TK11

Species: Sea Urchin
Alias: SPU_009079, TK11, Spk265
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: TK-Unique

Sequence

Name Sequence Type Origin Length Description Download
TK11.AA Protein None 497 None Fasta, JSON
TK11.kin_dom Protein Kinase Domain None 188 None Fasta, JSON

Protein domain

Protein domains of TK11.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
EGF TK11.AA EGF 93-128 38 1.1e-08 36.12 SMART 1-32 (32) Show / Hide
Range on Protein: 93-128
Range on HMM: 1-32/32
Sequence Identity: 38% (16 aa)

ACRYQPCLDN-----GDCILDDSARGYRCDCR-PGYSGRRCE
 |   ||  .     | ||      .|.| |. |||.| |||
ECA--PCHHGGCEQHGTCI------SYTC-CPGPGYTG-RCE

EGF TK11.AA EGF 94-126 36 3.6e-08 30.36 Pfam 1-36 (36) Show / Hide
Range on Protein: 94-126
Range on HMM: 1-36/36
Sequence Identity: 36% (14 aa)

CRYQ--PCLDNGDCILDDSARGYRCDCRPG---YSGRR
|  .  ||. .| |.  .   ||.|.| ||   |.|.|
CNPNNNPCHHHGTCVDTP--GGYTCQCPPGYLGYTGKR

EGF_CA TK11.AA EGF_CA 90-128 40 4.1e-05 15.97 SMART 1-34 (34) Show / Hide
Range on Protein: 90-128
Range on HMM: 1-34/34
Sequence Identity: 40% (17 aa)

DERACRYQPCLDNG---DCILDDSARGYRCDCRPGYSGRRCE
|   |   ||  .|    ||  .   .||| |.|||. |.||
DIDEC---PCQNGGPTGTCI--N-PGSYRC-CPPGYT-RHCE

EGF_2 TK11.AA EGF_2 94-127 27 0.000237 17.1 Pfam 1-29 (29) Show / Hide
Range on Protein: 94-127
Range on HMM: 1-29/29
Sequence Identity: 27% (10 aa)

CRYQPCLD-NGDCILDDSARG-YRCDCRPG-YSGRRC
|    |   .| |. .    |  .|.| .| ..|  |
C----CNGHHGTCNNQ----GCGKCQCDDGWWQGDHC

EGF TK11.AA EGF 134-155 29 10.828957 2.04 Pfam 1-23 (36) Show / Hide
Range on Protein: 134-155
Range on HMM: 1-23/36
Sequence Identity: 29% (7 aa)

CSLN--PCYENEICETIVDADFTC
|. |  ||  . .|      ..||
CNPNNNPCHHHGTCVDTP-GGYTC

Kinase TK11.AA TK-Unique 357-456 44 1.9e-49 168.67 In-house 133-235 (294) Show / Hide
Range on Protein: 357-456
Range on HMM: 133-235/294
Sequence Identity: 44% (47 aa)

LLNFACDIAQGMRHIAALRY--VYMNLCAKNVLITFNNKAKLCDFSMATEVQKPLNIPIPFIEPRNRGMKRWMAYEALL--EGQY-TMKSDVWSYGIVLW
|..||..||.|| ..| .|.  |...|||.|||.| ....|.||| ||..|..  | ..  .. ..| ..||||.|.|.  .|.| |.||||||.|...|
LYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT--NGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMW

EIVTL
||.||
EIFTL

Kinase TK11.AA TK 268-456 14 6.3e-42 137.84 In-house 1-390 (486) Show / Hide
Range on Protein: 268-456
Range on HMM: 1-390/486
Sequence Identity: 14% (58 aa)

