYNAVIIDFGMASTIT |.|| | |.| .|.|| ..|.. |. |||||.. .. HSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYR |
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| Kinase | Spk385.AA | CAMKL | 133-159 | 50 | 9e-06 | 14.23 | In-house | 4-31 (297) | Show / Hide |
Range on Protein: 133-159 Range on HMM: 4-31/297 Sequence Identity: 50% (14 aa) LKEIGRGSYGRVVIARH-RSTGVPLAIK .|..|.||.| | |.| | ||. ||| GKTLGKGSFGKVKLATHIRTTGEKVAIK |
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| Kinase | Spk385.AA | TyrKc | 130-395 | 13 | 1.2e-05 | -131.12 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 130-395 Range on HMM: 1-280/280 Sequence Identity: 13% (46 aa) IIALKEIGRGSYGRVVIARHRSTGVPLAIKEPSWSDNFASPGEMVEELKATRTR-------------ATKE----AMIQQLMSGSPYFPKFWGTLDLGNE | .|..|.| .|.|. .. . .. |.| . .. .|.. . .|.. |..|| | |. | |. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH--GDLKDYLR LCQAVEFVGCKKTGTGYPLHEPPSLSMGNVVKIAGDIVKGVMEFHDHGLLHNDLKNDNVLLEKRGKRYNAVIIDFGMASTITAP-----AKMVGVPKE-- .. |.| .... .| .| |.... | || |.|. ... . | |||.. |. .| . ..|| KHRPK-------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHK LKM-----------AYVHG---------------------GEADY-------IAPFGIWMSSQHPSLQMCFQSAVSSPIGERYLEVKTNFILTVSHRSPA . . .| |. | . .. . .. .. ... |. . . GGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMS--------------F--VCC VRELSKLGAQCMADNPDHRPSLDTIQSQI |. .. || . .|. ||. .| ... PDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | Spk385.AA | TKL | 361-395 | 22 | 2e-05 | 15.55 | In-house | 330-364 (364) | Show / Hide |
Range on Protein: 361-395 Range on HMM: 330-364/364 Sequence Identity: 22% (8 aa) SHRSPAVRELSKLGAQCMADNPDHRPSLDTIQSQI .. ... ....|| .|.. .|. ||| ..| ... CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | Spk385.AA | TKL | 231-294 | 20 | 4.8e-05 | 14.13 | In-house | 129-205 (364) | Show / Hide |
Range on Protein: 231-294 Range on HMM: 129-205/364 Sequence Identity: 20% (17 aa) LHEPPSLSMGNVVKIAGDIVKGVMEFHDHG--------LLHNDLKNDNVLLEKRGK-----------RYNAVIIDFGMASTIT || . ...| || .|. | .. ..| ||| .|.|. . .. ... | ||| . ... LH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMS |
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| Kinase | Spk385.AA | CAMK | 257-290 | 33 | 8.1e-05 | 10.68 | In-house | 196-243 (425) | Show / Hide |
Range on Protein: 257-290 Range on HMM: 196-243/425 Sequence Identity: 33% (16 aa) HDHGLLHNDLKNDNVLLEKRG--------------KRYNAVIIDFGMA |.|. | ||| .|.|| ... ...| |||||.| HSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFA |
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| Kinase | Spk385.AA | LISK | 243-290 | 36 | 0.000151 | 10.47 | In-house | 104-152 (296) | Show / Hide |
Range on Protein: 243-290 Range on HMM: 104-152/296 Sequence Identity: 36% (18 aa) VKIAGDIVKGVMEFHDHGLLHNDLKNDNVLLEKR-GKRYNAVIIDFGMA |||| || .| |. . .| ||| |.|. .. .......||| | VKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFA |
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| Kinase | Spk385.AA | TKL | 136-159 | 31 | 0.000196 | 11.89 | In-house | 1-32 (364) | Show / Hide |
Range on Protein: 136-159 Range on HMM: 1-32/364 Sequence Identity: 31% (10 aa) IGRGSYGRVVIARHRS--------TGVPLAIK ||.|..| | ...| || . |.| IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVK |
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| Kinase | Spk385.AA | Pkinase_Tyr | 130-159 | 29 | 0.002511 | 11.89 | Pfam | 1-34 (270) | Show / Hide |
Range on Protein: 130-159 Range on HMM: 1-34/270 Sequence Identity: 29% (10 aa) IIALKEIGRGSYGRVVIARHR----STGVPLAIK |. .|..|.|..|.|. .. . .|..| |.| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVK |
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| Kinase | Spk385.AA | Ciliate-C7 | 133-159 | 33 | 0.009305 | 5.21 | In-house | 1-27 (164) | Show / Hide |
Range on Protein: 133-159 Range on HMM: 1-27/164 Sequence Identity: 33% (9 aa) LKEIGRGSYGRVVIARHRSTGVPLAIK .. .|.|..| |..|. .| . ||| FRFLGQGQQGLVLLAKDQKTNMRYAIK |
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| Kinase | Spk385.AA | Pkinase_Tyr | 376-395 | 35 | 0.019172 | 8.9 | Pfam | 251-270 (270) | Show / Hide |
Range on Protein: 376-395 Range on HMM: 251-270/270 Sequence Identity: 35% (7 aa) QCMADNPDHRPSLDTIQSQI ||.. .|..||. |..|. QCWHYDPEDRPTFSEIHEQL |
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