LEMGKLLYSGEFS---YVCEGDLKQ----------------------GSDVPIKVAIKLHRDENDQESITEMR-------------NEFQVLANLGK---
...|| | .|.|     |..| ...                      .......||.|  ........  ..              .| .... .     
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNILMLLGQCNRVF---------------------EQSD------------QPPFEP-----------------------------------------
 ||||. |.| | ..                      .  |             |.| .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LPQDELLNFACDIAQGMRHIAAL------RYVYMNLCAKNVLITFNNK-----------AKLCDFS---
                               |.  .|| ....||.||......      ..| ..|.| |.|.. ||.           .|..||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----MATEVQKPLNIPIPFIEPRNRGMKR----------------------WMAYEALLEGQ---------YTMKSDVWSYGIVLWEIVTL
     .| ....  .      . ..|.| .                      ||| |.|....         .| ||||||.|...|||.|.
QGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTY

Kinase TK11.AA TK-Unique 268-354 27 6.1e-28 93.5 In-house 1-89 (294) Show / Hide
Range on Protein: 268-354
Range on HMM: 1-89/294
Sequence Identity: 27% (25 aa)

LEMGKLLYSGEFSYVCEGDLKQGS---DVPIKVAIKLHRDENDQESITEMRNEFQVLANLGKHPNILMLLGQCNRVFEQSDQPPFEPLPQ
||.|.....|.|..|. |......   | ...||.|...|......  .. .|.|.. .||.||||...||.| . . .. .  .|..|.
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPC

Kinase TK11.AA UTK 350-455 30 3.1e-23 76.32 In-house 113-235 (296) Show / Hide
Range on Protein: 350-455
Range on HMM: 113-235/296
Sequence Identity: 30% (38 aa)

EPLPQDELLNFACDIAQGMRHIAALRYVYMNLCAKNVLITFN-------NKAKLCDFS---MATEVQ-----KPLNIPIPFIEPRNRGM--KRWMAYEAL
. |  ...| .| ||| || ...  ..|  .|.|.|.|.. .       ...|..||    |. .|.            .   ......   |||| |||
HWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSN-RYWESYYYMAQHQDRWPIRWMAPEAL

LEG-QYTMKSDVWSYGIVLWEIVT
 .. ..| ||||||.|.|.|||.|
THHTRFTTKSDVWSFGVVCWEIWT

Kinase TK11.AA Tie 352-456 37 1.2e-21 62.03 In-house 111-209 (267) Show / Hide
Range on Protein: 352-456
Range on HMM: 111-209/267
Sequence Identity: 37% (39 aa)

LPQDELLNFACDIAQGMRHIAALRYVYMNLCAKNVLITFNNKAKLCDFSMATEVQKPLNIPIPFIEPRNRGMKRWMAYEALLEGQYTMKSDVWSYGIVLW
|  . .|.|| |.|.|| ...   ..   | |.|.|.  |  .|. || ..          .   .   |   |||| |.|    || ||||||||..||
LSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRGDE------VYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYGVLLW

EIVTL
|||.|
EIVSL

Kinase TK11.AA TyrKc 268-495 22 2.3e-17 57.94 SMART 1-280 (280) Show / Hide
Range on Protein: 268-495
Range on HMM: 1-280/280
Sequence Identity: 22% (69 aa)

LEMGKLLYSGEFSYVCEGDLKQGSDVPIKVAIKLHRDENDQESITEMRNEFQVLANLG-KHPNILMLLGQCNR-------------VFE-----------
...|| | .|.|  |..| .|      |.||.|  ...     . ....| ... .|| .||||. |.| |               |.|           
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QSDQPPFEPLPQDELLNFACDIAQGMRHIAALRYVYMNLCAKNVLITFNNKAKLCDFSMATEV------------QKP-----LN--IPIPFIEPRNRGM
.. .|    |. ..||.|. .||.||....  ...   | | |.|.. |. .| .|| .. ..             ..      .  .||          
RKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI----------

KRWMAYEALLEGQYTMKSDVWSYGIVLWEIVTLEWGEVMKQYYRG------SQPDMVGFVGSRNFPPQSSL--------APE------------------
 |||| |.. .| .| ||||||.|...||| |.      .| | |      |  ... .| ... .||           .|.                  
-RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYG-----QQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

-----IDTM
     .. .
TFSEIHECF

Kinase TK11.AA EGFR 356-455 36 6.7e-17 52.48 In-house 102-198 (258) Show / Hide
Range on Protein: 356-455
Range on HMM: 102-198/258
Sequence Identity: 36% (37 aa)

ELLNFACDIAQGMRHIAALRYVYMNLCAKNVLITFNNKAKLCDFSMATEVQKPLNIPIPFIEPRN-RGMKRWMAYEALLEGQYTMKSDVWSYGIVLWEIV
.|||..  ||.||      | |  .| | |||.   |. |  || .|    | |..    ..    .   .||| | .... || .|||||||. .||..
HLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLA----KLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELM

T
|
T

Kinase TK11.AA TKL 357-458 23 6.6e-15 50.13 In-house 134-287 (364) Show / Hide
Range on Protein: 357-458
Range on HMM: 134-287/364
Sequence Identity: 23% (36 aa)

LLNFACDIAQGMRHIAALR--------YVYMNLCAKNVLITFNNK--------------AKLCDFSMATEVQKPLNIPIPF--------------IEPRN
....| |||.|| .  . .         .. .|  ||.|.  |..              .|.|||  ......  |                      . 
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQ

RGMKRWMAYEALL----------------EGQYTMKSDVWSYGIVLWEIVTLEW
.| .|||| |.|                 ...|. |.||.|.|||||||.| ..
CGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR

Kinase TK11.AA FGFR 426-456 64 7.9e-15 46.92 In-house 204-234 (293) Show / Hide
Range on Protein: 426-456
Range on HMM: 204-234/293
Sequence Identity: 64% (20 aa)

WMAYEALLEGQYTMKSDVWSYGIVLWEIVTL
||| ||| .  || .|||||||. |||| |.
WMAPEALFDRVYTHQSDVWSYGVLLWEIMTY

Kinase TK11.AA Pkinase_Tyr 425-456 53 9.5e-15 50.58 Pfam 179-210 (270) Show / Hide
Range on Protein: 425-456
Range on HMM: 179-210/270
Sequence Identity: 53% (17 aa)

RWMAYEALLEGQYTMKSDVWSYGIVLWEIVTL
.||| |.. .| .| ||||||.|...|||.|.
KWMAPECINYGKFTTKSDVWSFGVLMWEIFTY

Kinase TK11.AA Pkinase_Tyr 268-337 31 2.2e-14 49.36 Pfam 1-73 (270) Show / Hide
Range on Protein: 268-337
Range on HMM: 1-73/270
Sequence Identity: 31% (23 aa)

LEMGKLLYSGEFSYVCEGDLK-QGSDVPIKVAIKLHRDENDQES--ITEMRNEFQVLANLGKHPNILMLLGQC
...|| | .|.|  |..| .| ....  |.||.|  ..  ..|   . .. .| ... .||.||||. |.| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVC

Kinase TK11.AA Src 425-455 61 2.6e-14 45.0 In-house 165-195 (255) Show / Hide
Range on Protein: 425-455
Range on HMM: 165-195/255
Sequence Identity: 61% (19 aa)

RWMAYEALLEGQYTMKSDVWSYGIVLWEIVT
.|.| ||...|..| ||||||.|| |.||||
KWTAPEAINYGRFTIKSDVWSFGILLTEIVT

Kinase TK11.AA Sev 425-456 59 3.1e-12 36.91 In-house 188-219 (277) Show / Hide
Range on Protein: 425-456
Range on HMM: 188-219/277
Sequence Identity: 59% (19 aa)

RWMAYEALLEGQYTMKSDVWSYGIVLWEIVTL
|||| | |. | .|  ||||..||  ||| ||
RWMAPESLMDGYFTTQSDVWAFGILCWEIMTL

Kinase TK11.AA DDR 425-456 50 8.4e-12 37.49 In-house 208-239 (306) Show / Hide
Range on Protein: 425-456
Range on HMM: 208-239/306
Sequence Identity: 50% (16 aa)

RWMAYEALLEGQYTMKSDVWSYGIVLWEIVTL
|||| |..| |  | |||||. |. .||. ..
RWMAWESILLGKFTTKSDVWAFGVTMWEMFMF

Kinase TK11.AA S_TKc 268-496 16 8.2e-10 -33.04 SMART 1-231 (231) Show / Hide
Range on Protein: 268-496
Range on HMM: 1-231/231
Sequence Identity: 16% (45 aa)

LEMGKLLYSGEFSYVCEGDLKQGSDVPIKVAIKLHRDENDQESITEMRNEFQVLANLGKHPNILMLLGQCN----------------RVFEQSDQPPFEP
 |..... .| |. |. .  |       .||||  .          .|.| |.| .  .||||  |.. .                  .|.  .. . ..
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LPQDELLNFACDIAQGMRHIAALRYVYMNLCAKNVLITFNNKAKLCDFSMATEVQKPLNIPIPFIEPRNRGMKRWMAYEALLEGQYTM-KSDVWSY
    .|  .   ... |.... ..  .. ..  |   |.|..     |.||| .|...                |   .|| | |   .|.  |.|.|| 
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GIVLWEIVT----LEWGEVMKQYYRGSQPDMVGFVGS---RN----FPPQSSLA----PEIDTMI
|..|.| ..     .  .... . .   |..  |.     ..          |.      ..  .
GCILYEMLCGYPPFP--QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase TK11.AA Pkinase_Tyr 350-407 34 2.4e-09 32.3 Pfam 106-163 (270) Show / Hide
Range on Protein: 350-407
Range on HMM: 106-163/270
Sequence Identity: 34% (20 aa)

EPLPQDELLNFACDIAQGMRHIAALRYVYMNLCAKNVLITFNNKAKLCDFSMATEVQK
.||.  .||... .||.|| . .. ...   |.|.|.|.| ||..| ||| .|  ...
QPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYN

Kinase TK11.AA Tie 277-338 29 2.1e-08 20.99 In-house 2-62 (267) Show / Hide
Range on Protein: 277-338
Range on HMM: 2-62/267
Sequence Identity: 29% (18 aa)

GEFSYVCEGDLKQGSDVPIKVAIKLHRDENDQESITEMRNEFQVLANLGKHPNILMLLGQCN
| |  |    .|.   . ..||||  ..   ..   .   |  |.  .|.||||. |.| |.
GNFGQVMKAMIKKDGLK-MEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACE

Kinase TK11.AA Sev 268-337 35 2.4e-08 23.76 In-house 1-72 (277) Show / Hide
Range on Protein: 268-337
Range on HMM: 1-72/277
Sequence Identity: 35% (26 aa)

LEMGKLLYSGEFSYVCEGDLKQGS---DVPIKVAIKLHRDE-NDQESITEMRNEFQVLANLGKHPNILMLLGQC
|.. ..| || |  | || .|      . ...||||  |    ||| . |.  | ..  .  |||||. ..| |
LKLRRFLGSGAFGEVYEGQAKDIDGVGEEEQRVAIKTLRKGSTDQEKQ-EFLKEAHLMSKF-KHPNIVCQMGVC

Kinase TK11.AA Src 356-399 36 3.4e-07 20.46 In-house 98-141 (255) Show / Hide
Range on Protein: 356-399
Range on HMM: 98-141/255
Sequence Identity: 36% (16 aa)

ELLNFACDIAQGMRHIAALRYVYMNLCAKNVLITFNNKAKLCDF
.|. .|. .|.||  . . .|.   | |.|||.  || .| .||
QLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADF

Kinase TK11.AA EGFR 268-337 38 3.5e-07 19.71 In-house 1-70 (258) Show / Hide
Range on Protein: 268-337
Range on HMM: 1-70/258
Sequence Identity: 38% (27 aa)

LEMGKLLYSGEFSYVCEG-DLKQGSDVPIKVAIKLHRDENDQESITEMRNEFQVLANLGKHPNILMLLGQC
|  .| | || |  |  |    .|  | | ||||  |.. ....  || .|  |.| . .||... ||| |
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASV-DHPHLVRLLGVC

Kinase TK11.AA DDR 268-337 20 3e-06 17.76 In-house 1-83 (306) Show / Hide
Range on Protein: 268-337
Range on HMM: 1-83/306
Sequence Identity: 20% (17 aa)

LEMGKLLYSGEFSYVCEGDLKQGSD-----VPIK--------VAIKLHRDENDQESITEMRNEFQVLANLGKHPNILMLLGQC
|  .... .|.|  | .  .  . |      ..         || |  | .  .    . . |  ... ...||||  |.| |
LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVC

Kinase TK11.AA UTK 268-337 24 1.2e-05 15.35 In-house 1-79 (296) Show / Hide
Range on Protein: 268-337
Range on HMM: 1-79/296
Sequence Identity: 24% (20 aa)

LEMGKLLYSGEFSYVCEGDLKQGS------DVPIKVAIKLHRDENDQESIT---EMRNEFQ---VLANLGKHPNILMLLGQC
.. |..| .|.|  |......| |      || .||.    .....| . .   . ..| .   .....  |||.| |.| |
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ---HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVC

Kinase TK11.AA TKL 274-335 21 1.2e-05 16.32 In-house 1-92 (364) Show / Hide
Range on Protein: 274-335
Range on HMM: 1-92/364
Sequence Identity: 21% (20 aa)

LYSGEFSYVCEGDLKQ---------GSDVPIKVAIKLHRDE-------------------NDQESITEMRNEFQVLANLGK--HPNILMLLG
. || |. |. | ...         | || .|.  . . ||                   ||.|.  ..  | ...  . .  ||||. ..|
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMG

Kinase TK11.AA FGFR 352-407 33 2.1e-05 14.34 In-house 133-188 (293) Show / Hide
Range on Protein: 352-407
Range on HMM: 133-188/293
Sequence Identity: 33% (19 aa)

LPQDELLNFACDIAQGMRHIAALRYVYMNLCAKNVLITFNNKAKLCDFSMATEVQK
| | .|  .|  .|.||   |  . .   | | |||.| ..  | |||  |  ...
LTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHC

Kinase TK11.AA Pkinase 425-455 34 0.000133 17.36 Pfam 176-207 (293) Show / Hide
Range on Protein: 425-455
Range on HMM: 176-207/293
Sequence Identity: 34% (11 aa)

RWMAYEALL-EGQYTMKSDVWSYGIVLWEIVT
..|| | ..    |. |.|.||.|..|.| ..
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC

Kinase TK11.AA DDR 357-402 27 0.000361 10.5 In-house 136-183 (306) Show / Hide
Range on Protein: 357-402
Range on HMM: 136-183/306
Sequence Identity: 27% (13 aa)

LLNFACDIAQGMRHIAALRYVYMNLCAKNVLITFNNKAKLCDFS--MA
..  . .|| ||.. . .. |   | ..|.|.  .  .| |||   |.
CVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMS

Kinase TK11.AA FGFR 268-337 29 0.000563 9.38 In-house 1-74 (293) Show / Hide
Range on Protein: 268-337
Range on HMM: 1-74/293
Sequence Identity: 29% (22 aa)

LEMGKLLYSGEFSYVCEGDLK----QGSDVPIKVAIKLHRDENDQESITEMRNEFQVLANLGKHPNILMLLGQC
| .|| |  | |  |  .  |    .  .  |.||.|   ..   . .     |  ..   |||.||. ||| |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCC

Kinase TK11.AA Pkinase 268-335 26 0.055508 8.09 Pfam 1-67 (293) Show / Hide
Range on Protein: 268-335
Range on HMM: 1-67/293
Sequence Identity: 26% (18 aa)

LEMGKLLYSGEFSYVCEGDLKQGSD-VPIKVAIKLHRDENDQESITEMRNEFQVLANLGKHPNILMLLG
.. |. . || |. |...  |  .. | .|.  | |.... ... .   .| |....| .||||. |..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRL-NHPNIVRLYD